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The map label for this gene is hisB

Identifier: 103488624

GI number: 103488624

Start: 3299781

End: 3300368

Strand: Reverse

Name: hisB

Synonym: Sala_3149

Alternate gene names: 103488624

Gene position: 3300368-3299781 (Counterclockwise)

Preceding gene: 103488629

Following gene: 103488623

Centisome position: 98.66

GC content: 62.41

Gene sequence:

>588_bases
ATGCGAACCGCCACCGTCCAGCGCACGACCAAGGAAACGGATATCGCGATCACCGTCAATCTCGACGGGACGGGCGATTA
TTCGGTGTCCACCGGCATCGGTTTCCTCGACCATATGGTCGAACAATTGTCGCGCCACTCGCTGATCGACATCTCGATGC
AGGTGAAGGGCGACCTCCATATCGACCAGCATCACACCGTCGAGGATTCGGCGCTCGCATTGGGCGAAGCGGTGGCCAAG
GCGCTCGGCGACAAGCGCGGGATCGCGCGTTACGGCGAGGCGCACGCGCCGATGGACGAAACGCTGACGCGCTGCGTGCT
CGACATTTCCGGGCGCCCGCACTGCGTTTACAAATCCAGCTTCTCGCAGCCGCGGCTGGGCGAGATGGACACCGAGATGT
TCCCGCACTGGTTCCACAGTTTCGCGCAGACCGCGGGGATCACGCTGCACATCGAAACGCTCTATGGCGAGAATAACCAT
CATATCGCCGAAAGCATGTACAAGGCGCTGGCCAGGGCGCTGCGCCAGGCGGTCGAGATCGATCCGCGCAAGGGCGATGC
GATTCCCTCGACCAAGGGCGTGCTCTAG

Upstream 100 bases:

>100_bases
CGTCGTCACTCATGGCCGAGGGGGATGGACGGGCAGCGTTCGCGGGTCAAGGGGGGAGAGTCGCCTTGCAACGCGAAAAA
TAGCGTCTAAGGGGCATGTC

Downstream 100 bases:

>100_bases
GAGCCGTCCATGAGCGTGATTGCCCTGATCGACTATGGCGCGGGCAATCTTCGCTCGGTGCATAATGCGCTCGTCGCGGC
GGGCGCGGACACTGTCGCCG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRTATVQRTTKETDIAITVNLDGTGDYSVSTGIGFLDHMVEQLSRHSLIDISMQVKGDLHIDQHHTVEDSALALGEAVAK
ALGDKRGIARYGEAHAPMDETLTRCVLDISGRPHCVYKSSFSQPRLGEMDTEMFPHWFHSFAQTAGITLHIETLYGENNH
HIAESMYKALARALRQAVEIDPRKGDAIPSTKGVL

Sequences:

>Translated_195_residues
MRTATVQRTTKETDIAITVNLDGTGDYSVSTGIGFLDHMVEQLSRHSLIDISMQVKGDLHIDQHHTVEDSALALGEAVAK
ALGDKRGIARYGEAHAPMDETLTRCVLDISGRPHCVYKSSFSQPRLGEMDTEMFPHWFHSFAQTAGITLHIETLYGENNH
HIAESMYKALARALRQAVEIDPRKGDAIPSTKGVL
>Mature_195_residues
MRTATVQRTTKETDIAITVNLDGTGDYSVSTGIGFLDHMVEQLSRHSLIDISMQVKGDLHIDQHHTVEDSALALGEAVAK
ALGDKRGIARYGEAHAPMDETLTRCVLDISGRPHCVYKSSFSQPRLGEMDTEMFPHWFHSFAQTAGITLHIETLYGENNH
HIAESMYKALARALRQAVEIDPRKGDAIPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=53.6082474226804, Blast_Score=212, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=41.743119266055, Blast_Score=178, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_SPHAL (Q1GNC0)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_618185.1
- ProteinModelPortal:   Q1GNC0
- SMR:   Q1GNC0
- GeneID:   4082485
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_3149
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   SALA317655:SALA_3149-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21510; Mature: 21510

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTATVQRTTKETDIAITVNLDGTGDYSVSTGIGFLDHMVEQLSRHSLIDISMQVKGDLH
CCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEE
IDQHHTVEDSALALGEAVAKALGDKRGIARYGEAHAPMDETLTRCVLDISGRPHCVYKSS
ECCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEECCC
FSQPRLGEMDTEMFPHWFHSFAQTAGITLHIETLYGENNHHIAESMYKALARALRQAVEI
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
DPRKGDAIPSTKGVL
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MRTATVQRTTKETDIAITVNLDGTGDYSVSTGIGFLDHMVEQLSRHSLIDISMQVKGDLH
CCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEE
IDQHHTVEDSALALGEAVAKALGDKRGIARYGEAHAPMDETLTRCVLDISGRPHCVYKSS
ECCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEECCC
FSQPRLGEMDTEMFPHWFHSFAQTAGITLHIETLYGENNHHIAESMYKALARALRQAVEI
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
DPRKGDAIPSTKGVL
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA