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The map label for this gene is tetA [H]

Identifier: 103488253

GI number: 103488253

Start: 2932398

End: 2933636

Strand: Direct

Name: tetA [H]

Synonym: Sala_2776

Alternate gene names: 103488253

Gene position: 2932398-2933636 (Clockwise)

Preceding gene: 103488251

Following gene: 103488255

Centisome position: 87.66

GC content: 68.68

Gene sequence:

>1239_bases
GTGACGGCTACGCGCACCATTCCCTTCATCGTCGTCACCATCTTCATCGACGCGGTCGGATTCGGCATCATCATGCCCGT
GCTGCCGCAGCTGGTGATGGAGGTCGGGCAGATCGACCTGCCCCACGCGATCGAGGTCGGCGCGTGGATCGGGCTGGTGA
TGGCGGTCGCGACCTTCCTTGCCTCGCCGGTGCTCGGCAACCTCTCCGACCGGTTCGGGCGGCGGCGCATATTGCTCCTC
GCGCTCGGCGGGCTCGCGGTCGATTATGCGCTGTTGACGGTGGTCGAGACGCTGCCGTGGCTGTTCGTCGCGCGCGCGCT
GTCGGGGATCTTCGGCGGCAGCTATGCCGCGGCGCAGGCGGCGATCGCCGACATCACCCCGCCGGAGGAACGCGCGCGCA
ACTTCGGCTTCGTCGGCGCGGCGTTCGGCGTCGGCTTTGTCGCCGGCCCCGCCATCGGCGGCTTCCTGGGCGAGATGAGC
CCGCGCGCGCCCTTTGTCGCCGCGGCGATCCTCGCCACCGCGAACATGCTCTATGGCTATTTCATCTTCCCCGAAACGCT
GCCGAAAGAGCGCCGCCGCGCCTTCGACTGGCGCCGCGCCAATCCGCTCGGCGCATGGAAGATGATGCGCGCGCTGCCCG
GAATGGACGGTGTGGCGGGCGTGCTCGTGCTGTGGCAGATCGCCAGCCTCGTCTATCCGATGACGTGGAGCTTTTACTGT
ATCGCGCAGCTAGGCTGGTCGCCGGGGATGATCGGCGCCAGCCTCGCCGCGGTGGGGGTGATGATCGCGCTGGGCCAGAT
GTTCGTCGTCGGTCCCGCGGTCGCGCGCTTTGGCGAGCGCGACGCGGCGACGTTCGGCCTCCTCGTCGCGGTGGCGGTCT
ATATCGGCTATGCCTTCACCACGTCGACGCTCGGCGCCTTCCTGCTGCTCATCCCCATTGCGTTGCAGGCGCCGGTGCAA
CCGTCGCTGATGGCGATGATGTCGCGCCGCGCCACCGCCGATACGCAGGGTGAAGTGCAGGGGGTTTCGGCGATGGCGAT
GGGACTGGGTCAGCTTGCCGCGCCGATGCTGTTAACGGGCACGATGGCCTATTTCACCGCCGACGCCGCCCCGGTGCATT
TCCCCGGCGCGGCGTTCCTCGTCGCCGCGATTTTCGGACTGCTGGCGATCGCGATGCTGCGCCGCCTGCCGCGCGCCACG
CAAACCGCGGATCAGATGCCGCCGTCGGTGACCGCATAG

Upstream 100 bases:

>100_bases
CGGAAATGTGCAGTTTCATCTATCGACAACGCATGAGGCAGGGATCGGTCGCGCTAATGGCAGCTAGAAGCGGCGTGCGC
CGCTCCAGGATAAAGCACAA

Downstream 100 bases:

>100_bases
CCCAGCGCCTCGAGCCCCGCCGTGAGCATCGCGGTGCATTCCGCGACCGCCGCCGCGTCGACCGAGCGGATGACGAAATT
GGCGCCGACCTTGCCTTCGC

Product: major facilitator transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTATRTIPFIVVTIFIDAVGFGIIMPVLPQLVMEVGQIDLPHAIEVGAWIGLVMAVATFLASPVLGNLSDRFGRRRILLL
ALGGLAVDYALLTVVETLPWLFVARALSGIFGGSYAAAQAAIADITPPEERARNFGFVGAAFGVGFVAGPAIGGFLGEMS
PRAPFVAAAILATANMLYGYFIFPETLPKERRRAFDWRRANPLGAWKMMRALPGMDGVAGVLVLWQIASLVYPMTWSFYC
IAQLGWSPGMIGASLAAVGVMIALGQMFVVGPAVARFGERDAATFGLLVAVAVYIGYAFTTSTLGAFLLLIPIALQAPVQ
PSLMAMMSRRATADTQGEVQGVSAMAMGLGQLAAPMLLTGTMAYFTADAAPVHFPGAAFLVAAIFGLLAIAMLRRLPRAT
QTADQMPPSVTA

Sequences:

