Click here to switch to the map view.

The map label for this gene is merR1 [H]

Identifier: 103488163

GI number: 103488163

Start: 2830060

End: 2830578

Strand: Direct

Name: merR1 [H]

Synonym: Sala_2686

Alternate gene names: 103488163

Gene position: 2830060-2830578 (Clockwise)

Preceding gene: 103488159

Following gene: 103488167

Centisome position: 84.6

GC content: 63.39

Gene sequence:

>519_bases
ATGCAAAACCATCGCCTTTCGGAAGAGCGCTACCGGCGGGCCGACCTCGCCAAAGCTACGGGCTGCAACCTCGAAACCAT
CCGCTATTATGAAAAGGTCGGCATGATGCCCGACCCACCCCGAACGGCGGCGGGCTACCGTGTTTATGGGGCAAGGCATG
TTTCGCGCCTTCGTTTCATCATGCGCGGGCGCGATCTGGGCTTCACCATCGAGGAGATCCGTAGCCTCCTCGCGCTCATC
GACTACGGCACGCAAACCTGCGGGGAGGTGAGGGCCAGGACCGAGCGCCATCTGAGCGATGTGCGCGCCAAGATCGCCGA
CCTTCGCCGCATCGAGACCGTCCTCGCCCGAACCGCAGCCAAATGTTCGGGAGACGCGGCACCCGAATGCCCCATCCTTG
ACGCGCTGGGGCATGAGGCACTGTCTTCGTCGTCGCACGCGATCATGGCATCACCTGTACCCCGACCACGGCCCACGACA
GCGAATGATGATCGAAGCCGCGAGCCAGCGTCGGCTTGA

Upstream 100 bases:

>100_bases
CAGCCTCGATGTTCGAATTGCTCATGCGAATCGTCTCTCGATCTTTATATGGTCACTGTGTAAGGTCTGTAGCAGCTACA
GACTCAAGGGCTATTTTCGG

Downstream 100 bases:

>100_bases
CGATTTCGAAATAGGGAGAAACGTCGAAATCGCGCGGCGTGAACAGGCTGTGATGACGGATATGCAGGATGTCGCGCACG
CAGCCGAGGCAATTCGGATC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MQNHRLSEERYRRADLAKATGCNLETIRYYEKVGMMPDPPRTAAGYRVYGARHVSRLRFIMRGRDLGFTIEEIRSLLALI
DYGTQTCGEVRARTERHLSDVRAKIADLRRIETVLARTAAKCSGDAAPECPILDALGHEALSSSSHAIMASPVPRPRPTT
ANDDRSREPASA

Sequences:

>Translated_172_residues
MQNHRLSEERYRRADLAKATGCNLETIRYYEKVGMMPDPPRTAAGYRVYGARHVSRLRFIMRGRDLGFTIEEIRSLLALI
DYGTQTCGEVRARTERHLSDVRAKIADLRRIETVLARTAAKCSGDAAPECPILDALGHEALSSSSHAIMASPVPRPRPTT
ANDDRSREPASA
>Mature_172_residues
MQNHRLSEERYRRADLAKATGCNLETIRYYEKVGMMPDPPRTAAGYRVYGARHVSRLRFIMRGRDLGFTIEEIRSLLALI
DYGTQTCGEVRARTERHLSDVRAKIADLRRIETVLARTAAKCSGDAAPECPILDALGHEALSSSSHAIMASPVPRPRPTT
ANDDRSREPASA

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=129, Percent_Identity=41.0852713178295, Blast_Score=93, Evalue=9e-21,
Organism=Escherichia coli, GI1786695, Length=123, Percent_Identity=31.7073170731707, Blast_Score=82, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 19165; Mature: 19165

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNHRLSEERYRRADLAKATGCNLETIRYYEKVGMMPDPPRTAAGYRVYGARHVSRLRFI
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
MRGRDLGFTIEEIRSLLALIDYGTQTCGEVRARTERHLSDVRAKIADLRRIETVLARTAA
HHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KCSGDAAPECPILDALGHEALSSSSHAIMASPVPRPRPTTANDDRSREPASA
HCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQNHRLSEERYRRADLAKATGCNLETIRYYEKVGMMPDPPRTAAGYRVYGARHVSRLRFI
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
MRGRDLGFTIEEIRSLLALIDYGTQTCGEVRARTERHLSDVRAKIADLRRIETVLARTAA
HHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KCSGDAAPECPILDALGHEALSSSSHAIMASPVPRPRPTTANDDRSREPASA
HCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]