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The map label for this gene is hisC

Identifier: 103488364

GI number: 103488364

Start: 3038668

End: 3039783

Strand: Direct

Name: hisC

Synonym: Sala_2887

Alternate gene names: 103488364

Gene position: 3038668-3039783 (Clockwise)

Preceding gene: 103488361

Following gene: 103488365

Centisome position: 90.84

GC content: 67.65

Gene sequence:

>1116_bases
ATGACCGACGCGACCCCCACCCTGACGCCCAAGCCGTGGATCAGCGGCATCGCCCCCTATGTGCCCGGCAAGTCGGCGGG
CGCCGACGGCCGCCCGCTCATCAAGCTGAGCGCGAACGAAAATCCGCTCGGCACGGGGGAGAAGGCGCGCGCGGCCTTTG
CCGCGGTGCAGTCGGCGCCCGACGCGCTGTCGCGCTATCCCGATCCGGGGTCGGTCGAATTGCGCGCGGCGATCGCCGCC
AAATATGGGCTCGACCCCGACCGGGTGATCTGCGGCAACGGCTCGGACGAACTGTTGCACCTCGCCGCCGGGACCTATGC
CGGGCCGGGCGACGAGATTCTTTATGTCCGCTATGGCTTTGCGGTCTATGAAATCGCCGCGCGGCGCGTCGGCGCAGTGC
CGGTCGAGGCCGACGACCGTGATTTTGCAACCGATGTCGATGCGTTGCTCGCCGCGGTGACCGACAGAACGCGCGTCGTC
TATCTCGCCAATCCGAACAATCCGACGGGGACGCTCGCGACGCGCGAAGAAGTTGGGCGGCTTTACGCCGGGTTGCCCCA
AAATGTGCTGTTCGTGATCGACCAGGCCTATGCCGAATATCTGACGCCGGACGAAGACGACGGCGGGCTGGAGCTGGCAA
AGACCCGGCCCAATGTCTTTGTCACGCGCACCTTCTCCAAAATCCACGGGCTTGCTGCCGAGCGCATCGGTTGGGGTTAT
GCGAGTGCCGATGTGATTGCGGCGCTGCACCGCATCCGCCTGCCGTTCAACGTCACCCGCGCCGGGCAGGCGGCGGCGGT
CGCGGCGCTCGGCGACGATGATTTCGTGAACCGCAGCCGCGCGCATAATGCCCGCTGGCGCGCCTGGCTGGCGGCGGAAC
TGGAGAGCCTGGGCAATCATGGCGTGCGCGTCGTCCCGTCGGCGACCAATTTCCTGCTCGTGCTGTTCGAGGGCGCGGTG
AGCGCCGAGACCGTCTATCACCGGCTGATGGACGCGGGCTATATCGTCCGCTGGCTCCCCGGACAGGGGATTCCGCAGGC
GCTGCGCATGACGATCGGCACCGAGGACGAGACGCGCGGGCTTGCGACGGCAATCCGCGCCGCGCTCGCCGGTTGA

Upstream 100 bases:

>100_bases
CTCCGCCTGAGCCTTTTCCGTTCCTCTTCGCACTCCGCGCCTCTACGCGAATCCCATCAACAAACTGGACTTGGCGGCCT
TAGCCGTTAAACGCCCCCGC

Downstream 100 bases:

>100_bases
TGGCGATCGGGCGCGTCGCGATCGTCGGGCTGGGCCTGATCGGCTCGTCGGTCGCGCGCGCGGTGAAGGCGCGGCTGCCC
GGCGTCGCGGTGGCGGGTTA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MTDATPTLTPKPWISGIAPYVPGKSAGADGRPLIKLSANENPLGTGEKARAAFAAVQSAPDALSRYPDPGSVELRAAIAA
KYGLDPDRVICGNGSDELLHLAAGTYAGPGDEILYVRYGFAVYEIAARRVGAVPVEADDRDFATDVDALLAAVTDRTRVV
YLANPNNPTGTLATREEVGRLYAGLPQNVLFVIDQAYAEYLTPDEDDGGLELAKTRPNVFVTRTFSKIHGLAAERIGWGY
ASADVIAALHRIRLPFNVTRAGQAAAVAALGDDDFVNRSRAHNARWRAWLAAELESLGNHGVRVVPSATNFLLVLFEGAV
SAETVYHRLMDAGYIVRWLPGQGIPQALRMTIGTEDETRGLATAIRAALAG

Sequences:

>Translated_371_residues
MTDATPTLTPKPWISGIAPYVPGKSAGADGRPLIKLSANENPLGTGEKARAAFAAVQSAPDALSRYPDPGSVELRAAIAA
KYGLDPDRVICGNGSDELLHLAAGTYAGPGDEILYVRYGFAVYEIAARRVGAVPVEADDRDFATDVDALLAAVTDRTRVV
YLANPNNPTGTLATREEVGRLYAGLPQNVLFVIDQAYAEYLTPDEDDGGLELAKTRPNVFVTRTFSKIHGLAAERIGWGY
ASADVIAALHRIRLPFNVTRAGQAAAVAALGDDDFVNRSRAHNARWRAWLAAELESLGNHGVRVVPSATNFLLVLFEGAV
SAETVYHRLMDAGYIVRWLPGQGIPQALRMTIGTEDETRGLATAIRAALAG
>Mature_370_residues
TDATPTLTPKPWISGIAPYVPGKSAGADGRPLIKLSANENPLGTGEKARAAFAAVQSAPDALSRYPDPGSVELRAAIAAK
YGLDPDRVICGNGSDELLHLAAGTYAGPGDEILYVRYGFAVYEIAARRVGAVPVEADDRDFATDVDALLAAVTDRTRVVY
LANPNNPTGTLATREEVGRLYAGLPQNVLFVIDQAYAEYLTPDEDDGGLELAKTRPNVFVTRTFSKIHGLAAERIGWGYA
SADVIAALHRIRLPFNVTRAGQAAAVAALGDDDFVNRSRAHNARWRAWLAAELESLGNHGVRVVPSATNFLLVLFEGAVS
AETVYHRLMDAGYIVRWLPGQGIPQALRMTIGTEDETRGLATAIRAALAG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=374, Percent_Identity=27.5401069518717, Blast_Score=109, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322075, Length=389, Percent_Identity=26.9922879177378, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_SPHAL (Q1GP30)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617925.1
- ProteinModelPortal:   Q1GP30
- SMR:   Q1GP30
- GeneID:   4080680
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2887
- NMPDR:   fig|317655.9.peg.2748
- HOGENOM:   HBG646350
- OMA:   NPANILC
- ProtClustDB:   PRK02731
- BioCyc:   SALA317655:SALA_2887-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39548; Mature: 39417

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDATPTLTPKPWISGIAPYVPGKSAGADGRPLIKLSANENPLGTGEKARAAFAAVQSAP
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCC
DALSRYPDPGSVELRAAIAAKYGLDPDRVICGNGSDELLHLAAGTYAGPGDEILYVRYGF
HHHHCCCCCCCEEEEEEEHHHCCCCCCEEEECCCCCCEEEEECCCCCCCCCCEEEEEECH
AVYEIAARRVGAVPVEADDRDFATDVDALLAAVTDRTRVVYLANPNNPTGTLATREEVGR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEECHHHHHH
LYAGLPQNVLFVIDQAYAEYLTPDEDDGGLELAKTRPNVFVTRTFSKIHGLAAERIGWGY
HHHCCCCHHEEEEEHHHHHHCCCCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHHCCCC
ASADVIAALHRIRLPFNVTRAGQAAAVAALGDDDFVNRSRAHNARWRAWLAAELESLGNH
HHHHHHHHHHHHCCCCEECCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHCCC
GVRVVPSATNFLLVLFEGAVSAETVYHRLMDAGYIVRWLPGQGIPQALRMTIGTEDETRG
CEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHEECCCCHHHHH
LATAIRAALAG
HHHHHHHHHCC
>Mature Secondary Structure 
TDATPTLTPKPWISGIAPYVPGKSAGADGRPLIKLSANENPLGTGEKARAAFAAVQSAP
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCC
DALSRYPDPGSVELRAAIAAKYGLDPDRVICGNGSDELLHLAAGTYAGPGDEILYVRYGF
HHHHCCCCCCCEEEEEEEHHHCCCCCCEEEECCCCCCEEEEECCCCCCCCCCEEEEEECH
AVYEIAARRVGAVPVEADDRDFATDVDALLAAVTDRTRVVYLANPNNPTGTLATREEVGR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEECHHHHHH
LYAGLPQNVLFVIDQAYAEYLTPDEDDGGLELAKTRPNVFVTRTFSKIHGLAAERIGWGY
HHHCCCCHHEEEEEHHHHHHCCCCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHHCCCC
ASADVIAALHRIRLPFNVTRAGQAAAVAALGDDDFVNRSRAHNARWRAWLAAELESLGNH
HHHHHHHHHHHHCCCCEECCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHCCC
GVRVVPSATNFLLVLFEGAVSAETVYHRLMDAGYIVRWLPGQGIPQALRMTIGTEDETRG
CEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHEECCCCHHHHH
LATAIRAALAG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA