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The map label for this gene is pepQ [H]

Identifier: 103488471

GI number: 103488471

Start: 3134588

End: 3136414

Strand: Reverse

Name: pepQ [H]

Synonym: Sala_2994

Alternate gene names: 103488471

Gene position: 3136414-3134588 (Counterclockwise)

Preceding gene: 103488474

Following gene: 103488470

Centisome position: 93.76

GC content: 67.16

Gene sequence:

>1827_bases
ATGTCCAGCCCCGTCCACGCCGAGCGCCTCGCCCGCGTCCGTGCCGAATTGAAAGCGCGCGGCCTCGATGGCTTCATCGT
GCCGATCAGCGACGAACATATGAGCGAATATGTCGGCGCCTATGCGCAGCGCATGGCCTGGCTGACCGGCTTTGGTGGAT
CGGCCGGGACCGCGGCGGTCCTGCCCGAAAAGGCGGCGGTGTTCGTCGACGGCCGCTACACCGTGCAGGTGCGCGACCAG
GTCGACGGGTCGCTCTTCGACTATGTCGGGGTGCCGCAGTCGAGCGTCGCCGAATGGCTGGGCAGCCATGTCAGCGCGGG
GCAGAGGGTTGGTTATGACCCCTGGCTGCACGGTATAGACTGGGTCCGCGGGCTGGAAAAGGCGCTGGCGGCGAAAGGTG
CGAGCCTTGTCGCGGTCGACAAGAATCCGGTCGACGCGGCATGGGACGACCAACCCGCGCCGAGCAACGCGCCGGTGAGC
GTTTATGATACGGCGCTCGCCGGACAGAGTGCGGTCGAGAAACGCGGTGTCATCGCCGACTGGCTGAAGGCGAAGGGGCT
CGACACGACGGTGATGACCGCGCTCGATTCGATCGCCTGGACCTTCAATATCCGTGGGGAGGACGTGAGCCACACGCCGG
TCGGGCTGGCCTTTGCACTGCTCCACGCCGACGCCACCGCCGATCTGTTCATCGCGCCCGAAAAAATCACCGACGCGGTG
CGCGCGCATCTGGGCAACAGCGTGCGGATTCACGACCGCAGCGCCTTTGAAGGCGCGCTGGCCGGGCTTGCGGGCAAGAA
AGTCGCTGTCGATCCCGACCGCGCGGTCGCGGCGATCTTTACCGCGCTCGAAAACGCGGGTGTGCAGGTCGAACGGCACC
GCGACCCCGCGGTGCTGCCCAAGGCGATCAAGAATCAAGTCGAACTGAGCGGCACGCGCGCTGCGCACCTTCGCGACGGC
GTCGCGGTGTCGCGTTTCCTCAAATGGATGGAGGAGGTCGCGCCGCAGGGCGGCCTCGACGAGCTGGGCGCGGCGGCGAA
GCTGCGCGAATTTCGCGAGGCAGGCGGCGCGCTCAAGGATCTGTCGTTCGACACCATTTCGGCGGCTGGCCCGAACGGCG
CGCTGCCGCATTACAAGGTCGACGAAACCACCAACCGCAGGATCGAGAGGGGCACGCTCTATCTGGTCGATTCGGGCGGA
CAATATGCCGACGGCACGACCGACATCACGCGCACGATCGCGATCGGGGCGCCCAGCGCCGAAATGCGGCGCCGCTTCAC
GCAGGTGCTGAAGGGTCATATCGCGCTGGCCACCGCGCGCTTTCCCAAGGGCACACGCGGCAGCCAGCTGGACATCCTCG
CGCGCCAGTATCTGTGGGCCGACGGGGTCGATTATGCGCATGGCACCGGGCATGGCGTCGGCACCTATCTCGCGGTCCAC
GAAGGGCCGCAGCGGATCGCCAAGCCGGCGGGCGGACAGGCGGGGACCGAGGAGCCGCTGCACGCGGGCATGATCCTGTC
GAACGAGCCCGGCTATTACAAGGCGGGGCATTTCGGCATCCGCATCGAAAATCTGGTGATCGTCGTGCCGCAAGAGATCG
ACGGCGCCGAGGAAGAGATGCTGGGGTTCGAGACGATCACCTTTGCGCCGATCGCGAGAGATCTGGTCGACGTGGCGCTG
CTGTCGTCCGCCGAGGCCGACTGGCTCGACGCCTATCATGCCGCGGTGTTCGAAAAGCTGTCGCCGGGAATGGACGAGGC
GATGCGCGACTGGCTTGCCGCCGCCTGCGCTCCGCTCGACCGCACCCCTGCCGCGCTCGCGGCCTGA

Upstream 100 bases:

