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The map label for this gene is hslU [H]

Identifier: 103487080

GI number: 103487080

Start: 1670905

End: 1672206

Strand: Direct

Name: hslU [H]

Synonym: Sala_1595

Alternate gene names: 103487080

Gene position: 1670905-1672206 (Clockwise)

Preceding gene: 103487079

Following gene: 103487081

Centisome position: 49.95

GC content: 66.28

Gene sequence:

>1302_bases
ATGAACAAAGATTTGACCCCGAAGGCGATCGTCGCCGCACTGGACACGCATATCATCGGCCAGGATGCGGCGAAGCGCGC
GGTCGCGGTGGCGCTGCGCAACCGCTGGCGCCGCCAGCAGCTGCCCGCCGAGCTGCGCGACGAGGTGACGCCGAAGAATA
TCCTGATGATCGGCCCCACCGGCTGCGGCAAGACCGAGATTTCGCGCCGCCTGGCCAAGCTCGCCGATGCGCCCTTCATC
AAGGTCGAGGCGACCAAGTTCACCGAGGTCGGCTATGTCGGCCGCGACGTCGAGCAGATCGCGCGCGACCTCGTCGAAGA
GGCGGTGCGGCTGGAAAAGGACCGCCGCCGCGACGCCGTGCGCGCCGCCGCCGAAGAGGCCGCGATGGAACGGCTGCTCG
ACGCGCTCACCGGCAAGGGCGCGAGCGAGGCGACGCGCCAGAGCTTTCGCCAACGCATCCGCGAAGGCCATCTCGACGAC
AGCGAGGTGGAGATCGAGGTCGCCGACGCGCCCGGCATGAGTTTCGAACTGCCCGGCCAGCCGGGGCAGATGAGCATGAT
CAACCTGTCCGACATGCTCGGCAAGGCGATGGGCGGCCTGCCCAGGAAACGCCGCAAGATGAAGGTGATCGACGCCGCGA
CGCGGTTGATCGAGGAGGAGCAGGACAAAAGGCTCGACCAGGACGATGTCGCCCGCGTCGCGCTCGCCGATGCCGAGGCC
AACGGCATCGTCTTCCTCGACGAGATCGACAAGATCGCGGTCAGCGACGTGCGCGGCGGATCGGTCAGTCGCGAGGGGGT
GCAGCGCGACCTCTTGCCGCTCATCGAGGGCACGACCGTCGCGACCAAATATGGCCCGATGAAGACCGATCATATCCTCT
TCATCGCGTCGGGCGCCTTTCACGTCGCCAAGCCCAGCGACCTGCTCCCCGAACTCCAGGGCCGCCTGCCGATCCGCGTC
GAACTCGGTGCGCTCACCGAGGAGGATTTCGTCCGCATCCTGAGCGAGACGAAGGCGGGGCTGCCCGAACAATATGTCGC
GCTGCTCGGCACCGAGGGCGTGACGCTGAACTTCGCCCCCGACGCGATCGCGCGCGTCGCGAAACTCGCCGCCGAAGTGA
ACGAAAAGGTCGAGAATATCGGCGCGCGCCGACTTCAGACGATCATGGAACGGCTGGTCGAGGAAATCAGCTTCACCGCC
GAGGATGCTCCCGGCGCGACGATCGACATCGACGCCGCCTATGTCGACCGCCAGCTTGCCGATGTCGTGGGCGACACCGA
TCTCAGCAAATATGTGCTTTAG

Upstream 100 bases:

>100_bases
GAGGTGCTGGCGAAAAAGGCGATGGCCGTCGCCGCCGAGATCTGCGTCTATACCAACGACCAGTTCACGCTCGAAACCAT
CGAAATCCAGGCGTAATCCC

Downstream 100 bases:

>100_bases
AGCGCGATGACATGATATTGACCCACCGTGACGGAGGCGATTCTGGCCGAGTGCGAGGCGCGAGGAGCGGCGCGATGCGG
GACATCGCGCCCGACGAGCA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MNKDLTPKAIVAALDTHIIGQDAAKRAVAVALRNRWRRQQLPAELRDEVTPKNILMIGPTGCGKTEISRRLAKLADAPFI
KVEATKFTEVGYVGRDVEQIARDLVEEAVRLEKDRRRDAVRAAAEEAAMERLLDALTGKGASEATRQSFRQRIREGHLDD
SEVEIEVADAPGMSFELPGQPGQMSMINLSDMLGKAMGGLPRKRRKMKVIDAATRLIEEEQDKRLDQDDVARVALADAEA
NGIVFLDEIDKIAVSDVRGGSVSREGVQRDLLPLIEGTTVATKYGPMKTDHILFIASGAFHVAKPSDLLPELQGRLPIRV
ELGALTEEDFVRILSETKAGLPEQYVALLGTEGVTLNFAPDAIARVAKLAAEVNEKVENIGARRLQTIMERLVEEISFTA
EDAPGATIDIDAAYVDRQLADVVGDTDLSKYVL

Sequences:

>Translated_433_residues
MNKDLTPKAIVAALDTHIIGQDAAKRAVAVALRNRWRRQQLPAELRDEVTPKNILMIGPTGCGKTEISRRLAKLADAPFI
KVEATKFTEVGYVGRDVEQIARDLVEEAVRLEKDRRRDAVRAAAEEAAMERLLDALTGKGASEATRQSFRQRIREGHLDD
SEVEIEVADAPGMSFELPGQPGQMSMINLSDMLGKAMGGLPRKRRKMKVIDAATRLIEEEQDKRLDQDDVARVALADAEA
NGIVFLDEIDKIAVSDVRGGSVSREGVQRDLLPLIEGTTVATKYGPMKTDHILFIASGAFHVAKPSDLLPELQGRLPIRV
ELGALTEEDFVRILSETKAGLPEQYVALLGTEGVTLNFAPDAIARVAKLAAEVNEKVENIGARRLQTIMERLVEEISFTA
EDAPGATIDIDAAYVDRQLADVVGDTDLSKYVL
>Mature_433_residues
MNKDLTPKAIVAALDTHIIGQDAAKRAVAVALRNRWRRQQLPAELRDEVTPKNILMIGPTGCGKTEISRRLAKLADAPFI
KVEATKFTEVGYVGRDVEQIARDLVEEAVRLEKDRRRDAVRAAAEEAAMERLLDALTGKGASEATRQSFRQRIREGHLDD
SEVEIEVADAPGMSFELPGQPGQMSMINLSDMLGKAMGGLPRKRRKMKVIDAATRLIEEEQDKRLDQDDVARVALADAEA
NGIVFLDEIDKIAVSDVRGGSVSREGVQRDLLPLIEGTTVATKYGPMKTDHILFIASGAFHVAKPSDLLPELQGRLPIRV
ELGALTEEDFVRILSETKAGLPEQYVALLGTEGVTLNFAPDAIARVAKLAAEVNEKVENIGARRLQTIMERLVEEISFTA
EDAPGATIDIDAAYVDRQLADVVGDTDLSKYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=442, Percent_Identity=57.0135746606335, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1786642, Length=110, Percent_Identity=43.6363636363636, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319704, Length=483, Percent_Identity=26.5010351966874, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24648291, Length=265, Percent_Identity=30.5660377358491, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24648289, Length=265, Percent_Identity=30.5660377358491, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 47406; Mature: 47406

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKDLTPKAIVAALDTHIIGQDAAKRAVAVALRNRWRRQQLPAELRDEVTPKNILMIGPT
CCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCC
GCGKTEISRRLAKLADAPFIKVEATKFTEVGYVGRDVEQIARDLVEEAVRLEKDRRRDAV
CCCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RAAAEEAAMERLLDALTGKGASEATRQSFRQRIREGHLDDSEVEIEVADAPGMSFELPGQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCC
PGQMSMINLSDMLGKAMGGLPRKRRKMKVIDAATRLIEEEQDKRLDQDDVARVALADAEA
CCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCCC
NGIVFLDEIDKIAVSDVRGGSVSREGVQRDLLPLIEGTTVATKYGPMKTDHILFIASGAF
CCEEEEECCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCE
HVAKPSDLLPELQGRLPIRVELGALTEEDFVRILSETKAGLPEQYVALLGTEGVTLNFAP
ECCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECH
DAIARVAKLAAEVNEKVENIGARRLQTIMERLVEEISFTAEDAPGATIDIDAAYVDRQLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHH
DVVGDTDLSKYVL
HHHCCCCHHHHCC
>Mature Secondary Structure
MNKDLTPKAIVAALDTHIIGQDAAKRAVAVALRNRWRRQQLPAELRDEVTPKNILMIGPT
CCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCC
GCGKTEISRRLAKLADAPFIKVEATKFTEVGYVGRDVEQIARDLVEEAVRLEKDRRRDAV
CCCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RAAAEEAAMERLLDALTGKGASEATRQSFRQRIREGHLDDSEVEIEVADAPGMSFELPGQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCC
PGQMSMINLSDMLGKAMGGLPRKRRKMKVIDAATRLIEEEQDKRLDQDDVARVALADAEA
CCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCCC
NGIVFLDEIDKIAVSDVRGGSVSREGVQRDLLPLIEGTTVATKYGPMKTDHILFIASGAF
CCEEEEECCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCE
HVAKPSDLLPELQGRLPIRVELGALTEEDFVRILSETKAGLPEQYVALLGTEGVTLNFAP
ECCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECH
DAIARVAKLAAEVNEKVENIGARRLQTIMERLVEEISFTAEDAPGATIDIDAAYVDRQLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHH
DVVGDTDLSKYVL
HHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA