BacMap

Definition	Sphingopyxis alaskensis RB2256, complete genome.
Accession	NC_008048
Length	3,345,170

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The map label for this gene is kduD [H]

Identifier: 103488511

GI number: 103488511

Start: 3182005

End: 3182760

Strand: Direct

Name: kduD [H]

Synonym: Sala_3035

Alternate gene names: 103488511

Gene position: 3182005-3182760 (Clockwise)

Preceding gene: 103488510

Following gene: 103488512

Centisome position: 95.12

GC content: 67.99

Gene sequence:

>756_bases
ATGACCGCATCATTCGATCTCGTCGGGCGCGTCGCGCTCGTGACCGGCGCCAACACGGGCATCGGGCAGGGGATCGCGTT
CGCGCTTGCCGATGCGGGCGCCGATATCGCCGCCGCGGGCCGCTCGCCCGCCGACGAGACCGTCGGCATGATACGCGGGC
TCGGTCGCAAGGCCGACAATTTCGCCGCCGACCTGTCGAGCGTCGCGGCGGTGCAGCCGCTCGTCGACACCGTGCTCGCG
GAGTTCGGCCGCATCGACATCCTCGTCAACAACGCCGGCATCATCCGCCGGGCCGATGCGCTCGATTTCACCGAGGAAGA
TTGGGATGCGGTAATGGACACCAATCTCAAGACGCTCTTCTTCCTCTGCCAGAGCGTCGGACGGCACATGATCGCGCGCG
GGTCGGGCAAGATTATCAACATCGCCTCGATGCTGACCTTTCAGGGGGGCGTCCGCGTGCCCAGCTACACCGCGTCGAAA
TCGGGGGTCGGCGGGCTCACCAAGCTGCTCGCGAACGAATGGGCGGCGAAGGGGGTCAACGTCAACGCGATCGCGCCCGG
CTATATCGCGACGAACAACACCGCCGCGCTGCAGGCCGATGAGACGCGCAGCCGGCAGATCATGGAGCGCATCCCGGCGG
GCCGCTGGGGCGACCCCGCCGACATCGGCGGCGCGGCGGTATTCCTGGCGTCGCGCGCGTCGGATTATGTGCAGGGGCAT
ATCCTCGCCGTCGACGGCGGCTGGCTGGCGCGATAA

Upstream 100 bases:

>100_bases
GCGGGTGAGAGGTTCGCCGACTATTTCTACGCCAATTCGCAGGACGAAGCGATCAGCGCCTATTTGACGAGCTTGTCTGC
GGAGCGGGCGCTCGCCTGAC

Downstream 100 bases:

>100_bases
CGAGAGGCTGCTCGAAAATCCCGGTTCGCCCTGCGCTTGTCGAAGGGCCGTTCTTTTCTTCAACCGCGAGAAGCGGACAA
GCGGTGCTTCGACAAGCCCG

Product: 2-deoxy-D-gluconate 3-dehydrogenase

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTASFDLVGRVALVTGANTGIGQGIAFALADAGADIAAAGRSPADETVGMIRGLGRKADNFAADLSSVAAVQPLVDTVLA
EFGRIDILVNNAGIIRRADALDFTEEDWDAVMDTNLKTLFFLCQSVGRHMIARGSGKIINIASMLTFQGGVRVPSYTASK
SGVGGLTKLLANEWAAKGVNVNAIAPGYIATNNTAALQADETRSRQIMERIPAGRWGDPADIGGAAVFLASRASDYVQGH
ILAVDGGWLAR

Sequences:

>Translated_251_residues
MTASFDLVGRVALVTGANTGIGQGIAFALADAGADIAAAGRSPADETVGMIRGLGRKADNFAADLSSVAAVQPLVDTVLA
EFGRIDILVNNAGIIRRADALDFTEEDWDAVMDTNLKTLFFLCQSVGRHMIARGSGKIINIASMLTFQGGVRVPSYTASK
SGVGGLTKLLANEWAAKGVNVNAIAPGYIATNNTAALQADETRSRQIMERIPAGRWGDPADIGGAAVFLASRASDYVQGH
ILAVDGGWLAR
>Mature_250_residues
TASFDLVGRVALVTGANTGIGQGIAFALADAGADIAAAGRSPADETVGMIRGLGRKADNFAADLSSVAAVQPLVDTVLAE
FGRIDILVNNAGIIRRADALDFTEEDWDAVMDTNLKTLFFLCQSVGRHMIARGSGKIINIASMLTFQGGVRVPSYTASKS
GVGGLTKLLANEWAAKGVNVNAIAPGYIATNNTAALQADETRSRQIMERIPAGRWGDPADIGGAAVFLASRASDYVQGHI
LAVDGGWLAR

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=250, Percent_Identity=38, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=33.0708661417323, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=32.7800829875519, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI19923817, Length=251, Percent_Identity=31.8725099601594, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=31.8548387096774, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI66933014, Length=183, Percent_Identity=32.7868852459016, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI126723750, Length=257, Percent_Identity=31.1284046692607, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=30.4526748971193, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4504505, Length=197, Percent_Identity=35.5329949238579, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=31.4516129032258, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI59889578, Length=190, Percent_Identity=34.7368421052632, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI7706318, Length=203, Percent_Identity=31.0344827586207, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4758504, Length=251, Percent_Identity=30.6772908366534, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI33667109, Length=189, Percent_Identity=31.2169312169312, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI20149619, Length=208, Percent_Identity=32.6923076923077, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI126723191, Length=187, Percent_Identity=31.5508021390374, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI31542939, Length=216, Percent_Identity=31.9444444444444, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI142976729, Length=194, Percent_Identity=28.3505154639175, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4503301, Length=196, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI210032110, Length=209, Percent_Identity=26.7942583732057, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI225579078, Length=202, Percent_Identity=29.7029702970297, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI209862901, Length=205, Percent_Identity=30.7317073170732, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI19923983, Length=205, Percent_Identity=30.7317073170732, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI40807363, Length=195, Percent_Identity=28.7179487179487, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI109715829, Length=242, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4557649, Length=198, Percent_Identity=26.2626262626263, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI83715985, Length=251, Percent_Identity=28.6852589641434, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=59.9206349206349, Blast_Score=314, Evalue=4e-87,
Organism=Escherichia coli, GI87082160, Length=248, Percent_Identity=43.9516129032258, Blast_Score=209, Evalue=1e-55,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=40.7114624505929, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=36.8852459016393, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=36.9047619047619, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=32.520325203252, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787905, Length=243, Percent_Identity=34.156378600823, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=31.7073170731707, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=29.5275590551181, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=30.6122448979592, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=28.0155642023346, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787820, Length=183, Percent_Identity=31.6939890710383, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787526, Length=191, Percent_Identity=28.7958115183246, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI2367365, Length=250, Percent_Identity=26.8, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=32.6612903225806, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=36.9477911646586, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=35.9183673469388, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=36, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25147288, Length=243, Percent_Identity=34.9794238683128, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=34, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17559104, Length=256, Percent_Identity=32.421875, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17562910, Length=257, Percent_Identity=33.852140077821, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=31.1787072243346, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17551412, Length=257, Percent_Identity=31.5175097276265, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17560150, Length=256, Percent_Identity=31.640625, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562906, Length=257, Percent_Identity=32.295719844358, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562990, Length=255, Percent_Identity=31.3725490196078, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562908, Length=257, Percent_Identity=31.9066147859922, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17538480, Length=270, Percent_Identity=31.1111111111111, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=32.6923076923077, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI72000259, Length=255, Percent_Identity=29.8039215686275, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=27.710843373494, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17560332, Length=257, Percent_Identity=29.5719844357977, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17538486, Length=257, Percent_Identity=31.1284046692607, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17560220, Length=257, Percent_Identity=30.3501945525292, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17531453, Length=257, Percent_Identity=31.5175097276265, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17565030, Length=257, Percent_Identity=30.3501945525292, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562904, Length=257, Percent_Identity=28.7937743190661, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17563726, Length=255, Percent_Identity=27.4509803921569, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17568967, Length=197, Percent_Identity=32.48730964467, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17536025, Length=254, Percent_Identity=30.7086614173228, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17564282, Length=188, Percent_Identity=31.9148936170213, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=33.160621761658, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI193203117, Length=190, Percent_Identity=33.1578947368421, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17561272, Length=251, Percent_Identity=33.8645418326693, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17536651, Length=249, Percent_Identity=30.1204819277108, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17508651, Length=255, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=267, Percent_Identity=31.0861423220974, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17555612, Length=220, Percent_Identity=32.2727272727273, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508895, Length=192, Percent_Identity=29.6875, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71997099, Length=209, Percent_Identity=29.6650717703349, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=195, Percent_Identity=28.7179487179487, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322861, Length=198, Percent_Identity=32.8282828282828, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324126, Length=247, Percent_Identity=27.9352226720648, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=245, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI23397609, Length=247, Percent_Identity=34.412955465587, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=36.6935483870968, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21357041, Length=248, Percent_Identity=35.4838709677419, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=34.2741935483871, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=29.4354838709677, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24644339, Length=262, Percent_Identity=32.824427480916, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24643142, Length=243, Percent_Identity=31.2757201646091, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859837, Length=189, Percent_Identity=36.5079365079365, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644337, Length=252, Percent_Identity=30.1587301587302, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=32.994923857868, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737361, Length=252, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640492, Length=214, Percent_Identity=27.5700934579439, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI161076933, Length=194, Percent_Identity=28.3505154639175, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24584748, Length=194, Percent_Identity=28.3505154639175, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21355631, Length=174, Percent_Identity=30.4597701149425, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21357673, Length=191, Percent_Identity=28.7958115183246, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24649181, Length=201, Percent_Identity=27.8606965174129, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24580925, Length=194, Percent_Identity=28.3505154639175, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574402, Length=199, Percent_Identity=29.1457286432161, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24584744, Length=199, Percent_Identity=29.1457286432161, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281364892, Length=172, Percent_Identity=29.0697674418605, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI22024069, Length=208, Percent_Identity=27.4038461538462, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 26091; Mature: 25960

