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The map label for this gene is yxbG [H]

Identifier: 103486732

GI number: 103486732

Start: 1295876

End: 1296658

Strand: Reverse

Name: yxbG [H]

Synonym: Sala_1245

Alternate gene names: 103486732

Gene position: 1296658-1295876 (Counterclockwise)

Preceding gene: 103486733

Following gene: 103486731

Centisome position: 38.76

GC content: 64.24

Gene sequence:

>783_bases
ATGAAAATCGATTCCGCGACCGCCGCCGTCGTCACCGGTGGCGCCTCCGGCCTCGGCCGCGCGACCGCCGAAGCGCTTGC
GGCCGCCGGCGTGAAGGTTGCGATCTTCGATATCAACGACGCACTCGGCGAGGAGGTGGCGGCGTCGATCGGCGGGCTGT
TCGTCCATGTCGATATCACCGACGAACAATCGGTGCTCGACGGCTATGCCAAGGCGCGTGCGGCAAACGGGCAGGAACGT
ATCTGCGTTCACTGTGCGATGACCTCGCGCCGCGGCAAGACACTCGCCTATGACAAGGAAAGCGGCCGATACCGCCGCAC
GCCAACCGCCGATTATGCCTTCGGCGTCGAAGGCATCCTCACCGCCAGCTATCGCGTCGCGTCAATTGCGGCCGAAGGCA
TGGCCACCCTTCCCGAACTGGAAGACGGCGAACGCGGCGCGATCATCCTCACCGCTTCGGTCGCGGCGCAGGATGGCCAG
ATCGGCCAGGTCATCTATGGCTCGGCGAAGGCGGGTGTGAACGGGCTGGTGCTGCCGATGGCACGCGACCTGATGGACCT
CGGCATTCGCGTCAATGCGATCATGCCGGGGGTGTTCGGCACGCCCTTGCTCAACAATATGAACCCGAAGGTCAGGGAAA
GCCTCGAAGCCTCCGTCCCCTTCCCCAAGCGGCTCGGCAAGGCCGAAGAATATGCCAGTCTCGCCATGGAGATGATCCGC
AATACCTATTTCAACGGTCAGGCCGTCCGCCTCGACGGCGCGATCCGCATGGCTCCGCGTTAA

Upstream 100 bases:

>100_bases
CTCAACACGATTGCCGAAAAGATCCTCGGACTGCCGCAGGATCACCGCCCCGACAAGGGCATTCCGTTCAACCAGATCCC
CGCCTGAAGGAGCCCTCCCC

Downstream 100 bases:

>100_bases
CGCTCCCCGAAAGGAAATATACATATGGCCGAAGCCTATATCATCGACGCCGTCCGCACCCCGCGCGGGATTGGCAAGCC
CGGCAAGGGCGCGTTGTCGC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKIDSATAAVVTGGASGLGRATAEALAAAGVKVAIFDINDALGEEVAASIGGLFVHVDITDEQSVLDGYAKARAANGQER
ICVHCAMTSRRGKTLAYDKESGRYRRTPTADYAFGVEGILTASYRVASIAAEGMATLPELEDGERGAIILTASVAAQDGQ
IGQVIYGSAKAGVNGLVLPMARDLMDLGIRVNAIMPGVFGTPLLNNMNPKVRESLEASVPFPKRLGKAEEYASLAMEMIR
NTYFNGQAVRLDGAIRMAPR

Sequences:

>Translated_260_residues
MKIDSATAAVVTGGASGLGRATAEALAAAGVKVAIFDINDALGEEVAASIGGLFVHVDITDEQSVLDGYAKARAANGQER
ICVHCAMTSRRGKTLAYDKESGRYRRTPTADYAFGVEGILTASYRVASIAAEGMATLPELEDGERGAIILTASVAAQDGQ
IGQVIYGSAKAGVNGLVLPMARDLMDLGIRVNAIMPGVFGTPLLNNMNPKVRESLEASVPFPKRLGKAEEYASLAMEMIR
NTYFNGQAVRLDGAIRMAPR
>Mature_260_residues
MKIDSATAAVVTGGASGLGRATAEALAAAGVKVAIFDINDALGEEVAASIGGLFVHVDITDEQSVLDGYAKARAANGQER
ICVHCAMTSRRGKTLAYDKESGRYRRTPTADYAFGVEGILTASYRVASIAAEGMATLPELEDGERGAIILTASVAAQDGQ
IGQVIYGSAKAGVNGLVLPMARDLMDLGIRVNAIMPGVFGTPLLNNMNPKVRESLEASVPFPKRLGKAEEYASLAMEMIR
NTYFNGQAVRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=41.897233201581, Blast_Score=181, Evalue=4e-46,
Organism=Homo sapiens, GI83715985, Length=253, Percent_Identity=39.5256916996047, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=26.1363636363636, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=24.8995983935743, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=29.1828793774319, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=29.6875, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788459, Length=263, Percent_Identity=27.3764258555133, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=26.9230769230769, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=40.0793650793651, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=27.3076923076923, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=27.4509803921569, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=42.2924901185771, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24639444, Length=256, Percent_Identity=30.078125, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 27282; Mature: 27282

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDSATAAVVTGGASGLGRATAEALAAAGVKVAIFDINDALGEEVAASIGGLFVHVDIT
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEEEC
DEQSVLDGYAKARAANGQERICVHCAMTSRRGKTLAYDKESGRYRRTPTADYAFGVEGIL
CCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEEECCCCCEECCCCCCHHCCCCCEE
TASYRVASIAAEGMATLPELEDGERGAIILTASVAAQDGQIGQVIYGSAKAGVNGLVLPM
ECCHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEECCCCCCCCEEEHHH
ARDLMDLGIRVNAIMPGVFGTPLLNNMNPKVRESLEASVPFPKRLGKAEEYASLAMEMIR
HHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHH
NTYFNGQAVRLDGAIRMAPR
HHCCCCEEEEECCEEEECCC
>Mature Secondary Structure
MKIDSATAAVVTGGASGLGRATAEALAAAGVKVAIFDINDALGEEVAASIGGLFVHVDIT
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEEEC
DEQSVLDGYAKARAANGQERICVHCAMTSRRGKTLAYDKESGRYRRTPTADYAFGVEGIL
CCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEEECCCCCEECCCCCCHHCCCCCEE
TASYRVASIAAEGMATLPELEDGERGAIILTASVAAQDGQIGQVIYGSAKAGVNGLVLPM
ECCHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEECCCCCCCCEEEHHH
ARDLMDLGIRVNAIMPGVFGTPLLNNMNPKVRESLEASVPFPKRLGKAEEYASLAMEMIR
HHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHH
NTYFNGQAVRLDGAIRMAPR
HHCCCCEEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]