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The map label for this gene is fumC [H]

Identifier: 103488627

GI number: 103488627

Start: 3301251

End: 3302666

Strand: Direct

Name: fumC [H]

Synonym: Sala_3152

Alternate gene names: 103488627

Gene position: 3301251-3302666 (Clockwise)

Preceding gene: 103488626

Following gene: 103488628

Centisome position: 98.69

GC content: 67.44

Gene sequence:

>1416_bases
ATGAGCGCGACGCGAACCGAAAGCGACAGCATCGGCGCGATCGAGGTGCCCGCCGATGCTTATTGGGGCGCGCAGACCGA
GCGCAGCCGCCACAATTTCGCCTTTCCCGCGCACGAACGCATGCCGGTGCCGATCATCCACGCGCTCGCGCGGATCAAGG
GCGCCGCTGCGCGCGTCAACCGGTCGCACGGCCTCGATTTCAAACTGGCAGATGCGATCGCGGAGGCCGCCGATGCGGTC
GCCGCAGGGCGTTACGACGACCAGTTCCCGCTCGCCATCTGGCAGACGGGCAGCGGCACCCAGTCGAACATGAACGCGAA
CGAGGTGATCGCCGGGCTGGCCAACGAGGCGCTCGCGGGCACGCGCGGCGGCAAGGCGCCGGTCCATCCCAACGACCATG
TCAACATGGGCCAGTCGTCGAACGACAGTTTTCCGACCGCGCTGCACGTCGCGGTCGCGGTCGAAACGACCGCGCGGCTG
CTGCCGTCGCTGATCGCCCTGACCGATGCGCTCGACGCCAAGGCGCGCGCGTGGGCCGACATCGTCAAGATCGGCCGCAC
GCACCTTCAGGACGCGACCCCGCTGACGCTGGGGCAGGAGTTTTCGGGCTATGTCCAGCAGCTGATCGCCTGCCGCGCAC
GGATCGAAGGGGCCTTGACGCACAATATCTGCAAGCTCGCGCAGGGCGGCACAGCAGTCGGCACCGGGCTCAACGCGCCT
GCCGGTTTCGACGCCGCGATCGCCGCCGAGCTGTCGCGCGCGACGGGCATCGCCTTTGAACCCGCACGCAACAAGTTCGA
GGCGCTGGCGTCGAACGACGGACTCGTCTTTTTCTCGGGCGCGCTGAACACGCTTGCGGTCGCGCTCACCAAGATCGCCA
ACGACATCCGCCTGCTCGGATCGGGCCCGCGCGCGGGGCTGGGCGAGCTCGACCTCCCCGCGAACGAGCCCGGCAGCTCG
ATCATGCCCGGCAAGGTCAACCCGACCCAGTGCGAGATGCTGACGATGGTTGCCGCGCAGGTGATCGGCAACCATCAGGC
AGTCACCGTCGGGGGAATGCAGGGGCATCTCGAACTTAACGTCTTCAAGCCGCTGATCGGCGCCAATGTGCTCCGCTCGA
TCGAGCTGCTCGCCATCGGCATGGCGGGCTTCACCGAACATTGCGTCGCGGGACTCCAGCCCAATCGCCCGCGCATCGAC
GAGCTGATGAACCGCTCGCTGATGCTCGTCACTGCGCTCGCCCCCGCAATCGGCTATGACAAGGCGGCAAAGATCGCCAA
ACATGCGCATGAGTCGGGGAGCACGCTTCGCGAGGCCGCGCTGGAGCTTGGCTATGTCGATGCCGCGACCTTCGACCGCC
TCGTCGATCCGCGCACGATGCTGGGGCCGGAACCCGGACCGCCTTCGGCGAATTGA

Upstream 100 bases:

>100_bases
GGCTTCGCCGCCGCGTCGGCGACATGGGATATTGGCAGATGCTCGGCCTTGTTGCGATGATCTGGGCGGGGGCGGTGCTG
GTGACAAGGATGCTCGCGGC

Downstream 100 bases:

>100_bases
TGGGGTGAAGGAGAAACGAGGATGATGGGTCGGATCATTGGCGGTATGGTGGGCCGGGCGATCGGCCGCAAGCGTGGCAA
CCACCCCATCGCCGGGACGA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSATRTESDSIGAIEVPADAYWGAQTERSRHNFAFPAHERMPVPIIHALARIKGAAARVNRSHGLDFKLADAIAEAADAV
AAGRYDDQFPLAIWQTGSGTQSNMNANEVIAGLANEALAGTRGGKAPVHPNDHVNMGQSSNDSFPTALHVAVAVETTARL
LPSLIALTDALDAKARAWADIVKIGRTHLQDATPLTLGQEFSGYVQQLIACRARIEGALTHNICKLAQGGTAVGTGLNAP
AGFDAAIAAELSRATGIAFEPARNKFEALASNDGLVFFSGALNTLAVALTKIANDIRLLGSGPRAGLGELDLPANEPGSS
IMPGKVNPTQCEMLTMVAAQVIGNHQAVTVGGMQGHLELNVFKPLIGANVLRSIELLAIGMAGFTEHCVAGLQPNRPRID
ELMNRSLMLVTALAPAIGYDKAAKIAKHAHESGSTLREAALELGYVDAATFDRLVDPRTMLGPEPGPPSAN

Sequences:

>Translated_471_residues
MSATRTESDSIGAIEVPADAYWGAQTERSRHNFAFPAHERMPVPIIHALARIKGAAARVNRSHGLDFKLADAIAEAADAV
AAGRYDDQFPLAIWQTGSGTQSNMNANEVIAGLANEALAGTRGGKAPVHPNDHVNMGQSSNDSFPTALHVAVAVETTARL
LPSLIALTDALDAKARAWADIVKIGRTHLQDATPLTLGQEFSGYVQQLIACRARIEGALTHNICKLAQGGTAVGTGLNAP
AGFDAAIAAELSRATGIAFEPARNKFEALASNDGLVFFSGALNTLAVALTKIANDIRLLGSGPRAGLGELDLPANEPGSS
IMPGKVNPTQCEMLTMVAAQVIGNHQAVTVGGMQGHLELNVFKPLIGANVLRSIELLAIGMAGFTEHCVAGLQPNRPRID
ELMNRSLMLVTALAPAIGYDKAAKIAKHAHESGSTLREAALELGYVDAATFDRLVDPRTMLGPEPGPPSAN
>Mature_470_residues
SATRTESDSIGAIEVPADAYWGAQTERSRHNFAFPAHERMPVPIIHALARIKGAAARVNRSHGLDFKLADAIAEAADAVA
AGRYDDQFPLAIWQTGSGTQSNMNANEVIAGLANEALAGTRGGKAPVHPNDHVNMGQSSNDSFPTALHVAVAVETTARLL
PSLIALTDALDAKARAWADIVKIGRTHLQDATPLTLGQEFSGYVQQLIACRARIEGALTHNICKLAQGGTAVGTGLNAPA
GFDAAIAAELSRATGIAFEPARNKFEALASNDGLVFFSGALNTLAVALTKIANDIRLLGSGPRAGLGELDLPANEPGSSI
MPGKVNPTQCEMLTMVAAQVIGNHQAVTVGGMQGHLELNVFKPLIGANVLRSIELLAIGMAGFTEHCVAGLQPNRPRIDE
LMNRSLMLVTALAPAIGYDKAAKIAKHAHESGSTLREAALELGYVDAATFDRLVDPRTMLGPEPGPPSAN

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=62.6898047722343, Blast_Score=568, Evalue=1e-162,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=58.7301587301587, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1787896, Length=463, Percent_Identity=58.5313174946004, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=37.4458874458874, Blast_Score=299, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17553882, Length=465, Percent_Identity=61.0752688172043, Blast_Score=558, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=329, Percent_Identity=61.3981762917933, Blast_Score=392, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324993, Length=465, Percent_Identity=58.9247311827957, Blast_Score=539, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=61.038961038961, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=61.038961038961, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=58.963282937365, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=58.7473002159827, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24583245, Length=467, Percent_Identity=51.3918629550321, Blast_Score=475, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49273; Mature: 49141

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATRTESDSIGAIEVPADAYWGAQTERSRHNFAFPAHERMPVPIIHALARIKGAAARVN
CCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RSHGLDFKLADAIAEAADAVAAGRYDDQFPLAIWQTGSGTQSNMNANEVIAGLANEALAG
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHC
TRGGKAPVHPNDHVNMGQSSNDSFPTALHVAVAVETTARLLPSLIALTDALDAKARAWAD
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEFSGYVQQLIACRARIEGALTHNICKLAQGGTAVGTGLNAP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
AGFDAAIAAELSRATGIAFEPARNKFEALASNDGLVFFSGALNTLAVALTKIANDIRLLG
CCCCHHHHHHHHHHCCCEECCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHEEEC
SGPRAGLGELDLPANEPGSSIMPGKVNPTQCEMLTMVAAQVIGNHQAVTVGGMQGHLELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEE
VFKPLIGANVLRSIELLAIGMAGFTEHCVAGLQPNRPRIDELMNRSLMLVTALAPAIGYD
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHCCH
KAAKIAKHAHESGSTLREAALELGYVDAATFDRLVDPRTMLGPEPGPPSAN
HHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCCCCCCCC
>Mature Secondary Structure 
SATRTESDSIGAIEVPADAYWGAQTERSRHNFAFPAHERMPVPIIHALARIKGAAARVN
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RSHGLDFKLADAIAEAADAVAAGRYDDQFPLAIWQTGSGTQSNMNANEVIAGLANEALAG
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHC
TRGGKAPVHPNDHVNMGQSSNDSFPTALHVAVAVETTARLLPSLIALTDALDAKARAWAD
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEFSGYVQQLIACRARIEGALTHNICKLAQGGTAVGTGLNAP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
AGFDAAIAAELSRATGIAFEPARNKFEALASNDGLVFFSGALNTLAVALTKIANDIRLLG
CCCCHHHHHHHHHHCCCEECCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHEEEC
SGPRAGLGELDLPANEPGSSIMPGKVNPTQCEMLTMVAAQVIGNHQAVTVGGMQGHLELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEE
VFKPLIGANVLRSIELLAIGMAGFTEHCVAGLQPNRPRIDELMNRSLMLVTALAPAIGYD
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHCCH
KAAKIAKHAHESGSTLREAALELGYVDAATFDRLVDPRTMLGPEPGPPSAN
HHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA