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The map label for this gene is tesB [H]

Identifier: 103486928

GI number: 103486928

Start: 1491180

End: 1492136

Strand: Reverse

Name: tesB [H]

Synonym: Sala_1443

Alternate gene names: 103486928

Gene position: 1492136-1491180 (Counterclockwise)

Preceding gene: 103486929

Following gene: 103486927

Centisome position: 44.61

GC content: 66.88

Gene sequence:

>957_bases
TTGGACGATCGCATGAGCCTGACTCCCGCCGCGATTCAGGCTCGCATCGAACGCGCGCGCAAAATCCAGGCCGCCGTTCC
GCCCGAAAAGGTCGTCGCCGCGGTGACGCGCCTGTTCGACCTCGAACCCGTCGCGGGGCTGGAGGACGAGTTCACCTTTC
CCGCCTTTGCCAAGCCGACGCGCCAGCGCATTTTCGGCGGGCAGGTGATCGCGCAGGCGCTCGTCGCGGCGGCGCGCACC
GTCGATCCGGGCAAGGCGGCGCATTCGCTGCACGCCTATTTCCTGCGCGGCGGCGACGAGGCCAAGCCGCTGCATTTCCG
CGTCCACCGCGATTTCGACGGGCGCAGCTTCGCCAATCGCCGCGTCGTCGTGCGGCAGGATGGCAAGGTGATCTTCAACC
TCACCGCATCCTTTCACGCGCCCGAGCCGGGCGTCGCGCACCAGACGCCGATGCCCGACCTGCGGCCACCCGAAGACTGC
GCCGAGTTCGTCGAGAACATCGCCGCCGACCCCAATGTCAGCGACGCGCAACTTGACCAGATGGCGTGGCTGCGGCCGTT
CGAGATGCGCAGTTCCCGCCCGCCCTCGACCGAAGCGGCGACGGCGCATTATCAATGGTACCGGCTTGCGGCGCCGATCG
GCGACGATCCGCTGCTCCATCGCGCGTTTCTGGCCTATGCCTCGGATATGGGGCTTTTGTCCTCGTCGCTCCGGCCGCAC
GGGTTCACCTGGTCGACGCCGGGGCTTTTCTCGACCAGCCTCGATCATGCGATGTGGTTCCACGACGACATCCGTGTCGA
CGACTGGTTCGTCTATGTGATGGACAGCGATTGGACCGGCGGCAGCCGCGGCATCAATCGCGGCCTGATCTATCGCCAGG
ACGGCACGCTGATCGCTTCGGCGATGCAGGAAGGATTGCTGCGCATCACGCCCTCCGAAGGCGCTGCGGGCGGATAG

Upstream 100 bases:

>100_bases
CGCGCCACGCCGGTCGAGCTCGATTTCGAGCAGGTTGAGCGCATGAAGTGACGACCCCGACAGGTTGTCATCCCGGCGAA
GACGGGGATCCAGCGAAAGA

Downstream 100 bases:

>100_bases
GCCCGGATCTCGTCATCGCATCGGCCACTGGCGCTTGCCTTTCTCAGCCTTTCGGTCTAACGGCGCCGCTTCGCAACAGA
TACGGTTGTGATTCCGCGCG

Product: palmitoyl-CoA hydrolase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MDDRMSLTPAAIQARIERARKIQAAVPPEKVVAAVTRLFDLEPVAGLEDEFTFPAFAKPTRQRIFGGQVIAQALVAAART
VDPGKAAHSLHAYFLRGGDEAKPLHFRVHRDFDGRSFANRRVVVRQDGKVIFNLTASFHAPEPGVAHQTPMPDLRPPEDC
AEFVENIAADPNVSDAQLDQMAWLRPFEMRSSRPPSTEAATAHYQWYRLAAPIGDDPLLHRAFLAYASDMGLLSSSLRPH
GFTWSTPGLFSTSLDHAMWFHDDIRVDDWFVYVMDSDWTGGSRGINRGLIYRQDGTLIASAMQEGLLRITPSEGAAGG

Sequences:

>Translated_318_residues
MDDRMSLTPAAIQARIERARKIQAAVPPEKVVAAVTRLFDLEPVAGLEDEFTFPAFAKPTRQRIFGGQVIAQALVAAART
VDPGKAAHSLHAYFLRGGDEAKPLHFRVHRDFDGRSFANRRVVVRQDGKVIFNLTASFHAPEPGVAHQTPMPDLRPPEDC
AEFVENIAADPNVSDAQLDQMAWLRPFEMRSSRPPSTEAATAHYQWYRLAAPIGDDPLLHRAFLAYASDMGLLSSSLRPH
GFTWSTPGLFSTSLDHAMWFHDDIRVDDWFVYVMDSDWTGGSRGINRGLIYRQDGTLIASAMQEGLLRITPSEGAAGG
>Mature_318_residues
MDDRMSLTPAAIQARIERARKIQAAVPPEKVVAAVTRLFDLEPVAGLEDEFTFPAFAKPTRQRIFGGQVIAQALVAAART
VDPGKAAHSLHAYFLRGGDEAKPLHFRVHRDFDGRSFANRRVVVRQDGKVIFNLTASFHAPEPGVAHQTPMPDLRPPEDC
AEFVENIAADPNVSDAQLDQMAWLRPFEMRSSRPPSTEAATAHYQWYRLAAPIGDDPLLHRAFLAYASDMGLLSSSLRPH
GFTWSTPGLFSTSLDHAMWFHDDIRVDDWFVYVMDSDWTGGSRGINRGLIYRQDGTLIASAMQEGLLRITPSEGAAGG

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=290, Percent_Identity=38.6206896551724, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1786657, Length=258, Percent_Identity=39.1472868217054, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17558508, Length=274, Percent_Identity=36.4963503649635, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71988741, Length=265, Percent_Identity=35.8490566037736, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17531889, Length=274, Percent_Identity=33.9416058394161, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI115532456, Length=274, Percent_Identity=33.9416058394161, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17531885, Length=274, Percent_Identity=33.9416058394161, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI212645202, Length=281, Percent_Identity=29.8932384341637, Blast_Score=107, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 35164; Mature: 35164

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDRMSLTPAAIQARIERARKIQAAVPPEKVVAAVTRLFDLEPVAGLEDEFTFPAFAKPT
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
RQRIFGGQVIAQALVAAARTVDPGKAAHSLHAYFLRGGDEAKPLHFRVHRDFDGRSFANR
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCCCCCCEEEEEECCCCCCCCCCC
RVVVRQDGKVIFNLTASFHAPEPGVAHQTPMPDLRPPEDCAEFVENIAADPNVSDAQLDQ
EEEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
MAWLRPFEMRSSRPPSTEAATAHYQWYRLAAPIGDDPLLHRAFLAYASDMGLLSSSLRPH
HHHCCCHHHHCCCCCCCCCHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GFTWSTPGLFSTSLDHAMWFHDDIRVDDWFVYVMDSDWTGGSRGINRGLIYRQDGTLIAS
CCCCCCCCCCCCCHHHHHEECCCCEECEEEEEEEECCCCCCCCCCCCCEEEECCCCHHHH
AMQEGLLRITPSEGAAGG
HHHCCCEEECCCCCCCCC
>Mature Secondary Structure
MDDRMSLTPAAIQARIERARKIQAAVPPEKVVAAVTRLFDLEPVAGLEDEFTFPAFAKPT
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
RQRIFGGQVIAQALVAAARTVDPGKAAHSLHAYFLRGGDEAKPLHFRVHRDFDGRSFANR
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCCCCCCEEEEEECCCCCCCCCCC
RVVVRQDGKVIFNLTASFHAPEPGVAHQTPMPDLRPPEDCAEFVENIAADPNVSDAQLDQ
EEEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
MAWLRPFEMRSSRPPSTEAATAHYQWYRLAAPIGDDPLLHRAFLAYASDMGLLSSSLRPH
HHHCCCHHHHCCCCCCCCCHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GFTWSTPGLFSTSLDHAMWFHDDIRVDDWFVYVMDSDWTGGSRGINRGLIYRQDGTLIAS
CCCCCCCCCCCCCHHHHHEECCCCEECEEEEEEEECCCCCCCCCCCCCEEEECCCCHHHH
AMQEGLLRITPSEGAAGG
HHHCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]