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The map label for this gene is folK [H]

Identifier: 107021833

GI number: 107021833

Start: 299306

End: 299848

Strand: Reverse

Name: folK [H]

Synonym: Bcen_0273

Alternate gene names: 107021833

Gene position: 299848-299306 (Counterclockwise)

Preceding gene: 107021834

Following gene: 107021832

Centisome position: 9.1

GC content: 66.85

Gene sequence:

>543_bases
ATGACGGTTGCATATATCGGACTGGGGGCGAATCTCGGCGATGCGCGCCAGACCCTGAAGGACGCGGTGGTGTGCCTCGC
GCAGCAGCGCACCATCTCGATCCTCGGCAAGTCGAGCCTGTATCGCACGGCGCCTTTCGAAGCGGGCGGCGACGACTACT
ACAACTGCGTCGTCAAGCTCGACACGACGCTGTCGGCCCGCGAGCTGCTCGCGCTCTGCCAGAAGATCGAACATCACTTC
GGCCGCGAGCGCCCGTATCGCAATGCACCGCGCACGCTCGACCTCGACATCCTGCTGTTCGGCGCCGATTCGATCGACGA
ACCCGACCTGATCGTCCCGCACCCGCGCCTCACCGACCGCGCATTCGCGCTCGTGCCGCTCGTCGAGATCGAGCCGGCGC
TCGACATCCCCGCGCGCGGCCGTGCCGACGCCTTTCTCGCCGCCGTCGCGGATCAGCGCGTCGAAAAGGTGCAAACCTGC
CAGTGCCTGATGCAGAAGGCGCTCGCTGCCGGCGAAGACGCCGACAAGACCCGCTGCCGATGA

Upstream 100 bases:

>100_bases
GTGAAGGTGCCGCCGAGCAGGCGCCGGACACCGCAGGCGGTACCGCGAGCGGTTCCGACGACTGACGCGCGCGCCGGCGA
ACGACGTAGGAAGTGATGCC

Downstream 100 bases:

>100_bases
ACTCGACTCCGCTGACCGTCACCGCGCCCGACCTGCGCGCCCCGCACCGCTATCTCGTGATCGAAGGGCCGATCGGCGTC
GGCAAGACGTCGCTCGCGCG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTVAYIGLGANLGDARQTLKDAVVCLAQQRTISILGKSSLYRTAPFEAGGDDYYNCVVKLDTTLSARELLALCQKIEHHF
GRERPYRNAPRTLDLDILLFGADSIDEPDLIVPHPRLTDRAFALVPLVEIEPALDIPARGRADAFLAAVADQRVEKVQTC
QCLMQKALAAGEDADKTRCR

Sequences:

>Translated_180_residues
MTVAYIGLGANLGDARQTLKDAVVCLAQQRTISILGKSSLYRTAPFEAGGDDYYNCVVKLDTTLSARELLALCQKIEHHF
GRERPYRNAPRTLDLDILLFGADSIDEPDLIVPHPRLTDRAFALVPLVEIEPALDIPARGRADAFLAAVADQRVEKVQTC
QCLMQKALAAGEDADKTRCR
>Mature_179_residues
TVAYIGLGANLGDARQTLKDAVVCLAQQRTISILGKSSLYRTAPFEAGGDDYYNCVVKLDTTLSARELLALCQKIEHHFG
RERPYRNAPRTLDLDILLFGADSIDEPDLIVPHPRLTDRAFALVPLVEIEPALDIPARGRADAFLAAVADQRVEKVQTCQ
CLMQKALAAGEDADKTRCR

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=44.6043165467626, Blast_Score=102, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324073, Length=134, Percent_Identity=37.3134328358209, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19782; Mature: 19651

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAYIGLGANLGDARQTLKDAVVCLAQQRTISILGKSSLYRTAPFEAGGDDYYNCVVKL
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEEEEE
DTTLSARELLALCQKIEHHFGRERPYRNAPRTLDLDILLFGADSIDEPDLIVPHPRLTDR
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCCCCC
AFALVPLVEIEPALDIPARGRADAFLAAVADQRVEKVQTCQCLMQKALAAGEDADKTRCR
CEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TVAYIGLGANLGDARQTLKDAVVCLAQQRTISILGKSSLYRTAPFEAGGDDYYNCVVKL
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEEEEE
DTTLSARELLALCQKIEHHFGRERPYRNAPRTLDLDILLFGADSIDEPDLIVPHPRLTDR
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCCCCC
AFALVPLVEIEPALDIPARGRADAFLAAVADQRVEKVQTCQCLMQKALAAGEDADKTRCR
CEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]