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The map label for this gene is lon [H]

Identifier: 103486290

GI number: 103486290

Start: 803907

End: 806303

Strand: Direct

Name: lon [H]

Synonym: Sala_0798

Alternate gene names: 103486290

Gene position: 803907-806303 (Clockwise)

Preceding gene: 103486289

Following gene: 103486291

Centisome position: 24.03

GC content: 63.45

Gene sequence:

>2397_bases
ATGACGCAATCCTATCCCCTTCTGCCGCTGCGTGACATCGTCGTTTTCCCGCACATGATCGTGCCGCTGTTCGTCGGTCG
CGACCGTTCGGTGGCCGCGCTCGAAGCCGCGATGGAGGCGGGCAAGGAGATATTCCTCGTCGCCCAGCTCGATCCGGGCG
AGGACGATCCGCAGCGCGACGACCTTTACGACGTCGGCGTGATCGCGACGGTGCTCCAGTTGCTCAAGCTGCCCGACGGC
ACCGTTCGCGTGCTCGTCGAGGGCAAGGAACGCGCGAAGCTCCTGGCGCTCACCGACGAGGACAGGGCGGTGATGGCGAG
CGTCAAGCCGATCGCCGACACCGTCGACGACAGCGTCGATACTGCGGCGCTGATGCGCTCGGTCGTCGACCAGTTCGAAA
ATTATGCCAAGCTCAACAAGAAGATGCCCGCCGAAACCGCGGTGCAGCTGTCCCAGATCGACGACGCCTCGCGCCTCGCC
GATTCGGTTGCCGGCAATCTCAACATCAAGGTTGCCGACAAACAGGCTTTGCTCGTCGAGGATGCGCCGTCGAAGCGGCT
CGAAATGGTGTTCGCCTTCATGGAAGGCGAGCTCGGCGTGCTGCAGGTCGAAAAGAAGATCCGCGGCCGCGTGAAGCGCC
AGATGGAAAAGAGCCAGCGCGAATACTACCTCAACGAACAGTTGAAGGCGATCCAGCGCGAACTCGGCAACGACAATGGC
GAAGGCGGCGACGACCTTGCTGAACTGCAACTCAAGATCGACAGCCTCAAAATGTCGAAGGAGGCCAGGGCCAAGGCGAA
TGCCGAGCTGAAAAAGCTGCGCGCGATGGCGCCCATGTCGGCCGAGGCGACGGTGGTGCGCAACTATCTCGACACGCTGA
TCGGCCTGCCGTGGGGCAAGAAATCGAAGCTCAAGAAGGATATCGCCAAGGCGCAGGCGATCCTCGACGACGACCATTAT
GCGCTGGAGAAGGTCAAGGACCGGATCGTCGAATATCTCGCGGTGCAGGCGCGCACCAACAAGCTGAAAGGCCCGATCCT
CTGCCTCGTCGGCCCGCCGGGCGTCGGCAAGACTTCGCTCGGCCGTTCGATCGCGAAGGCGACGGGCCGCGAGTTCGTGC
GCCAGTCGTTGGGCGGCGTGCGCGACGAAGCCGAGATCCGCGGCCACCGCCGCACCTACATCGGTTCGCTGCCGGGCAAG
ATCGTGACCAATCTCAAAAAGGCGGGCACGATGAACCCGCTGTTCCTGCTCGACGAGATCGACAAGCTGGGGCAGGATTT
CCGCGGCGATCCGGCGTCGGCGCTGCTCGAAGTGCTCGACCCCGAACAGAATGCGAAGTTCCAGGATCATTATCTGGAAA
TCGACGTCGACCTTAGCGACATCATGTTCGTGACGACGGCGAACTCGCTCAACCTGCCGCAGCCGCTGCTCGACCGCATG
GAGATCATCCGGCTCGAAGGCTATACCGAGGATGAGAAGGTCGAGATCGCGAAGCGCCACCTGATCGCCAAGCAGGTCGA
GGCGCACGGGCTCAAGGATGGCGAGTTCGAACTGACCGAGGACGGTCTGCGCGATCTCATCCGCTATTACACGCGCGAGG
CGGGCGTCCGCACGCTCGAGCGCGAGATAGCGCGTCTTGCGCGCAAGGCGCTGCGCAAGATACTCGAGGGCAAGGCGGAA
AGCGTGACGATCACGCCCGAAAACCTGTCCGACTTTTCGGGCGTGCGGAAGTATAGGCACGGCATCAGCGATCTCGAGGA
TCAGGTCGGCGCCGTGACCGGCCTTGCCTGGACCGAGGTCGGCGGCGAATTGCTGACGATCGAGGCGGTCACCGCATCGG
GCAAGGGGCAGGTCAAGACGACCGGCAAGCTCGGCGAAGTGATGACCGAGTCGGTGCAGGCCGCATTGTCCTTCGTCAAA
GCACGCGCGCCCGCCTATGGCATCAAGCCCAGCCTGTTCGCGCGCAAGGACATCCACATCCACCTGCCCGAAGGCGCGGT
ACCCAAGGACGGGCCTTCGGCGGGCGTCGGCATGGTCACCGCGATGATCTCGACGCTCACCGGCATCGCCGTGCGCAAGG
ATGTCGCGATGACCGGCGAGGTCACACTGCGCGGCCGCGTGCTCGCGATCGGCGGACTCAAGGAAAAGCTGCTTGCCGCG
CTTCGCGGGGGCATCAAGACGGTGCTGATCCCCGAGGAGAATGAAAAGGATCTCGTGGAAATCCCGGCGAACATAACGAG
CGGGCTCAAAATCATTCCGGTCAGCCACGTCGACCAGGTGCTTGCCGAAGCGCTCGTTTCGCCGGTCGAACCGATCGAAT
GGACCGAGGCGGACGAGCTTGCCGCCTCGCCGCCGATCGGCGTCGGCAGCGATCCCGAAAGCGCGATTCGCCACTGA

Upstream 100 bases:

>100_bases
ACTCCTGCATTGAATGCGCGGCAAGTTACGCCATATTAGCGTGGACCACCCTATAAGTAACGACGGTGCGCCCGGTCGCG
GCGCTCGTCGAGGAGCCGTA

Downstream 100 bases:

>100_bases
GTCGCCCGCAGCGGACGGTTATTCGCCCCAGCTTCGTCGCAAAATCGGCGTTTCGGGGGGATTTTCTCCCTTTTTTGCTT
TGACAAGCCGGGGGCAAACA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 798; Mature: 797

Protein sequence:

>798_residues
MTQSYPLLPLRDIVVFPHMIVPLFVGRDRSVAALEAAMEAGKEIFLVAQLDPGEDDPQRDDLYDVGVIATVLQLLKLPDG
TVRVLVEGKERAKLLALTDEDRAVMASVKPIADTVDDSVDTAALMRSVVDQFENYAKLNKKMPAETAVQLSQIDDASRLA
DSVAGNLNIKVADKQALLVEDAPSKRLEMVFAFMEGELGVLQVEKKIRGRVKRQMEKSQREYYLNEQLKAIQRELGNDNG
EGGDDLAELQLKIDSLKMSKEARAKANAELKKLRAMAPMSAEATVVRNYLDTLIGLPWGKKSKLKKDIAKAQAILDDDHY
ALEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSLGRSIAKATGREFVRQSLGGVRDEAEIRGHRRTYIGSLPGK
IVTNLKKAGTMNPLFLLDEIDKLGQDFRGDPASALLEVLDPEQNAKFQDHYLEIDVDLSDIMFVTTANSLNLPQPLLDRM
EIIRLEGYTEDEKVEIAKRHLIAKQVEAHGLKDGEFELTEDGLRDLIRYYTREAGVRTLEREIARLARKALRKILEGKAE
SVTITPENLSDFSGVRKYRHGISDLEDQVGAVTGLAWTEVGGELLTIEAVTASGKGQVKTTGKLGEVMTESVQAALSFVK
ARAPAYGIKPSLFARKDIHIHLPEGAVPKDGPSAGVGMVTAMISTLTGIAVRKDVAMTGEVTLRGRVLAIGGLKEKLLAA
LRGGIKTVLIPEENEKDLVEIPANITSGLKIIPVSHVDQVLAEALVSPVEPIEWTEADELAASPPIGVGSDPESAIRH

Sequences:

>Translated_798_residues
MTQSYPLLPLRDIVVFPHMIVPLFVGRDRSVAALEAAMEAGKEIFLVAQLDPGEDDPQRDDLYDVGVIATVLQLLKLPDG
TVRVLVEGKERAKLLALTDEDRAVMASVKPIADTVDDSVDTAALMRSVVDQFENYAKLNKKMPAETAVQLSQIDDASRLA
DSVAGNLNIKVADKQALLVEDAPSKRLEMVFAFMEGELGVLQVEKKIRGRVKRQMEKSQREYYLNEQLKAIQRELGNDNG
EGGDDLAELQLKIDSLKMSKEARAKANAELKKLRAMAPMSAEATVVRNYLDTLIGLPWGKKSKLKKDIAKAQAILDDDHY
ALEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSLGRSIAKATGREFVRQSLGGVRDEAEIRGHRRTYIGSLPGK
IVTNLKKAGTMNPLFLLDEIDKLGQDFRGDPASALLEVLDPEQNAKFQDHYLEIDVDLSDIMFVTTANSLNLPQPLLDRM
EIIRLEGYTEDEKVEIAKRHLIAKQVEAHGLKDGEFELTEDGLRDLIRYYTREAGVRTLEREIARLARKALRKILEGKAE
SVTITPENLSDFSGVRKYRHGISDLEDQVGAVTGLAWTEVGGELLTIEAVTASGKGQVKTTGKLGEVMTESVQAALSFVK
ARAPAYGIKPSLFARKDIHIHLPEGAVPKDGPSAGVGMVTAMISTLTGIAVRKDVAMTGEVTLRGRVLAIGGLKEKLLAA
LRGGIKTVLIPEENEKDLVEIPANITSGLKIIPVSHVDQVLAEALVSPVEPIEWTEADELAASPPIGVGSDPESAIRH
>Mature_797_residues
TQSYPLLPLRDIVVFPHMIVPLFVGRDRSVAALEAAMEAGKEIFLVAQLDPGEDDPQRDDLYDVGVIATVLQLLKLPDGT
VRVLVEGKERAKLLALTDEDRAVMASVKPIADTVDDSVDTAALMRSVVDQFENYAKLNKKMPAETAVQLSQIDDASRLAD
SVAGNLNIKVADKQALLVEDAPSKRLEMVFAFMEGELGVLQVEKKIRGRVKRQMEKSQREYYLNEQLKAIQRELGNDNGE
GGDDLAELQLKIDSLKMSKEARAKANAELKKLRAMAPMSAEATVVRNYLDTLIGLPWGKKSKLKKDIAKAQAILDDDHYA
LEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSLGRSIAKATGREFVRQSLGGVRDEAEIRGHRRTYIGSLPGKI
VTNLKKAGTMNPLFLLDEIDKLGQDFRGDPASALLEVLDPEQNAKFQDHYLEIDVDLSDIMFVTTANSLNLPQPLLDRME
IIRLEGYTEDEKVEIAKRHLIAKQVEAHGLKDGEFELTEDGLRDLIRYYTREAGVRTLEREIARLARKALRKILEGKAES
VTITPENLSDFSGVRKYRHGISDLEDQVGAVTGLAWTEVGGELLTIEAVTASGKGQVKTTGKLGEVMTESVQAALSFVKA
RAPAYGIKPSLFARKDIHIHLPEGAVPKDGPSAGVGMVTAMISTLTGIAVRKDVAMTGEVTLRGRVLAIGGLKEKLLAAL
RGGIKTVLIPEENEKDLVEIPANITSGLKIIPVSHVDQVLAEALVSPVEPIEWTEADELAASPPIGVGSDPESAIRH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=784, Percent_Identity=40.0510204081633, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI21396489, Length=659, Percent_Identity=41.4264036418816, Blast_Score=513, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=761, Percent_Identity=60.9724047306176, Blast_Score=946, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=702, Percent_Identity=39.6011396011396, Blast_Score=477, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=547, Percent_Identity=39.1224862888483, Blast_Score=413, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6319449, Length=698, Percent_Identity=40.974212034384, Blast_Score=490, Evalue=1e-139,
Organism=Drosophila melanogaster, GI221513036, Length=597, Percent_Identity=42.8810720268007, Blast_Score=487, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24666867, Length=597, Percent_Identity=42.8810720268007, Blast_Score=486, Evalue=1e-137,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87175; Mature: 87043

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSYPLLPLRDIVVFPHMIVPLFVGRDRSVAALEAAMEAGKEIFLVAQLDPGEDDPQRD
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCC
DLYDVGVIATVLQLLKLPDGTVRVLVEGKERAKLLALTDEDRAVMASVKPIADTVDDSVD
CHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHH
TAALMRSVVDQFENYAKLNKKMPAETAVQLSQIDDASRLADSVAGNLNIKVADKQALLVE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCEEEEE
DAPSKRLEMVFAFMEGELGVLQVEKKIRGRVKRQMEKSQREYYLNEQLKAIQRELGNDNG
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EGGDDLAELQLKIDSLKMSKEARAKANAELKKLRAMAPMSAEATVVRNYLDTLIGLPWGK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
KSKLKKDIAKAQAILDDDHYALEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHH
GRSIAKATGREFVRQSLGGVRDEAEIRGHRRTYIGSLPGKIVTNLKKAGTMNPLFLLDEI
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHH
DKLGQDFRGDPASALLEVLDPEQNAKFQDHYLEIDVDLSDIMFVTTANSLNLPQPLLDRM
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECHHHEEEEEECCCCCCCHHHHHHH
EIIRLEGYTEDEKVEIAKRHLIAKQVEAHGLKDGEFELTEDGLRDLIRYYTREAGVRTLE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
REIARLARKALRKILEGKAESVTITPENLSDFSGVRKYRHGISDLEDQVGAVTGLAWTEV
HHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHC
GGELLTIEAVTASGKGQVKTTGKLGEVMTESVQAALSFVKARAPAYGIKPSLFARKDIHI
CCEEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCEEE
HLPEGAVPKDGPSAGVGMVTAMISTLTGIAVRKDVAMTGEVTLRGRVLAIGGLKEKLLAA
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCEEEEEEEEEECCHHHHHHHH
LRGGIKTVLIPEENEKDLVEIPANITSGLKIIPVSHVDQVLAEALVSPVEPIEWTEADEL
HHCCCEEEEECCCCCCCCEEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHH
AASPPIGVGSDPESAIRH
CCCCCCCCCCCCHHHHCC
>Mature Secondary Structure 
TQSYPLLPLRDIVVFPHMIVPLFVGRDRSVAALEAAMEAGKEIFLVAQLDPGEDDPQRD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCC
DLYDVGVIATVLQLLKLPDGTVRVLVEGKERAKLLALTDEDRAVMASVKPIADTVDDSVD
CHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHH
TAALMRSVVDQFENYAKLNKKMPAETAVQLSQIDDASRLADSVAGNLNIKVADKQALLVE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCEEEEE
DAPSKRLEMVFAFMEGELGVLQVEKKIRGRVKRQMEKSQREYYLNEQLKAIQRELGNDNG
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EGGDDLAELQLKIDSLKMSKEARAKANAELKKLRAMAPMSAEATVVRNYLDTLIGLPWGK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
KSKLKKDIAKAQAILDDDHYALEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHH
GRSIAKATGREFVRQSLGGVRDEAEIRGHRRTYIGSLPGKIVTNLKKAGTMNPLFLLDEI
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHH
DKLGQDFRGDPASALLEVLDPEQNAKFQDHYLEIDVDLSDIMFVTTANSLNLPQPLLDRM
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECHHHEEEEEECCCCCCCHHHHHHH
EIIRLEGYTEDEKVEIAKRHLIAKQVEAHGLKDGEFELTEDGLRDLIRYYTREAGVRTLE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
REIARLARKALRKILEGKAESVTITPENLSDFSGVRKYRHGISDLEDQVGAVTGLAWTEV
HHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHC
GGELLTIEAVTASGKGQVKTTGKLGEVMTESVQAALSFVKARAPAYGIKPSLFARKDIHI
CCEEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCEEE
HLPEGAVPKDGPSAGVGMVTAMISTLTGIAVRKDVAMTGEVTLRGRVLAIGGLKEKLLAA
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCEEEEEEEEEECCHHHHHHHH
LRGGIKTVLIPEENEKDLVEIPANITSGLKIIPVSHVDQVLAEALVSPVEPIEWTEADEL
HHCCCEEEEECCCCCCCCEEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHH
AASPPIGVGSDPESAIRH
CCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655539 [H]