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The map label for this gene is lysA [H]

Identifier: 103487413

GI number: 103487413

Start: 2034388

End: 2035617

Strand: Reverse

Name: lysA [H]

Synonym: Sala_1929

Alternate gene names: 103487413

Gene position: 2035617-2034388 (Counterclockwise)

Preceding gene: 103487414

Following gene: 103487412

Centisome position: 60.85

GC content: 70.49

Gene sequence:

>1230_bases
ATGAAGCCGCACGGGCCAATCCCGCCCGGATTCCGGGCCGACCCTGACGGGATGCTGCTGATCGGCGGCGACCGTGCCGA
ATCGCTGGCCGATGTCGCGGGCGATACGCCGCTCTTCGTCTATGACAGCGCGATGCTGGCCGCGCGCGCCGCCGAATGGC
GCGCGGCGATGCCCGCCGCTGTGCAGCTCCATTATGCGATGAAGGCCAATCCCTATCCGCCGCTGCTTGCCTTCATGGCG
GGGCTGGTCGACGGGTTCGACGTGGCGTCGGGCGGCGAGTTGAAGGCGGCGCTGGCGAGCGGGATGGATGCCGCGCACAT
CAGCTTCGCCGGGCCGGGCAAGCGCGACCGCGAGCTGGAGGCGGCGCTTGAAGCAGGCGCGACGCTGAACCTCGAATCCG
CGGGCGAGGCAGAGCGCGCATTGGCGATCGCGGCGCACCTGGGCGCGACGCCGCGGCTCGCGGTGCGCGTCAATCCCGAC
TTCGACCTCAAGGGATCGGGGATGAAGATGGGCGGCGGCGCCAAGCCCTTCGGGGTCGATGCTGCCGCGGTTCCGGCGCT
CGTGCGCCGCCTGATCGATGCGGGCGCCGACTGGCGGGGTTTTCATATTTTCGCCGGATCGCAAGCGCTTGACGCGGCCG
CCATCGCCGAAATGCAGGCGCAGACGGTCGCGCTCGCGGCGCGGCTTGCGGACGCGATCGGGACTGCGCCGCCGCTCGTC
AATCTGGGCGGCGGGATGGGGGTGCCCTATTTCCCCGGTGATACCGCGGTCGATGCGGCGGCGGTGGGGGAAGCGCTCGG
CGAGACGCTGGCCGCGCGCGACGCCGCGCTGGCGGACAGCCGCTTTGCGATGGAACTGGGTCGCTGGCTCGTGGCCGAGG
CGGGGGTTTATCTGACGCGCATCGTCGACCGGAAGGTCAGCCATGGCGAAACCTTCCTCGTCACCGACGGCGGCCTGCAT
CACCAGTTGGCGGCAAGCGGCAATTTCGGCACCGTCATCCGTCGCAACTATCCGATCGCGGTGGCGAACGCCTTTGGCCG
TGAGCCCGTCGAGACCGTTGCGGTCGTTGGCTGCCTGTGCACCCCGCTCGACCGGCTTGGCGATCAGGTCGCACTGCCGC
GCGCCGACGTCGGCGATCTGATCGCGATCTTCCAGGCCGGGGCCTATGGCGCGAGCGCGAGTCCGGCGGCGTTTCTGGGG
CAGGGGCCGGCGCGCGAGCTGCTGGTATAG

Upstream 100 bases:

>100_bases
AGCCGCAGGTCATCGAATGGCGCGATGCGCTGCCGCGCAATCCCAATGGCAAGCTCGACCGGGTGGCGATCGCCGCCGAT
TGGACGAGGGTGATGGCGGC

Downstream 100 bases:

>100_bases
CCTCTCGATTCTGTTCCTTTCCGGGACATATCTGGAAGCGTACGGGCCGAACTTATGCCAATACTAACATTATGTTCACC
CTTTTCGCGCAATGGCGGAC

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKPHGPIPPGFRADPDGMLLIGGDRAESLADVAGDTPLFVYDSAMLAARAAEWRAAMPAAVQLHYAMKANPYPPLLAFMA
GLVDGFDVASGGELKAALASGMDAAHISFAGPGKRDRELEAALEAGATLNLESAGEAERALAIAAHLGATPRLAVRVNPD
FDLKGSGMKMGGGAKPFGVDAAAVPALVRRLIDAGADWRGFHIFAGSQALDAAAIAEMQAQTVALAARLADAIGTAPPLV
NLGGGMGVPYFPGDTAVDAAAVGEALGETLAARDAALADSRFAMELGRWLVAEAGVYLTRIVDRKVSHGETFLVTDGGLH
HQLAASGNFGTVIRRNYPIAVANAFGREPVETVAVVGCLCTPLDRLGDQVALPRADVGDLIAIFQAGAYGASASPAAFLG
QGPARELLV

Sequences:

>Translated_409_residues
MKPHGPIPPGFRADPDGMLLIGGDRAESLADVAGDTPLFVYDSAMLAARAAEWRAAMPAAVQLHYAMKANPYPPLLAFMA
GLVDGFDVASGGELKAALASGMDAAHISFAGPGKRDRELEAALEAGATLNLESAGEAERALAIAAHLGATPRLAVRVNPD
FDLKGSGMKMGGGAKPFGVDAAAVPALVRRLIDAGADWRGFHIFAGSQALDAAAIAEMQAQTVALAARLADAIGTAPPLV
NLGGGMGVPYFPGDTAVDAAAVGEALGETLAARDAALADSRFAMELGRWLVAEAGVYLTRIVDRKVSHGETFLVTDGGLH
HQLAASGNFGTVIRRNYPIAVANAFGREPVETVAVVGCLCTPLDRLGDQVALPRADVGDLIAIFQAGAYGASASPAAFLG
QGPARELLV
>Mature_409_residues
MKPHGPIPPGFRADPDGMLLIGGDRAESLADVAGDTPLFVYDSAMLAARAAEWRAAMPAAVQLHYAMKANPYPPLLAFMA
GLVDGFDVASGGELKAALASGMDAAHISFAGPGKRDRELEAALEAGATLNLESAGEAERALAIAAHLGATPRLAVRVNPD
FDLKGSGMKMGGGAKPFGVDAAAVPALVRRLIDAGADWRGFHIFAGSQALDAAAIAEMQAQTVALAARLADAIGTAPPLV
NLGGGMGVPYFPGDTAVDAAAVGEALGETLAARDAALADSRFAMELGRWLVAEAGVYLTRIVDRKVSHGETFLVTDGGLH
HQLAASGNFGTVIRRNYPIAVANAFGREPVETVAVVGCLCTPLDRLGDQVALPRADVGDLIAIFQAGAYGASASPAAFLG
QGPARELLV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=402, Percent_Identity=25.3731343283582, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562780, Length=386, Percent_Identity=22.5388601036269, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24586472, Length=371, Percent_Identity=22.911051212938, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24586474, Length=368, Percent_Identity=25.2717391304348, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 41847; Mature: 41847

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPHGPIPPGFRADPDGMLLIGGDRAESLADVAGDTPLFVYDSAMLAARAAEWRAAMPAA
CCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCHH
VQLHYAMKANPYPPLLAFMAGLVDGFDVASGGELKAALASGMDAAHISFAGPGKRDRELE
EEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHH
AALEAGATLNLESAGEAERALAIAAHLGATPRLAVRVNPDFDLKGSGMKMGGGAKPFGVD
HHHHCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEECCCCCCCCCCC
AAAVPALVRRLIDAGADWRGFHIFAGSQALDAAAIAEMQAQTVALAARLADAIGTAPPLV
HHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
NLGGGMGVPYFPGDTAVDAAAVGEALGETLAARDAALADSRFAMELGRWLVAEAGVYLTR
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVDRKVSHGETFLVTDGGLHHQLAASGNFGTVIRRNYPIAVANAFGREPVETVAVVGCLC
HHHHHCCCCCEEEEECCCCCEEEECCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHH
TPLDRLGDQVALPRADVGDLIAIFQAGAYGASASPAAFLGQGPARELLV
CCHHHCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHCC
>Mature Secondary Structure
MKPHGPIPPGFRADPDGMLLIGGDRAESLADVAGDTPLFVYDSAMLAARAAEWRAAMPAA
CCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCHH
VQLHYAMKANPYPPLLAFMAGLVDGFDVASGGELKAALASGMDAAHISFAGPGKRDRELE
EEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHH
AALEAGATLNLESAGEAERALAIAAHLGATPRLAVRVNPDFDLKGSGMKMGGGAKPFGVD
HHHHCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEECCCCCCCCCCC
AAAVPALVRRLIDAGADWRGFHIFAGSQALDAAAIAEMQAQTVALAARLADAIGTAPPLV
HHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
NLGGGMGVPYFPGDTAVDAAAVGEALGETLAARDAALADSRFAMELGRWLVAEAGVYLTR
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVDRKVSHGETFLVTDGGLHHQLAASGNFGTVIRRNYPIAVANAFGREPVETVAVVGCLC
HHHHHCCCCCEEEEECCCCCEEEECCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHH
TPLDRLGDQVALPRADVGDLIAIFQAGAYGASASPAAFLGQGPARELLV
CCHHHCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]