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The map label for this gene is dapA

Identifier: 103487216

GI number: 103487216

Start: 1821946

End: 1822821

Strand: Reverse

Name: dapA

Synonym: Sala_1731

Alternate gene names: 103487216

Gene position: 1822821-1821946 (Counterclockwise)

Preceding gene: 103487219

Following gene: 103487215

Centisome position: 54.49

GC content: 66.89

Gene sequence:

>876_bases
ATGTTTTCGGGTTCGATTCCCGCCCTGGTGACGCCATTCCGCGATGGAGCGTTCGACGCGCCCACCTTCGCGCGTCTTGT
GGACTGGCAGGTCAAAGAAGGAACGAGCGCACTGGTTCCGTGCGGCACGACCGGCGAAAGCCCGACGCTGAGCTTTGACG
AACATTATCGCGTGATCGACTGTTGCATCGAGGCGGCGGCGGGGCGCGTCCCGGTGATCGCCGGCTGCGGATCGAACGAT
ACCGCGACCGCGATCCGCCATATGCGCCACGCGCAGGCGTCGGGCGCCGATGCGGCGCTGATCGTCGCGCCCTATTACAA
CCGGCCGAGCCAGGAAGGGATGATCGCGCATTTCAAGGCGCTGGCCGATGCCAGCGACCTGCCGATCGTCGTCTATAATG
TCCCCGGCCGCACCGTCGCCGACATCAGCGCCGAAACGATGTGCAAGCTCGCCGAAATCCCGACCGTCGTGGCGGTCAAG
GATGCGAGCGGCGACCTGGCGCGCGTGACCGTCCACCGCAAGGGGGCGCGGCACGGCTTCTGCCAATTGTCGGGCAATGA
CGAGCTGTGGCTGCCACACGCGGTGATGGGCGGCGCGGGCTGCATCTCGGTCACCGCCAATGTCGCGCCGCGCCTCTGCG
CCGATTTCGCCGCCGCCTGTGCTGCGGGAGAGTGGACGCGCGCGCTGGCGCTCCATGACCGGCTGTTCGATTTGCACAAG
GCGATGTTCTCCGACACGTCGCCGGGGCCGGTCAAATATGCGCTCTCGCGCGTCCACGACTGGTTTTCGCCCGAAGTGCG
CCTACCTATCATTCCGGCGTCCGGCGCATCGCGCGCGGTCGTCGACGCCGCGCTGGCGTCGGCAGGAGTGATTTAG

Upstream 100 bases:

>100_bases
CGTAATGCCAAACTCCTTGCGGGGCGCTGAATAGACGTTCAATAGCGGCGCGCGGGCCGGATTCTATCGGTCGGGCCATG
TCCTTGTAAAGGAGCGGAGC

Downstream 100 bases:

>100_bases
GCATGTTTCGCCCAAGCCTTTCCGATTCGTGTCGAGCGAAGTCGAGACGCCCATCGGCCGCGCGCGCCCTGGGGGTGTCT
CGACTTCGCTCGATGCGAAC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MFSGSIPALVTPFRDGAFDAPTFARLVDWQVKEGTSALVPCGTTGESPTLSFDEHYRVIDCCIEAAAGRVPVIAGCGSND
TATAIRHMRHAQASGADAALIVAPYYNRPSQEGMIAHFKALADASDLPIVVYNVPGRTVADISAETMCKLAEIPTVVAVK
DASGDLARVTVHRKGARHGFCQLSGNDELWLPHAVMGGAGCISVTANVAPRLCADFAAACAAGEWTRALALHDRLFDLHK
AMFSDTSPGPVKYALSRVHDWFSPEVRLPIIPASGASRAVVDAALASAGVI

Sequences:

>Translated_291_residues
MFSGSIPALVTPFRDGAFDAPTFARLVDWQVKEGTSALVPCGTTGESPTLSFDEHYRVIDCCIEAAAGRVPVIAGCGSND
TATAIRHMRHAQASGADAALIVAPYYNRPSQEGMIAHFKALADASDLPIVVYNVPGRTVADISAETMCKLAEIPTVVAVK
DASGDLARVTVHRKGARHGFCQLSGNDELWLPHAVMGGAGCISVTANVAPRLCADFAAACAAGEWTRALALHDRLFDLHK
AMFSDTSPGPVKYALSRVHDWFSPEVRLPIIPASGASRAVVDAALASAGVI
>Mature_291_residues
MFSGSIPALVTPFRDGAFDAPTFARLVDWQVKEGTSALVPCGTTGESPTLSFDEHYRVIDCCIEAAAGRVPVIAGCGSND
TATAIRHMRHAQASGADAALIVAPYYNRPSQEGMIAHFKALADASDLPIVVYNVPGRTVADISAETMCKLAEIPTVVAVK
DASGDLARVTVHRKGARHGFCQLSGNDELWLPHAVMGGAGCISVTANVAPRLCADFAAACAAGEWTRALALHDRLFDLHK
AMFSDTSPGPVKYALSRVHDWFSPEVRLPIIPASGASRAVVDAALASAGVI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=269, Percent_Identity=28.996282527881, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI13540533, Length=236, Percent_Identity=27.1186440677966, Blast_Score=78, Evalue=8e-15,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=43.1506849315069, Blast_Score=234, Evalue=4e-63,
Organism=Escherichia coli, GI87082415, Length=297, Percent_Identity=29.2929292929293, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1786463, Length=251, Percent_Identity=31.4741035856574, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1789620, Length=242, Percent_Identity=29.7520661157025, Blast_Score=105, Evalue=3e-24,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_SPHAL (Q1GSC8)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616777.1
- ProteinModelPortal:   Q1GSC8
- SMR:   Q1GSC8
- GeneID:   4081193
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1731
- NMPDR:   fig|317655.9.peg.1663
- HOGENOM:   HBG358848
- OMA:   SGEDMTA
- ProtClustDB:   PRK03170
- BioCyc:   SALA317655:SALA_1731-MONOMER
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 30567; Mature: 30567

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 160-160 BINDING 105-105

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSGSIPALVTPFRDGAFDAPTFARLVDWQVKEGTSALVPCGTTGESPTLSFDEHYRVID
CCCCCCCCEEECCCCCCCCCCHHHHHHHEEECCCCCEEEECCCCCCCCCCCHHHHHHHHH
CCIEAAAGRVPVIAGCGSNDTATAIRHMRHAQASGADAALIVAPYYNRPSQEGMIAHFKA
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHH
LADASDLPIVVYNVPGRTVADISAETMCKLAEIPTVVAVKDASGDLARVTVHRKGARHGF
HCCCCCCCEEEEECCCCEEECCCHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCCCCCE
CQLSGNDELWLPHAVMGGAGCISVTANVAPRLCADFAAACAAGEWTRALALHDRLFDLHK
EEECCCCCEEECHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AMFSDTSPGPVKYALSRVHDWFSPEVRLPIIPASGASRAVVDAALASAGVI
HHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MFSGSIPALVTPFRDGAFDAPTFARLVDWQVKEGTSALVPCGTTGESPTLSFDEHYRVID
CCCCCCCCEEECCCCCCCCCCHHHHHHHEEECCCCCEEEECCCCCCCCCCCHHHHHHHHH
CCIEAAAGRVPVIAGCGSNDTATAIRHMRHAQASGADAALIVAPYYNRPSQEGMIAHFKA
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHH
LADASDLPIVVYNVPGRTVADISAETMCKLAEIPTVVAVKDASGDLARVTVHRKGARHGF
HCCCCCCCEEEEECCCCEEECCCHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCCCCCE
CQLSGNDELWLPHAVMGGAGCISVTANVAPRLCADFAAACAAGEWTRALALHDRLFDLHK
EEECCCCCEEECHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AMFSDTSPGPVKYALSRVHDWFSPEVRLPIIPASGASRAVVDAALASAGVI
HHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA