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The map label for this gene is ctaB

Identifier: 103486889

GI number: 103486889

Start: 1457227

End: 1458153

Strand: Reverse

Name: ctaB

Synonym: Sala_1403

Alternate gene names: 103486889

Gene position: 1458153-1457227 (Counterclockwise)

Preceding gene: 103486890

Following gene: 103486888

Centisome position: 43.59

GC content: 64.94

Gene sequence:

>927_bases
ATGGCCGGAGTGATTATGGCGCAAAGCCTGACCCATGATGCGATGACGCTCCCCGCCGACTGGCGCGACCTGCTCGCGCT
GACCAAGCCGCGCGTCATGTCGCTGGTGGTGTTCACCGCGCTGTGCGGCCTGCTCGCGGCGCCGGGTGACGTGCATCCGG
TGCTGGGTTTTTCGTCGATCCTCGCGATCGCGCTGGGGGCAGGGGCGTCGGGCGCGCTCAACCAATGGTATGAGGCGGGG
CTCGACGCCAGGATGAAGCGCACCGCAGGCCGCCCGCTGCCCGCCGGACGGCTCGATCCGCAGACGGCGTTGCAGTTCGG
GATCGGGCTCGCTGCCTTTTCGCTGTTCCTGATGCTCTTCGCGTCGAACTGGCAGGCGACCGTGCTGCTTGCGGGCTCGA
TCCTCTTTTACGTCGTCATCTACACGATGTGGCTGAAGCCCCGGACGCCGCAGAATATCGTCATCGGCGGCGCAGCGGGG
GCCTTTCCGCCGCTGATCGGCTGGGTCGCGGCAACAGGATCGATCGCGCCGCTGCCGGTGCTGCTCTTTCTGCTCATCTT
CCTGTGGACGCCGCCGCATTTCTGGGCGCTCGCGCTGTTCGTCCGCTCGGATTATGCCGCCGCCGGCATTCCGATGATGC
CCGTCGTCGCGGGCGAAAAATCGACGCGGCGCCAGATCCTTTTTTATGCGCTGATTATGGCCGCGGCTGCGATCGCGCCC
TGGCCGCTGGGCTATACCGGTGCGCTTTATGGCTGGACGGCGATTTTGCTCTCGGCAATCTTTGTCCTGTTGTCGGTGCA
GGTCGGCATCCGAACGACGGCCGAGGACGACAGGATGCAGCCCGAAAAGCGGCTTTTCGCTTTCTCGATCGCCTATCTTT
TCATCCTGTTCGGCGCGGTGGTGGCCGATCATTGGTGGCCGCTATGA

Upstream 100 bases:

>100_bases
CGCTGTCGAGCCCGCCGCCGTTCCACCAGTTCAACGAACTGCCGCGTATCGCCTGACAGGCCGCGCCCTCTGCTGACTTC
CGGCAGGGGGCGCAGCCCTG

Downstream 100 bases:

>100_bases
CGAACGAACCCGACCAGCCGCCCTTCGACGAGGCCGAATATCGGCGCCGCCAGCGCAGCCGCGCGAATATGATGGCGTGG
ATGCTCGGTGCGCTCGCGGT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MAGVIMAQSLTHDAMTLPADWRDLLALTKPRVMSLVVFTALCGLLAAPGDVHPVLGFSSILAIALGAGASGALNQWYEAG
LDARMKRTAGRPLPAGRLDPQTALQFGIGLAAFSLFLMLFASNWQATVLLAGSILFYVVIYTMWLKPRTPQNIVIGGAAG
AFPPLIGWVAATGSIAPLPVLLFLLIFLWTPPHFWALALFVRSDYAAAGIPMMPVVAGEKSTRRQILFYALIMAAAAIAP
WPLGYTGALYGWTAILLSAIFVLLSVQVGIRTTAEDDRMQPEKRLFAFSIAYLFILFGAVVADHWWPL

Sequences:

>Translated_308_residues
MAGVIMAQSLTHDAMTLPADWRDLLALTKPRVMSLVVFTALCGLLAAPGDVHPVLGFSSILAIALGAGASGALNQWYEAG
LDARMKRTAGRPLPAGRLDPQTALQFGIGLAAFSLFLMLFASNWQATVLLAGSILFYVVIYTMWLKPRTPQNIVIGGAAG
AFPPLIGWVAATGSIAPLPVLLFLLIFLWTPPHFWALALFVRSDYAAAGIPMMPVVAGEKSTRRQILFYALIMAAAAIAP
WPLGYTGALYGWTAILLSAIFVLLSVQVGIRTTAEDDRMQPEKRLFAFSIAYLFILFGAVVADHWWPL
>Mature_307_residues
AGVIMAQSLTHDAMTLPADWRDLLALTKPRVMSLVVFTALCGLLAAPGDVHPVLGFSSILAIALGAGASGALNQWYEAGL
DARMKRTAGRPLPAGRLDPQTALQFGIGLAAFSLFLMLFASNWQATVLLAGSILFYVVIYTMWLKPRTPQNIVIGGAAGA
FPPLIGWVAATGSIAPLPVLLFLLIFLWTPPHFWALALFVRSDYAAAGIPMMPVVAGEKSTRRQILFYALIMAAAAIAPW
PLGYTGALYGWTAILLSAIFVLLSVQVGIRTTAEDDRMQPEKRLFAFSIAYLFILFGAVVADHWWPL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=194, Percent_Identity=34.020618556701, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1786631, Length=271, Percent_Identity=29.520295202952, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71998235, Length=271, Percent_Identity=30.6273062730627, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=214, Percent_Identity=31.7757009345794, Blast_Score=93, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19921064, Length=267, Percent_Identity=30.7116104868914, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_SPHAL (Q1GTA5)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616450.1
- GeneID:   4081759
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1403
- NMPDR:   fig|317655.9.peg.1337
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- ProtClustDB:   PRK04375
- BioCyc:   SALA317655:SALA_1403-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33187; Mature: 33056

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12593cd4)-; HASH(0xd9901bc)-; HASH(0x12464b28)-; HASH(0x1257a450)-; HASH(0x1110f5e8)-; HASH(0x11d19f94)-; HASH(0x1109d274)-; HASH(0x11a4cddc)-; HASH(0x12194234)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGVIMAQSLTHDAMTLPADWRDLLALTKPRVMSLVVFTALCGLLAAPGDVHPVLGFSSI
CCCHHHHHHHCCCCEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LAIALGAGASGALNQWYEAGLDARMKRTAGRPLPAGRLDPQTALQFGIGLAAFSLFLMLF
HHHHHCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASNWQATVLLAGSILFYVVIYTMWLKPRTPQNIVIGGAAGAFPPLIGWVAATGSIAPLPV
HCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCHHHH
LLFLLIFLWTPPHFWALALFVRSDYAAAGIPMMPVVAGEKSTRRQILFYALIMAAAAIAP
HHHHHHHHCCCHHHHHHHHHHHHCCHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCC
WPLGYTGALYGWTAILLSAIFVLLSVQVGIRTTAEDDRMQPEKRLFAFSIAYLFILFGAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHCCHHHHHHHHHHHHHHHHHHHH
VADHWWPL
HHHHCCCH
>Mature Secondary Structure 
AGVIMAQSLTHDAMTLPADWRDLLALTKPRVMSLVVFTALCGLLAAPGDVHPVLGFSSI
CCHHHHHHHCCCCEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LAIALGAGASGALNQWYEAGLDARMKRTAGRPLPAGRLDPQTALQFGIGLAAFSLFLMLF
HHHHHCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASNWQATVLLAGSILFYVVIYTMWLKPRTPQNIVIGGAAGAFPPLIGWVAATGSIAPLPV
HCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCHHHH
LLFLLIFLWTPPHFWALALFVRSDYAAAGIPMMPVVAGEKSTRRQILFYALIMAAAAIAP
HHHHHHHHCCCHHHHHHHHHHHHCCHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCC
WPLGYTGALYGWTAILLSAIFVLLSVQVGIRTTAEDDRMQPEKRLFAFSIAYLFILFGAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHCCHHHHHHHHHHHHHHHHHHHH
VADHWWPL
HHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA