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The map label for this gene is apt

Identifier: 103486828

GI number: 103486828

Start: 1402686

End: 1403240

Strand: Reverse

Name: apt

Synonym: Sala_1342

Alternate gene names: 103486828

Gene position: 1403240-1402686 (Counterclockwise)

Preceding gene: 103486829

Following gene: 103486827

Centisome position: 41.95

GC content: 67.93

Gene sequence:

>555_bases
ATGATCGCCCTCCCGCCGCAGCCGGATCTCGACCTTGCGTCGCTGGTCCGCACCATCCCCGATTTTCCCAGGCCGGGCAT
CCAGTTTCGCGACATCACCACGCTGATCGGCGACGCCGTCGGCTTTGCCGAAAGCGTACGCCGATTGAGCGCGTGCGCCG
CGGCCTATCGTCCCGACCTGATCGTCGCGGTCGAGGCGCGCGGTTTCCTGTTCGGCGCGGCGATGGCGACCGCGATGGGG
CTGGGTGTCGTGCCGGTGCGCAAGGCGGGCAAGCTGCCCGGCGTCACGATCGGTGTCGATTATGAACTCGAATATGGCAC
CGACCGGCTCGAGCTGCACGAAGGGGCGGTGCTGCCGGGGCACCGCGTCGTGCTGGTCGATGATTTGCTCGCGACGGGCG
GCACGATCCTCGCCACGGCGGCACTGATGCGGAGCGTCGGGGCCGAGGTTGCGGCGGCGCTCTTCGTTATCGACCTGCCA
GATTTGGGTGGGTCTGCGCGCTTGGGTGCGGCGGGGCTGCGTTGCGAGACGCTGATTGCCTTCAACGGCGATTAG

Upstream 100 bases:

>100_bases
TGATCGGCTTCCTGCTGATCTTTACCGTGCTGACCTATTTGTCGTACCGCAACATCTGGGCCGACAAGAAGCATTGAGTG
CCGCGGAGGGCGACCGGTTG

Downstream 100 bases:

>100_bases
AGCGGCGTGCTGGATGAACGTGGATAAGCACGCAACTCTTGGGGCGCTTCTATCCAGCGATCCGCCGCGAATGGAAGCAT
TGGCAGCTGTCGCTGCCCTG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MIALPPQPDLDLASLVRTIPDFPRPGIQFRDITTLIGDAVGFAESVRRLSACAAAYRPDLIVAVEARGFLFGAAMATAMG
LGVVPVRKAGKLPGVTIGVDYELEYGTDRLELHEGAVLPGHRVVLVDDLLATGGTILATAALMRSVGAEVAAALFVIDLP
DLGGSARLGAAGLRCETLIAFNGD

Sequences:

>Translated_184_residues
MIALPPQPDLDLASLVRTIPDFPRPGIQFRDITTLIGDAVGFAESVRRLSACAAAYRPDLIVAVEARGFLFGAAMATAMG
LGVVPVRKAGKLPGVTIGVDYELEYGTDRLELHEGAVLPGHRVVLVDDLLATGGTILATAALMRSVGAEVAAALFVIDLP
DLGGSARLGAAGLRCETLIAFNGD
>Mature_184_residues
MIALPPQPDLDLASLVRTIPDFPRPGIQFRDITTLIGDAVGFAESVRRLSACAAAYRPDLIVAVEARGFLFGAAMATAMG
LGVVPVRKAGKLPGVTIGVDYELEYGTDRLELHEGAVLPGHRVVLVDDLLATGGTILATAALMRSVGAEVAAALFVIDLP
DLGGSARLGAAGLRCETLIAFNGD

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=157, Percent_Identity=44.5859872611465, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI71773201, Length=122, Percent_Identity=48.3606557377049, Blast_Score=114, Evalue=4e-26,
Organism=Escherichia coli, GI1786675, Length=172, Percent_Identity=50.5813953488372, Blast_Score=166, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17509087, Length=178, Percent_Identity=41.0112359550562, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=164, Percent_Identity=37.8048780487805, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320649, Length=164, Percent_Identity=36.5853658536585, Blast_Score=88, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17136334, Length=182, Percent_Identity=39.010989010989, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_SPHAL (Q1GTG6)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616389.1
- ProteinModelPortal:   Q1GTG6
- SMR:   Q1GTG6
- GeneID:   4082810
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1342
- NMPDR:   fig|317655.9.peg.1275
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   SALA317655:SALA_1342-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19078; Mature: 19078

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALPPQPDLDLASLVRTIPDFPRPGIQFRDITTLIGDAVGFAESVRRLSACAAAYRPDL
CCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IVAVEARGFLFGAAMATAMGLGVVPVRKAGKLPGVTIGVDYELEYGTDRLELHEGAVLPG
EEEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEEEEECCCCCEEEECCCCCCCC
HRVVLVDDLLATGGTILATAALMRSVGAEVAAALFVIDLPDLGGSARLGAAGLRCETLIA
CEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEEEEEEE
FNGD
ECCC
>Mature Secondary Structure
MIALPPQPDLDLASLVRTIPDFPRPGIQFRDITTLIGDAVGFAESVRRLSACAAAYRPDL
CCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IVAVEARGFLFGAAMATAMGLGVVPVRKAGKLPGVTIGVDYELEYGTDRLELHEGAVLPG
EEEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEEEEECCCCCEEEECCCCCCCC
HRVVLVDDLLATGGTILATAALMRSVGAEVAAALFVIDLPDLGGSARLGAAGLRCETLIA
CEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEEEEEEE
FNGD
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA