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The map label for this gene is uvrC

Identifier: 103486571

GI number: 103486571

Start: 1110898

End: 1112832

Strand: Direct

Name: uvrC

Synonym: Sala_1082

Alternate gene names: 103486571

Gene position: 1110898-1112832 (Clockwise)

Preceding gene: 103486568

Following gene: 103486572

Centisome position: 33.21

GC content: 66.36

Gene sequence:

>1935_bases
ATGGTTCGCCCCAACGCTCCCGACCGGTTCAACGAGGAAAAGGCCACCTATGTCGTGCGCGGCGATGGCGAGGGGGGCGA
CAAACCCGATCTCGACCGCGGTGCCGAGGTGATTCGCAGCGTCGTGCGCAAATTGCCTGCGCGTCCGGGCGTTTACCGGA
TGCTCGATGCGCGCGGCGACGTGCTCTATGTGGGGAAGGCGCGCGCGCTCAGGAATCGCGTCACCAGTTATACCCAGGTC
GCGCGCCTGCCGCAGCGATTGCAGCGGATGGTCGCACAGACGCGCGCGATGGAGATCGTCACGACGACGAGCGAAGCCGA
AGCGCTGCTGCTCGAAGCGCAACTCATCAAACGGTATCGTCCGCCCTACAATGTGTTGCTGCGCGACGACAAAAGCTTTC
CCTTCATCCTGCTGCGCACCGACCATGATTTCCCGCGGGTGCAGAAACACCGCGGCGCGCGGCGCGCCAAGGGGCGCTAT
TATGGGCCGTTTGCGAGCGCGGGGTCGGTCGCGCGCACGCTCAACGCGCTGCAAAAGACCTTCCTGCTGCGCAGCTGCAC
CGACAGCTTTTTCGCCAACCGCTCGCGCCCGTGTCTGCTTTACCAGATCCGCCGCTGCTCGGCGCCGTGCGTCGATCGCA
TCTCGAAGGAGGATTATGCCGGGCTGGTCAGCGACGCGCAGGACTTTCTGGAGGGCCGCTCGACCGCGGTGCAGAAACGC
CTCGGCGAAGCGATGACCAGGGCGGCCGACGCGATGGATTTCGAGCAGGCGGCGGTGCTGCGCGACCGGCTGAAGGCGCT
GACCTTCATCCAGGGCAGCCAGTCGGTCCACGCCGACGGGCTGGGCGATGCCGATGTTTTTGCGCTCGCGGCGAAGGGCG
GGCAGCTGTGTATCGCCGGTTTCTTCATTCGCGGCGGGCAGAATTGGGGGCATCGCAGCTTCTTTCCGGCGCATGTCGCC
GGCGTACCCGAGACGGAGGTCATGGCGAGCTTCCTGATGCAGTTTTACGAGGGCGTGCCGCCGCCGAAGCTGATCCTCGT
CGACCGCGAGCCCGACGAGAGCGCGTTGCTGGCCGAGGCGCTGGGCGAGACGGCGGGGCGCAAGGTCGAGATCAGCGTGC
CGCAGCGCGGCAACCGCAAGCGCCTGCTCGATCAGGCGGTGCGCAACGCGGGCGAGGAGCTCGACCGGCGGCTCGCCGAG
AGCAGCAGCCAGGCGAAGCTGGGGCGCGAGCTGGCGGACCTGTTCGATCTGGAAAACCCGCCGCAGCGGATCGAGATTTA
CGACAACAGCCATATCCAGGGCACCAGCGCCCTGGGCGCAATGGTCGTCGCAGGGCCGGAGGGGTGGATGAAGGGCGCCT
ATCGCAAGTTCAACATCAAGCGCGCCGAGACGCAGCCCGGCGACGATTTCGCGATGATGCGCGAGGTATTCCAGCGTCGC
TTCGCGCGCGCGATCGAGGAAGATCCCGAACGGACGAAGGGCGAATGGCCCGATCTGGTGCTGATCGACGGCGGCAAGGG
GCAGGTGTCGGCGGTTGCGGCGGTTTTTTCCGAGCTGGGTATCGACGACCTCCCGTTCGTCGGCGTTGCGAAAGGCCCCG
ATCGCAATGCGGGACGCGAGACCTTTTACCTGCCCGACGGGCGCGAGTTCACGCTGCCGACCAACAATGCCGTGCTCTTC
TATATCCAGCGGTTGCGCGACGAGGCGCACCGTTTTGCGATCGGCGCGCACCGCGCGAAACGCGCGAAGGCGATGGGAAG
CTCGCCGCTCGACGAAGTGCCCGGCATCGGCCCGGCGCGCAAAAAGGCGCTGTTGATGCATTTCGGCACCACGCGCGCGA
TCAAGGGCGCGAGTCTGGAGGATTTGCAGAAGGCGCCGGGGGTGAGCGCGGCGGTGGCGCAGGCGGTGTATGATTTCTAC
AATCCGGGAGGGTGA

Upstream 100 bases:

>100_bases
GACGAGCGCGAGTATTCCGCGTAAGTTCATGCAACCCCTCCCATGGGCTTTTGCCGCGCACACTATGGCGGCTCGCCTCG
CCTTCGCCTACATGCAATTC

Downstream 100 bases:

>100_bases
GCATTTTTTCATCGTCATCCCGGCGAAGGCCGGGATCTCACCCTGTCGCCCGGACGCAACGGCGAGACCCTGGCCTTCGC
CAGGGTGACGGAATAGGAGA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MVRPNAPDRFNEEKATYVVRGDGEGGDKPDLDRGAEVIRSVVRKLPARPGVYRMLDARGDVLYVGKARALRNRVTSYTQV
ARLPQRLQRMVAQTRAMEIVTTTSEAEALLLEAQLIKRYRPPYNVLLRDDKSFPFILLRTDHDFPRVQKHRGARRAKGRY
YGPFASAGSVARTLNALQKTFLLRSCTDSFFANRSRPCLLYQIRRCSAPCVDRISKEDYAGLVSDAQDFLEGRSTAVQKR
LGEAMTRAADAMDFEQAAVLRDRLKALTFIQGSQSVHADGLGDADVFALAAKGGQLCIAGFFIRGGQNWGHRSFFPAHVA
GVPETEVMASFLMQFYEGVPPPKLILVDREPDESALLAEALGETAGRKVEISVPQRGNRKRLLDQAVRNAGEELDRRLAE
SSSQAKLGRELADLFDLENPPQRIEIYDNSHIQGTSALGAMVVAGPEGWMKGAYRKFNIKRAETQPGDDFAMMREVFQRR
FARAIEEDPERTKGEWPDLVLIDGGKGQVSAVAAVFSELGIDDLPFVGVAKGPDRNAGRETFYLPDGREFTLPTNNAVLF
YIQRLRDEAHRFAIGAHRAKRAKAMGSSPLDEVPGIGPARKKALLMHFGTTRAIKGASLEDLQKAPGVSAAVAQAVYDFY
NPGG

Sequences:

>Translated_644_residues
MVRPNAPDRFNEEKATYVVRGDGEGGDKPDLDRGAEVIRSVVRKLPARPGVYRMLDARGDVLYVGKARALRNRVTSYTQV
ARLPQRLQRMVAQTRAMEIVTTTSEAEALLLEAQLIKRYRPPYNVLLRDDKSFPFILLRTDHDFPRVQKHRGARRAKGRY
YGPFASAGSVARTLNALQKTFLLRSCTDSFFANRSRPCLLYQIRRCSAPCVDRISKEDYAGLVSDAQDFLEGRSTAVQKR
LGEAMTRAADAMDFEQAAVLRDRLKALTFIQGSQSVHADGLGDADVFALAAKGGQLCIAGFFIRGGQNWGHRSFFPAHVA
GVPETEVMASFLMQFYEGVPPPKLILVDREPDESALLAEALGETAGRKVEISVPQRGNRKRLLDQAVRNAGEELDRRLAE
SSSQAKLGRELADLFDLENPPQRIEIYDNSHIQGTSALGAMVVAGPEGWMKGAYRKFNIKRAETQPGDDFAMMREVFQRR
FARAIEEDPERTKGEWPDLVLIDGGKGQVSAVAAVFSELGIDDLPFVGVAKGPDRNAGRETFYLPDGREFTLPTNNAVLF
YIQRLRDEAHRFAIGAHRAKRAKAMGSSPLDEVPGIGPARKKALLMHFGTTRAIKGASLEDLQKAPGVSAAVAQAVYDFY
NPGG
>Mature_644_residues
MVRPNAPDRFNEEKATYVVRGDGEGGDKPDLDRGAEVIRSVVRKLPARPGVYRMLDARGDVLYVGKARALRNRVTSYTQV
ARLPQRLQRMVAQTRAMEIVTTTSEAEALLLEAQLIKRYRPPYNVLLRDDKSFPFILLRTDHDFPRVQKHRGARRAKGRY
YGPFASAGSVARTLNALQKTFLLRSCTDSFFANRSRPCLLYQIRRCSAPCVDRISKEDYAGLVSDAQDFLEGRSTAVQKR
LGEAMTRAADAMDFEQAAVLRDRLKALTFIQGSQSVHADGLGDADVFALAAKGGQLCIAGFFIRGGQNWGHRSFFPAHVA
GVPETEVMASFLMQFYEGVPPPKLILVDREPDESALLAEALGETAGRKVEISVPQRGNRKRLLDQAVRNAGEELDRRLAE
SSSQAKLGRELADLFDLENPPQRIEIYDNSHIQGTSALGAMVVAGPEGWMKGAYRKFNIKRAETQPGDDFAMMREVFQRR
FARAIEEDPERTKGEWPDLVLIDGGKGQVSAVAAVFSELGIDDLPFVGVAKGPDRNAGRETFYLPDGREFTLPTNNAVLF
YIQRLRDEAHRFAIGAHRAKRAKAMGSSPLDEVPGIGPARKKALLMHFGTTRAIKGASLEDLQKAPGVSAAVAQAVYDFY
NPGG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=40.5582922824302, Blast_Score=450, Evalue=1e-127,
Organism=Escherichia coli, GI1788037, Length=188, Percent_Identity=30.3191489361702, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_SPHAL (Q1GU73)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616132.1
- ProteinModelPortal:   Q1GU73
- GeneID:   4081557
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1082
- NMPDR:   fig|317655.9.peg.1020
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   SALA317655:SALA_1082-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 71215; Mature: 71215

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRPNAPDRFNEEKATYVVRGDGEGGDKPDLDRGAEVIRSVVRKLPARPGVYRMLDARGD
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
VLYVGKARALRNRVTSYTQVARLPQRLQRMVAQTRAMEIVTTTSEAEALLLEAQLIKRYR
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCC
PPYNVLLRDDKSFPFILLRTDHDFPRVQKHRGARRAKGRYYGPFASAGSVARTLNALQKT
CCCEEEEECCCCCCEEEEECCCCCHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHH
FLLRSCTDSFFANRSRPCLLYQIRRCSAPCVDRISKEDYAGLVSDAQDFLEGRSTAVQKR
HHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
LGEAMTRAADAMDFEQAAVLRDRLKALTFIQGSQSVHADGLGDADVFALAAKGGQLCIAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEECCCCCEEEEE
FFIRGGQNWGHRSFFPAHVAGVPETEVMASFLMQFYEGVPPPKLILVDREPDESALLAEA
EEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
LGETAGRKVEISVPQRGNRKRLLDQAVRNAGEELDRRLAESSSQAKLGRELADLFDLENP
HHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
PQRIEIYDNSHIQGTSALGAMVVAGPEGWMKGAYRKFNIKRAETQPGDDFAMMREVFQRR
CCEEEEECCCCCCCCHHHCEEEEECCHHHHHCCHHEECEEECCCCCCCHHHHHHHHHHHH
FARAIEEDPERTKGEWPDLVLIDGGKGQVSAVAAVFSELGIDDLPFVGVAKGPDRNAGRE
HHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCE
TFYLPDGREFTLPTNNAVLFYIQRLRDEAHRFAIGAHRAKRAKAMGSSPLDEVPGIGPAR
EEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHH
KKALLMHFGTTRAIKGASLEDLQKAPGVSAAVAQAVYDFYNPGG
HHEEEEECCCHHHCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVRPNAPDRFNEEKATYVVRGDGEGGDKPDLDRGAEVIRSVVRKLPARPGVYRMLDARGD
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
VLYVGKARALRNRVTSYTQVARLPQRLQRMVAQTRAMEIVTTTSEAEALLLEAQLIKRYR
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCC
PPYNVLLRDDKSFPFILLRTDHDFPRVQKHRGARRAKGRYYGPFASAGSVARTLNALQKT
CCCEEEEECCCCCCEEEEECCCCCHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHH
FLLRSCTDSFFANRSRPCLLYQIRRCSAPCVDRISKEDYAGLVSDAQDFLEGRSTAVQKR
HHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
LGEAMTRAADAMDFEQAAVLRDRLKALTFIQGSQSVHADGLGDADVFALAAKGGQLCIAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEECCCCCEEEEE
FFIRGGQNWGHRSFFPAHVAGVPETEVMASFLMQFYEGVPPPKLILVDREPDESALLAEA
EEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
LGETAGRKVEISVPQRGNRKRLLDQAVRNAGEELDRRLAESSSQAKLGRELADLFDLENP
HHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
PQRIEIYDNSHIQGTSALGAMVVAGPEGWMKGAYRKFNIKRAETQPGDDFAMMREVFQRR
CCEEEEECCCCCCCCHHHCEEEEECCHHHHHCCHHEECEEECCCCCCCHHHHHHHHHHHH
FARAIEEDPERTKGEWPDLVLIDGGKGQVSAVAAVFSELGIDDLPFVGVAKGPDRNAGRE
HHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCE
TFYLPDGREFTLPTNNAVLFYIQRLRDEAHRFAIGAHRAKRAKAMGSSPLDEVPGIGPAR
EEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHH
KKALLMHFGTTRAIKGASLEDLQKAPGVSAAVAQAVYDFYNPGG
HHEEEEECCCHHHCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA