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The map label for this gene is ispB [H]

Identifier: 107021658

GI number: 107021658

Start: 103448

End: 104443

Strand: Reverse

Name: ispB [H]

Synonym: Bcen_0098

Alternate gene names: 107021658

Gene position: 104443-103448 (Counterclockwise)

Preceding gene: 107021663

Following gene: 107021657

Centisome position: 3.17

GC content: 66.47

Gene sequence:

>996_bases
ATGTCGTCGTCCACCGCCTCCCCCACCCTCAGCGCCGCCCACCTGCTCGCCCCGATCACCAGCGACATGGAGCAGGTGAA
TCGCGTTATCCGGCAAAGCCTCGCGTCCGACGTGCTGCTGATCAACCAGATCGCCGAGTACATCATCGGCGCGGGCGGCA
AGCGGCTGCGTCCGGCGTTGCTGCTGCTCGTCGCCGGCGCGCTCGGCGAAACGTCGCACCAGCGGCACGTGCTGGCCGCC
GTCGTCGAGTTCATCCACACGGCCACGCTGCTGCATGACGACGTCGTCGACGAATCCGAACTGCGCCGCGGCCGCCAGAC
CGCCAATGCGCTGTTCGGCAACGCGGCGAGCGTGCTGGTAGGCGATTACCTCTACTCGCGCTCGTTCGAGATGATGGTCG
GCGTCGGCAAGATGCGCGTGATGGAGATCCTGTCCGAAGCGACGACGATCATTTCCGAAGGCGAGGTGCTGCAGCTCCTC
AACATGCACGACGCGGACGTCGACGAAACGCGCTACATGCAGGTGATCCGCTACAAGACGGCGAAGCTGTTCGAGGCATC
GGCGCGCTTGGGCGCGGTGCTCGCGGGCGCCGATGCGCCCACCGAGGCCGCCGCCGCCGAATACGGCCGCCGGATCGGCA
CCGCATTCCAGATCATGGACGACTGGCTCGACTACGCCGGCACCGCCGAGGCGATGGGCAAGAATGCCGGCGACGACTTG
CGCGAAGGCAAGCCGACGCTGCCGCTCATCTATCTGATCGAACGCGGCACGCCCGAACAGTCGGCGCTCGCACGCGAGGC
GATCGAACAGGGCGGCACCGATCGCTTCGACACGATTTTCGAAGCGATCACGCGCTCGGGCGCGCTCGATCACACGCTCG
AATGCGCACGTCAGGAAGCGCAGGCGGCGGCGGCAGCGATTGCCGCGTTCCCCGATTCGATCTACAAGGAAAGCCTGCTC
GGGTTGTGCTCGTACTCGACGTCGCGGCAGTCATGA

Upstream 100 bases:

>100_bases
GCCTCTGCCGGACGGCCAAAATCGCGCCGCCGGCACGTCTGACAGACCGGCATATCGCGGATTCGACTTATAATCCGCCG
CATCACCCAATTCCATCATC

Downstream 100 bases:

>100_bases
ACACGCCGCGAACGGAAAGCGATGCTCTGTCTCGAAAATTTTCTTCGTCAAAGTATTCCCTTTTAGAAAAAACATCGTTA
TAGTTACGTTCTTGCTTGAG

Product: trans-hexaprenyltranstransferase

Products: NA

Alternate protein names: All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSSSTASPTLSAAHLLAPITSDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPALLLLVAGALGETSHQRHVLAA
VVEFIHTATLLHDDVVDESELRRGRQTANALFGNAASVLVGDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQLL
NMHDADVDETRYMQVIRYKTAKLFEASARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAEAMGKNAGDDL
REGKPTLPLIYLIERGTPEQSALAREAIEQGGTDRFDTIFEAITRSGALDHTLECARQEAQAAAAAIAAFPDSIYKESLL
GLCSYSTSRQS

Sequences:

>Translated_331_residues
MSSSTASPTLSAAHLLAPITSDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPALLLLVAGALGETSHQRHVLAA
VVEFIHTATLLHDDVVDESELRRGRQTANALFGNAASVLVGDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQLL
NMHDADVDETRYMQVIRYKTAKLFEASARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAEAMGKNAGDDL
REGKPTLPLIYLIERGTPEQSALAREAIEQGGTDRFDTIFEAITRSGALDHTLECARQEAQAAAAAIAAFPDSIYKESLL
GLCSYSTSRQS
>Mature_330_residues
SSSTASPTLSAAHLLAPITSDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPALLLLVAGALGETSHQRHVLAAV
VEFIHTATLLHDDVVDESELRRGRQTANALFGNAASVLVGDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQLLN
MHDADVDETRYMQVIRYKTAKLFEASARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAEAMGKNAGDDLR
EGKPTLPLIYLIERGTPEQSALAREAIEQGGTDRFDTIFEAITRSGALDHTLECARQEAQAAAAAIAAFPDSIYKESLLG
LCSYSTSRQS

Specific function: Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=308, Percent_Identity=29.2207792207792, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI4758430, Length=209, Percent_Identity=23.444976076555, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI83700220, Length=209, Percent_Identity=23.444976076555, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789578, Length=309, Percent_Identity=51.7799352750809, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1786623, Length=244, Percent_Identity=31.9672131147541, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17505681, Length=302, Percent_Identity=32.4503311258278, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319475, Length=242, Percent_Identity=30.5785123966942, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325188, Length=236, Percent_Identity=24.1525423728814, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24651612, Length=287, Percent_Identity=31.0104529616725, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI281365769, Length=332, Percent_Identity=24.6987951807229, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24660002, Length=332, Percent_Identity=24.6987951807229, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.90 [H]

Molecular weight: Translated: 35667; Mature: 35536

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSTASPTLSAAHLLAPITSDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LLLVAGALGETSHQRHVLAAVVEFIHTATLLHDDVVDESELRRGRQTANALFGNAASVLV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHH
GDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQLLNMHDADVDETRYMQVIRYKT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
AKLFEASARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAEAMGKNAGDDL
HHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHH
REGKPTLPLIYLIERGTPEQSALAREAIEQGGTDRFDTIFEAITRSGALDHTLECARQEA
HCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
QAAAAAIAAFPDSIYKESLLGLCSYSTSRQS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSSTASPTLSAAHLLAPITSDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LLLVAGALGETSHQRHVLAAVVEFIHTATLLHDDVVDESELRRGRQTANALFGNAASVLV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHH
GDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQLLNMHDADVDETRYMQVIRYKT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
AKLFEASARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAEAMGKNAGDDL
HHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHH
REGKPTLPLIYLIERGTPEQSALAREAIEQGGTDRFDTIFEAITRSGALDHTLECARQEA
HCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
QAAAAAIAAFPDSIYKESLLGLCSYSTSRQS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8312607; 9278503; 2670911; 8037730 [H]