Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 107021841

GI number: 107021841

Start: 307141

End: 309144

Strand: Reverse

Name: mutL [H]

Synonym: Bcen_0281

Alternate gene names: 107021841

Gene position: 309144-307141 (Counterclockwise)

Preceding gene: 107021843

Following gene: 107021840

Centisome position: 9.38

GC content: 70.51

Gene sequence:

>2004_bases
ATGTCCGATATCACCGAAACGGCCGCGGGCGCCGCGCCCGCCCCCGCCGCGCGCCCGCTGCGCGCGATCCAGCCCCTGCC
CGACCAGCTGATCAGCCAGATCGCCGCCGGCGAGGTCGTCGAACGCCCGGCGTCGGTCGTCAAGGAGCTGCTCGAGAACG
CGATGGACGCCGGCGCGACGACGCTGCGCATCGTGCTGGAAGAAGGCGGTGTCAAGCGCATCTCGATCACCGACGACGGC
TGCGGAATTCCGCCCGACGAACTGGCGCTCGCGCTGATGCGCCACGCGACCAGCAAGATCCGCTCGCTTGAGGAGCTCGA
GGCGGTCGCGACGCTGGGGTTTCGCGGCGAAGCGCTCGCGTCGATCGCGTCGGTGGCCGAAATGTCGATCACGAGCCGGA
CGGCCGACGCCGCGCATGCGATGAAGATCGATGCGCAGACGGGCGTGCTGTCGCCCGCCGCCGGCTCGATCGGCACGACG
ATCGAGGTGCGCGAGCTGTACTTCAACACGCCCGCGCGGCGCAAGTTCCTGAAGAGCGAGCAGACCGAATTCGGCCACTG
CCTGGAAATGATCCGTCGCGCGGCGCTCGCGCGGCCGGACGTCGCGATCTCGGTGCTGCACAACGGCAAGGCCGTCGAGC
ACTGGAATGCGACCGAGCCCGCGCAGCGCGTAGCGAAAATCCTCGGCGACAGCTTCGCGACCGCGCACCTGCCGCTCGAC
GAGCAGGCCGGCCCGCTCGCCGTCTACGGCTGCGCCGGCCTGCCGACCGCGAGCCGCGGGCGCGCCGACCAGCAGTATTT
CTTCGTGAACGGGCGCTTCGTGCGCGACAAGCTGCTGACGCACGCTGTGCGCGCGGCCTACGAGGACGTGCTGCACGGCG
ACCGCTACCCGTCGTACGTGCTGTTTCTCGACCTGCCGCCAGAAGCCGTCGACGTGAACGTGCATCCGTCGAAGATCGAA
GTACGGTTCCGCGATTCGCGCTCGATCCACCAGTACGTGTTCCACGCGGTCCAGCGAGCGCTCGCGCGCCACGCGGGCGC
GTCGCCGGAAACCACCGCGGGCGGCCATGCCGCACATCTCGAACCGGCCCCGCGCGGGCCCGCGTCGTTCCTCGACACAC
CGCTCGGTCAGGGCACGAGCCACACGACCGGTGGCACGGGCGGCAGCGGCTTCTCGTCGCCATCGTCTTCATCGTCGGCG
GGCAACACGTGGATGCGCCAGGCGCGGATGACGCAGGGCACGCTGCCCGTCGCGCAGCCGCTCGCGCTCTACGACGCGCT
GTTCGGCCGCAAGGACAGCGGCGCGGGCACGCCGGACGGCACGACGCTCATCGCGCGCGATGCGGCCGATTCGACCGACG
CGCCAGCCGCGCCGCTGCAGGGCTTCGCCGCGTCGCCGCTCGCCGCCGGCGCGCACGACGAGCAGCCGCTCGGCTTCGCG
CTCGGCCAGATCCACGGCATCTACGTGCTCGCGCAGAATGCGTACGGGCTCGTGATCGTCGACATGCACGCGGCCCACGA
ACGAATCCTGTACGAGCAGTTCAAGAGTGCGCTCGCCGACCGCACGGTCGCCGTGCAGTCGCTGCTGCTGCCGATCTCGA
TGACGGCCACGCCGGTCGAGATCGGCACGGTCGAGGAAGAGCGCGACACGCTCGAATCGCTCGGCTTCGACCTCGCGGTA
CTGTCGCCGACGACGCTCGCGATCCGCGCGGTGCCGGCGCTGCTGAAGGATGCCGACCTGCAGTCGCTCGCGCGCGCGGT
GCTCGCCGATCTGCACGCGTTCGGCGGCTCGCGCGTGCTCACCGAGCGCCAGCACGAACTGCTCGGCACGCTCGCGTGCC
ATCACGCGGTGCGCGCGAACCGGCGCCTGACGCTCGACGAGATGAACGCGCTGCTGCGCCAGATGGAGGCGACCGAGCGC
GCGGACCAGTGCAATCACGGCCGGCCGACCTGGTATCAGCTCACGCTGAACGATCTCGACCGTCTCTTCATGCGCGGGCA
ATGA

Upstream 100 bases:

>100_bases
TGCAACGGGGTGATGATACCGAAACTACCTTAAGGCTCCGTGAAAAAACGTAACGGCCGGCCGCGCCGGCACGCGTTCGC
CGCCTCGCTATAATTCGGCC

Downstream 100 bases:

>100_bases
GCGCTTCTTCGCAGTCCCGCCCGACGACGATCGCCTGCCTGCTCGGCCCCACCGCTTCGGGCAAGACGGCCGCGGCGCTG
GCGCTCGCCGCGCGCCGCCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MSDITETAAGAAPAPAARPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENAMDAGATTLRIVLEEGGVKRISITDDG
CGIPPDELALALMRHATSKIRSLEELEAVATLGFRGEALASIASVAEMSITSRTADAAHAMKIDAQTGVLSPAAGSIGTT
IEVRELYFNTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGKAVEHWNATEPAQRVAKILGDSFATAHLPLD
EQAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIE
VRFRDSRSIHQYVFHAVQRALARHAGASPETTAGGHAAHLEPAPRGPASFLDTPLGQGTSHTTGGTGGSGFSSPSSSSSA
GNTWMRQARMTQGTLPVAQPLALYDALFGRKDSGAGTPDGTTLIARDAADSTDAPAAPLQGFAASPLAAGAHDEQPLGFA
LGQIHGIYVLAQNAYGLVIVDMHAAHERILYEQFKSALADRTVAVQSLLLPISMTATPVEIGTVEEERDTLESLGFDLAV
LSPTTLAIRAVPALLKDADLQSLARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATER
ADQCNHGRPTWYQLTLNDLDRLFMRGQ

Sequences:

>Translated_667_residues
MSDITETAAGAAPAPAARPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENAMDAGATTLRIVLEEGGVKRISITDDG
CGIPPDELALALMRHATSKIRSLEELEAVATLGFRGEALASIASVAEMSITSRTADAAHAMKIDAQTGVLSPAAGSIGTT
IEVRELYFNTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGKAVEHWNATEPAQRVAKILGDSFATAHLPLD
EQAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIE
VRFRDSRSIHQYVFHAVQRALARHAGASPETTAGGHAAHLEPAPRGPASFLDTPLGQGTSHTTGGTGGSGFSSPSSSSSA
GNTWMRQARMTQGTLPVAQPLALYDALFGRKDSGAGTPDGTTLIARDAADSTDAPAAPLQGFAASPLAAGAHDEQPLGFA
LGQIHGIYVLAQNAYGLVIVDMHAAHERILYEQFKSALADRTVAVQSLLLPISMTATPVEIGTVEEERDTLESLGFDLAV
LSPTTLAIRAVPALLKDADLQSLARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATER
ADQCNHGRPTWYQLTLNDLDRLFMRGQ
>Mature_666_residues
SDITETAAGAAPAPAARPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENAMDAGATTLRIVLEEGGVKRISITDDGC
GIPPDELALALMRHATSKIRSLEELEAVATLGFRGEALASIASVAEMSITSRTADAAHAMKIDAQTGVLSPAAGSIGTTI
EVRELYFNTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGKAVEHWNATEPAQRVAKILGDSFATAHLPLDE
QAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIEV
RFRDSRSIHQYVFHAVQRALARHAGASPETTAGGHAAHLEPAPRGPASFLDTPLGQGTSHTTGGTGGSGFSSPSSSSSAG
NTWMRQARMTQGTLPVAQPLALYDALFGRKDSGAGTPDGTTLIARDAADSTDAPAAPLQGFAASPLAAGAHDEQPLGFAL
GQIHGIYVLAQNAYGLVIVDMHAAHERILYEQFKSALADRTVAVQSLLLPISMTATPVEIGTVEEERDTLESLGFDLAVL
SPTTLAIRAVPALLKDADLQSLARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERA
DQCNHGRPTWYQLTLNDLDRLFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=329, Percent_Identity=34.9544072948328, Blast_Score=198, Evalue=2e-50,
Organism=Homo sapiens, GI189458898, Length=351, Percent_Identity=28.4900284900285, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4505911, Length=351, Percent_Identity=28.4900284900285, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI189458896, Length=341, Percent_Identity=29.6187683284457, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI310128478, Length=351, Percent_Identity=26.4957264957265, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI4505913, Length=351, Percent_Identity=26.4957264957265, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=31.6239316239316, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI310128480, Length=304, Percent_Identity=24.3421052631579, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI91992162, Length=271, Percent_Identity=27.3062730627306, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI91992160, Length=271, Percent_Identity=27.3062730627306, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1790612, Length=587, Percent_Identity=39.0119250425894, Blast_Score=338, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=35, Blast_Score=168, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17562796, Length=364, Percent_Identity=26.0989010989011, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=313, Percent_Identity=34.185303514377, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=367, Percent_Identity=26.158038147139, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6325093, Length=704, Percent_Identity=20.3125, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=386, Percent_Identity=24.0932642487047, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17136968, Length=313, Percent_Identity=34.8242811501597, Blast_Score=179, Evalue=8e-45,
Organism=Drosophila melanogaster, GI17136970, Length=367, Percent_Identity=26.158038147139, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71218; Mature: 71087

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDITETAAGAAPAPAARPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENAMDAGAT
CCCHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
TLRIVLEEGGVKRISITDDGCGIPPDELALALMRHATSKIRSLEELEAVATLGFRGEALA
EEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SIASVAEMSITSRTADAAHAMKIDAQTGVLSPAAGSIGTTIEVRELYFNTPARRKFLKSE
HHHHHHHHHHHHHCHHHHHHEEEECCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHH
QTEFGHCLEMIRRAALARPDVAISVLHNGKAVEHWNATEPAQRVAKILGDSFATAHLPLD
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHCCCCCEEECCCC
EQAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYV
CCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQYVFHAVQRALARHAGASPETTAGGHAAHL
EEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEC
EPAPRGPASFLDTPLGQGTSHTTGGTGGSGFSSPSSSSSAGNTWMRQARMTQGTLPVAQP
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHH
LALYDALFGRKDSGAGTPDGTTLIARDAADSTDAPAAPLQGFAASPLAAGAHDEQPLGFA
HHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LGQIHGIYVLAQNAYGLVIVDMHAAHERILYEQFKSALADRTVAVQSLLLPISMTATPVE
HHHHCEEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IGTVEEERDTLESLGFDLAVLSPTTLAIRAVPALLKDADLQSLARAVLADLHAFGGSRVL
ECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
TERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLNDLD
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHH
RLFMRGQ
HHHHCCC
>Mature Secondary Structure 
SDITETAAGAAPAPAARPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENAMDAGAT
CCHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
TLRIVLEEGGVKRISITDDGCGIPPDELALALMRHATSKIRSLEELEAVATLGFRGEALA
EEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SIASVAEMSITSRTADAAHAMKIDAQTGVLSPAAGSIGTTIEVRELYFNTPARRKFLKSE
HHHHHHHHHHHHHCHHHHHHEEEECCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHH
QTEFGHCLEMIRRAALARPDVAISVLHNGKAVEHWNATEPAQRVAKILGDSFATAHLPLD
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHCCCCCEEECCCC
EQAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYV
CCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQYVFHAVQRALARHAGASPETTAGGHAAHL
EEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEC
EPAPRGPASFLDTPLGQGTSHTTGGTGGSGFSSPSSSSSAGNTWMRQARMTQGTLPVAQP
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHH
LALYDALFGRKDSGAGTPDGTTLIARDAADSTDAPAAPLQGFAASPLAAGAHDEQPLGFA
HHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LGQIHGIYVLAQNAYGLVIVDMHAAHERILYEQFKSALADRTVAVQSLLLPISMTATPVE
HHHHCEEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IGTVEEERDTLESLGFDLAVLSPTTLAIRAVPALLKDADLQSLARAVLADLHAFGGSRVL
ECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
TERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLNDLD
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHH
RLFMRGQ
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]