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The map label for this gene is ribBA [H]

Identifier: 103487142

GI number: 103487142

Start: 1742646

End: 1743242

Strand: Reverse

Name: ribBA [H]

Synonym: Sala_1657

Alternate gene names: 103487142

Gene position: 1743242-1742646 (Counterclockwise)

Preceding gene: 103487143

Following gene: 103487139

Centisome position: 52.11

GC content: 65.33

Gene sequence:

>597_bases
ATGCCCGACATCGATCAGGCCATCGAGGCTCTCGGGCGGGGAGAGATCATCGTCATCACCGGTGACCGTTTGCGTGGAGG
CGATATTGATTTTGCGCTCGCCGCGCGTCACGCAACGGCCGAAGCGCTCAATTTCATGGCCAATCACGGTCGTGGTCTCA
TCTGTCTTGCCATGCGACCGGAACGCGCCGTGCGGCTGGGCATCAGCCTGATCAATCCCGGCGCCGACCGCCAGTCGGGG
CGCCCTTTCGGCCGGTCGATCGAGGCGCGCGAAGGCGTCGGGACGGGCATATCTGCGGCCGACCGGGCACAGACCGTCCG
CGTCGCCGCTTCTCCCGACGCTTCGGGCGACGATCTTGTGTCACCGGGCCATATATTCCCGCTGATCGGCGCGCCGGGCG
GGGTGAGGGAAAGGGCCGCAGCCGCCGAAGCGGCGATCGAACTATGTTCGCTGGCGGGAGCAGGCGACATGGCCGTCATC
TGTTCGATCATGCGGGACGACGGCGAAATGGCGCGGATCGACGATCTCGATGCCTTTATCGCCCGGCATCGCATGCCAGT
CGCCGATATCGACGTCCTGCTCGATCGGTTGCGTTGA

Upstream 100 bases:

>100_bases
CGAATGTCTCGAGGATCGGGCGCGATTTCAGCTCGAACTGGTCGCCGACCAGCTTGTGTCCGGCGCGAGCAGCTTTGCCG
CCGCCAGAAAGGTCGCCTGA

Downstream 100 bases:

>100_bases
CGCCCGGCACTGCGGACGAAACGCTTCCAGTCCTGCCGGAAGCGACCGATATCCATCGCTGAGCGACGTCGCTCTAACAC
CTGGCATCGCCGCGTTGCGC

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MPDIDQAIEALGRGEIIVITGDRLRGGDIDFALAARHATAEALNFMANHGRGLICLAMRPERAVRLGISLINPGADRQSG
RPFGRSIEAREGVGTGISAADRAQTVRVAASPDASGDDLVSPGHIFPLIGAPGGVRERAAAAEAAIELCSLAGAGDMAVI
CSIMRDDGEMARIDDLDAFIARHRMPVADIDVLLDRLR

Sequences:

>Translated_198_residues
MPDIDQAIEALGRGEIIVITGDRLRGGDIDFALAARHATAEALNFMANHGRGLICLAMRPERAVRLGISLINPGADRQSG
RPFGRSIEAREGVGTGISAADRAQTVRVAASPDASGDDLVSPGHIFPLIGAPGGVRERAAAAEAAIELCSLAGAGDMAVI
CSIMRDDGEMARIDDLDAFIARHRMPVADIDVLLDRLR
>Mature_197_residues
PDIDQAIEALGRGEIIVITGDRLRGGDIDFALAARHATAEALNFMANHGRGLICLAMRPERAVRLGISLINPGADRQSGR
PFGRSIEAREGVGTGISAADRAQTVRVAASPDASGDDLVSPGHIFPLIGAPGGVRERAAAAEAAIELCSLAGAGDMAVIC
SIMRDDGEMARIDDLDAFIARHRMPVADIDVLLDRLR

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=191, Percent_Identity=36.1256544502618, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320695, Length=203, Percent_Identity=33.0049261083744, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 20786; Mature: 20655

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIDQAIEALGRGEIIVITGDRLRGGDIDFALAARHATAEALNFMANHGRGLICLAMRP
CCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
ERAVRLGISLINPGADRQSGRPFGRSIEAREGVGTGISAADRAQTVRVAASPDASGDDLV
CHHHEEEHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
SPGHIFPLIGAPGGVRERAAAAEAAIELCSLAGAGDMAVICSIMRDDGEMARIDDLDAFI
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEHHHHHHHHH
ARHRMPVADIDVLLDRLR
HHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PDIDQAIEALGRGEIIVITGDRLRGGDIDFALAARHATAEALNFMANHGRGLICLAMRP
CCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
ERAVRLGISLINPGADRQSGRPFGRSIEAREGVGTGISAADRAQTVRVAASPDASGDDLV
CHHHEEEHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
SPGHIFPLIGAPGGVRERAAAAEAAIELCSLAGAGDMAVICSIMRDDGEMARIDDLDAFI
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEHHHHHHHHH
ARHRMPVADIDVLLDRLR
HHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]