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASFDLVGRVALVTGANTGIGQGIAFALADAGADIAAAGRSPADETVGMIRGLGRKADN
CCCCHHHHHEEEEEECCCCCCCCCHHEEEHHCCCCEEECCCCCHHHHHHHHHHCCCCCHH
FAADLSSVAAVQPLVDTVLAEFGRIDILVNNAGIIRRADALDFTEEDWDAVMDTNLKTLF
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHCCHHHHH
FLCQSVGRHMIARGSGKIINIASMLTFQGGVRVPSYTASKSGVGGLTKLLANEWAAKGVN
HHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
VNAIAPGYIATNNTAALQADETRSRQIMERIPAGRWGDPADIGGAAVFLASRASDYVQGH
EEEECCCEEEECCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHCEE
ILAVDGGWLAR
EEEECCCCCCC
>Mature Secondary Structure 
TASFDLVGRVALVTGANTGIGQGIAFALADAGADIAAAGRSPADETVGMIRGLGRKADN
CCCHHHHHEEEEEECCCCCCCCCHHEEEHHCCCCEEECCCCCHHHHHHHHHHCCCCCHH
FAADLSSVAAVQPLVDTVLAEFGRIDILVNNAGIIRRADALDFTEEDWDAVMDTNLKTLF
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHCCHHHHH
FLCQSVGRHMIARGSGKIINIASMLTFQGGVRVPSYTASKSGVGGLTKLLANEWAAKGVN
HHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
VNAIAPGYIATNNTAALQADETRSRQIMERIPAGRWGDPADIGGAAVFLASRASDYVQGH
EEEECCCEEEECCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHCEE
ILAVDGGWLAR
EEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 2836407; 1766386 [H]