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The map label for this gene is guaB [H]

Identifier: 103486516

GI number: 103486516

Start: 1060403

End: 1061860

Strand: Direct

Name: guaB [H]

Synonym: Sala_1027

Alternate gene names: 103486516

Gene position: 1060403-1061860 (Clockwise)

Preceding gene: 103486505

Following gene: 103486517

Centisome position: 31.7

GC content: 66.46

Gene sequence:

>1458_bases
ATGGAAATCATCACCGGCCTGACCTTCGACGATGTGCTGCTGGTGCCGGGCGCGTCGGACATCTTGCCGTCGGACGCCAA
TCTGGCGACGCAGTTGACCAGCGAGATCAGCCTCAACATTCCGATCCTGTCGTCGGCGATGGATACGGTGACGGAAGCCG
ACATGGCGATATTGATGGCGCAGATCGGCGGCATCGGCGTCCTCCATCGCAACCTGACCATCGAGGAGCAGGCCGCCGCC
GTCCGGCAGGTCAAGCGGTTCGAGAGCGGGATGATCGTCAACCCGATCACCATTACCCCCGACGCGCCGCTTTCCGATGC
CACCGCGCTGATGAACCAGCACCGGATTTCGGGTATTCCCGTCGTCGAAAGCGGCGGCAAGCTCGTCGGCATCCTGACGC
ACCGCGACGTGCGTTTCGCCGACAATCCGGGCCAGCCGGTGCGCGAGTTGATGACCGCCGAAAATCTGGCGACCGTCCGC
CCAGGCGTCGGGCAGGACGAGGCGCGCAGGCTGCTCCACCAGCGGCGCATCGAAAAGCTGCTGGTCGTTGACGACGACTA
TCACTGCATCGGCCTGATCACCGTCAAGGATATGGAAAAGGCGGTCAATTTCCCCGATGCGACGAAGGATGCCAGCGGCC
GCCTGCGTGTCGCGGCGGCGACGAACACCGGCGACAGCGGGGTCGAGCGCGCCGAGGCGCTGCTGGACGCCGAATGCGAC
CTGATCGTCGTCGACACGGCGCACGGCCACAGCAAGGGCGTCGGGCAGACCGTCGAGCGCATCAAGAAATTGTCGAACCG
GGTGCAGGTTCTCGCGGGCAATGTCGCGACGGGCGACGCGACCAGGGCGCTGATCGATGCGGGCGCGGACGGGGTCAAGG
TCGGCATCGGCCCCGGCTCGATCTGCACGACGCGCGTCGTCGCGGGGGTCGGCGTGCCACAGCTGACCGCGATCCTCGAC
AGCGTCGAGGCGGCGGCGAAGCTCGGCGTGCCGGTGATTGCCGATGGTGGCTTGCGCACCTCGGGCGACATCGCCAAGGC
GCTGGCTGCGGGCGCGTCGAGCGTCATGGTCGGCTCGCTGCTCGCGGGGACGGCCGAGGCGCCGGGCGAAACCTTCCTCT
TTCAGGGGCGCACCTATAAAAGCTATCGCGGTATGGGCAGCGTCGGCGCGATGGCGCGCGGCAGCGCCGACCGCTATTTC
CAGCAGGATATCAAGGACCAGATGAAGCTGGTGCCCGAAGGGATCGAAGGCCAGGTGCCGTTCAAGGGGCCTGCGAAGGA
CGTGATTCACCAGCTTGTCGGCGGCGTGAAGGCGGCGATGGGTTATACGGGAAGCCGGACGCTCAAGGATCTGCGCGAGC
GCGCGAAGTTCGTGCGCATCACCAACGCGGGGCTGCGCGAAAGCCATGTCCACGATGTCGCGATCACGCGCGAGGCGCCG
AATTACCCGGCGGGCTGA

Upstream 100 bases:

>100_bases
CGGGCGCGACTGGTTACATGGGCCGCCACCAAATGATTCGCGCGTGCCGCACTCGACCACAGGGGTTTGCGCACCGCCTT
GCAGCAGAAAGTGGCGACCC

Downstream 100 bases:

>100_bases
GGATAATAGAATGCGCGGCGACGTTGCTTCGGCGAGCCCTTCCCCTTCAGCGGAGGGGTTGGGGTGGGGCTCATCGGCCT
TGCGCAAGGCCGATGAGCTC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MEIITGLTFDDVLLVPGASDILPSDANLATQLTSEISLNIPILSSAMDTVTEADMAILMAQIGGIGVLHRNLTIEEQAAA
VRQVKRFESGMIVNPITITPDAPLSDATALMNQHRISGIPVVESGGKLVGILTHRDVRFADNPGQPVRELMTAENLATVR
PGVGQDEARRLLHQRRIEKLLVVDDDYHCIGLITVKDMEKAVNFPDATKDASGRLRVAAATNTGDSGVERAEALLDAECD
LIVVDTAHGHSKGVGQTVERIKKLSNRVQVLAGNVATGDATRALIDAGADGVKVGIGPGSICTTRVVAGVGVPQLTAILD
SVEAAAKLGVPVIADGGLRTSGDIAKALAAGASSVMVGSLLAGTAEAPGETFLFQGRTYKSYRGMGSVGAMARGSADRYF
QQDIKDQMKLVPEGIEGQVPFKGPAKDVIHQLVGGVKAAMGYTGSRTLKDLRERAKFVRITNAGLRESHVHDVAITREAP
NYPAG

Sequences:

>Translated_485_residues
MEIITGLTFDDVLLVPGASDILPSDANLATQLTSEISLNIPILSSAMDTVTEADMAILMAQIGGIGVLHRNLTIEEQAAA
VRQVKRFESGMIVNPITITPDAPLSDATALMNQHRISGIPVVESGGKLVGILTHRDVRFADNPGQPVRELMTAENLATVR
PGVGQDEARRLLHQRRIEKLLVVDDDYHCIGLITVKDMEKAVNFPDATKDASGRLRVAAATNTGDSGVERAEALLDAECD
LIVVDTAHGHSKGVGQTVERIKKLSNRVQVLAGNVATGDATRALIDAGADGVKVGIGPGSICTTRVVAGVGVPQLTAILD
SVEAAAKLGVPVIADGGLRTSGDIAKALAAGASSVMVGSLLAGTAEAPGETFLFQGRTYKSYRGMGSVGAMARGSADRYF
QQDIKDQMKLVPEGIEGQVPFKGPAKDVIHQLVGGVKAAMGYTGSRTLKDLRERAKFVRITNAGLRESHVHDVAITREAP
NYPAG
>Mature_485_residues
MEIITGLTFDDVLLVPGASDILPSDANLATQLTSEISLNIPILSSAMDTVTEADMAILMAQIGGIGVLHRNLTIEEQAAA
VRQVKRFESGMIVNPITITPDAPLSDATALMNQHRISGIPVVESGGKLVGILTHRDVRFADNPGQPVRELMTAENLATVR
PGVGQDEARRLLHQRRIEKLLVVDDDYHCIGLITVKDMEKAVNFPDATKDASGRLRVAAATNTGDSGVERAEALLDAECD
LIVVDTAHGHSKGVGQTVERIKKLSNRVQVLAGNVATGDATRALIDAGADGVKVGIGPGSICTTRVVAGVGVPQLTAILD
SVEAAAKLGVPVIADGGLRTSGDIAKALAAGASSVMVGSLLAGTAEAPGETFLFQGRTYKSYRGMGSVGAMARGSADRYF
QQDIKDQMKLVPEGIEGQVPFKGPAKDVIHQLVGGVKAAMGYTGSRTLKDLRERAKFVRITNAGLRESHVHDVAITREAP
NYPAG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=40.9185803757829, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=40.9185803757829, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=40.9185803757829, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=40.9185803757829, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=40.7172995780591, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=39.2931392931393, Blast_Score=320, Evalue=3e-87,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=40.0835073068894, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=37.9958246346555, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI50541954, Length=251, Percent_Identity=39.4422310756972, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50541952, Length=251, Percent_Identity=39.4422310756972, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50541948, Length=251, Percent_Identity=39.4422310756972, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50541956, Length=251, Percent_Identity=39.4422310756972, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI156104880, Length=266, Percent_Identity=35.7142857142857, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1788855, Length=480, Percent_Identity=56.6666666666667, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1786293, Length=249, Percent_Identity=37.3493975903614, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=498, Percent_Identity=36.3453815261044, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=37.6190476190476, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=249, Percent_Identity=37.7510040160643, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=39.9585921325052, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=39.1304347826087, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=39.9585921325052, Blast_Score=325, Evalue=9e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=38.4615384615385, Blast_Score=241, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=40.3361344537815, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=38.3333333333333, Blast_Score=317, Evalue=9e-87,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=38.3333333333333, Blast_Score=317, Evalue=9e-87,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=38.496583143508, Blast_Score=283, Evalue=2e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 50936; Mature: 50936

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIITGLTFDDVLLVPGASDILPSDANLATQLTSEISLNIPILSSAMDTVTEADMAILMA
CCEECCCCCCCEEECCCCHHCCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHH
QIGGIGVLHRNLTIEEQAAAVRQVKRFESGMIVNPITITPDAPLSDATALMNQHRISGIP
HHCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEEECCCCCCHHHHHHHHHHCCCCCC
VVESGGKLVGILTHRDVRFADNPGQPVRELMTAENLATVRPGVGQDEARRLLHQRRIEKL
EEECCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEE
LVVDDDYHCIGLITVKDMEKAVNFPDATKDASGRLRVAAATNTGDSGVERAEALLDAECD
EEECCCCEEEEEEEEHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
LIVVDTAHGHSKGVGQTVERIKKLSNRVQVLAGNVATGDATRALIDAGADGVKVGIGPGS
EEEEECCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHCCCCCEEEECCCCC
ICTTRVVAGVGVPQLTAILDSVEAAAKLGVPVIADGGLRTSGDIAKALAAGASSVMVGSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCHHHHHHHH
LAGTAEAPGETFLFQGRTYKSYRGMGSVGAMARGSADRYFQQDIKDQMKLVPEGIEGQVP
HHCCCCCCCCEEEEECCCCHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
FKGPAKDVIHQLVGGVKAAMGYTGSRTLKDLRERAKFVRITNAGLRESHVHDVAITREAP
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCC
NYPAG
CCCCC
>Mature Secondary Structure
MEIITGLTFDDVLLVPGASDILPSDANLATQLTSEISLNIPILSSAMDTVTEADMAILMA
CCEECCCCCCCEEECCCCHHCCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHH
QIGGIGVLHRNLTIEEQAAAVRQVKRFESGMIVNPITITPDAPLSDATALMNQHRISGIP
HHCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEEECCCCCCHHHHHHHHHHCCCCCC
VVESGGKLVGILTHRDVRFADNPGQPVRELMTAENLATVRPGVGQDEARRLLHQRRIEKL
EEECCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEE
LVVDDDYHCIGLITVKDMEKAVNFPDATKDASGRLRVAAATNTGDSGVERAEALLDAECD
EEECCCCEEEEEEEEHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
LIVVDTAHGHSKGVGQTVERIKKLSNRVQVLAGNVATGDATRALIDAGADGVKVGIGPGS
EEEEECCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHCCCCCEEEECCCCC
ICTTRVVAGVGVPQLTAILDSVEAAAKLGVPVIADGGLRTSGDIAKALAAGASSVMVGSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCHHHHHHHH
LAGTAEAPGETFLFQGRTYKSYRGMGSVGAMARGSADRYFQQDIKDQMKLVPEGIEGQVP
HHCCCCCCCCEEEEECCCCHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
FKGPAKDVIHQLVGGVKAAMGYTGSRTLKDLRERAKFVRITNAGLRESHVHDVAITREAP
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCC
NYPAG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA