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The map label for this gene is fdh [H]

Identifier: 107022944

GI number: 107022944

Start: 1531900

End: 1533105

Strand: Reverse

Name: fdh [H]

Synonym: Bcen_1392

Alternate gene names: 107022944

Gene position: 1533105-1531900 (Counterclockwise)

Preceding gene: 107022945

Following gene: 107022942

Centisome position: 46.53

GC content: 69.24

Gene sequence:

>1206_bases
ATGAAAGCAGTCGTATTTCACGGCATCGGCGATATTCGCATCGACACGGTGCCCGATCCGGAAGTCTCCGCGACGACCGA
CGCGGTCGTGCGTCTCACGGCCAGCGCGATCTGCGGCACCGATCTGCACATGGTGCGCGGCACGCTCGGCGGCATGAAGC
CGGGCACGATTCTCGGCCACGAAGGCGTCGGCATCGTCGAGGCGGTCGGACGCGACGTGCGTAACCTGCGGCGCGGCGAT
CGCGTGCTGATTCCGTCGACGATCGCATGCGGCAGTTGCGCCTACTGTCGCGCGGGCTATACCGCGCAATGCGACGTCGC
GAATCCGGGCGGGCCGCGTGCGGGCACGTCGTTCTTCGGTGGGCCGGCCGAAACGGGCCCGGTCGACGGGCTGCAGGCCG
AATACGCGCGCACGCCGCTTGCGCATGCGAGCCTGATCCGGCTGCCCGATGCGATCGACGACGATCGCGCGATCCTGATG
TCGGACATTTTCCCCACCGGCTATTTCGGCGCGCAGCTCGCGGAAGTGAAGCCGGGCGATACGGTCGCCGTGTTCGGCGC
GGGGCCGGTCGGGCAGTTCGCGATCGCGAGCGCGAAGCTGATGGGCGCCGGACGCGTGATCGCGATCGACCGCATCGCGT
CGCGGCTCGAGATGGCGTGCGCGCAGGGCGCCGAGATCGTCGATTTCTCCGAGGACGATCCGGTCGATACGGTGCTGCGG
CTCACCGGCGGGATCGGCGTCGATCGTGTGATCGACGCGGTGGGCGTCGACGCGATGCGCGCGACGCACGGGCCGGCCGC
GGCCGATCGCGATGCCGCGCGCGCATTCGATGCCGAAGTCGACGCGATCGTGCCGCACCGCAAGCCGGACGGCCGCAACT
GGGTGCCGGGCGACGGGCCGTCGCAGGTGCTGCAATGGGCGGTGCGCGCGGTCGCGAAGGCCGGCACGATCTCGGTGATC
GGCGTGTACCCGCCGGCCGCGCGCGTGTTTCCGATCGGCGAGGCGATGAACCGCAACCTGACGATCAAGATGGGCAACTG
CAATCACCGGACGGTGACGCCGCCGCTCGTCGAACTGGTGCGCAGCGGCGCATTCGATCCGCTGTCGGTGCTCACGCGTA
CCGAGCCGCTGACCAACGCGATCGATGCGTATCGCGCGTTCGACGTGCGCGAGCCGGGGTGGATGAAGGTGAAGCTCGCA
CCATGA

Upstream 100 bases:

>100_bases
TCTCCAATGGCGCGCCGCGCGCGCTCCACAGGCGCATGCCTTGCTCGATCGGCTCGACGGTGACCTTCACCGTTTCCGCT
TTCGACAAGGAGGGCCTGAC

Downstream 100 bases:

