BacMap

Definition	Burkholderia cenocepacia AU 1054 chromosome 1, complete sequence.
Accession	NC_008060
Length	3,294,563

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The map label for this gene is yusZ [H]

Identifier: 107023003

GI number: 107023003

Start: 1607865

End: 1608698

Strand: Reverse

Name: yusZ [H]

Synonym: Bcen_1451

Alternate gene names: 107023003

Gene position: 1608698-1607865 (Counterclockwise)

Preceding gene: 107023005

Following gene: 107023002

Centisome position: 48.83

GC content: 69.42

Gene sequence:

>834_bases
ATGGCATCCGGCAACATCATGCTCATCACCGGCGTCAGCAGCGGGTTCGGCCGTGCGCTGGCCCAGGAAGCGCTGGCCGC
CGGTCACACGGTGGTTGGTACGGTGCGCGGCGCGCAGGCGGCGCGCGACTTCGAAGCGTTGTCCCCGCAGGCGGCCGTCG
CGCGGGTGCTCGACGTGACCGACTTCGAGCGTATCGACGGCGTCGTCGCGGACATCGAGGCGAACGTCGGGCCCGTCGAC
GTGCTGGTGAACAACGCGGGTTACGGGCACGAAGGGATCATGGAGGAGGCGCCGCTCGACGAGATGCGCCGGCAGTTCGA
CGTGAACGTGTTCGGCGCGGTCGCGATGATGAAGGCCGTCGTGCCGTTCATGCGCGAACGCCGGCGCGGCCGCATCCTGA
ACATCACGTCGATGGGCGGGCACATCACGATGCCGGGCATCGCGTACTACTGCGGCAGCAAGTTCGCGCTGGAGGGCATT
TCCGAGACGCTCGGCAAGGAACTCGAACCGTTCGGCATCGCGGTGACGGCCGTCGCGCCAGGTTCGTTCCGCACCGACTG
GGCTGGCCGCTCGATGGCGCGCACGCCGCGCTCGATCGCCGACTACGACGCGTTGTTCGATCCGATCCGCCGCGCGCGGG
AGGAGAAAAGCGGCAAGCAGCCAGGCGACCCCGCGAAGGCCGCGCGGGCGATGCTCGCCGTGATCGCGGCGGACCATCCG
CCCGCGCATCTGCTGCTCGGCAGCGACGCGCTGCGGCTCGTGCGGAACAAGCTGGCGGCGCTGGACGAAGAAATCCGCGC
GTGGGAAGCCGTGACGGTGTCGACGGACGGTTGA

Upstream 100 bases:

>100_bases
ACTCATAGTTTTGTGCAAGAAAATCAGCGGAATCGGGCTTATTCGGCGTCGTTCGTCAGACTAGTATGCATGCTTCAATC
GACATTCGGGAGAGGCTCAC

Downstream 100 bases:

>100_bases
CGGCTGACGCGCGCGGCGTCGTTCGTTTCCTGCCGGTGGATGATCGGCCATCGCATTGCACGATGGCGTCGTGGTTTCAC
AATAATGGCCGATAATGGCA

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFA [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MASGNIMLITGVSSGFGRALAQEALAAGHTVVGTVRGAQAARDFEALSPQAAVARVLDVTDFERIDGVVADIEANVGPVD
VLVNNAGYGHEGIMEEAPLDEMRRQFDVNVFGAVAMMKAVVPFMRERRRGRILNITSMGGHITMPGIAYYCGSKFALEGI
SETLGKELEPFGIAVTAVAPGSFRTDWAGRSMARTPRSIADYDALFDPIRRAREEKSGKQPGDPAKAARAMLAVIAADHP
PAHLLLGSDALRLVRNKLAALDEEIRAWEAVTVSTDG

Sequences:

>Translated_277_residues
MASGNIMLITGVSSGFGRALAQEALAAGHTVVGTVRGAQAARDFEALSPQAAVARVLDVTDFERIDGVVADIEANVGPVD
VLVNNAGYGHEGIMEEAPLDEMRRQFDVNVFGAVAMMKAVVPFMRERRRGRILNITSMGGHITMPGIAYYCGSKFALEGI
SETLGKELEPFGIAVTAVAPGSFRTDWAGRSMARTPRSIADYDALFDPIRRAREEKSGKQPGDPAKAARAMLAVIAADHP
PAHLLLGSDALRLVRNKLAALDEEIRAWEAVTVSTDG
>Mature_276_residues
ASGNIMLITGVSSGFGRALAQEALAAGHTVVGTVRGAQAARDFEALSPQAAVARVLDVTDFERIDGVVADIEANVGPVDV
LVNNAGYGHEGIMEEAPLDEMRRQFDVNVFGAVAMMKAVVPFMRERRRGRILNITSMGGHITMPGIAYYCGSKFALEGIS
ETLGKELEPFGIAVTAVAPGSFRTDWAGRSMARTPRSIADYDALFDPIRRAREEKSGKQPGDPAKAARAMLAVIAADHPP
AHLLLGSDALRLVRNKLAALDEEIRAWEAVTVSTDG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7657478, Length=260, Percent_Identity=34.6153846153846, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI4503817, Length=221, Percent_Identity=29.8642533936652, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI20149619, Length=192, Percent_Identity=32.8125, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI223718074, Length=269, Percent_Identity=31.5985130111524, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI7706318, Length=196, Percent_Identity=30.6122448979592, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI50726952, Length=266, Percent_Identity=30.4511278195489, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI22507405, Length=191, Percent_Identity=31.9371727748691, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI40548397, Length=259, Percent_Identity=26.2548262548263, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI214010158, Length=259, Percent_Identity=26.2548262548263, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI214010156, Length=259, Percent_Identity=26.2548262548263, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI22758144, Length=259, Percent_Identity=26.2548262548263, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI44680136, Length=185, Percent_Identity=31.8918918918919, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI44680133, Length=185, Percent_Identity=31.8918918918919, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI17738292, Length=185, Percent_Identity=31.8918918918919, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI150247226, Length=273, Percent_Identity=27.4725274725275, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI119392083, Length=187, Percent_Identity=32.620320855615, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI19743808, Length=222, Percent_Identity=28.3783783783784, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI210032110, Length=186, Percent_Identity=31.7204301075269, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI142976729, Length=192, Percent_Identity=29.6875, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI109715829, Length=259, Percent_Identity=27.027027027027, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40807363, Length=192, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI4504503, Length=193, Percent_Identity=31.6062176165803, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI32483357, Length=193, Percent_Identity=30.5699481865285, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI157739938, Length=191, Percent_Identity=25.6544502617801, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI40254992, Length=185, Percent_Identity=30.8108108108108, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI210032112, Length=182, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI126723750, Length=193, Percent_Identity=27.979274611399, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI25282469, Length=220, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI33667109, Length=219, Percent_Identity=30.5936073059361, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031737, Length=193, Percent_Identity=31.0880829015544, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=30.6010928961749, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI59889578, Length=136, Percent_Identity=27.9411764705882, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=186, Percent_Identity=37.0967741935484, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1790717, Length=187, Percent_Identity=33.1550802139037, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786701, Length=191, Percent_Identity=31.9371727748691, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1787820, Length=179, Percent_Identity=31.8435754189944, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082100, Length=217, Percent_Identity=29.9539170506912, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788459, Length=191, Percent_Identity=31.413612565445, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786812, Length=187, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787905, Length=229, Percent_Identity=31.8777292576419, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI2367365, Length=186, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789208, Length=195, Percent_Identity=29.7435897435897, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=25.78125, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17557780, Length=196, Percent_Identity=31.6326530612245, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115534660, Length=183, Percent_Identity=30.0546448087432, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17507613, Length=197, Percent_Identity=29.4416243654822, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32563809, Length=197, Percent_Identity=29.4416243654822, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193203117, Length=213, Percent_Identity=29.1079812206573, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193203115, Length=212, Percent_Identity=28.7735849056604, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193210355, Length=250, Percent_Identity=26.8, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=183, Percent_Identity=28.9617486338798, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=214, Percent_Identity=29.4392523364486, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=233, Percent_Identity=24.8927038626609, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=190, Percent_Identity=28.9473684210526, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=190, Percent_Identity=27.8947368421053, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=234, Percent_Identity=24.3589743589744, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=202, Percent_Identity=28.2178217821782, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71997402, Length=197, Percent_Identity=26.3959390862944, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=196, Percent_Identity=29.5918367346939, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=198, Percent_Identity=28.2828282828283, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17570069, Length=196, Percent_Identity=26.530612244898, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=239, Percent_Identity=27.1966527196653, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=214, Percent_Identity=28.0373831775701, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=196, Percent_Identity=27.0408163265306, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=200, Percent_Identity=30, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=195, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6322861, Length=190, Percent_Identity=28.9473684210526, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322067, Length=193, Percent_Identity=28.4974093264249, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=186, Percent_Identity=29.0322580645161, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281364892, Length=220, Percent_Identity=30.4545454545455, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21358495, Length=190, Percent_Identity=33.1578947368421, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI116007236, Length=208, Percent_Identity=27.4038461538462, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21356301, Length=216, Percent_Identity=28.2407407407407, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641232, Length=195, Percent_Identity=30.2564102564103, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24651139, Length=197, Percent_Identity=29.4416243654822, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357041, Length=237, Percent_Identity=27.4261603375527, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641388, Length=195, Percent_Identity=30.2564102564103, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI23397609, Length=187, Percent_Identity=32.0855614973262, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI116007238, Length=182, Percent_Identity=27.4725274725275, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221510726, Length=128, Percent_Identity=35.15625, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24643142, Length=179, Percent_Identity=28.4916201117318, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24648944, Length=209, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640492, Length=208, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281364494, Length=221, Percent_Identity=28.0542986425339, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355631, Length=170, Percent_Identity=30, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571526, Length=189, Percent_Identity=29.1005291005291, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24648693, Length=197, Percent_Identity=28.9340101522843, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355889, Length=197, Percent_Identity=28.9340101522843, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24580925, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644339, Length=243, Percent_Identity=25.5144032921811, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571387, Length=194, Percent_Identity=29.3814432989691, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24649181, Length=192, Percent_Identity=29.6875, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581726, Length=138, Percent_Identity=28.9855072463768, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007234, Length=195, Percent_Identity=29.2307692307692, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 29501; Mature: 29370

