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The map label for this gene is deoA

Identifier: 107023142

GI number: 107023142

Start: 1764509

End: 1765825

Strand: Reverse

Name: deoA

Synonym: Bcen_1591

Alternate gene names: 107023142

Gene position: 1765825-1764509 (Counterclockwise)

Preceding gene: 107023143

Following gene: 107023141

Centisome position: 53.6

GC content: 71.53

Gene sequence:

>1317_bases
ATGTTTCTACCGCAGGAATTCATTCGCAGGAAGCGTGACGGGCAGCCGCTCGATCGCGACGACATGGCCGCGTTCGTGCG
CGGCGTGACCGACGGCAGCGTGACCGAGGGCCAGGTGGCCGCGTTCGCGATGGCCGTGTATTTCAACGACCTGAGCACCG
ACGAGCGCGTCGCGCTGACGCTCGCGCAGCGCGATTCGGGCGACGTGCTCGACTGGCGCGCACTCGATCTCGGCGGGCCG
GTGATCGACAAGCATTCGACGGGCGGCGTCGGCGACGTCGTGTCGCTGATGCTCGGGCCGATGGTGGCCGCGTGCGGCGG
CTACGTGCCGATGATCTCGGGGCGCGGGCTCGGCCATACCGGCGGCACGCTCGACAAGTTGAGCGCGATCCCCGGTTACG
ACGTGATGCCCGATACGGATGCGTTTCGCCGCACGGTGCGCGAGGTCGGCGTCGCGATCATCGGGCAGACCGCGCGGCTC
GCGCCGGCCGACAAGCGCATCTATGCGATCCGCGACGTGACGGCGACCGTCGAATCGGTCGCGATGATCACCGCGTCGAT
CTTGTCGAAGAAGCTCGCGGCGGGGCTCGACGGGCTCGTGATGGACGTCAAGGTCGGCTCCGGCGCGTTCATGCCGACCG
CGGAGAAATCGGCGGAACTGGCGCGCAGCATCGTCGACGTCGGCAATGGCGCCGGCATGAAGACGACCGCGATCCTCACC
GACATGAACCAGTCGCTCGCGCCGTGCGCGGGCAATGCGCTCGAGGTGGCGTGCGCGATCGACTACCTGACGGGCAAGTC
GCGTCCCGCCCGTTTGCACGACGTGACGATGGCGCTGTCGGCGGAGCTGCTCGTCACCGGCGGGCTGGCGCGCGATGCCG
CCCATGCGCGCGAGAAGCTGCAGCAGGCGCTCGATTCGGGCGCGGCCGCCGAGCGTTTCGCGCGCATGGTCGCCGCGCTC
GGCGGCCCGGCCGACCTGCTCGACGCGCCCGCGCGGCATCTGGCGCGGGCGGCGGTGATCGTGCCGGTTCCGGCTCCCGT
GAGCGGCGTGGTGCAGCGGGTCGACTGCCGCGCGCTCGGGCTCGCGGTGGTCGCGCTCGGCGGCGGCCGCACGCGCGCGG
AGGATGCGATCGACGTCAGCGTCGGCTTGTCGGCGCTCGCGGAGATCGGGCAGCGCATCGAGGCCGGCGAGCCGCTGGGT
TTCGTGCACGCCCGCGACGAAGCGGCCGCGGCCCACGCGGTGGATGCGATCCGCCGCGGCTACGTGCTCGGCGAGACCGG
CGAAGCGCCGCCGACCCTTTACCAGCGCGTCGACTGA

Upstream 100 bases:

>100_bases
CGGCCGCGACGCTGTCGAACCTGATGAGCGCGGCGATTGCCGGCCTGTTTTTCTCGCTGCATTGAACCGTACAGTCGACT
CCGATCGAAGCGAGGCAACG

Downstream 100 bases:

>100_bases
CCGCGCTCCCGGAGGCTTCACCACGATGGAACGAGACGAACTGATCGAACAGGCGAAGGCGGCGCGCGAACGCGCGTATG
CGCCGTATTCGCGCTTCAAG

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MFLPQEFIRRKRDGQPLDRDDMAAFVRGVTDGSVTEGQVAAFAMAVYFNDLSTDERVALTLAQRDSGDVLDWRALDLGGP
VIDKHSTGGVGDVVSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLSAIPGYDVMPDTDAFRRTVREVGVAIIGQTARL
APADKRIYAIRDVTATVESVAMITASILSKKLAAGLDGLVMDVKVGSGAFMPTAEKSAELARSIVDVGNGAGMKTTAILT
DMNQSLAPCAGNALEVACAIDYLTGKSRPARLHDVTMALSAELLVTGGLARDAAHAREKLQQALDSGAAAERFARMVAAL
GGPADLLDAPARHLARAAVIVPVPAPVSGVVQRVDCRALGLAVVALGGGRTRAEDAIDVSVGLSALAEIGQRIEAGEPLG
FVHARDEAAAAHAVDAIRRGYVLGETGEAPPTLYQRVD

Sequences:

