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The map label for this gene is ung [H]

Identifier: 103487859

GI number: 103487859

Start: 2499373

End: 2500077

Strand: Reverse

Name: ung [H]

Synonym: Sala_2378

Alternate gene names: 103487859

Gene position: 2500077-2499373 (Counterclockwise)

Preceding gene: 103487860

Following gene: 103487858

Centisome position: 74.74

GC content: 69.22

Gene sequence:

>705_bases
ATGGCCGAGGTCAAACTGCATCCCGACTGGCTCGCGCGCATCGGCGGCGAGTTTGCGCAGCCCTATATGGCGGCGCTCAA
GCAGTTCCTCGCCGACGAGCGCGCGAAGGGCAAGACCATCTATCCGCGCCCGCGCGACTGGTTCGCGGCATTGGACGCGA
CGCCGCCGGACGCGGTGCGCGTCGTGATTTTGGGGCAGGACCCCTATCACGGGCCGGGGCAGGCGCATGGGCTTTGCTTT
TCGGTCCAGCCCGGCGTGCGCCTGCCGCCGAGCCTGGTCAACATCTACAAGGAATTGCGCAGCGACCTGGGTATCGCACC
CGCGCCGCACGGCCACCTGGCGCATTGGGCACGGCAGGGGGTGCTGCTGCTCAACAATTGCCTGACGGTCGAGGCGGGGC
AAGCGGCGTCGCATCAGGGCAAGGGATGGGAAAAGTTCACCGACGCCGCGGTCGCCGCGGTCGCCGCCGACCCGGCGCCC
AAGGTGTTCATCCTGTGGGGCAGCCATGCGCAGAAGAAGGCGGCGAATGTGCCGGGGCTGGGCGCGGGCAGTCCGCACCT
GATTCTGCGCGCGCCGCACCCCTCGCCATTGTCGGCGCATAACGGCTTTTTCGGGTCGCGGCCGTTCAGCCAGGCCAATG
CCTTTCTGGAGGCGCAGGGGCGCGGCGCGATCGACTGGCGGCTGCCCGACGATCCCGGCGCATGA

Upstream 100 bases:

>100_bases
GGAGGGGCTGTCTATTCCTTATGTCCGCAATCGGTCGCTTTCAGCCATTTGCGAGGAGGCAGGGCTGGACAAGCCTGCTC
CCCTCTGGTGAAGCGCCGTC

Downstream 100 bases:

>100_bases
GCCTGACCGGATGAACCTGCTCGCCGATCCGGTGACGCTGGCGGTGCTCGTCGCCGCGGTCGTGCTGCTCGGCATGGCGA
AGGGCGGGCTGGCGGGGGTA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MAEVKLHPDWLARIGGEFAQPYMAALKQFLADERAKGKTIYPRPRDWFAALDATPPDAVRVVILGQDPYHGPGQAHGLCF
SVQPGVRLPPSLVNIYKELRSDLGIAPAPHGHLAHWARQGVLLLNNCLTVEAGQAASHQGKGWEKFTDAAVAAVAADPAP
KVFILWGSHAQKKAANVPGLGAGSPHLILRAPHPSPLSAHNGFFGSRPFSQANAFLEAQGRGAIDWRLPDDPGA

Sequences:

>Translated_234_residues
MAEVKLHPDWLARIGGEFAQPYMAALKQFLADERAKGKTIYPRPRDWFAALDATPPDAVRVVILGQDPYHGPGQAHGLCF
SVQPGVRLPPSLVNIYKELRSDLGIAPAPHGHLAHWARQGVLLLNNCLTVEAGQAASHQGKGWEKFTDAAVAAVAADPAP
KVFILWGSHAQKKAANVPGLGAGSPHLILRAPHPSPLSAHNGFFGSRPFSQANAFLEAQGRGAIDWRLPDDPGA
>Mature_233_residues
AEVKLHPDWLARIGGEFAQPYMAALKQFLADERAKGKTIYPRPRDWFAALDATPPDAVRVVILGQDPYHGPGQAHGLCFS
VQPGVRLPPSLVNIYKELRSDLGIAPAPHGHLAHWARQGVLLLNNCLTVEAGQAASHQGKGWEKFTDAAVAAVAADPAPK
VFILWGSHAQKKAANVPGLGAGSPHLILRAPHPSPLSAHNGFFGSRPFSQANAFLEAQGRGAIDWRLPDDPGA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=219, Percent_Identity=51.1415525114155, Blast_Score=210, Evalue=7e-55,
Organism=Homo sapiens, GI6224979, Length=220, Percent_Identity=50.9090909090909, Blast_Score=210, Evalue=1e-54,
Organism=Escherichia coli, GI1788934, Length=218, Percent_Identity=53.6697247706422, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17556304, Length=219, Percent_Identity=44.7488584474886, Blast_Score=191, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6323620, Length=232, Percent_Identity=43.5344827586207, Blast_Score=183, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25020; Mature: 24889

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVKLHPDWLARIGGEFAQPYMAALKQFLADERAKGKTIYPRPRDWFAALDATPPDAVR
CCCEEECHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCEE
VVILGQDPYHGPGQAHGLCFSVQPGVRLPPSLVNIYKELRSDLGIAPAPHGHLAHWARQG
EEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
VLLLNNCLTVEAGQAASHQGKGWEKFTDAAVAAVAADPAPKVFILWGSHAQKKAANVPGL
EEEECCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCC
GAGSPHLILRAPHPSPLSAHNGFFGSRPFSQANAFLEAQGRGAIDWRLPDDPGA
CCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHEEEECCCCEEEEECCCCCCC
>Mature Secondary Structure 
AEVKLHPDWLARIGGEFAQPYMAALKQFLADERAKGKTIYPRPRDWFAALDATPPDAVR
CCEEECHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCEE
VVILGQDPYHGPGQAHGLCFSVQPGVRLPPSLVNIYKELRSDLGIAPAPHGHLAHWARQG
EEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
VLLLNNCLTVEAGQAASHQGKGWEKFTDAAVAAVAADPAPKVFILWGSHAQKKAANVPGL
EEEECCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCC
GAGSPHLILRAPHPSPLSAHNGFFGSRPFSQANAFLEAQGRGAIDWRLPDDPGA
CCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHEEEECCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]