>Translated_412_residues
MTATRTIPFIVVTIFIDAVGFGIIMPVLPQLVMEVGQIDLPHAIEVGAWIGLVMAVATFLASPVLGNLSDRFGRRRILLL
ALGGLAVDYALLTVVETLPWLFVARALSGIFGGSYAAAQAAIADITPPEERARNFGFVGAAFGVGFVAGPAIGGFLGEMS
PRAPFVAAAILATANMLYGYFIFPETLPKERRRAFDWRRANPLGAWKMMRALPGMDGVAGVLVLWQIASLVYPMTWSFYC
IAQLGWSPGMIGASLAAVGVMIALGQMFVVGPAVARFGERDAATFGLLVAVAVYIGYAFTTSTLGAFLLLIPIALQAPVQ
PSLMAMMSRRATADTQGEVQGVSAMAMGLGQLAAPMLLTGTMAYFTADAAPVHFPGAAFLVAAIFGLLAIAMLRRLPRAT
QTADQMPPSVTA
>Mature_411_residues
TATRTIPFIVVTIFIDAVGFGIIMPVLPQLVMEVGQIDLPHAIEVGAWIGLVMAVATFLASPVLGNLSDRFGRRRILLLA
LGGLAVDYALLTVVETLPWLFVARALSGIFGGSYAAAQAAIADITPPEERARNFGFVGAAFGVGFVAGPAIGGFLGEMSP
RAPFVAAAILATANMLYGYFIFPETLPKERRRAFDWRRANPLGAWKMMRALPGMDGVAGVLVLWQIASLVYPMTWSFYCI
AQLGWSPGMIGASLAAVGVMIALGQMFVVGPAVARFGERDAATFGLLVAVAVYIGYAFTTSTLGAFLLLIPIALQAPVQP
SLMAMMSRRATADTQGEVQGVSAMAMGLGQLAAPMLLTGTMAYFTADAAPVHFPGAAFLVAAIFGLLAIAMLRRLPRATQ
TADQMPPSVTA

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=356, Percent_Identity=26.4044943820225, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI94721311, Length=420, Percent_Identity=23.5714285714286, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI225703104, Length=152, Percent_Identity=33.5526315789474, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI225703102, Length=152, Percent_Identity=33.5526315789474, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71996331, Length=356, Percent_Identity=26.9662921348315, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17551570, Length=168, Percent_Identity=26.7857142857143, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357569, Length=378, Percent_Identity=25.3968253968254, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI221513297, Length=357, Percent_Identity=26.3305322128852, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24656463, Length=383, Percent_Identity=25.065274151436, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656468, Length=383, Percent_Identity=25.065274151436, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI161080926, Length=383, Percent_Identity=25.065274151436, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI161080924, Length=383, Percent_Identity=25.065274151436, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17738085, Length=363, Percent_Identity=24.7933884297521, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667561, Length=158, Percent_Identity=32.2784810126582, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667557, Length=148, Percent_Identity=33.1081081081081, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43394; Mature: 43263

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATRTIPFIVVTIFIDAVGFGIIMPVLPQLVMEVGQIDLPHAIEVGAWIGLVMAVATFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
ASPVLGNLSDRFGRRRILLLALGGLAVDYALLTVVETLPWLFVARALSGIFGGSYAAAQA
HHHHHCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AIADITPPEERARNFGFVGAAFGVGFVAGPAIGGFLGEMSPRAPFVAAAILATANMLYGY
HHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FIFPETLPKERRRAFDWRRANPLGAWKMMRALPGMDGVAGVLVLWQIASLVYPMTWSFYC
EECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IAQLGWSPGMIGASLAAVGVMIALGQMFVVGPAVARFGERDAATFGLLVAVAVYIGYAFT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
TSTLGAFLLLIPIALQAPVQPSLMAMMSRRATADTQGEVQGVSAMAMGLGQLAAPMLLTG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TMAYFTADAAPVHFPGAAFLVAAIFGLLAIAMLRRLPRATQTADQMPPSVTA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TATRTIPFIVVTIFIDAVGFGIIMPVLPQLVMEVGQIDLPHAIEVGAWIGLVMAVATFL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
ASPVLGNLSDRFGRRRILLLALGGLAVDYALLTVVETLPWLFVARALSGIFGGSYAAAQA
HHHHHCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AIADITPPEERARNFGFVGAAFGVGFVAGPAIGGFLGEMSPRAPFVAAAILATANMLYGY
HHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FIFPETLPKERRRAFDWRRANPLGAWKMMRALPGMDGVAGVLVLWQIASLVYPMTWSFYC
EECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IAQLGWSPGMIGASLAAVGVMIALGQMFVVGPAVARFGERDAATFGLLVAVAVYIGYAFT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
TSTLGAFLLLIPIALQAPVQPSLMAMMSRRATADTQGEVQGVSAMAMGLGQLAAPMLLTG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TMAYFTADAAPVHFPGAAFLVAAIFGLLAIAMLRRLPRATQTADQMPPSVTA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]