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The map label for this gene is cytR [H]

Identifier: 103486513

GI number: 103486513

Start: 1057627

End: 1058655

Strand: Reverse

Name: cytR [H]

Synonym: Sala_1024

Alternate gene names: 103486513

Gene position: 1058655-1057627 (Counterclockwise)

Preceding gene: 103486514

Following gene: 103486512

Centisome position: 31.65

GC content: 67.83

Gene sequence:

>1029_bases
ATGGCAACATTGAGGGACGTCGCCCGCGAAGCAGGAGTTTCGGTCGCGACCGCATCGCGCGCGATCAACGGTCTGGGCAA
TGTCACCGCGCCGACGCGCGCGGCGGTGATGGCGGCGGTAAAGAAGCTCAATTTCGTGCCGCACAGCGGCGCGCGCAGCC
TGACGCGGCGCAGGACCGACACTGTCGGGGTCATCCTGCCCGACCTGTTCGGCGAGTTCTTCTCCGAGATCATTCGCGGT
ATCGACCTCGTTGCGCATGAATCGGGGATGCACCTGCTGCTCGGCAACATGCACGGCAGCACGCACGAAACCGCCGCTGC
GATCGCGGCGATGCGCGGCCGCGTCGATGGCCTGCTCGTGATGCCGCCGGACCTCAAGCCCGAACTGCTCGCCGACTATC
TCGACCCCGCGCTGCCGACGGTGCTGCTCAATTACGACGCCGGGCCGCTCGATCTTCCCTTCGTCGCGGTCGACAATTAT
CAGGGCGCCTATCGGATGACCGAAGCGCTGCTGGCGCGCGGCGCGAAACAGGTGGTCCACATCGCCGGCCCCAAGCATAA
TCGCGACGCGCGCGACCGCCAGCGCGGCTTCACCGATGCGATGGCGAAAATCGGCGGCGTCCGCACGCCGGCAATCCTGC
CGGGCGACTTTTCCGAGGAAAGCGGCGCGCAGGCGGCGCGGCTGCTGGTGCAGGGCCAATTGCCCGCCGACGCGGTGTTC
GCGGCCAACGACCAGATGGCGGTCGGGCTGATCGCGGGGCTGGCCGAAGCGGGCAAGTCGGTGCCGAGCGACATCATGGT
CGCGGGCTTCGACGATATTCCGCTCGCGCGTCACCTCAACCCGTCGCTTTCGACGATGCAGGTGCATATCGACCGGTTGG
GATCGACCGCGATGATGCTGCTGCTGCGCATGTTGCGCGGCGAAACGCTTGGCGCGGCGAACGCGACGATCCTGACCCCC
GAGTTGGTCATCCGCGGGACGACGGGCGGTGAAACCGCGCCCGTACCCAGCAGCGGGGCGCGCCCGTGA

Upstream 100 bases:

>100_bases
TAACCGGTTACTCTACGCCGCTTTCCATTGCCCGCCTGAAACGGGGCAGGCGAGTCGCGCAGGCGGTGCGAAACGACGCA
AGCAAAAGGGGGCCCGCGGC

Downstream 100 bases:

>100_bases
TTCCCGAAGGCGCCCAATGCGATTGACCCGGCGCCAATTGACAGGCGCACTCGCGGCGCTGCCCCTGCTCCCCATGCTCG
GCGGCTGCGAGGAGCGGCAC

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MATLRDVAREAGVSVATASRAINGLGNVTAPTRAAVMAAVKKLNFVPHSGARSLTRRRTDTVGVILPDLFGEFFSEIIRG
IDLVAHESGMHLLLGNMHGSTHETAAAIAAMRGRVDGLLVMPPDLKPELLADYLDPALPTVLLNYDAGPLDLPFVAVDNY
QGAYRMTEALLARGAKQVVHIAGPKHNRDARDRQRGFTDAMAKIGGVRTPAILPGDFSEESGAQAARLLVQGQLPADAVF
AANDQMAVGLIAGLAEAGKSVPSDIMVAGFDDIPLARHLNPSLSTMQVHIDRLGSTAMMLLLRMLRGETLGAANATILTP
ELVIRGTTGGETAPVPSSGARP

Sequences:

>Translated_342_residues
MATLRDVAREAGVSVATASRAINGLGNVTAPTRAAVMAAVKKLNFVPHSGARSLTRRRTDTVGVILPDLFGEFFSEIIRG
IDLVAHESGMHLLLGNMHGSTHETAAAIAAMRGRVDGLLVMPPDLKPELLADYLDPALPTVLLNYDAGPLDLPFVAVDNY
QGAYRMTEALLARGAKQVVHIAGPKHNRDARDRQRGFTDAMAKIGGVRTPAILPGDFSEESGAQAARLLVQGQLPADAVF
AANDQMAVGLIAGLAEAGKSVPSDIMVAGFDDIPLARHLNPSLSTMQVHIDRLGSTAMMLLLRMLRGETLGAANATILTP
ELVIRGTTGGETAPVPSSGARP
>Mature_341_residues
ATLRDVAREAGVSVATASRAINGLGNVTAPTRAAVMAAVKKLNFVPHSGARSLTRRRTDTVGVILPDLFGEFFSEIIRGI
DLVAHESGMHLLLGNMHGSTHETAAAIAAMRGRVDGLLVMPPDLKPELLADYLDPALPTVLLNYDAGPLDLPFVAVDNYQ
GAYRMTEALLARGAKQVVHIAGPKHNRDARDRQRGFTDAMAKIGGVRTPAILPGDFSEESGAQAARLLVQGQLPADAVFA
ANDQMAVGLIAGLAEAGKSVPSDIMVAGFDDIPLARHLNPSLSTMQVHIDRLGSTAMMLLLRMLRGETLGAANATILTPE
LVIRGTTGGETAPVPSSGARP

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=329, Percent_Identity=33.434650455927, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1790194, Length=333, Percent_Identity=35.4354354354354, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1787948, Length=310, Percent_Identity=34.8387096774194, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788474, Length=305, Percent_Identity=33.7704918032787, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789202, Length=292, Percent_Identity=32.8767123287671, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789068, Length=312, Percent_Identity=29.8076923076923, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI48994940, Length=309, Percent_Identity=27.831715210356, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1786540, Length=331, Percent_Identity=30.8157099697885, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787580, Length=315, Percent_Identity=26.984126984127, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790715, Length=310, Percent_Identity=25.8064516129032, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789456, Length=349, Percent_Identity=25.7879656160458, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787906, Length=305, Percent_Identity=26.2295081967213, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786268, Length=294, Percent_Identity=24.4897959183673, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 35924; Mature: 35793

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLRDVAREAGVSVATASRAINGLGNVTAPTRAAVMAAVKKLNFVPHSGARSLTRRRTD
CCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
TVGVILPDLFGEFFSEIIRGIDLVAHESGMHLLLGNMHGSTHETAAAIAAMRGRVDGLLV
HHEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEE
MPPDLKPELLADYLDPALPTVLLNYDAGPLDLPFVAVDNYQGAYRMTEALLARGAKQVVH
ECCCCCHHHHHHHHCHHHCEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCCHHEEE
IAGPKHNRDARDRQRGFTDAMAKIGGVRTPAILPGDFSEESGAQAARLLVQGQLPADAVF
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCEEE
AANDQMAVGLIAGLAEAGKSVPSDIMVAGFDDIPLARHLNPSLSTMQVHIDRLGSTAMML
ECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHCCCCHHHHHHHHHHHCHHHHHH
LLRMLRGETLGAANATILTPELVIRGTTGGETAPVPSSGARP
HHHHHCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATLRDVAREAGVSVATASRAINGLGNVTAPTRAAVMAAVKKLNFVPHSGARSLTRRRTD
CHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
TVGVILPDLFGEFFSEIIRGIDLVAHESGMHLLLGNMHGSTHETAAAIAAMRGRVDGLLV
HHEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEE
MPPDLKPELLADYLDPALPTVLLNYDAGPLDLPFVAVDNYQGAYRMTEALLARGAKQVVH
ECCCCCHHHHHHHHCHHHCEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCCHHEEE
IAGPKHNRDARDRQRGFTDAMAKIGGVRTPAILPGDFSEESGAQAARLLVQGQLPADAVF
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCEEE
AANDQMAVGLIAGLAEAGKSVPSDIMVAGFDDIPLARHLNPSLSTMQVHIDRLGSTAMML
ECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHCCCCHHHHHHHHHHHCHHHHHH
LLRMLRGETLGAANATILTPELVIRGTTGGETAPVPSSGARP
HHHHHCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]