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The map label for this gene is dnaX [H]

Identifier: 103486288

GI number: 103486288

Start: 801674

End: 803371

Strand: Direct

Name: dnaX [H]

Synonym: Sala_0796

Alternate gene names: 103486288

Gene position: 801674-803371 (Clockwise)

Preceding gene: 103486287

Following gene: 103486289

Centisome position: 23.97

GC content: 66.37

Gene sequence:

>1698_bases
ATGAGCGATTCCGCCCACGACGAAACCCCGATGCTGGGCATGGACCTGCCCGAGGCACCTGCGCCCGCGGCATCGTCCGG
CCCTTACCGTGTTCTGGCACGCAAATATCGCCCGCAAACCTTTGCGGAGCTGATCGGGCAGGATGCGATGGTGAAGACGC
TGGGCAATGCGATCGCGCGCGACCGGCTGGCGCACGCCTTCCTGATGACCGGGGTGCGCGGGGTCGGCAAGACATCGACC
GCGCGGCTGATCGCCAAGGCTTTGAACTGCATCGGCCCCGACGGGCAGGGCGGGCCGACGATCGACCCCTGCGGCGTGTG
CGAACCGTGCCGCGCGATCACCGAGGGTCGCCACATCGACGTCATCGAGATGGACGCCGCGTCGAACACCGGCGTCGACG
ATGTGCGCGAGATTATCGAGGCGGTGCGCTATGCTGCGGTGTCGGCGCGCTACAAGATCTATATCATCGACGAAGTGCAT
ATGTTGTCGCGTAATGCCTTCAATGCGCTCCTGAAAACGCTCGAAGAGCCGCCGCCGCACGTCAAGTTCCTGTTCGCGAC
CACCGAGGTCAACAAGGTGCCGGTGACGGTGCTGTCGCGCTGCCAGCGGTTCGACCTGCGCCGCATCACCCCCGACATGC
TGTTCGCGCATTTCAGCGCGATTTTGCAGAAAGAGGGCGTCGAGGCCGAGGCGCCCGCGATCTGGCTGATCGCCAATGCC
GCCGAAGGATCGGTGCGCGACGGCCTGTCGATCCTCGACCAGGCGATCGCCCACGCCGATCTGGACGGCGGTGGCAAGGT
CAGCGCCGAACAGGTGCGCGCCATGCTCGGCCTGTCCGATCGTTCGTCGATCGCCGGGCTGATGGCGGCGATTCTCGAGG
GGAACAGCGGCGGCGCGATCGACCTTGCGCGCGCGCAATATGCGCTGGGGATCGAACCCGTCGCGATGGTGCGCGGCCTG
ATGGAGCTGACCCATGCGATCACGCTCGCGAAGGTATCGCGCCACGACGATCCCGCGCTCGCCGTGGCCGACCGCGAACG
CATCACCGACTGGGCGCAAAAGCTGGGCTTTGCTCCGTTGAACCGGCTGTGGCAATTGCTGCTCAAGGGCCATGACGAGG
TGCTGCGCGCGAACAATCCGCTCGAACATCTCGAAATGCTGCTGCTGCGCGTCATCTATGCCGCGTCGTTGCCCGATCCG
GGTGAGCTTGCGAAATTGCTCGAATCGGGCGGCATACCGGCGATGCCCGTCGCAGCCGCCGCGGCGGCGACAGGGTCGGA
ACGCGCCGCGGCGGACCCTGCGCCCGCAGCCGGGCCCACCACAGGCGCGCTCACCATCGCACAGATTCACCGGCTCCTCG
AAAGCACGGGACATCATCAGCTTGCGCGGCAGGTTTACGACGATCTCCGGATTCTGGAGCTGGAGCCGGGTCGCCTTGTC
TATGCACCCGTCTCCGCGCTCGACGGCGATTTTGCGCGACGGCTCGGCGAAGCGCTGTTCGGTCAGACGGGCAGCCGCTG
GCAAGTGCGCGAAGGCACGGGCGAGGGGCGCCCCAGCCTGGCGCAGATGAAGGCGGCGCAGCGCGCCGATAATGAGGCAC
GCATTCGCGAACTGCCCGTCGTGAAGGCCGCGCTGGCGGCCTTTCCCGACGCGCGGCTTGTCGAAGGCGACAATAATCAG
CATAGGTCGAACCCATGA

Upstream 100 bases:

>100_bases
GTCCGGAAGGAAGCAGCCGCAACGAATTCGCTGCGGGTCGTTCCGGCTCCCACCCATTTCCCCCTTCGACAAGACCGCGG
CGTCCCCCTAAGACGGGGCC

Downstream 100 bases:

>100_bases
AATCCATCGAAGAAATGATGAAGGCGGCGCAGGAAGCCGCCGCCGCCGTGCAGGCACAGATGCAGGAGGCGCAGGCGAGG
CTCGACAGCGTCGAGGTCGA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MSDSAHDETPMLGMDLPEAPAPAASSGPYRVLARKYRPQTFAELIGQDAMVKTLGNAIARDRLAHAFLMTGVRGVGKTST
ARLIAKALNCIGPDGQGGPTIDPCGVCEPCRAITEGRHIDVIEMDAASNTGVDDVREIIEAVRYAAVSARYKIYIIDEVH
MLSRNAFNALLKTLEEPPPHVKFLFATTEVNKVPVTVLSRCQRFDLRRITPDMLFAHFSAILQKEGVEAEAPAIWLIANA
AEGSVRDGLSILDQAIAHADLDGGGKVSAEQVRAMLGLSDRSSIAGLMAAILEGNSGGAIDLARAQYALGIEPVAMVRGL
MELTHAITLAKVSRHDDPALAVADRERITDWAQKLGFAPLNRLWQLLLKGHDEVLRANNPLEHLEMLLLRVIYAASLPDP
GELAKLLESGGIPAMPVAAAAAATGSERAAADPAPAAGPTTGALTIAQIHRLLESTGHHQLARQVYDDLRILELEPGRLV
YAPVSALDGDFARRLGEALFGQTGSRWQVREGTGEGRPSLAQMKAAQRADNEARIRELPVVKAALAAFPDARLVEGDNNQ
HRSNP

Sequences:

>Translated_565_residues
MSDSAHDETPMLGMDLPEAPAPAASSGPYRVLARKYRPQTFAELIGQDAMVKTLGNAIARDRLAHAFLMTGVRGVGKTST
ARLIAKALNCIGPDGQGGPTIDPCGVCEPCRAITEGRHIDVIEMDAASNTGVDDVREIIEAVRYAAVSARYKIYIIDEVH
MLSRNAFNALLKTLEEPPPHVKFLFATTEVNKVPVTVLSRCQRFDLRRITPDMLFAHFSAILQKEGVEAEAPAIWLIANA
AEGSVRDGLSILDQAIAHADLDGGGKVSAEQVRAMLGLSDRSSIAGLMAAILEGNSGGAIDLARAQYALGIEPVAMVRGL
MELTHAITLAKVSRHDDPALAVADRERITDWAQKLGFAPLNRLWQLLLKGHDEVLRANNPLEHLEMLLLRVIYAASLPDP
GELAKLLESGGIPAMPVAAAAAATGSERAAADPAPAAGPTTGALTIAQIHRLLESTGHHQLARQVYDDLRILELEPGRLV
YAPVSALDGDFARRLGEALFGQTGSRWQVREGTGEGRPSLAQMKAAQRADNEARIRELPVVKAALAAFPDARLVEGDNNQ
HRSNP
>Mature_564_residues
SDSAHDETPMLGMDLPEAPAPAASSGPYRVLARKYRPQTFAELIGQDAMVKTLGNAIARDRLAHAFLMTGVRGVGKTSTA
RLIAKALNCIGPDGQGGPTIDPCGVCEPCRAITEGRHIDVIEMDAASNTGVDDVREIIEAVRYAAVSARYKIYIIDEVHM
LSRNAFNALLKTLEEPPPHVKFLFATTEVNKVPVTVLSRCQRFDLRRITPDMLFAHFSAILQKEGVEAEAPAIWLIANAA
EGSVRDGLSILDQAIAHADLDGGGKVSAEQVRAMLGLSDRSSIAGLMAAILEGNSGGAIDLARAQYALGIEPVAMVRGLM
ELTHAITLAKVSRHDDPALAVADRERITDWAQKLGFAPLNRLWQLLLKGHDEVLRANNPLEHLEMLLLRVIYAASLPDPG
ELAKLLESGGIPAMPVAAAAAATGSERAAADPAPAAGPTTGALTIAQIHRLLESTGHHQLARQVYDDLRILELEPGRLVY
APVSALDGDFARRLGEALFGQTGSRWQVREGTGEGRPSLAQMKAAQRADNEARIRELPVVKAALAAFPDARLVEGDNNQH
RSNP

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=286, Percent_Identity=26.5734265734266, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI194306571, Length=270, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI194306567, Length=270, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4506491, Length=370, Percent_Identity=23.7837837837838, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI31881687, Length=370, Percent_Identity=23.7837837837838, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI31563534, Length=321, Percent_Identity=22.7414330218069, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1786676, Length=377, Percent_Identity=44.0318302387268, Blast_Score=299, Evalue=4e-82,
Organism=Escherichia coli, GI1787341, Length=141, Percent_Identity=34.0425531914894, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=292, Percent_Identity=23.972602739726, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322528, Length=257, Percent_Identity=25.6809338521401, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=241, Percent_Identity=25.3112033195021, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 60539; Mature: 60408

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50222 EF_HAND_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSAHDETPMLGMDLPEAPAPAASSGPYRVLARKYRPQTFAELIGQDAMVKTLGNAIAR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHH
DRLAHAFLMTGVRGVGKTSTARLIAKALNCIGPDGQGGPTIDPCGVCEPCRAITEGRHID
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCEE
VIEMDAASNTGVDDVREIIEAVRYAAVSARYKIYIIDEVHMLSRNAFNALLKTLEEPPPH
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCC
VKFLFATTEVNKVPVTVLSRCQRFDLRRITPDMLFAHFSAILQKEGVEAEAPAIWLIANA
EEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
AEGSVRDGLSILDQAIAHADLDGGGKVSAEQVRAMLGLSDRSSIAGLMAAILEGNSGGAI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
DLARAQYALGIEPVAMVRGLMELTHAITLAKVSRHDDPALAVADRERITDWAQKLGFAPL
EHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCHH
NRLWQLLLKGHDEVLRANNPLEHLEMLLLRVIYAASLPDPGELAKLLESGGIPAMPVAAA
HHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHH
AAATGSERAAADPAPAAGPTTGALTIAQIHRLLESTGHHQLARQVYDDLRILELEPGRLV
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEECCCCEE
YAPVSALDGDFARRLGEALFGQTGSRWQVREGTGEGRPSLAQMKAAQRADNEARIRELPV
EECHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
VKAALAAFPDARLVEGDNNQHRSNP
HHHHHHHCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
SDSAHDETPMLGMDLPEAPAPAASSGPYRVLARKYRPQTFAELIGQDAMVKTLGNAIAR
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHH
DRLAHAFLMTGVRGVGKTSTARLIAKALNCIGPDGQGGPTIDPCGVCEPCRAITEGRHID
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCEE
VIEMDAASNTGVDDVREIIEAVRYAAVSARYKIYIIDEVHMLSRNAFNALLKTLEEPPPH
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCC
VKFLFATTEVNKVPVTVLSRCQRFDLRRITPDMLFAHFSAILQKEGVEAEAPAIWLIANA
EEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
AEGSVRDGLSILDQAIAHADLDGGGKVSAEQVRAMLGLSDRSSIAGLMAAILEGNSGGAI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
DLARAQYALGIEPVAMVRGLMELTHAITLAKVSRHDDPALAVADRERITDWAQKLGFAPL
EHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCHH
NRLWQLLLKGHDEVLRANNPLEHLEMLLLRVIYAASLPDPGELAKLLESGGIPAMPVAAA
HHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHH
AAATGSERAAADPAPAAGPTTGALTIAQIHRLLESTGHHQLARQVYDDLRILELEPGRLV
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEECCCCEE
YAPVSALDGDFARRLGEALFGQTGSRWQVREGTGEGRPSLAQMKAAQRADNEARIRELPV
EECHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
VKAALAAFPDARLVEGDNNQHRSNP
HHHHHHHCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]