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The map label for this gene is hemE

Identifier: 103488320

GI number: 103488320

Start: 2995278

End: 2996306

Strand: Direct

Name: hemE

Synonym: Sala_2843

Alternate gene names: 103488320

Gene position: 2995278-2996306 (Clockwise)

Preceding gene: 103488307

Following gene: 103488321

Centisome position: 89.54

GC content: 67.06

Gene sequence:

>1029_bases
GTGAAGGCGTCACCGAAGAAGCTGCTCGCGACGTTGCGCGGAGCGCGGCACGAGCGAACGCCGCTCTGGCTGATGCGCCA
GGCCGGGCGCTATCTTCCCGAATATCGCGCCCTTCGCGAGAGCAAGGGCGGATTCCTCGAGCTGTGCTACGATCCCGAAG
CCGCCGCCGAAGTCACGTTGCAGCCGATCCGCCGCTTCGGTTTCGACGGCGCGATCCTTTTCTCCGACATTCTCGTCATC
CCGCACGCGCTCGGCCAGCATCTGTGGTTCGAGGCGGGCGAAGGTCCGCGGCTTGCGCCGCCGCTCGTCGATGGCGCCTT
GGCGTCACTCGAAGCCGCGCCGCAGCGCCTCGATCCCGTCTATGCGACGGTCGCGCGCGTCGCAGCCTCGCTGCCGCCCG
AAACGACCTTTCTCGGCTTTGCGGGCAGCCCGTGGACCGTCGCGACCTATATGGTCGCGGGACGGGGATCGAAGGATCAG
GCGGCGGCGCGGCGGATGGCCTTCGCCGACCCGGCCGCGTTCGGCGCCATCATCGATGCGATTGCCGATCTGACCGTGAC
CTATTTGTCGGGCCAGATCGAACAGGGCGTCGACGCGGTGCAGCTTTTCGACAGCTGGGCGGGCAGCCTCAGCCCCGCGC
AGTTCGAACAATGGGTGATCGCCCCCAATGCCGGAATCGTCCGCCGTCTGAAGGCGCTGCACCCTGACACGCCGGTGATC
GGCTTTCCGAAGGGCGCGGGGGGCAAGCTTCGTGCCTATGCCGAAGAAACCGGCGTCGATGCGATCGGCCTCGACGAAAC
GGTCGATCCGACATGGGCCGATGCCGCCTTGCCGTCACAGCTGCCCGTCCAGGGCAATCTCGACCCGCTCGCGCTCGTTG
CGGGTGGTGCGGCGCTCGATGCCGCGATCGACCGCATCCTTGCGGCTTTTCCGTCGCGCCCCCATATCTTCAATCTGGGC
CACGGGATCGTTCCCGACACCCCGGTTGCCCATGTCGAACATCTCATCAAGCGCGTTCGCGGCGGATAA

Upstream 100 bases:

>100_bases
TTGGCAAAACGGGTGGCCCAGCCTAAAGCCCGGCTTATCTTTTGACCTACAACCATCACAATCATCTTTAAAACTATATG
ATGAGAGAAAGAGGGGCCGC

Downstream 100 bases:

>100_bases
TATGGCAGACTGGGCAGGATTTCTGGGGGCGACGATGCTTTGGGTCAAAGCCGCGCATATCATTTTCGTGATTTTCCTGA
TGGCCGGCCTGTTCATGATG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKASPKKLLATLRGARHERTPLWLMRQAGRYLPEYRALRESKGGFLELCYDPEAAAEVTLQPIRRFGFDGAILFSDILVI
PHALGQHLWFEAGEGPRLAPPLVDGALASLEAAPQRLDPVYATVARVAASLPPETTFLGFAGSPWTVATYMVAGRGSKDQ
AAARRMAFADPAAFGAIIDAIADLTVTYLSGQIEQGVDAVQLFDSWAGSLSPAQFEQWVIAPNAGIVRRLKALHPDTPVI
GFPKGAGGKLRAYAEETGVDAIGLDETVDPTWADAALPSQLPVQGNLDPLALVAGGAALDAAIDRILAAFPSRPHIFNLG
HGIVPDTPVAHVEHLIKRVRGG

Sequences:

>Translated_342_residues
MKASPKKLLATLRGARHERTPLWLMRQAGRYLPEYRALRESKGGFLELCYDPEAAAEVTLQPIRRFGFDGAILFSDILVI
PHALGQHLWFEAGEGPRLAPPLVDGALASLEAAPQRLDPVYATVARVAASLPPETTFLGFAGSPWTVATYMVAGRGSKDQ
AAARRMAFADPAAFGAIIDAIADLTVTYLSGQIEQGVDAVQLFDSWAGSLSPAQFEQWVIAPNAGIVRRLKALHPDTPVI
GFPKGAGGKLRAYAEETGVDAIGLDETVDPTWADAALPSQLPVQGNLDPLALVAGGAALDAAIDRILAAFPSRPHIFNLG
HGIVPDTPVAHVEHLIKRVRGG
>Mature_342_residues
MKASPKKLLATLRGARHERTPLWLMRQAGRYLPEYRALRESKGGFLELCYDPEAAAEVTLQPIRRFGFDGAILFSDILVI
PHALGQHLWFEAGEGPRLAPPLVDGALASLEAAPQRLDPVYATVARVAASLPPETTFLGFAGSPWTVATYMVAGRGSKDQ
AAARRMAFADPAAFGAIIDAIADLTVTYLSGQIEQGVDAVQLFDSWAGSLSPAQFEQWVIAPNAGIVRRLKALHPDTPVI
GFPKGAGGKLRAYAEETGVDAIGLDETVDPTWADAALPSQLPVQGNLDPLALVAGGAALDAAIDRILAAFPSRPHIFNLG
HGIVPDTPVAHVEHLIKRVRGG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=329, Percent_Identity=38.6018237082067, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI2367337, Length=320, Percent_Identity=44.0625, Blast_Score=246, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6320252, Length=334, Percent_Identity=33.5329341317365, Blast_Score=182, Evalue=6e-47,
Organism=Drosophila melanogaster, GI221330099, Length=341, Percent_Identity=38.41642228739, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI19921920, Length=341, Percent_Identity=38.41642228739, Blast_Score=218, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_SPHAL (Q1GP74)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617881.1
- ProteinModelPortal:   Q1GP74
- SMR:   Q1GP74
- GeneID:   4080636
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2843
- NMPDR:   fig|317655.9.peg.2708
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   SALA317655:SALA_2843-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 36408; Mature: 36408

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 76-76 BINDING 150-150 BINDING 205-205 BINDING 321-321

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKASPKKLLATLRGARHERTPLWLMRQAGRYLPEYRALRESKGGFLELCYDPEAAAEVTL
CCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCHHHHHHH
QPIRRFGFDGAILFSDILVIPHALGQHLWFEAGEGPRLAPPLVDGALASLEAAPQRLDPV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YATVARVAASLPPETTFLGFAGSPWTVATYMVAGRGSKDQAAARRMAFADPAAFGAIIDA
HHHHHHHHHCCCCCCEEEECCCCCHHEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHH
IADLTVTYLSGQIEQGVDAVQLFDSWAGSLSPAQFEQWVIAPNAGIVRRLKALHPDTPVI
HHHHHHHHHHCHHHHCHHHHHHHHHHCCCCCHHHHHCEEECCCHHHHHHHHHHCCCCCEE
GFPKGAGGKLRAYAEETGVDAIGLDETVDPTWADAALPSQLPVQGNLDPLALVAGGAALD
ECCCCCCCCEEEHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHH
AAIDRILAAFPSRPHIFNLGHGIVPDTPVAHVEHLIKRVRGG
HHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKASPKKLLATLRGARHERTPLWLMRQAGRYLPEYRALRESKGGFLELCYDPEAAAEVTL
CCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCHHHHHHH
QPIRRFGFDGAILFSDILVIPHALGQHLWFEAGEGPRLAPPLVDGALASLEAAPQRLDPV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YATVARVAASLPPETTFLGFAGSPWTVATYMVAGRGSKDQAAARRMAFADPAAFGAIIDA
HHHHHHHHHCCCCCCEEEECCCCCHHEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHH
IADLTVTYLSGQIEQGVDAVQLFDSWAGSLSPAQFEQWVIAPNAGIVRRLKALHPDTPVI
HHHHHHHHHHCHHHHCHHHHHHHHHHCCCCCHHHHHCEEECCCHHHHHHHHHHCCCCCEE
GFPKGAGGKLRAYAEETGVDAIGLDETVDPTWADAALPSQLPVQGNLDPLALVAGGAALD
ECCCCCCCCEEEHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHH
AAIDRILAAFPSRPHIFNLGHGIVPDTPVAHVEHLIKRVRGG
HHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA