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The map label for this gene is copA [H]

Identifier: 103486276

GI number: 103486276

Start: 791654

End: 793426

Strand: Direct

Name: copA [H]

Synonym: Sala_0784

Alternate gene names: 103486276

Gene position: 791654-793426 (Clockwise)

Preceding gene: 103486274

Following gene: 103486277

Centisome position: 23.67

GC content: 66.22

Gene sequence:

>1773_bases
ATGCAGATCGACAGACGCGGGTTCGTGAACGGGGCGCTCGGTGGTGGGGCGCTCGCGGCGCTCGCGGCCTGCTATCCGGC
GTGGGCGCAGCCGGTATCGGCTGGGATCGCGCCGCCGCTGCCCAGCGTGTCGGGCACCGACATCCGGCTGCGCATTGCGC
GTCAGACGCTGCGCGTCGACGGCAAGGTCACGCGGGCGATCGGCATCAACGGCACCGTGCCGGGTCCGCTGATCCGGCTG
AAGGAGGGGCAGCAGGCGCGGCTCACCGTCGTCAACGACCTCGACGAGGATAGTTCGATCCACTGGCACGGGCTGATCCT
GCCCTTCCACATGGACGGCGTGCCGGGGGTGAGCTTTCCGGGCATCAAGCCCCGTTCGACCTTCGTTTACGAGTTTCCCG
TCGTCCAGTCGGGGACCTATTGGTATCACAGCCATTCGGGGTTGCAGGAACAGCTTGGCCATTATGGTCCGATCGTCATC
GACCCCGCCGATGCCGATCCTGTCGCCTTCGATCGCGAGCATGTGATCGTCCTGTCGGACCACAGCCGCCTGTCGCCGCA
CGAAATCTTTCGCAAGCTCAAGGTCAATCCGGGCCATTTCAACATGCAGCGTCAGACGCTCGCCGGATTGCTCGCGGGGG
AGGACCAGCCGCTGAAGGAACGGCTGGCGTGGGGCGCGATGCGGATGGACCCCACCGACGTCGCCGACGTCAACGGTTCG
ACCTATACATTCCTCGTCAACGGCTATGGTCCGCAGGACAATTGGACCGCGCTGTTCCGCCCCGGCGAGCGCGTGCGGCT
GCGCATCGTCAACGCTTCGGCGATGACGATCTTCAACGTTCGCATTCCGGGGCTGGCGATGACGGTGGTGCAGGCCGACG
GGCTGAACGTCCGTCCCGTCGATGTCGAGGAGTTTCAGATCGGCGTTGCCGAAACTTATGATGTCGTCGTCACGCCCGTC
GAGGACCGTGCCTATACGCTAGTCGCCGAGGCGAACGACCGCTCGGGGATGGCGCGCGCGACGCTGACGCCGCGCGCCGG
GCTGTTCGCGCCCGTTCCCGCGTTGCGCGCCCGCCCGCTGGCGACGATGAAGGATATGGGAATGGGCAGCATGGCGGAGA
GCGGCGGCGGCGATGGCGCCTGCACCGCCGAACATGCCGCGATGGGCCATTGCACCCCCGCGGGCGAGGGCGCGCACGCC
GGTCATGGCGGCATGGACCACAATATGCGCGATTTCTCGGTTGCGCCGCAGGTCAAACGCGATCCCGGCGTCCAGTCGAT
TTCTCCCATGCCCGTCGACCGGATGGGCGAGCCGGGGCAGGGGCTGGAGGATGTCGGGCACCGCGTGCTCACCTATCACG
ACCTCGTCGCGCTCGACCGCAATCCCGATGTGCGCGCGCCTTCCCGCTCGCTCGACATCCACCTCACCGGCAATATGGAA
CGTTTCATGTGGTCGTTCGACGGGGTCAAGATGTCCGACCATCACGAGCCCATTCCCTTCACCCTGGGCGAGCGCGTGCG
CGTGAACCTCATCAACGATTCGATGATGAGCCACCCCATTCACCTGCACGGTCACTTCTTCGAACTGGTGACGGGCAAGG
GCGACCATGCGCCGCGCAAGCATACGGTGATAGTCCAGCCGGGCGGGATCGCGACCTTCGACTTCACCGCCGACGCGCTC
GGCGACTGGGCCTTCCACTGCCACCTTCTCTATCACATGCACGCGGGCATGATGCGCGTCGTCAGCGTGCGGCCGAAGGG
AGAGGCGGCGTGA

Upstream 100 bases:

>100_bases
CTCAAAATCGAGTTCCGCAAGGAGTGCTGGTTCGAGTCCGGCCAGGGGCACCACCGCCGCCGTCAGTCGCGGCGGAGAGT
TTCCAGTTATCGGGATGGAT

Downstream 100 bases:

>100_bases
CGCGCGCGCTGCTGCTGGCCGGTCTGTCGCTTGGCATTTTTACCGCGTCCGCCGCGGCGCAGTCGCCCCATGGGGGGCAT
CATGCGCCGACTGCCGGGCC

Product: copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MQIDRRGFVNGALGGGALAALAACYPAWAQPVSAGIAPPLPSVSGTDIRLRIARQTLRVDGKVTRAIGINGTVPGPLIRL
KEGQQARLTVVNDLDEDSSIHWHGLILPFHMDGVPGVSFPGIKPRSTFVYEFPVVQSGTYWYHSHSGLQEQLGHYGPIVI
DPADADPVAFDREHVIVLSDHSRLSPHEIFRKLKVNPGHFNMQRQTLAGLLAGEDQPLKERLAWGAMRMDPTDVADVNGS
TYTFLVNGYGPQDNWTALFRPGERVRLRIVNASAMTIFNVRIPGLAMTVVQADGLNVRPVDVEEFQIGVAETYDVVVTPV
EDRAYTLVAEANDRSGMARATLTPRAGLFAPVPALRARPLATMKDMGMGSMAESGGGDGACTAEHAAMGHCTPAGEGAHA
GHGGMDHNMRDFSVAPQVKRDPGVQSISPMPVDRMGEPGQGLEDVGHRVLTYHDLVALDRNPDVRAPSRSLDIHLTGNME
RFMWSFDGVKMSDHHEPIPFTLGERVRVNLINDSMMSHPIHLHGHFFELVTGKGDHAPRKHTVIVQPGGIATFDFTADAL
GDWAFHCHLLYHMHAGMMRVVSVRPKGEAA

Sequences:

>Translated_590_residues
MQIDRRGFVNGALGGGALAALAACYPAWAQPVSAGIAPPLPSVSGTDIRLRIARQTLRVDGKVTRAIGINGTVPGPLIRL
KEGQQARLTVVNDLDEDSSIHWHGLILPFHMDGVPGVSFPGIKPRSTFVYEFPVVQSGTYWYHSHSGLQEQLGHYGPIVI
DPADADPVAFDREHVIVLSDHSRLSPHEIFRKLKVNPGHFNMQRQTLAGLLAGEDQPLKERLAWGAMRMDPTDVADVNGS
TYTFLVNGYGPQDNWTALFRPGERVRLRIVNASAMTIFNVRIPGLAMTVVQADGLNVRPVDVEEFQIGVAETYDVVVTPV
EDRAYTLVAEANDRSGMARATLTPRAGLFAPVPALRARPLATMKDMGMGSMAESGGGDGACTAEHAAMGHCTPAGEGAHA
GHGGMDHNMRDFSVAPQVKRDPGVQSISPMPVDRMGEPGQGLEDVGHRVLTYHDLVALDRNPDVRAPSRSLDIHLTGNME
RFMWSFDGVKMSDHHEPIPFTLGERVRVNLINDSMMSHPIHLHGHFFELVTGKGDHAPRKHTVIVQPGGIATFDFTADAL
GDWAFHCHLLYHMHAGMMRVVSVRPKGEAA
>Mature_590_residues
MQIDRRGFVNGALGGGALAALAACYPAWAQPVSAGIAPPLPSVSGTDIRLRIARQTLRVDGKVTRAIGINGTVPGPLIRL
KEGQQARLTVVNDLDEDSSIHWHGLILPFHMDGVPGVSFPGIKPRSTFVYEFPVVQSGTYWYHSHSGLQEQLGHYGPIVI
DPADADPVAFDREHVIVLSDHSRLSPHEIFRKLKVNPGHFNMQRQTLAGLLAGEDQPLKERLAWGAMRMDPTDVADVNGS
TYTFLVNGYGPQDNWTALFRPGERVRLRIVNASAMTIFNVRIPGLAMTVVQADGLNVRPVDVEEFQIGVAETYDVVVTPV
EDRAYTLVAEANDRSGMARATLTPRAGLFAPVPALRARPLATMKDMGMGSMAESGGGDGACTAEHAAMGHCTPAGEGAHA
GHGGMDHNMRDFSVAPQVKRDPGVQSISPMPVDRMGEPGQGLEDVGHRVLTYHDLVALDRNPDVRAPSRSLDIHLTGNME
RFMWSFDGVKMSDHHEPIPFTLGERVRVNLINDSMMSHPIHLHGHFFELVTGKGDHAPRKHTVIVQPGGIATFDFTADAL
GDWAFHCHLLYHMHAGMMRVVSVRPKGEAA

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=377, Percent_Identity=25.1989389920424, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321067, Length=562, Percent_Identity=23.3096085409253, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320714, Length=294, Percent_Identity=25.1700680272109, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323703, Length=265, Percent_Identity=28.6792452830189, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859919, Length=567, Percent_Identity=24.8677248677249, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28574104, Length=308, Percent_Identity=29.2207792207792, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24585842, Length=275, Percent_Identity=29.4545454545455, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281360167, Length=275, Percent_Identity=29.4545454545455, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221330000, Length=275, Percent_Identity=29.8181818181818, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221329998, Length=275, Percent_Identity=29.4545454545455, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650186, Length=276, Percent_Identity=25, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 64137; Mature: 64137

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIDRRGFVNGALGGGALAALAACYPAWAQPVSAGIAPPLPSVSGTDIRLRIARQTLRVD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHHHCC
GKVTRAIGINGTVPGPLIRLKEGQQARLTVVNDLDEDSSIHWHGLILPFHMDGVPGVSFP
CEEEEEEECCCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEEEEEEEEECCCCCCCCCC
GIKPRSTFVYEFPVVQSGTYWYHSHSGLQEQLGHYGPIVIDPADADPVAFDREHVIVLSD
CCCCCCEEEEEECEEECCEEEEECCCCHHHHHCCCCCEEECCCCCCCCEECCCEEEEECC
HSRLSPHEIFRKLKVNPGHFNMQRQTLAGLLAGEDQPLKERLAWGAMRMDPTDVADVNGS
CCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCC
TYTFLVNGYGPQDNWTALFRPGERVRLRIVNASAMTIFNVRIPGLAMTVVQADGLNVRPV
EEEEEEECCCCCCCCEEEECCCCEEEEEEEECCEEEEEEEECCCEEEEEEECCCCEECCC
DVEEFQIGVAETYDVVVTPVEDRAYTLVAEANDRSGMARATLTPRAGLFAPVPALRARPL
CHHHEEECEEEEEEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHCCCC
ATMKDMGMGSMAESGGGDGACTAEHAAMGHCTPAGEGAHAGHGGMDHNMRDFSVAPQVKR
HHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DPGVQSISPMPVDRMGEPGQGLEDVGHRVLTYHDLVALDRNPDVRAPSRSLDIHLTGNME
CCCCCCCCCCCHHHCCCCCCCHHHHCCEEEEEEEEEEECCCCCCCCCCCEEEEEECCCHH
RFMWSFDGVKMSDHHEPIPFTLGERVRVNLINDSMMSHPIHLHGHFFELVTGKGDHAPRK
HEEEEECCEEECCCCCCCCEECCCEEEEEEECCHHHCCCEEEEEEEEEEEECCCCCCCCC
HTVIVQPGGIATFDFTADALGDWAFHCHLLYHMHAGMMRVVSVRPKGEAA
EEEEECCCCEEEEECCHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCC
>Mature Secondary Structure
MQIDRRGFVNGALGGGALAALAACYPAWAQPVSAGIAPPLPSVSGTDIRLRIARQTLRVD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHHHCC
GKVTRAIGINGTVPGPLIRLKEGQQARLTVVNDLDEDSSIHWHGLILPFHMDGVPGVSFP
CEEEEEEECCCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEEEEEEEEECCCCCCCCCC
GIKPRSTFVYEFPVVQSGTYWYHSHSGLQEQLGHYGPIVIDPADADPVAFDREHVIVLSD
CCCCCCEEEEEECEEECCEEEEECCCCHHHHHCCCCCEEECCCCCCCCEECCCEEEEECC
HSRLSPHEIFRKLKVNPGHFNMQRQTLAGLLAGEDQPLKERLAWGAMRMDPTDVADVNGS
CCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCC
TYTFLVNGYGPQDNWTALFRPGERVRLRIVNASAMTIFNVRIPGLAMTVVQADGLNVRPV
EEEEEEECCCCCCCCEEEECCCCEEEEEEEECCEEEEEEEECCCEEEEEEECCCCEECCC
DVEEFQIGVAETYDVVVTPVEDRAYTLVAEANDRSGMARATLTPRAGLFAPVPALRARPL
CHHHEEECEEEEEEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHCCCC
ATMKDMGMGSMAESGGGDGACTAEHAAMGHCTPAGEGAHAGHGGMDHNMRDFSVAPQVKR
HHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DPGVQSISPMPVDRMGEPGQGLEDVGHRVLTYHDLVALDRNPDVRAPSRSLDIHLTGNME
CCCCCCCCCCCHHHCCCCCCCHHHHCCEEEEEEEEEEECCCCCCCCCCCEEEEEECCCHH
RFMWSFDGVKMSDHHEPIPFTLGERVRVNLINDSMMSHPIHLHGHFFELVTGKGDHAPRK
HEEEEECCEEECCCCCCCCEECCCEEEEEEECCHHHCCCEEEEEEEEEEEECCCCCCCCC
HTVIVQPGGIATFDFTADALGDWAFHCHLLYHMHAGMMRVVSVRPKGEAA
EEEEECCCCEEEEECCHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]