>Translated_438_residues
MFLPQEFIRRKRDGQPLDRDDMAAFVRGVTDGSVTEGQVAAFAMAVYFNDLSTDERVALTLAQRDSGDVLDWRALDLGGP
VIDKHSTGGVGDVVSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLSAIPGYDVMPDTDAFRRTVREVGVAIIGQTARL
APADKRIYAIRDVTATVESVAMITASILSKKLAAGLDGLVMDVKVGSGAFMPTAEKSAELARSIVDVGNGAGMKTTAILT
DMNQSLAPCAGNALEVACAIDYLTGKSRPARLHDVTMALSAELLVTGGLARDAAHAREKLQQALDSGAAAERFARMVAAL
GGPADLLDAPARHLARAAVIVPVPAPVSGVVQRVDCRALGLAVVALGGGRTRAEDAIDVSVGLSALAEIGQRIEAGEPLG
FVHARDEAAAAHAVDAIRRGYVLGETGEAPPTLYQRVD
>Mature_438_residues
MFLPQEFIRRKRDGQPLDRDDMAAFVRGVTDGSVTEGQVAAFAMAVYFNDLSTDERVALTLAQRDSGDVLDWRALDLGGP
VIDKHSTGGVGDVVSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLSAIPGYDVMPDTDAFRRTVREVGVAIIGQTARL
APADKRIYAIRDVTATVESVAMITASILSKKLAAGLDGLVMDVKVGSGAFMPTAEKSAELARSIVDVGNGAGMKTTAILT
DMNQSLAPCAGNALEVACAIDYLTGKSRPARLHDVTMALSAELLVTGGLARDAAHAREKLQQALDSGAAAERFARMVAAL
GGPADLLDAPARHLARAAVIVPVPAPVSGVVQRVDCRALGLAVVALGGGRTRAEDAIDVSVGLSALAEIGQRIEAGEPLG
FVHARDEAAAAHAVDAIRRGYVLGETGEAPPTLYQRVD

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=428, Percent_Identity=42.5233644859813, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI4503445, Length=428, Percent_Identity=42.5233644859813, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI166158922, Length=428, Percent_Identity=42.5233644859813, Blast_Score=280, Evalue=1e-75,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=58.675799086758, Blast_Score=518, Evalue=1e-148,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_BURCA (Q1BV59)

Other databases:

- EMBL:   CP000378
- RefSeq:   YP_621469.1
- ProteinModelPortal:   Q1BV59
- SMR:   Q1BV59
- STRING:   Q1BV59
- GeneID:   4092876
- GenomeReviews:   CP000378_GR
- KEGG:   bcn:Bcen_1591
- eggNOG:   COG0213
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- ProtClustDB:   PRK05820
- BioCyc:   BCEN331271:BCEN_1591-MONOMER
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 45455; Mature: 45455

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLPQEFIRRKRDGQPLDRDDMAAFVRGVTDGSVTEGQVAAFAMAVYFNDLSTDERVALT
CCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEE
LAQRDSGDVLDWRALDLGGPVIDKHSTGGVGDVVSLMLGPMVAACGGYVPMISGRGLGHT
EEECCCCCEEEEEEEECCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
GGTLDKLSAIPGYDVMPDTDAFRRTVREVGVAIIGQTARLAPADKRIYAIRDVTATVESV
CCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEEHHHHHHHHHH
AMITASILSKKLAAGLDGLVMDVKVGSGAFMPTAEKSAELARSIVDVGNGAGMKTTAILT
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHEEH
DMNQSLAPCAGNALEVACAIDYLTGKSRPARLHDVTMALSAELLVTGGLARDAAHAREKL
HCCCCCCCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHEECCHHHHHHHHHHHH
QQALDSGAAAERFARMVAALGGPADLLDAPARHLARAAVIVPVPAPVSGVVQRVDCRALG
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHE
LAVVALGGGRTRAEDAIDVSVGLSALAEIGQRIEAGEPLGFVHARDEAAAAHAVDAIRRG
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCC
YVLGETGEAPPTLYQRVD
EEECCCCCCCHHHHHCCC
>Mature Secondary Structure
MFLPQEFIRRKRDGQPLDRDDMAAFVRGVTDGSVTEGQVAAFAMAVYFNDLSTDERVALT
CCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEE
LAQRDSGDVLDWRALDLGGPVIDKHSTGGVGDVVSLMLGPMVAACGGYVPMISGRGLGHT
EEECCCCCEEEEEEEECCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
GGTLDKLSAIPGYDVMPDTDAFRRTVREVGVAIIGQTARLAPADKRIYAIRDVTATVESV
CCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEEHHHHHHHHHH
AMITASILSKKLAAGLDGLVMDVKVGSGAFMPTAEKSAELARSIVDVGNGAGMKTTAILT
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHEEH
DMNQSLAPCAGNALEVACAIDYLTGKSRPARLHDVTMALSAELLVTGGLARDAAHAREKL
HCCCCCCCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHEECCHHHHHHHHHHHH
QQALDSGAAAERFARMVAALGGPADLLDAPARHLARAAVIVPVPAPVSGVVQRVDCRALG
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHE
LAVVALGGGRTRAEDAIDVSVGLSALAEIGQRIEAGEPLGFVHARDEAAAAHAVDAIRRG
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCC
YVLGETGEAPPTLYQRVD
EEECCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA