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The map label for this gene is fabZ

Identifier: 103487434

GI number: 103487434

Start: 2056184

End: 2056645

Strand: Reverse

Name: fabZ

Synonym: Sala_1950

Alternate gene names: 103487434

Gene position: 2056645-2056184 (Counterclockwise)

Preceding gene: 103487435

Following gene: 103487433

Centisome position: 61.48

GC content: 65.15

Gene sequence:

>462_bases
GTGGGCGAGGCCATGGGCGCGGCGGACATCCGCCGGGTTTTGAGCCTGCTCCCGCATCGTTATCCGATGCTGCTGGTCGA
CCGGGTGGTTTCGATGGTCAAGGACCAGTCGATCCATGCGGTCAAGGCGGTGACGATGAACGAGCCCTTTTTCCAGGGCC
ATTTCCCCGGCCGGCCCATCATGCCCGGCGTCCTCATCGTCGAGGCGCTGGCGCAGGCGGGCGGCGTGCTCGCGATCGAA
TCGCTGGGCCTCGCGGGCAGCGGCAAGCTCGTCTATTTCATGGGCATCGACGGGGTAAAGTTCCGCAAGCCGGTTGAACC
CGGCCACCTGCTCGACCTGCACGTCACGATTCTCCAGGCGAAGCGCAATATCTGCAAGTTCGAGGGGCGGGCAATGCTGG
GCGGTCAACTCGCGACCGAATGCCAGTTCACCGCGATGATCGCCGATCCGCCGGGCGACTAG

Upstream 100 bases:

>100_bases
TGGACGCCGCGCGCGCGGCGCAGCCCGGTGCGGCGGCTCCGGCGCCGACCGGCAACCAGCCGACGACGCGCTAAGCGCGA
TGGCGGCCGGGGAAGACAGC

Downstream 100 bases:

>100_bases
GGCGGAGACCTCCCCTTATATGTCATCCCGGCCTTCGCCGGGATGACGATCAACGGGGTGCAGGTGTTGCATTTTCCCCG
ATTGCCCAGTAAGGGCGCCG

Product: beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ

Products: trans-Delta2-enoyl-acyl-ACP; H2O [C]

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MGEAMGAADIRRVLSLLPHRYPMLLVDRVVSMVKDQSIHAVKAVTMNEPFFQGHFPGRPIMPGVLIVEALAQAGGVLAIE
SLGLAGSGKLVYFMGIDGVKFRKPVEPGHLLDLHVTILQAKRNICKFEGRAMLGGQLATECQFTAMIADPPGD

Sequences:

>Translated_153_residues
MGEAMGAADIRRVLSLLPHRYPMLLVDRVVSMVKDQSIHAVKAVTMNEPFFQGHFPGRPIMPGVLIVEALAQAGGVLAIE
SLGLAGSGKLVYFMGIDGVKFRKPVEPGHLLDLHVTILQAKRNICKFEGRAMLGGQLATECQFTAMIADPPGD
>Mature_152_residues
GEAMGAADIRRVLSLLPHRYPMLLVDRVVSMVKDQSIHAVKAVTMNEPFFQGHFPGRPIMPGVLIVEALAQAGGVLAIES
LGLAGSGKLVYFMGIDGVKFRKPVEPGHLLDLHVTILQAKRNICKFEGRAMLGGQLATECQFTAMIADPPGD

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=140, Percent_Identity=49.2857142857143, Blast_Score=145, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_SPHAL (Q1GRR0)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616995.1
- ProteinModelPortal:   Q1GRR0
- SMR:   Q1GRR0
- GeneID:   4080499
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1950
- NMPDR:   fig|317655.9.peg.1881
- HOGENOM:   HBG433282
- OMA:   KERRGVA
- ProtClustDB:   CLSK835358
- BioCyc:   SALA317655:SALA_1950-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.- [C]

Molecular weight: Translated: 16478; Mature: 16347

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: ACT_SITE 54-54

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEAMGAADIRRVLSLLPHRYPMLLVDRVVSMVKDQSIHAVKAVTMNEPFFQGHFPGRPI
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCCC
MPGVLIVEALAQAGGVLAIESLGLAGSGKLVYFMGIDGVKFRKPVEPGHLLDLHVTILQA
CCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEECCCCCCCCEEHHHHHHHHH
KRNICKFEGRAMLGGQLATECQFTAMIADPPGD
HHHHHHCCCCEEECCCCCCCEEEEEEEECCCCC
>Mature Secondary Structure 
GEAMGAADIRRVLSLLPHRYPMLLVDRVVSMVKDQSIHAVKAVTMNEPFFQGHFPGRPI
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCCC
MPGVLIVEALAQAGGVLAIESLGLAGSGKLVYFMGIDGVKFRKPVEPGHLLDLHVTILQA
CCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEECCCCCCCCEEHHHHHHHHH
KRNICKFEGRAMLGGQLATECQFTAMIADPPGD
HHHHHHCCCCEEECCCCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-3-hydroxy-acyl-ACP [C]

Specific reaction: D-3-hydroxy-acyl-ACP = trans-Delta2-enoyl-acyl-ACP + H2O [C]

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA