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The map label for this gene is adiC [H]

Identifier: 103488642

GI number: 103488642

Start: 3317407

End: 3318717

Strand: Reverse

Name: adiC [H]

Synonym: Sala_3167

Alternate gene names: 103488642

Gene position: 3318717-3317407 (Counterclockwise)

Preceding gene: 103488643

Following gene: 103488639

Centisome position: 99.21

GC content: 68.27

Gene sequence:

>1311_bases
GTGAGCGATCCCGCAAATCGCCACGAAAGGCCGCGCCGCAAGCTCGGCCTTTCGATGGCGATTGCGCTGGTCATGGGCAA
TATGATCGGCTCGGGGGTGTTTCTGCTGCCCGCGAGCCTCGCCCCCTTTGGCTGGAACGGTGTCGCGGGCTGGGCGATCA
CGATAGGCGGCGCGCTCGCACTCGCCTTCGTCCTCGCGCGGTTGACCGCCCTCCACCCCGACGCGGGCGGGCCAACCGGC
TTCGTCGAGCGCGCCTTTGGCCGCATCCCCAGTTTCATGATCGGCTGGGCCTATTGGGTGTCGGTGTGGACCGCGAACGT
GACGCTCGCGGTCGCGGCGGTGAGCTTCCTCAGCCTGTTCGTGCCGGCACTGGGGCAGCATACGGCGCTGTCGACGATCG
CGCTGATCTGGATCGTCACCGCGATCAACTGGCGCGGCGCGCGCGCGGCGGGACAGTTTCAGGTCGTGACCCTGCTCATC
AAGCTGATCCCGCTCGTCACCGTCATCATCCTGATCCCCATCGCCTTTGGCCGCAGCGAGCCCGTCGCGCTCACCCCCTT
TCCCGCCGACGGGCTGTCGCTCGCGGCCGTCAGCGGGTCGGCGATCCTGACGCTCTGGGCGCTGCTGGGTTTTGAATCGG
CGAGCGTCGCCGCCGACAAGGTCGCCAATCCCGCCGTCACCATCCCGCGCGCGACCATCGTCGGCACGCTCGCGACGGGC
ATCCTCTATCTGATCGTCTGTTCGGCGATCGCGCTGATGCTGCCCGCGGCGGAAGTCGCGAAATCGGAGGCCCCCTTTTC
GCTGTTCGTCGAAACCTGGTGGGGCCGCGAGCCTGCGCTGTTCATCGGCGCCTTTGCGGCGGTCAGCGCGCTGGGCACGC
TGAACGGCTGGACGCTGATCCAGGCGGAGCTGCCCGCGACGCTCGCACGGCAGGGGTTGCTCCCTTCATGGTTCGGGCGT
GAGAACCGCCATGGCACGCCGACCGCGGCACTGCTGCTGTCGAGCGCGATCGCCACCGCCTGCGTCCTCCTCAACAGCAG
CAAGTCGACGAGCGAGATGTTCACCTTCATGGCGGTGCTCTCGACCTCGGTGACCCTGTGGCTCTACCTCGCCTGCGCCG
CCGCGGCGCTGCGGATGCGCGTCGCGATCCCGGTCGCGCTGATCGGCCTCGTCTATGCCGTCTGGACTTTGTGGGGTGCG
GGGATCGGTGTCAGCGCGATGAGCCTCATATTGATGGCCGCAGGGTTGCCGCTCTACGCTTGGACCATGCTGTCAGCGCC
AGCGGGGCGCGAAGAGCCCCCGGTCGCGTAG

Upstream 100 bases:

>100_bases
GGCGATCCCGACGGCATCAGCAGCACGGGCGGCGTCTTCTACGACACGGTCATCCGCCCGCGGCTGATCGGAATCAAGGT
GAGCAAGGACTTCTGACCGG

Downstream 100 bases:

>100_bases
GATCACTGCAGCCGCATTATGCCCCGGCGCGCCGGTGACGCCGCCGCCCGGATGCGTGCCCGCGCCGCACATATACAGCC
CCTTCACCGGCCCGCGATAG

Product: amino acid permease-associated region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSDPANRHERPRRKLGLSMAIALVMGNMIGSGVFLLPASLAPFGWNGVAGWAITIGGALALAFVLARLTALHPDAGGPTG
FVERAFGRIPSFMIGWAYWVSVWTANVTLAVAAVSFLSLFVPALGQHTALSTIALIWIVTAINWRGARAAGQFQVVTLLI
KLIPLVTVIILIPIAFGRSEPVALTPFPADGLSLAAVSGSAILTLWALLGFESASVAADKVANPAVTIPRATIVGTLATG
ILYLIVCSAIALMLPAAEVAKSEAPFSLFVETWWGREPALFIGAFAAVSALGTLNGWTLIQAELPATLARQGLLPSWFGR
ENRHGTPTAALLLSSAIATACVLLNSSKSTSEMFTFMAVLSTSVTLWLYLACAAAALRMRVAIPVALIGLVYAVWTLWGA
GIGVSAMSLILMAAGLPLYAWTMLSAPAGREEPPVA

Sequences:

>Translated_436_residues
MSDPANRHERPRRKLGLSMAIALVMGNMIGSGVFLLPASLAPFGWNGVAGWAITIGGALALAFVLARLTALHPDAGGPTG
FVERAFGRIPSFMIGWAYWVSVWTANVTLAVAAVSFLSLFVPALGQHTALSTIALIWIVTAINWRGARAAGQFQVVTLLI
KLIPLVTVIILIPIAFGRSEPVALTPFPADGLSLAAVSGSAILTLWALLGFESASVAADKVANPAVTIPRATIVGTLATG
ILYLIVCSAIALMLPAAEVAKSEAPFSLFVETWWGREPALFIGAFAAVSALGTLNGWTLIQAELPATLARQGLLPSWFGR
ENRHGTPTAALLLSSAIATACVLLNSSKSTSEMFTFMAVLSTSVTLWLYLACAAAALRMRVAIPVALIGLVYAVWTLWGA
GIGVSAMSLILMAAGLPLYAWTMLSAPAGREEPPVA
>Mature_435_residues
SDPANRHERPRRKLGLSMAIALVMGNMIGSGVFLLPASLAPFGWNGVAGWAITIGGALALAFVLARLTALHPDAGGPTGF
VERAFGRIPSFMIGWAYWVSVWTANVTLAVAAVSFLSLFVPALGQHTALSTIALIWIVTAINWRGARAAGQFQVVTLLIK
LIPLVTVIILIPIAFGRSEPVALTPFPADGLSLAAVSGSAILTLWALLGFESASVAADKVANPAVTIPRATIVGTLATGI
LYLIVCSAIALMLPAAEVAKSEAPFSLFVETWWGREPALFIGAFAAVSALGTLNGWTLIQAELPATLARQGLLPSWFGRE
NRHGTPTAALLLSSAIATACVLLNSSKSTSEMFTFMAVLSTSVTLWLYLACAAAALRMRVAIPVALIGLVYAVWTLWGAG
IGVSAMSLILMAAGLPLYAWTMLSAPAGREEPPVA

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI187423910, Length=374, Percent_Identity=24.5989304812834, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI7657591, Length=374, Percent_Identity=24.5989304812834, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI2367353, Length=417, Percent_Identity=33.3333333333333, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1786908, Length=411, Percent_Identity=30.4136253041363, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1790575, Length=405, Percent_Identity=32.0987654320988, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1787890, Length=436, Percent_Identity=29.1284403669725, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87082250, Length=374, Percent_Identity=26.7379679144385, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1786302, Length=392, Percent_Identity=23.469387755102, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789017, Length=329, Percent_Identity=25.8358662613982, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786789, Length=400, Percent_Identity=24.25, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790584, Length=255, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=414, Percent_Identity=24.6376811594203, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221331183, Length=458, Percent_Identity=23.3624454148472, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17647653, Length=458, Percent_Identity=23.3624454148472, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664379, Length=458, Percent_Identity=23.3624454148472, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550968, Length=382, Percent_Identity=25.130890052356, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921172, Length=382, Percent_Identity=25.130890052356, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24667468, Length=382, Percent_Identity=24.3455497382199, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641993, Length=397, Percent_Identity=26.448362720403, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 45567; Mature: 45436

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPANRHERPRRKLGLSMAIALVMGNMIGSGVFLLPASLAPFGWNGVAGWAITIGGALA
CCCCCCHHHCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHH
LAFVLARLTALHPDAGGPTGFVERAFGRIPSFMIGWAYWVSVWTANVTLAVAAVSFLSLF
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPALGQHTALSTIALIWIVTAINWRGARAAGQFQVVTLLIKLIPLVTVIILIPIAFGRSE
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVALTPFPADGLSLAAVSGSAILTLWALLGFESASVAADKVANPAVTIPRATIVGTLATG
CEEECCCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHCCCCCEECCHHHHHHHHHHH
ILYLIVCSAIALMLPAAEVAKSEAPFSLFVETWWGREPALFIGAFAAVSALGTLNGWTLI
HHHHHHHHHHHHHHCHHHHHCCCCCCEEEEEHHCCCCCHHHHHHHHHHHHHHCCCCCEEE
QAELPATLARQGLLPSWFGRENRHGTPTAALLLSSAIATACVLLNSSKSTSEMFTFMAVL
EECCCHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
STSVTLWLYLACAAAALRMRVAIPVALIGLVYAVWTLWGAGIGVSAMSLILMAAGLPLYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHH
WTMLSAPAGREEPPVA
HHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SDPANRHERPRRKLGLSMAIALVMGNMIGSGVFLLPASLAPFGWNGVAGWAITIGGALA
CCCCCHHHCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHH
LAFVLARLTALHPDAGGPTGFVERAFGRIPSFMIGWAYWVSVWTANVTLAVAAVSFLSLF
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPALGQHTALSTIALIWIVTAINWRGARAAGQFQVVTLLIKLIPLVTVIILIPIAFGRSE
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVALTPFPADGLSLAAVSGSAILTLWALLGFESASVAADKVANPAVTIPRATIVGTLATG
CEEECCCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHCCCCCEECCHHHHHHHHHHH
ILYLIVCSAIALMLPAAEVAKSEAPFSLFVETWWGREPALFIGAFAAVSALGTLNGWTLI
HHHHHHHHHHHHHHCHHHHHCCCCCCEEEEEHHCCCCCHHHHHHHHHHHHHHCCCCCEEE
QAELPATLARQGLLPSWFGRENRHGTPTAALLLSSAIATACVLLNSSKSTSEMFTFMAVL
EECCCHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
STSVTLWLYLACAAAALRMRVAIPVALIGLVYAVWTLWGAGIGVSAMSLILMAAGLPLYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHH
WTMLSAPAGREEPPVA
HHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]