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The map label for this gene is fmt

Identifier: 104779337

GI number: 104779337

Start: 25207

End: 26139

Strand: Reverse

Name: fmt

Synonym: PSEEN0024

Alternate gene names: 104779337

Gene position: 26139-25207 (Counterclockwise)

Preceding gene: 104779338

Following gene: 104779336

Centisome position: 0.44

GC content: 67.63

Gene sequence:

>933_bases
ATGCGCATCGTCTTCGCAGGCACTCCAGAGTTTGCCGCCGAACACCTCAAGGCCCTGCTCGACAGCCCGTACGAGATCGT
GGCCGTCTACACCCAGCCCGACCGCCCGGCTGGCCGTGGCCAGAAGCTCATGCCGAGCGCAGTGAAGGCACTGGCCGTTG
CCCACGACATCCCGGTGTACCAGCCGCAGACCCTGCGCAACCCCGAGGCGCAAGCCGAGCTCGCCGCGCTCAAGCCGGAC
CTGATGGTGGTGGTCGCCTATGGCCTGATCCTGCCGCAAGTGGTGCTGGATATTCCGCGCCTGGGTTGCATCAACAGCCA
TGCCTCCCTGCTGCCGCGCTGGCGCGGGGCGGCGCCGATCCAGCGTGCCGTGGAAGCCGGCGACGCCGAGAGCGGCGTGA
CCGTGATGCGTATGGAAGCGGGCCTGGATACCGGCCCGATGTTGCTCAAGGTGGTTACCCCGATCAGCGCCGAGGACACT
GGCGGCACCCTGCACGACCGCCTCGCCGCCATGGGCCCGGGCGCCGTGGTGCAGGCCATCGCCGGCCTGGCCGACGGTTC
GCTGCAAGGTGAAGTACAGGACGATACCCTGGCCACTTATGCACACAAGCTGAACAAGGACGAGGCGCGCATCGACTGGA
ACCGCCCAGCCGTCGAACTGGAACGCCTGATCCGTGCCTTCAACCCGTGGCCGGTGTGCCACAGCACCCTCGACGGCGAA
AGCGTGAAGGTGCTGGCCGCCAACTTGTCCACAGGCAAGGGCACTCCTGGTGAGATCCTCTCCGCCAGCAAGGACGGCCT
GGTCGTCGCCTGCGGTGATGGCGCCCTGAGCCTGACCCGCCTGCAACTGCCCGGCGGCAAGGCCCTGGCCTTCAGCGACC
TGTTCAACAGCCGCCGCGAGAAGTTCGCCGGTGGCAAGGTGCTCGGCCAATGA

Upstream 100 bases:

>100_bases
GAAGAAGCTGGAAAAGCAGCACCGCCAGCAAGCCTGATCCCCACCTTCCAGAAGGCTTGCTCCGGCAAGCCTTTTTCTTT
TTCAAGGAAGCGAGAACTCC

Downstream 100 bases:

>100_bases
ACCCACGCCTGGCCGCCGCCCGTGCCCTTGCCGCCGTGCTCAGCGGCAAGGCCTCGCTGAACAGCTCGCTGCCGGCGCAA
CTGGACAAGGTCGACGAGCG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSAVKALAVAHDIPVYQPQTLRNPEAQAELAALKPD
LMVVVAYGLILPQVVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISAEDT
GGTLHDRLAAMGPGAVVQAIAGLADGSLQGEVQDDTLATYAHKLNKDEARIDWNRPAVELERLIRAFNPWPVCHSTLDGE
SVKVLAANLSTGKGTPGEILSASKDGLVVACGDGALSLTRLQLPGGKALAFSDLFNSRREKFAGGKVLGQ

Sequences:

>Translated_310_residues
MRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSAVKALAVAHDIPVYQPQTLRNPEAQAELAALKPD
LMVVVAYGLILPQVVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISAEDT
GGTLHDRLAAMGPGAVVQAIAGLADGSLQGEVQDDTLATYAHKLNKDEARIDWNRPAVELERLIRAFNPWPVCHSTLDGE
SVKVLAANLSTGKGTPGEILSASKDGLVVACGDGALSLTRLQLPGGKALAFSDLFNSRREKFAGGKVLGQ
>Mature_310_residues
MRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSAVKALAVAHDIPVYQPQTLRNPEAQAELAALKPD
LMVVVAYGLILPQVVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISAEDT
GGTLHDRLAAMGPGAVVQAIAGLADGSLQGEVQDDTLATYAHKLNKDEARIDWNRPAVELERLIRAFNPWPVCHSTLDGE
SVKVLAANLSTGKGTPGEILSASKDGLVVACGDGALSLTRLQLPGGKALAFSDLFNSRREKFAGGKVLGQ

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=308, Percent_Identity=28.8961038961039, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI21614513, Length=312, Percent_Identity=29.4871794871795, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI164663775, Length=317, Percent_Identity=29.0220820189274, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1789683, Length=310, Percent_Identity=59.0322580645161, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1788589, Length=297, Percent_Identity=29.6296296296296, Blast_Score=141, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI133930964, Length=304, Percent_Identity=29.6052631578947, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24585660, Length=324, Percent_Identity=29.0123456790123, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45550868, Length=302, Percent_Identity=28.476821192053, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571984, Length=240, Percent_Identity=30.4166666666667, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_PSEE4 (Q1IH35)

Other databases:

- EMBL:   CT573326
- RefSeq:   YP_605835.1
- ProteinModelPortal:   Q1IH35
- SMR:   Q1IH35
- STRING:   Q1IH35
- GeneID:   4085959
- GenomeReviews:   CT573326_GR
- KEGG:   pen:PSEEN0024
- NMPDR:   fig|384676.6.peg.21
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- PhylomeDB:   Q1IH35
- ProtClustDB:   PRK00005
- BioCyc:   PENT384676:PSEEN0024-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 32758; Mature: 32758

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSAVKALAVAHDIPVY
CEEEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
QPQTLRNPEAQAELAALKPDLMVVVAYGLILPQVVLDIPRLGCINSHASLLPRWRGAAPI
CCHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCHH
QRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISAEDTGGTLHDRLAAMGPGAVVQAI
HHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHH
AGLADGSLQGEVQDDTLATYAHKLNKDEARIDWNRPAVELERLIRAFNPWPVCHSTLDGE
HHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCCCHHCCCCCC
SVKVLAANLSTGKGTPGEILSASKDGLVVACGDGALSLTRLQLPGGKALAFSDLFNSRRE
CEEEEEEECCCCCCCCHHHHCCCCCCEEEEECCCCEEEEEEECCCCCEEHHHHHHHHHHH
KFAGGKVLGQ
HHCCCCCCCC
>Mature Secondary Structure
MRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSAVKALAVAHDIPVY
CEEEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
QPQTLRNPEAQAELAALKPDLMVVVAYGLILPQVVLDIPRLGCINSHASLLPRWRGAAPI
CCHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCHH
QRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISAEDTGGTLHDRLAAMGPGAVVQAI
HHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHH
AGLADGSLQGEVQDDTLATYAHKLNKDEARIDWNRPAVELERLIRAFNPWPVCHSTLDGE
HHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCCCHHCCCCCC
SVKVLAANLSTGKGTPGEILSASKDGLVVACGDGALSLTRLQLPGGKALAFSDLFNSRRE
CEEEEEEECCCCCCCCHHHHCCCCCCEEEEECCCCEEEEEEECCCCCEEHHHHHHHHHHH
KFAGGKVLGQ
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA