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The map label for this gene is tktA [H]

Identifier: 103486806

GI number: 103486806

Start: 1377996

End: 1379978

Strand: Reverse

Name: tktA [H]

Synonym: Sala_1320

Alternate gene names: 103486806

Gene position: 1379978-1377996 (Counterclockwise)

Preceding gene: 103486810

Following gene: 103486805

Centisome position: 41.25

GC content: 64.45

Gene sequence:

>1983_bases
ATGACATATCCCGAAGGCCATTCGGCCGAACGCCAGCTCGCCAACGCGATCCGTGCGCTTGCGATGGACGCCGTGCAGGC
CGCGAACAGCGGCCATCCGGGGATGCCGATGGGCATGGCCGACGTCGCCACGGTGCTGTATTCGGACTATCTGAAGTTCG
ACCCGACCGATCCCAAATGGGCCGATCGCGACCGATTCGTGCTGTCGGCGGGCCATGGGTCGATGCTCGCCTATGCAACG
CTGCACCTCGCGGGCTATGCGCGCCCGACGATCGAGGACATCCGTAATTTCCGCCAGCTGCACAGCCCGTGCGCGGGACA
TCCCGAAAATTTCGAGCTTGAAGGCGTCGAAACCACCACTGGTCCGCTGGGGCAGGGGCTCGCGACCGCGGTGGGCATGG
CGATCGCCGAGCGGCACCTGAATGCGCTCTACGGCGATGGACTGGTCGATCACCGCACCTGGGTGATCGCAGGCGACGGC
TGTTTGATGGAGGGCATCAACCACGAGGCGATCGGGCTGGCTGGGCATCTTGGGCTCGGGCGTCTGACCGTGCTGTGGGA
CGATAACAAGATCACCATCGACGGATCGACCGACCTGTCGACGAGCGAGGATGTCGCCGCGCGCTATGCCGCGACCGGCT
GGCACGTCGAAAGCTGCGACGGGCATGACCCGGCCGACATCCGCCGTGCGATCGACGCCGCGCTCGCCGATCCGCGCCCT
TCGCTGATCGCGTGCCGGACGATCATCGGTTTCGGCGCGCCGAACAAGCAGGGGACCTCTGCAACGCACGGGGCGCCGCT
CGGCGCCGACGAGATCGCGGCGGCGCGCCGGGAACTGGGCTGGACCGCCGAGCCTTTCGTCATCCCGGCCGACATTGCCG
CAGCGTGGGCGTCCTTTGGCGAGAAAGGCAAGAAACTTCACAACGAGTGGAATAGTCGCCTCGCAACTAGCGAAAAGAAA
AACGATTTTGAAGCACGGCTGAATGGCAAAGTCGCCCCGGGCGCTGCCTTCAAAGCCTATCTCGACGGCCTTGCTGCCGA
ACCGCCGAAGGTCGCAACGCGCAAGGCTTCGGAGAACACGCTGAGCGCGCTCACCGTCGATATTGCGGCGCTCGTCGGGG
GCAGCGCCGACCTGACCGGTTCGAACAACACCAAAACATCATCGACCAAGCCACTGACCAGAAATGATTATTCGGGACGC
TATATTTATTATGGCATCCGCGAATTCGGCATGGCCGCGGCGATGAACGGCATGGCGCTGCACGGCGGCGTCGTCCCCTA
TGGCGGCACCTTCCTGGTGTTCGCCGATTATTGCCGCGCCGCGATCCGCCTGTCGGCGCTCCAGAAACAGCGCGTCGTCT
ATGTGATGACCCACGACAGTATCGGCCTGGGCGAGGATGGTCCCACGCACCAGCCGATCGAACATCTCCAGTCGCTGCGT
GCGATGCCCAACCTGCTTGTGATGCGCCCCGCCGACGCGGTCGAAACCGCCGAATGCTGGGCGCTCGCGCTCGCGCAGGA
GGGGCGCCCGTCGCTGCTCGCGCTGACGCGCCAGAACTTGCCGCCGCTGCGCCATGACGTCACGGAAAATCGTTGTGCTA
AAGGCGGTTATCGCCTGCGTGGGGCTTCGGCGGCACGCAAGGTCGTGCTGGTTGCGACGGGTTCCGAAGTGTCGCTGGCG
ATGGACGTCGCCGACAAGCTGGAAGCCGCCGGTCATGGCGCCGATGTCGTTTCGATGGTGTCGACTGAATTGTTCGACGA
ACAGGACGCCGCTTATCAAGCCGACGTCCTGCCCGATGATGCGCTGATCGTGTCGATCGAGGCGGGCACGACCTTTGGCT
GGGAACGCTACACCGGCCGCGACGGCCTGCGTTTCGGCATCGACAGTTTTGGCGCCTCGGCACCCATCGAAGACCTATTC
AGGCATTTCGGCCTTACCGCCGATGCCATCACCCCCCAGATCCTGGCCCGGCTGAGCCATTAA

Upstream 100 bases:

>100_bases
CGGGGGAAATTGTGCCGCGAGCGGTTGACTCCTGCCCGTACGGCCGCAAAGGGCAGTCGCACCGAATCCGGCCACCCAAA
CATCCTTTCCCGGGGGACTC

Downstream 100 bases:

>100_bases
GGACCGGCCGACCATTCGCAGAAAGGACAATTCGACATGGCAGTGAAAGTCGCAATCAACGGTTTCGGACGCATCGGCCG
CCTCGTGGCGCGCGCCATTC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MTYPEGHSAERQLANAIRALAMDAVQAANSGHPGMPMGMADVATVLYSDYLKFDPTDPKWADRDRFVLSAGHGSMLAYAT
LHLAGYARPTIEDIRNFRQLHSPCAGHPENFELEGVETTTGPLGQGLATAVGMAIAERHLNALYGDGLVDHRTWVIAGDG
CLMEGINHEAIGLAGHLGLGRLTVLWDDNKITIDGSTDLSTSEDVAARYAATGWHVESCDGHDPADIRRAIDAALADPRP
SLIACRTIIGFGAPNKQGTSATHGAPLGADEIAAARRELGWTAEPFVIPADIAAAWASFGEKGKKLHNEWNSRLATSEKK
NDFEARLNGKVAPGAAFKAYLDGLAAEPPKVATRKASENTLSALTVDIAALVGGSADLTGSNNTKTSSTKPLTRNDYSGR
YIYYGIREFGMAAAMNGMALHGGVVPYGGTFLVFADYCRAAIRLSALQKQRVVYVMTHDSIGLGEDGPTHQPIEHLQSLR
AMPNLLVMRPADAVETAECWALALAQEGRPSLLALTRQNLPPLRHDVTENRCAKGGYRLRGASAARKVVLVATGSEVSLA
MDVADKLEAAGHGADVVSMVSTELFDEQDAAYQADVLPDDALIVSIEAGTTFGWERYTGRDGLRFGIDSFGASAPIEDLF
RHFGLTADAITPQILARLSH

Sequences:

>Translated_660_residues
MTYPEGHSAERQLANAIRALAMDAVQAANSGHPGMPMGMADVATVLYSDYLKFDPTDPKWADRDRFVLSAGHGSMLAYAT
LHLAGYARPTIEDIRNFRQLHSPCAGHPENFELEGVETTTGPLGQGLATAVGMAIAERHLNALYGDGLVDHRTWVIAGDG
CLMEGINHEAIGLAGHLGLGRLTVLWDDNKITIDGSTDLSTSEDVAARYAATGWHVESCDGHDPADIRRAIDAALADPRP
SLIACRTIIGFGAPNKQGTSATHGAPLGADEIAAARRELGWTAEPFVIPADIAAAWASFGEKGKKLHNEWNSRLATSEKK
NDFEARLNGKVAPGAAFKAYLDGLAAEPPKVATRKASENTLSALTVDIAALVGGSADLTGSNNTKTSSTKPLTRNDYSGR
YIYYGIREFGMAAAMNGMALHGGVVPYGGTFLVFADYCRAAIRLSALQKQRVVYVMTHDSIGLGEDGPTHQPIEHLQSLR
AMPNLLVMRPADAVETAECWALALAQEGRPSLLALTRQNLPPLRHDVTENRCAKGGYRLRGASAARKVVLVATGSEVSLA
MDVADKLEAAGHGADVVSMVSTELFDEQDAAYQADVLPDDALIVSIEAGTTFGWERYTGRDGLRFGIDSFGASAPIEDLF
RHFGLTADAITPQILARLSH
>Mature_659_residues
TYPEGHSAERQLANAIRALAMDAVQAANSGHPGMPMGMADVATVLYSDYLKFDPTDPKWADRDRFVLSAGHGSMLAYATL
HLAGYARPTIEDIRNFRQLHSPCAGHPENFELEGVETTTGPLGQGLATAVGMAIAERHLNALYGDGLVDHRTWVIAGDGC
LMEGINHEAIGLAGHLGLGRLTVLWDDNKITIDGSTDLSTSEDVAARYAATGWHVESCDGHDPADIRRAIDAALADPRPS
LIACRTIIGFGAPNKQGTSATHGAPLGADEIAAARRELGWTAEPFVIPADIAAAWASFGEKGKKLHNEWNSRLATSEKKN
DFEARLNGKVAPGAAFKAYLDGLAAEPPKVATRKASENTLSALTVDIAALVGGSADLTGSNNTKTSSTKPLTRNDYSGRY
IYYGIREFGMAAAMNGMALHGGVVPYGGTFLVFADYCRAAIRLSALQKQRVVYVMTHDSIGLGEDGPTHQPIEHLQSLRA
MPNLLVMRPADAVETAECWALALAQEGRPSLLALTRQNLPPLRHDVTENRCAKGGYRLRGASAARKVVLVATGSEVSLAM
DVADKLEAAGHGADVVSMVSTELFDEQDAAYQADVLPDDALIVSIEAGTTFGWERYTGRDGLRFGIDSFGASAPIEDLFR
HFGLTADAITPQILARLSH

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=504, Percent_Identity=27.1825396825397, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI4507521, Length=504, Percent_Identity=27.1825396825397, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI133778974, Length=592, Percent_Identity=26.3513513513513, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI225637459, Length=587, Percent_Identity=21.1243611584327, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI225637461, Length=557, Percent_Identity=21.0053859964093, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI225637463, Length=554, Percent_Identity=21.1191335740072, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=50.6042296072508, Blast_Score=635, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=657, Percent_Identity=50.3805175038052, Blast_Score=624, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17539652, Length=596, Percent_Identity=26.006711409396, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=655, Percent_Identity=45.8015267175573, Blast_Score=513, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6319593, Length=657, Percent_Identity=43.0745814307458, Blast_Score=486, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45551847, Length=574, Percent_Identity=27.3519163763066, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI45550715, Length=574, Percent_Identity=27.3519163763066, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24666278, Length=500, Percent_Identity=28.8, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24645119, Length=527, Percent_Identity=26.9449715370019, Blast_Score=157, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 70390; Mature: 70259

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYPEGHSAERQLANAIRALAMDAVQAANSGHPGMPMGMADVATVLYSDYLKFDPTDPKW
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
ADRDRFVLSAGHGSMLAYATLHLAGYARPTIEDIRNFRQLHSPCAGHPENFELEGVETTT
CCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCC
GPLGQGLATAVGMAIAERHLNALYGDGLVDHRTWVIAGDGCLMEGINHEAIGLAGHLGLG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEECCCCCCCEEEEECCCCC
RLTVLWDDNKITIDGSTDLSTSEDVAARYAATGWHVESCDGHDPADIRRAIDAALADPRP
EEEEEECCCEEEECCCCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCC
SLIACRTIIGFGAPNKQGTSATHGAPLGADEIAAARRELGWTAEPFVIPADIAAAWASFG
CHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHH
EKGKKLHNEWNSRLATSEKKNDFEARLNGKVAPGAAFKAYLDGLAAEPPKVATRKASENT
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCHH
LSALTVDIAALVGGSADLTGSNNTKTSSTKPLTRNDYSGRYIYYGIREFGMAAAMNGMAL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCEEE
HGGVVPYGGTFLVFADYCRAAIRLSALQKQRVVYVMTHDSIGLGEDGPTHQPIEHLQSLR
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHH
AMPNLLVMRPADAVETAECWALALAQEGRPSLLALTRQNLPPLRHDVTENRCAKGGYRLR
CCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEHHCCCCCHHHHHHHHHHHCCCCEEE
GASAARKVVLVATGSEVSLAMDVADKLEAAGHGADVVSMVSTELFDEQDAAYQADVLPDD
CCCCCCEEEEEEECCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEECCCCCCC
ALIVSIEAGTTFGWERYTGRDGLRFGIDSFGASAPIEDLFRHFGLTADAITPQILARLSH
EEEEEEECCCCCCCCCCCCCCCCEECHHHCCCCCCHHHHHHHHCCCHHHHCHHHHHHHCC
>Mature Secondary Structure 
TYPEGHSAERQLANAIRALAMDAVQAANSGHPGMPMGMADVATVLYSDYLKFDPTDPKW
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
ADRDRFVLSAGHGSMLAYATLHLAGYARPTIEDIRNFRQLHSPCAGHPENFELEGVETTT
CCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCC
GPLGQGLATAVGMAIAERHLNALYGDGLVDHRTWVIAGDGCLMEGINHEAIGLAGHLGLG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEECCCCCCCEEEEECCCCC
RLTVLWDDNKITIDGSTDLSTSEDVAARYAATGWHVESCDGHDPADIRRAIDAALADPRP
EEEEEECCCEEEECCCCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCC
SLIACRTIIGFGAPNKQGTSATHGAPLGADEIAAARRELGWTAEPFVIPADIAAAWASFG
CHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHH
EKGKKLHNEWNSRLATSEKKNDFEARLNGKVAPGAAFKAYLDGLAAEPPKVATRKASENT
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCHH
LSALTVDIAALVGGSADLTGSNNTKTSSTKPLTRNDYSGRYIYYGIREFGMAAAMNGMAL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCEEE
HGGVVPYGGTFLVFADYCRAAIRLSALQKQRVVYVMTHDSIGLGEDGPTHQPIEHLQSLR
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHH
AMPNLLVMRPADAVETAECWALALAQEGRPSLLALTRQNLPPLRHDVTENRCAKGGYRLR
CCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEHHCCCCCHHHHHHHHHHHCCCCEEE
GASAARKVVLVATGSEVSLAMDVADKLEAAGHGADVVSMVSTELFDEQDAAYQADVLPDD
CCCCCCEEEEEEECCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEECCCCCCC
ALIVSIEAGTTFGWERYTGRDGLRFGIDSFGASAPIEDLFRHFGLTADAITPQILARLSH
EEEEEEECCCCCCCCCCCCCCCCEECHHHCCCCCCHHHHHHHHCCCHHHHCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8635754; 9256491 [H]