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The map label for this gene is hemA [H]

Identifier: 103486694

GI number: 103486694

Start: 1246738

End: 1247958

Strand: Reverse

Name: hemA [H]

Synonym: Sala_1206

Alternate gene names: 103486694

Gene position: 1247958-1246738 (Counterclockwise)

Preceding gene: 103486695

Following gene: 103486693

Centisome position: 37.31

GC content: 62.9

Gene sequence:

>1221_bases
GTGAATTACAACGATATTTTCGCTCGCGCGATCGACCGGCTGCATGAAGAGGGACGCTACCGCGTCTTTATCGATATCCT
GCGCAACAAGGGGGCTTATCCCAACGCGCGCTGCTTTGCGGGACACAACGGGCCAAAACCGATCACCGTGTGGTGCTCGA
ACGACTATCTTGCGATGGGCCAGCATCCGAAGGTCATCGAGGCGATGGAAGCGGCGCTGCACGACGTCGGCGCCGGGTCG
GGCGGAACGCGCAACATCGGCGGCAACACGCACTATCACATCGACCTCGAGGCCGAACTCGCCGACCTGCACGGCAAGGA
GGGCGCGCTGCTCTTCACATCGGGCTATATCTCGAACGAGGCGACGCTCGGCACGCTGGGCAAGCTGCTCCCGAACTGCA
TCATCTATTCGGACGAACTCAACCACGCTTCGATGATCGCGGGTATCCGCAATTCGGGCTGCGAAAAGCGCGTGTGGCGG
CACAACGACCTGGAGCATCTCGAGGAACTGCTCGCCGCCGACGATCCCGAGGCGGCAAAGCTGATCGCGTTCGAAAGCGT
CTACTCGATGGACGGCGATGTCGCCCCGATCCACGCGATCTGCGATCTTGCAGAGAAATATAACGCGCTTACCTATTGCG
ACGAAGTCCATGCCGTCGGCATGTACGGCCCGCGCGGCGGCGGCATCACCGACCGCGACGAGGCCGCGCACCGCGTGACG
ATCATCGAGGGGACGCTCGGCAAGGCGTTTGGCGTGATGGGCGGCTACATCGCCGCCGACAGGAATATCGTCGACGTGAT
CCGCTCCTATGCGCCGGGCTTCATCTTCACGACCAGCCTCTCGCCCGTGCTTGTCGCCGGGGTGCTCGCGAGTGTGCGTC
ACCTGAAGCAATCGAGCGTCGAGCGCGACGCGCAACAGGCAGCTGCCGCCTATCTCAAGCAATGTTTCCGCGACGCGGGC
CTGCCGGTGATGGATTCGACGACGCACATCGTCCCGCTGATGGTTGGCGACCCGGTGCGCGCAAAGAAGATCAGCGACAT
ATTGCTCGCCGAATATGGCGTCTATGTCCAGCCGATCAATTTCCCGACCGTGCCGCGCGGCACCGAACGCCTGCGCTTCA
CCCCCGGCCCCGCGCATGACGAAGCGATGATGCGCGAGTTGACCAGCGCGCTCGTCGAAATCTGGGACCGGCTGGAATTG
CAGCTCCAGAAGGCGGCGTGA

Upstream 100 bases:

>100_bases
CTGGCCTTCGGCGCTTTTCGGCGTTATTGGCCCGCATGTTAACAGCCGCCTGGGAAGCGGCGCCCAGAGCTTTACTGGCA
CCTGACTGCGGGGCTGAAAC

Downstream 100 bases:

>100_bases
CCGAAGCGCCCGGTTTCGATGAGGTTGTCGTCGGGCGTCGCTCGATCCGCGGCTTCCTCGACAAGCCCGTTTCCAAAGAG
CTGATCGCGGAAATCATCGC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNYNDIFARAIDRLHEEGRYRVFIDILRNKGAYPNARCFAGHNGPKPITVWCSNDYLAMGQHPKVIEAMEAALHDVGAGS
GGTRNIGGNTHYHIDLEAELADLHGKEGALLFTSGYISNEATLGTLGKLLPNCIIYSDELNHASMIAGIRNSGCEKRVWR
HNDLEHLEELLAADDPEAAKLIAFESVYSMDGDVAPIHAICDLAEKYNALTYCDEVHAVGMYGPRGGGITDRDEAAHRVT
IIEGTLGKAFGVMGGYIAADRNIVDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLKQSSVERDAQQAAAAYLKQCFRDAG
LPVMDSTTHIVPLMVGDPVRAKKISDILLAEYGVYVQPINFPTVPRGTERLRFTPGPAHDEAMMRELTSALVEIWDRLEL
QLQKAA

Sequences:

>Translated_406_residues
MNYNDIFARAIDRLHEEGRYRVFIDILRNKGAYPNARCFAGHNGPKPITVWCSNDYLAMGQHPKVIEAMEAALHDVGAGS
GGTRNIGGNTHYHIDLEAELADLHGKEGALLFTSGYISNEATLGTLGKLLPNCIIYSDELNHASMIAGIRNSGCEKRVWR
HNDLEHLEELLAADDPEAAKLIAFESVYSMDGDVAPIHAICDLAEKYNALTYCDEVHAVGMYGPRGGGITDRDEAAHRVT
IIEGTLGKAFGVMGGYIAADRNIVDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLKQSSVERDAQQAAAAYLKQCFRDAG
LPVMDSTTHIVPLMVGDPVRAKKISDILLAEYGVYVQPINFPTVPRGTERLRFTPGPAHDEAMMRELTSALVEIWDRLEL
QLQKAA
>Mature_406_residues
MNYNDIFARAIDRLHEEGRYRVFIDILRNKGAYPNARCFAGHNGPKPITVWCSNDYLAMGQHPKVIEAMEAALHDVGAGS
GGTRNIGGNTHYHIDLEAELADLHGKEGALLFTSGYISNEATLGTLGKLLPNCIIYSDELNHASMIAGIRNSGCEKRVWR
HNDLEHLEELLAADDPEAAKLIAFESVYSMDGDVAPIHAICDLAEKYNALTYCDEVHAVGMYGPRGGGITDRDEAAHRVT
IIEGTLGKAFGVMGGYIAADRNIVDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLKQSSVERDAQQAAAAYLKQCFRDAG
LPVMDSTTHIVPLMVGDPVRAKKISDILLAEYGVYVQPINFPTVPRGTERLRFTPGPAHDEAMMRELTSALVEIWDRLEL
QLQKAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=406, Percent_Identity=49.5073891625616, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI83977440, Length=406, Percent_Identity=49.5073891625616, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI83977444, Length=406, Percent_Identity=49.5073891625616, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI4502025, Length=406, Percent_Identity=49.0147783251232, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI40316939, Length=406, Percent_Identity=49.0147783251232, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI7657118, Length=377, Percent_Identity=34.2175066312997, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=35.632183908046, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI119220554, Length=371, Percent_Identity=29.9191374663073, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI4758668, Length=372, Percent_Identity=30.1075268817204, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI5454084, Length=251, Percent_Identity=25.4980079681275, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1790046, Length=351, Percent_Identity=35.6125356125356, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786993, Length=332, Percent_Identity=34.3373493975904, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=385, Percent_Identity=33.5064935064935, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=28.0555555555556, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17560914, Length=353, Percent_Identity=27.7620396600567, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=353, Percent_Identity=27.7620396600567, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71982617, Length=243, Percent_Identity=26.7489711934156, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=243, Percent_Identity=26.7489711934156, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=45.260663507109, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6320267, Length=422, Percent_Identity=28.436018957346, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=247, Percent_Identity=23.8866396761134, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137420, Length=403, Percent_Identity=47.6426799007444, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24662918, Length=356, Percent_Identity=36.2359550561798, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI17136286, Length=349, Percent_Identity=28.6532951289398, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24653280, Length=279, Percent_Identity=25.8064516129032, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24653276, Length=279, Percent_Identity=25.8064516129032, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24653278, Length=279, Percent_Identity=25.8064516129032, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44372; Mature: 44372

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYNDIFARAIDRLHEEGRYRVFIDILRNKGAYPNARCFAGHNGPKPITVWCSNDYLAMG
CCHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCEEECCCCCCCCEEEEECCCEEECC
QHPKVIEAMEAALHDVGAGSGGTRNIGGNTHYHIDLEAELADLHGKEGALLFTSGYISNE
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEHHHHCCCCCCEEEEEECCCCCC
ATLGTLGKLLPNCIIYSDELNHASMIAGIRNSGCEKRVWRHNDLEHLEELLAADDPEAAK
CHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCCCCHHH
LIAFESVYSMDGDVAPIHAICDLAEKYNALTYCDEVHAVGMYGPRGGGITDRDEAAHRVT
HEEHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEE
IIEGTLGKAFGVMGGYIAADRNIVDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLKQSSV
EEECCHHHHHHHHCCHHHCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
ERDAQQAAAAYLKQCFRDAGLPVMDSTTHIVPLMVGDPVRAKKISDILLAEYGVYVQPIN
HHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECC
FPTVPRGTERLRFTPGPAHDEAMMRELTSALVEIWDRLELQLQKAA
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYNDIFARAIDRLHEEGRYRVFIDILRNKGAYPNARCFAGHNGPKPITVWCSNDYLAMG
CCHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCEEECCCCCCCCEEEEECCCEEECC
QHPKVIEAMEAALHDVGAGSGGTRNIGGNTHYHIDLEAELADLHGKEGALLFTSGYISNE
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEHHHHCCCCCCEEEEEECCCCCC
ATLGTLGKLLPNCIIYSDELNHASMIAGIRNSGCEKRVWRHNDLEHLEELLAADDPEAAK
CHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCCCCHHH
LIAFESVYSMDGDVAPIHAICDLAEKYNALTYCDEVHAVGMYGPRGGGITDRDEAAHRVT
HEEHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEE
IIEGTLGKAFGVMGGYIAADRNIVDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLKQSSV
EEECCHHHHHHHHCCHHHCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
ERDAQQAAAAYLKQCFRDAGLPVMDSTTHIVPLMVGDPVRAKKISDILLAEYGVYVQPIN
HHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECC
FPTVPRGTERLRFTPGPAHDEAMMRELTSALVEIWDRLELQLQKAA
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]