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The map label for this gene is metC [H]

Identifier: 103487893

GI number: 103487893

Start: 2548517

End: 2549764

Strand: Reverse

Name: metC [H]

Synonym: Sala_2413

Alternate gene names: 103487893

Gene position: 2549764-2548517 (Counterclockwise)

Preceding gene: 103487894

Following gene: 103487892

Centisome position: 76.22

GC content: 64.02

Gene sequence:

>1248_bases
ATGCAGGATAATCATGACGGAAAATGGCTCGAGGAGCCGGCGAGCCCGAAAGGGCACGCTTGGCAGGATCCGACGCGTGC
CGTGCACGGCGGTCCCCGCCCGCGCGATCAGCGGGGCCTCATCAATCCGCCCGTCGATCGAGCCTCGACCATTATCTACG
ACAGCGTCGAGGCCTATATGGACCGGCACCAGGGTCTCTACGATGAGGTCATCTATGGCCTGTACGGAACGCGAACGACC
TTTGCGCTCGCCGAGGCTGTCAGCGAACTTGAAGGCGGCTGCAACACCGTCATCACCTCGTCCGGAACCAGCGCGATCGC
GCTGGCCCTCACGGCTTTCGTGGCCGGGGGCGATCATCTGCTCGTTGCGGATTGCGTCTATGGGCCGACCCGCAAGTTTC
TGACCGACGTTCTCGCGCGTTTCGGGGTCGAGGTGGAATATTTCCGGCCCGATATCGGAGCGGAGATTGCCGGGCTGTGC
CGCAGCAACACCCGGCTCATCTATATGGAGACCCCGGGCTCGCAGACATTCGATATGATCGACGTCCCCGCGATCACGGC
CGTTGCACGCAGCCGGGGCATATTGACCGCTCTCGACAACACCTGGGCGACGCCGCTTTTCTTCAAGCCCTTGGCCCACG
GGGTCGACATCTCGCTTGCTTCGGCAACCAAATATCTCTCGGGGCACTCCGACTGTCTGCTCGGCACGATGACGGCCGCC
AGTGATGCCGTCTACCGCCAGCTCAAGGACGCGGCGGCGCGCTGGGGCAACTGCGCGAGTCCCGACAATTGCTATCTGGT
CCACCGGGGCATCAGGACGCTCGATGCGCGCCTTGAACGCCACCAGCGTACCGCGGCGACGCTGATCGAATGGTTCGCCC
AGCAACCCGAAGTGGTTGCGGTCCGCTATCCGGCTCATCCCGCCGACCCCGGCCATGCGATCTGGAAGCGGGATTTCACC
GGTGCGTCCGGATTGTTCGGTGTTCAGCTCGACGGTCTTACCCCGCCCCAAACTAGCGCCTTTTTCAACGAATTCTCGTT
ATTCCAGCTGGGTTCGAGCTGGGGCGGCTTCGAAAGTCTCGCGGTTCCGGCGTGGCCCGCTCCGATCCGCGATTTTCCGA
ATGGCGAGGCAGATGGGGCGCTGATCCGCATTCACGCCGGACTCGAAGCGCCGCAGGATCTGATCGCCGACCTCGCCGCA
GCCTTCGCGCGGGTACGAGCGCTACGCGGCCGGGGGCAGGCGTCATGA

Upstream 100 bases:

>100_bases
CCCTATTTCGCCGAAGCCTATCTTTTCACCGGGACAATCTTCTTCCTCCTCTGTTTCTCCCTGTCCCGGCTCAGCATGAA
GATCGAACGGAAACTAGACT

Downstream 100 bases:

>100_bases
CCGACGCCTCGGGCCACGCGGCCGTCAGCTTGCGGCAGGTCGACAAATATTATGGCGCCTATCATGCGCTCCGCTCGATC
GACCTCGAAATCGCCCCGCG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MQDNHDGKWLEEPASPKGHAWQDPTRAVHGGPRPRDQRGLINPPVDRASTIIYDSVEAYMDRHQGLYDEVIYGLYGTRTT
FALAEAVSELEGGCNTVITSSGTSAIALALTAFVAGGDHLLVADCVYGPTRKFLTDVLARFGVEVEYFRPDIGAEIAGLC
RSNTRLIYMETPGSQTFDMIDVPAITAVARSRGILTALDNTWATPLFFKPLAHGVDISLASATKYLSGHSDCLLGTMTAA
SDAVYRQLKDAAARWGNCASPDNCYLVHRGIRTLDARLERHQRTAATLIEWFAQQPEVVAVRYPAHPADPGHAIWKRDFT
GASGLFGVQLDGLTPPQTSAFFNEFSLFQLGSSWGGFESLAVPAWPAPIRDFPNGEADGALIRIHAGLEAPQDLIADLAA
AFARVRALRGRGQAS

Sequences:

>Translated_415_residues
MQDNHDGKWLEEPASPKGHAWQDPTRAVHGGPRPRDQRGLINPPVDRASTIIYDSVEAYMDRHQGLYDEVIYGLYGTRTT
FALAEAVSELEGGCNTVITSSGTSAIALALTAFVAGGDHLLVADCVYGPTRKFLTDVLARFGVEVEYFRPDIGAEIAGLC
RSNTRLIYMETPGSQTFDMIDVPAITAVARSRGILTALDNTWATPLFFKPLAHGVDISLASATKYLSGHSDCLLGTMTAA
SDAVYRQLKDAAARWGNCASPDNCYLVHRGIRTLDARLERHQRTAATLIEWFAQQPEVVAVRYPAHPADPGHAIWKRDFT
GASGLFGVQLDGLTPPQTSAFFNEFSLFQLGSSWGGFESLAVPAWPAPIRDFPNGEADGALIRIHAGLEAPQDLIADLAA
AFARVRALRGRGQAS
>Mature_415_residues
MQDNHDGKWLEEPASPKGHAWQDPTRAVHGGPRPRDQRGLINPPVDRASTIIYDSVEAYMDRHQGLYDEVIYGLYGTRTT
FALAEAVSELEGGCNTVITSSGTSAIALALTAFVAGGDHLLVADCVYGPTRKFLTDVLARFGVEVEYFRPDIGAEIAGLC
RSNTRLIYMETPGSQTFDMIDVPAITAVARSRGILTALDNTWATPLFFKPLAHGVDISLASATKYLSGHSDCLLGTMTAA
SDAVYRQLKDAAARWGNCASPDNCYLVHRGIRTLDARLERHQRTAATLIEWFAQQPEVVAVRYPAHPADPGHAIWKRDFT
GASGLFGVQLDGLTPPQTSAFFNEFSLFQLGSSWGGFESLAVPAWPAPIRDFPNGEADGALIRIHAGLEAPQDLIADLAA
AFARVRALRGRGQAS

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=357, Percent_Identity=31.0924369747899, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI299473759, Length=233, Percent_Identity=33.0472103004292, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI25453487, Length=356, Percent_Identity=28.3707865168539, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789383, Length=393, Percent_Identity=41.4758269720102, Blast_Score=304, Evalue=6e-84,
Organism=Escherichia coli, GI1790375, Length=392, Percent_Identity=34.9489795918367, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=29.1105121293801, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17560056, Length=341, Percent_Identity=29.6187683284457, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17538055, Length=376, Percent_Identity=28.9893617021277, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321170, Length=329, Percent_Identity=42.2492401215805, Blast_Score=259, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6319307, Length=398, Percent_Identity=30.1507537688442, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=391, Percent_Identity=26.5984654731458, Blast_Score=109, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6323333, Length=386, Percent_Identity=25.9067357512953, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321254, Length=354, Percent_Identity=24.0112994350282, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19922554, Length=387, Percent_Identity=31.5245478036176, Blast_Score=184, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44925; Mature: 44925

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDNHDGKWLEEPASPKGHAWQDPTRAVHGGPRPRDQRGLINPPVDRASTIIYDSVEAYM
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
DRHQGLYDEVIYGLYGTRTTFALAEAVSELEGGCNTVITSSGTSAIALALTAFVAGGDHL
HHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCEE
LVADCVYGPTRKFLTDVLARFGVEVEYFRPDIGAEIAGLCRSNTRLIYMETPGSQTFDMI
EEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCCCEE
DVPAITAVARSRGILTALDNTWATPLFFKPLAHGVDISLASATKYLSGHSDCLLGTMTAA
CCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCCEEHHHHHHHHCCCCCCEEEHHHHH
SDAVYRQLKDAAARWGNCASPDNCYLVHRGIRTLDARLERHQRTAATLIEWFAQQPEVVA
HHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VRYPAHPADPGHAIWKRDFTGASGLFGVQLDGLTPPQTSAFFNEFSLFQLGSSWGGFESL
EECCCCCCCCCCHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
AVPAWPAPIRDFPNGEADGALIRIHAGLEAPQDLIADLAAAFARVRALRGRGQAS
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQDNHDGKWLEEPASPKGHAWQDPTRAVHGGPRPRDQRGLINPPVDRASTIIYDSVEAYM
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
DRHQGLYDEVIYGLYGTRTTFALAEAVSELEGGCNTVITSSGTSAIALALTAFVAGGDHL
HHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCEE
LVADCVYGPTRKFLTDVLARFGVEVEYFRPDIGAEIAGLCRSNTRLIYMETPGSQTFDMI
EEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCCCEE
DVPAITAVARSRGILTALDNTWATPLFFKPLAHGVDISLASATKYLSGHSDCLLGTMTAA
CCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCCEEHHHHHHHHCCCCCCEEEHHHHH
SDAVYRQLKDAAARWGNCASPDNCYLVHRGIRTLDARLERHQRTAATLIEWFAQQPEVVA
HHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VRYPAHPADPGHAIWKRDFTGASGLFGVQLDGLTPPQTSAFFNEFSLFQLGSSWGGFESL
EECCCCCCCCCCHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
AVPAWPAPIRDFPNGEADGALIRIHAGLEAPQDLIADLAAAFARVRALRGRGQAS
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]