>100_bases
CGACGACCCCACGAACCGAAACCGGGAGCACTGCAATGACCGATCAATACGACAACTGTATGGCCGCTTGCGACGCCTGC
GCGCACGCATGCGATACCTG

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKAVVFHGIGDIRIDTVPDPEVSATTDAVVRLTASAICGTDLHMVRGTLGGMKPGTILGHEGVGIVEAVGRDVRNLRRGD
RVLIPSTIACGSCAYCRAGYTAQCDVANPGGPRAGTSFFGGPAETGPVDGLQAEYARTPLAHASLIRLPDAIDDDRAILM
SDIFPTGYFGAQLAEVKPGDTVAVFGAGPVGQFAIASAKLMGAGRVIAIDRIASRLEMACAQGAEIVDFSEDDPVDTVLR
LTGGIGVDRVIDAVGVDAMRATHGPAAADRDAARAFDAEVDAIVPHRKPDGRNWVPGDGPSQVLQWAVRAVAKAGTISVI
GVYPPAARVFPIGEAMNRNLTIKMGNCNHRTVTPPLVELVRSGAFDPLSVLTRTEPLTNAIDAYRAFDVREPGWMKVKLA
P

Sequences:

>Translated_401_residues
MKAVVFHGIGDIRIDTVPDPEVSATTDAVVRLTASAICGTDLHMVRGTLGGMKPGTILGHEGVGIVEAVGRDVRNLRRGD
RVLIPSTIACGSCAYCRAGYTAQCDVANPGGPRAGTSFFGGPAETGPVDGLQAEYARTPLAHASLIRLPDAIDDDRAILM
SDIFPTGYFGAQLAEVKPGDTVAVFGAGPVGQFAIASAKLMGAGRVIAIDRIASRLEMACAQGAEIVDFSEDDPVDTVLR
LTGGIGVDRVIDAVGVDAMRATHGPAAADRDAARAFDAEVDAIVPHRKPDGRNWVPGDGPSQVLQWAVRAVAKAGTISVI
GVYPPAARVFPIGEAMNRNLTIKMGNCNHRTVTPPLVELVRSGAFDPLSVLTRTEPLTNAIDAYRAFDVREPGWMKVKLA
P
>Mature_401_residues
MKAVVFHGIGDIRIDTVPDPEVSATTDAVVRLTASAICGTDLHMVRGTLGGMKPGTILGHEGVGIVEAVGRDVRNLRRGD
RVLIPSTIACGSCAYCRAGYTAQCDVANPGGPRAGTSFFGGPAETGPVDGLQAEYARTPLAHASLIRLPDAIDDDRAILM
SDIFPTGYFGAQLAEVKPGDTVAVFGAGPVGQFAIASAKLMGAGRVIAIDRIASRLEMACAQGAEIVDFSEDDPVDTVLR
LTGGIGVDRVIDAVGVDAMRATHGPAAADRDAARAFDAEVDAIVPHRKPDGRNWVPGDGPSQVLQWAVRAVAKAGTISVI
GVYPPAARVFPIGEAMNRNLTIKMGNCNHRTVTPPLVELVRSGAFDPLSVLTRTEPLTNAIDAYRAFDVREPGWMKVKLA
P

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=282, Percent_Identity=31.9148936170213, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4501933, Length=282, Percent_Identity=30.4964539007092, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71743840, Length=253, Percent_Identity=31.2252964426877, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI262073058, Length=253, Percent_Identity=31.2252964426877, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI34577061, Length=246, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI156627571, Length=263, Percent_Identity=30.0380228136882, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI71565154, Length=285, Percent_Identity=31.9298245614035, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71565152, Length=249, Percent_Identity=32.1285140562249, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4501939, Length=234, Percent_Identity=29.4871794871795, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI156523966, Length=234, Percent_Identity=29.4871794871795, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786825, Length=412, Percent_Identity=36.1650485436893, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI87082125, Length=217, Percent_Identity=33.1797235023041, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI87081918, Length=221, Percent_Identity=33.9366515837104, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790045, Length=242, Percent_Identity=32.6446280991736, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787863, Length=225, Percent_Identity=30.2222222222222, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788075, Length=265, Percent_Identity=29.0566037735849, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786552, Length=251, Percent_Identity=32.6693227091633, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI226510992, Length=231, Percent_Identity=31.1688311688312, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788407, Length=224, Percent_Identity=29.4642857142857, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790718, Length=211, Percent_Identity=26.5402843601896, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=390, Percent_Identity=26.1538461538462, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=229, Percent_Identity=27.5109170305677, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=287, Percent_Identity=28.9198606271777, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=254, Percent_Identity=30.7086614173228, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=286, Percent_Identity=28.6713286713287, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=240, Percent_Identity=32.0833333333333, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=252, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320033, Length=255, Percent_Identity=35.2941176470588, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=265, Percent_Identity=31.6981132075472, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=265, Percent_Identity=31.6981132075472, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=266, Percent_Identity=28.1954887218045, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=281, Percent_Identity=27.0462633451957, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=252, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=288, Percent_Identity=26.3888888888889, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=250, Percent_Identity=29.2, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=252, Percent_Identity=30.1587301587302, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=236, Percent_Identity=27.1186440677966, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137530, Length=264, Percent_Identity=29.9242424242424, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17737897, Length=265, Percent_Identity=29.811320754717, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737895, Length=254, Percent_Identity=31.496062992126, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45550770, Length=207, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45551930, Length=207, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221457811, Length=207, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42005; Mature: 42005

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVFHGIGDIRIDTVPDPEVSATTDAVVRLTASAICGTDLHMVRGTLGGMKPGTILGH
CCEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEECC
EGVGIVEAVGRDVRNLRRGDRVLIPSTIACGSCAYCRAGYTAQCDVANPGGPRAGTSFFG
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCC
GPAETGPVDGLQAEYARTPLAHASLIRLPDAIDDDRAILMSDIFPTGYFGAQLAEVKPGD
CCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCCCCCEEEEHHCCCCCCCCCEEEECCCCC
TVAVFGAGPVGQFAIASAKLMGAGRVIAIDRIASRLEMACAQGAEIVDFSEDDPVDTVLR
EEEEEECCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
LTGGIGVDRVIDAVGVDAMRATHGPAAADRDAARAFDAEVDAIVPHRKPDGRNWVPGDGP
HHCCCCHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHCCCCCEECCCCCCCCCCCCCCCCH
SQVLQWAVRAVAKAGTISVIGVYPPAARVFPIGEAMNRNLTIKMGNCNHRTVTPPLVELV
HHHHHHHHHHHHCCCCEEEEEECCCCCEEEECHHHHCCEEEEEECCCCCCCCCHHHHHHH
RSGAFDPLSVLTRTEPLTNAIDAYRAFDVREPGWMKVKLAP
HCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECC
>Mature Secondary Structure
MKAVVFHGIGDIRIDTVPDPEVSATTDAVVRLTASAICGTDLHMVRGTLGGMKPGTILGH
CCEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEECC
EGVGIVEAVGRDVRNLRRGDRVLIPSTIACGSCAYCRAGYTAQCDVANPGGPRAGTSFFG
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCC
GPAETGPVDGLQAEYARTPLAHASLIRLPDAIDDDRAILMSDIFPTGYFGAQLAEVKPGD
CCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCCCCCEEEEHHCCCCCCCCCEEEECCCCC
TVAVFGAGPVGQFAIASAKLMGAGRVIAIDRIASRLEMACAQGAEIVDFSEDDPVDTVLR
EEEEEECCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
LTGGIGVDRVIDAVGVDAMRATHGPAAADRDAARAFDAEVDAIVPHRKPDGRNWVPGDGP
HHCCCCHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHCCCCCEECCCCCCCCCCCCCCCCH
SQVLQWAVRAVAKAGTISVIGVYPPAARVFPIGEAMNRNLTIKMGNCNHRTVTPPLVELV
HHHHHHHHHHHHCCCCEEEEEECCCCCEEEECHHHHCCEEEEEECCCCCCCCCHHHHHHH
RSGAFDPLSVLTRTEPLTNAIDAYRAFDVREPGWMKVKLAP
HCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]