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGNIMLITGVSSGFGRALAQEALAAGHTVVGTVRGAQAARDFEALSPQAAVARVLDVT
CCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHH
DFERIDGVVADIEANVGPVDVLVNNAGYGHEGIMEEAPLDEMRRQFDVNVFGAVAMMKAV
HHHHHCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHH
VPFMRERRRGRILNITSMGGHITMPGIAYYCGSKFALEGISETLGKELEPFGIAVTAVAP
HHHHHHHHCCCEEEEECCCCEEECCHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEECC
GSFRTDWAGRSMARTPRSIADYDALFDPIRRAREEKSGKQPGDPAKAARAMLAVIAADHP
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
PAHLLLGSDALRLVRNKLAALDEEIRAWEAVTVSTDG
CCEEEECHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
>Mature Secondary Structure 
ASGNIMLITGVSSGFGRALAQEALAAGHTVVGTVRGAQAARDFEALSPQAAVARVLDVT
CCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHH
DFERIDGVVADIEANVGPVDVLVNNAGYGHEGIMEEAPLDEMRRQFDVNVFGAVAMMKAV
HHHHHCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHH
VPFMRERRRGRILNITSMGGHITMPGIAYYCGSKFALEGISETLGKELEPFGIAVTAVAP
HHHHHHHHCCCEEEEECCCCEEECCHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEECC
GSFRTDWAGRSMARTPRSIADYDALFDPIRRAREEKSGKQPGDPAKAARAMLAVIAADHP
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
PAHLLLGSDALRLVRNKLAALDEEIRAWEAVTVSTDG
CCEEEECHHHHHHHHHHHHHHHHHHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377; 8396117 [H]