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The map label for this gene is hpd [H]

Identifier: 103488594

GI number: 103488594

Start: 3269701

End: 3270792

Strand: Direct

Name: hpd [H]

Synonym: Sala_3119

Alternate gene names: 103488594

Gene position: 3269701-3270792 (Clockwise)

Preceding gene: 103488593

Following gene: 103488595

Centisome position: 97.74

GC content: 63.19

Gene sequence:

>1092_bases
ATGGCCGACCTGTTCGAAAACCCGCTGGGCCTCGACGGCTTCGAGTTCGTCGAGTTTTCGGCGCCCGAAAAGGGCATTCT
CGAGCCTGTGTTCGAACGCATGGGCTTTACCCGGATCGCGCGCCACCGGTCGAAAGACGTGCAATTGTGGCGTCAGGGCG
ACATCAATCTGATCGCCAATTACGAACCCCGCTCTCCCGCTGCCTATTTCGCCGCCGAACATGGCCCGTCGGCGTGCGGC
ATGGGGTGGCGCTGCCGCGATGCGGCCAAAGCCTATGCGGAAGCGATCGAGCGCGGCGCCGAGCCGGTCGAAACGACTCC
CGGCCCGATGGAACTGCGCCTGCCCGCGATCCGCGGCATCGGCGGCTCGATTATCTATCTGATCGACCGCTATGGCGACG
ATCTCAGCATCTACGACATCGACTTCGTTTACGAGGAGGGCGTCGACCGCCATCCGGTCGGCGCGGGGCTGAAGGTCATC
GATCACCTGACGCACAATGTCTATGGCGGCCGCATGGCGCATTGGGCGGCGTTCTACGAGCGCATCGCGGGTTTTCGCGA
AATCCGCTATTTCGACATCAAGGGTGAATATACCGGCCTCACGTCAAAGGCGATGACCGCGCCCGACGGCAAGATACGCA
TTCCGCTGAACGAGGAGGGCGCCGGCGGCGGCGGCCAGATCGAGGAATATCTGCGCGCCTACAATGGCGAGGGTATCCAG
CATATCGCCTTTGCCTGCGACGACCTCTACGCCGCGTGGGACAGGCTGAAAGCGCTCGGCAACCCCTTCGCGCCATCGCC
GCCCGACACCTATTATGAAATGCTCGCCGAGCGCCTGCCCGGCCATGGCGAGCCGGTCGAGGAACTGAAATCGCGCGGCA
TATTGCTCGACGGTTCGACGACCGAGGGCGATCCGCGCCTGCTGCTCCAGATTTTCGGGCAGACGGTGATCGGCCCGGTT
TTCTTCGAGTTCATCCAGCGCAAGAAGGACGAAGGCTTCGGCGAGGGCAATTTCACCGCGCTGTTCAAGTCGATGGAACT
CGACCAGATCCGCCGCGGCGCGCTCAACGTCGAAGCGGAGCCCGCCGAATGA

Upstream 100 bases:

>100_bases
TTGATAGCCCCTCCCTGAAGGGGAGGGCGTCATCGCCGCATTGACTCGCCTTCCCCAATCCATCATAATAGTTTCAATTG
AAACCATATGGGGAATGACC

Downstream 100 bases:

>100_bases
CCAGCCCGATCAAACTGGGGGGCGTCCACCACGCCGCCTATCGCTGCAAGGATGCGAAGGAGACGGTCGAATGGTACGAG
GCCATGCTCGGCATGACCTA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MADLFENPLGLDGFEFVEFSAPEKGILEPVFERMGFTRIARHRSKDVQLWRQGDINLIANYEPRSPAAYFAAEHGPSACG
MGWRCRDAAKAYAEAIERGAEPVETTPGPMELRLPAIRGIGGSIIYLIDRYGDDLSIYDIDFVYEEGVDRHPVGAGLKVI
DHLTHNVYGGRMAHWAAFYERIAGFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEEGAGGGGQIEEYLRAYNGEGIQ
HIAFACDDLYAAWDRLKALGNPFAPSPPDTYYEMLAERLPGHGEPVEELKSRGILLDGSTTEGDPRLLLQIFGQTVIGPV
FFEFIQRKKDEGFGEGNFTALFKSMELDQIRRGALNVEAEPAE

Sequences:

>Translated_363_residues
MADLFENPLGLDGFEFVEFSAPEKGILEPVFERMGFTRIARHRSKDVQLWRQGDINLIANYEPRSPAAYFAAEHGPSACG
MGWRCRDAAKAYAEAIERGAEPVETTPGPMELRLPAIRGIGGSIIYLIDRYGDDLSIYDIDFVYEEGVDRHPVGAGLKVI
DHLTHNVYGGRMAHWAAFYERIAGFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEEGAGGGGQIEEYLRAYNGEGIQ
HIAFACDDLYAAWDRLKALGNPFAPSPPDTYYEMLAERLPGHGEPVEELKSRGILLDGSTTEGDPRLLLQIFGQTVIGPV
FFEFIQRKKDEGFGEGNFTALFKSMELDQIRRGALNVEAEPAE
>Mature_362_residues
ADLFENPLGLDGFEFVEFSAPEKGILEPVFERMGFTRIARHRSKDVQLWRQGDINLIANYEPRSPAAYFAAEHGPSACGM
GWRCRDAAKAYAEAIERGAEPVETTPGPMELRLPAIRGIGGSIIYLIDRYGDDLSIYDIDFVYEEGVDRHPVGAGLKVID
HLTHNVYGGRMAHWAAFYERIAGFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEEGAGGGGQIEEYLRAYNGEGIQH
IAFACDDLYAAWDRLKALGNPFAPSPPDTYYEMLAERLPGHGEPVEELKSRGILLDGSTTEGDPRLLLQIFGQTVIGPVF
FEFIQRKKDEGFGEGNFTALFKSMELDQIRRGALNVEAEPAE

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=302, Percent_Identity=29.1390728476821, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4504477, Length=302, Percent_Identity=29.1390728476821, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17555220, Length=309, Percent_Identity=31.7152103559871, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550752, Length=319, Percent_Identity=24.7648902821317, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356105, Length=304, Percent_Identity=32.8947368421053, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24667510, Length=304, Percent_Identity=32.8947368421053, Blast_Score=128, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40380; Mature: 40249

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLFENPLGLDGFEFVEFSAPEKGILEPVFERMGFTRIARHRSKDVQLWRQGDINLIAN
CCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCHHHHHHHCCCCHHHEECCCEEEEEC
YEPRSPAAYFAAEHGPSACGMGWRCRDAAKAYAEAIERGAEPVETTPGPMELRLPAIRGI
CCCCCCHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHCC
GGSIIYLIDRYGDDLSIYDIDFVYEEGVDRHPVGAGLKVIDHLTHNVYGGRMAHWAAFYE
CCEEEEEEECCCCCEEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
RIAGFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEEGAGGGGQIEEYLRAYNGEGIQ
HHCCHHHEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCHH
HIAFACDDLYAAWDRLKALGNPFAPSPPDTYYEMLAERLPGHGEPVEELKSRGILLDGST
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCEEEECCC
TEGDPRLLLQIFGQTVIGPVFFEFIQRKKDEGFGEGNFTALFKSMELDQIRRGALNVEAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCC
PAE
CCC
>Mature Secondary Structure 
ADLFENPLGLDGFEFVEFSAPEKGILEPVFERMGFTRIARHRSKDVQLWRQGDINLIAN
CCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCHHHHHHHCCCCHHHEECCCEEEEEC
YEPRSPAAYFAAEHGPSACGMGWRCRDAAKAYAEAIERGAEPVETTPGPMELRLPAIRGI
CCCCCCHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHCC
GGSIIYLIDRYGDDLSIYDIDFVYEEGVDRHPVGAGLKVIDHLTHNVYGGRMAHWAAFYE
CCEEEEEEECCCCCEEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
RIAGFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEEGAGGGGQIEEYLRAYNGEGIQ
HHCCHHHEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCHH
HIAFACDDLYAAWDRLKALGNPFAPSPPDTYYEMLAERLPGHGEPVEELKSRGILLDGST
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCEEEECCC
TEGDPRLLLQIFGQTVIGPVFFEFIQRKKDEGFGEGNFTALFKSMELDQIRRGALNVEAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCC
PAE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]