>100_bases
AATTGCGGCCAGAAACATCCAAATAGCGCGCACAAGACAACTCCCGCAGCATCGCCCGCATGGGCCGGAACGGCTGCGAT
GTAGGAACAAGGAAGCGACC

Downstream 100 bases:

>100_bases
GCCGGTGCAATGACCGGCCATCGCAGCACGGTGCCGCTCGCCGATTTCCGCGTGCAGGAGCGCGTGCGTGTGCGCTTCAA
CGAGATCGACGGGCAGAATA

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSSPVHAERLARVRAELKARGLDGFIVPISDEHMSEYVGAYAQRMAWLTGFGGSAGTAAVLPEKAAVFVDGRYTVQVRDQ
VDGSLFDYVGVPQSSVAEWLGSHVSAGQRVGYDPWLHGIDWVRGLEKALAAKGASLVAVDKNPVDAAWDDQPAPSNAPVS
VYDTALAGQSAVEKRGVIADWLKAKGLDTTVMTALDSIAWTFNIRGEDVSHTPVGLAFALLHADATADLFIAPEKITDAV
RAHLGNSVRIHDRSAFEGALAGLAGKKVAVDPDRAVAAIFTALENAGVQVERHRDPAVLPKAIKNQVELSGTRAAHLRDG
VAVSRFLKWMEEVAPQGGLDELGAAAKLREFREAGGALKDLSFDTISAAGPNGALPHYKVDETTNRRIERGTLYLVDSGG
QYADGTTDITRTIAIGAPSAEMRRRFTQVLKGHIALATARFPKGTRGSQLDILARQYLWADGVDYAHGTGHGVGTYLAVH
EGPQRIAKPAGGQAGTEEPLHAGMILSNEPGYYKAGHFGIRIENLVIVVPQEIDGAEEEMLGFETITFAPIARDLVDVAL
LSSAEADWLDAYHAAVFEKLSPGMDEAMRDWLAAACAPLDRTPAALAA

Sequences:

>Translated_608_residues
MSSPVHAERLARVRAELKARGLDGFIVPISDEHMSEYVGAYAQRMAWLTGFGGSAGTAAVLPEKAAVFVDGRYTVQVRDQ
VDGSLFDYVGVPQSSVAEWLGSHVSAGQRVGYDPWLHGIDWVRGLEKALAAKGASLVAVDKNPVDAAWDDQPAPSNAPVS
VYDTALAGQSAVEKRGVIADWLKAKGLDTTVMTALDSIAWTFNIRGEDVSHTPVGLAFALLHADATADLFIAPEKITDAV
RAHLGNSVRIHDRSAFEGALAGLAGKKVAVDPDRAVAAIFTALENAGVQVERHRDPAVLPKAIKNQVELSGTRAAHLRDG
VAVSRFLKWMEEVAPQGGLDELGAAAKLREFREAGGALKDLSFDTISAAGPNGALPHYKVDETTNRRIERGTLYLVDSGG
QYADGTTDITRTIAIGAPSAEMRRRFTQVLKGHIALATARFPKGTRGSQLDILARQYLWADGVDYAHGTGHGVGTYLAVH
EGPQRIAKPAGGQAGTEEPLHAGMILSNEPGYYKAGHFGIRIENLVIVVPQEIDGAEEEMLGFETITFAPIARDLVDVAL
LSSAEADWLDAYHAAVFEKLSPGMDEAMRDWLAAACAPLDRTPAALAA
>Mature_607_residues
SSPVHAERLARVRAELKARGLDGFIVPISDEHMSEYVGAYAQRMAWLTGFGGSAGTAAVLPEKAAVFVDGRYTVQVRDQV
DGSLFDYVGVPQSSVAEWLGSHVSAGQRVGYDPWLHGIDWVRGLEKALAAKGASLVAVDKNPVDAAWDDQPAPSNAPVSV
YDTALAGQSAVEKRGVIADWLKAKGLDTTVMTALDSIAWTFNIRGEDVSHTPVGLAFALLHADATADLFIAPEKITDAVR
AHLGNSVRIHDRSAFEGALAGLAGKKVAVDPDRAVAAIFTALENAGVQVERHRDPAVLPKAIKNQVELSGTRAAHLRDGV
AVSRFLKWMEEVAPQGGLDELGAAAKLREFREAGGALKDLSFDTISAAGPNGALPHYKVDETTNRRIERGTLYLVDSGGQ
YADGTTDITRTIAIGAPSAEMRRRFTQVLKGHIALATARFPKGTRGSQLDILARQYLWADGVDYAHGTGHGVGTYLAVHE
GPQRIAKPAGGQAGTEEPLHAGMILSNEPGYYKAGHFGIRIENLVIVVPQEIDGAEEEMLGFETITFAPIARDLVDVALL
SSAEADWLDAYHAAVFEKLSPGMDEAMRDWLAAACAPLDRTPAALAA

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=633, Percent_Identity=37.7567140600316, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI93141226, Length=605, Percent_Identity=35.702479338843, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI264681565, Length=633, Percent_Identity=36.3349131121643, Blast_Score=372, Evalue=1e-103,
Organism=Escherichia coli, GI1788728, Length=209, Percent_Identity=36.3636363636364, Blast_Score=93, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17509539, Length=624, Percent_Identity=36.3782051282051, Blast_Score=358, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI25149105, Length=599, Percent_Identity=30.2170283806344, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6322999, Length=656, Percent_Identity=31.0975609756098, Blast_Score=302, Evalue=1e-82,
Organism=Drosophila melanogaster, GI17137632, Length=615, Percent_Identity=36.4227642276423, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI161078230, Length=585, Percent_Identity=33.1623931623932, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI21357287, Length=585, Percent_Identity=33.1623931623932, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 64797; Mature: 64666

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPVHAERLARVRAELKARGLDGFIVPISDEHMSEYVGAYAQRMAWLTGFGGSAGTAAV
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LPEKAAVFVDGRYTVQVRDQVDGSLFDYVGVPQSSVAEWLGSHVSAGQRVGYDPWLHGID
CCCCEEEEECCEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
WVRGLEKALAAKGASLVAVDKNPVDAAWDDQPAPSNAPVSVYDTALAGQSAVEKRGVIAD
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHCCHHHHHHCCHHHH
WLKAKGLDTTVMTALDSIAWTFNIRGEDVSHTPVGLAFALLHADATADLFIAPEKITDAV
HHHHCCCCHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHHH
RAHLGNSVRIHDRSAFEGALAGLAGKKVAVDPDRAVAAIFTALENAGVQVERHRDPAVLP
HHHCCCCEEEECCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCEEEECCCCCHHH
KAIKNQVELSGTRAAHLRDGVAVSRFLKWMEEVAPQGGLDELGAAAKLREFREAGGALKD
HHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
LSFDTISAAGPNGALPHYKVDETTNRRIERGTLYLVDSGGQYADGTTDITRTIAIGAPSA
CCCCCCCCCCCCCCCCCEECCCCCCCEEECCEEEEEECCCCCCCCCCCCEEEEEECCCCH
EMRRRFTQVLKGHIALATARFPKGTRGSQLDILARQYLWADGVDYAHGTGHGVGTYLAVH
HHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEE
EGPQRIAKPAGGQAGTEEPLHAGMILSNEPGYYKAGHFGIRIENLVIVVPQEIDGAEEEM
CCHHHHCCCCCCCCCCCCCCCCCEEEECCCCCEECCCEEEEEEEEEEEECCCCCCCHHHH
LGFETITFAPIARDLVDVALLSSAEADWLDAYHAAVFEKLSPGMDEAMRDWLAAACAPLD
HCCHHEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
RTPAALAA
CCCHHHCC
>Mature Secondary Structure 
SSPVHAERLARVRAELKARGLDGFIVPISDEHMSEYVGAYAQRMAWLTGFGGSAGTAAV
CCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LPEKAAVFVDGRYTVQVRDQVDGSLFDYVGVPQSSVAEWLGSHVSAGQRVGYDPWLHGID
CCCCEEEEECCEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
WVRGLEKALAAKGASLVAVDKNPVDAAWDDQPAPSNAPVSVYDTALAGQSAVEKRGVIAD
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHCCHHHHHHCCHHHH
WLKAKGLDTTVMTALDSIAWTFNIRGEDVSHTPVGLAFALLHADATADLFIAPEKITDAV
HHHHCCCCHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHHH
RAHLGNSVRIHDRSAFEGALAGLAGKKVAVDPDRAVAAIFTALENAGVQVERHRDPAVLP
HHHCCCCEEEECCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCEEEECCCCCHHH
KAIKNQVELSGTRAAHLRDGVAVSRFLKWMEEVAPQGGLDELGAAAKLREFREAGGALKD
HHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
LSFDTISAAGPNGALPHYKVDETTNRRIERGTLYLVDSGGQYADGTTDITRTIAIGAPSA
CCCCCCCCCCCCCCCCCEECCCCCCCEEECCEEEEEECCCCCCCCCCCCEEEEEECCCCH
EMRRRFTQVLKGHIALATARFPKGTRGSQLDILARQYLWADGVDYAHGTGHGVGTYLAVH
HHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEE
EGPQRIAKPAGGQAGTEEPLHAGMILSNEPGYYKAGHFGIRIENLVIVVPQEIDGAEEEM
CCHHHHCCCCCCCCCCCCCCCCCEEEECCCCCEECCCEEEEEEEEEEEECCCCCCCHHHH
LGFETITFAPIARDLVDVALLSSAEADWLDAYHAAVFEKLSPGMDEAMRDWLAAACAPLD
HCCHHEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
RTPAALAA
CCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]