Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 103486270

GI number: 103486270

Start: 784880

End: 785878

Strand: Reverse

Name: gyaR [H]

Synonym: Sala_0778

Alternate gene names: 103486270

Gene position: 785878-784880 (Counterclockwise)

Preceding gene: 103486272

Following gene: 103486265

Centisome position: 23.49

GC content: 67.27

Gene sequence:

>999_bases
ATGCCCGATTCTTCCCGCCCGAAACGCCCGCGCGTCATCGTCACCCGCCAGTTGATGCCGCATGTCGAGGCGCGCATGGC
CGAATTGTTCGATGTCGCACTGTCGGCGCACGACCATGCCTTTACAAAGGACGAGCTGAAGGCCGCGGTCGCCGATTGCG
ACGTGCTCGTGCCGACGGTGACCGACACGATCGACGCCGAAGTGATCGGGGCGGCGGGCGACCGGCTGAAGCTGATCGCC
AATTTCGGCGCCGGGGTCGACCATATCGACCTCGCCGCAGCGCGCGCGAAGGGCATCATGGTGTCGAATACGCCCGGCGT
CTTTACCGAGGACACCGCCGACATGACGATGGCGCTGATCCTCAGCGTTCCGCGCCGCCTGGCCGAGGGCGAAAAGCTGA
TGCGGTCGGGCAAGTGGGCCGGCTGGGCGCCGAGCGCGATGCTGGGTCACCGCGTCGGCGGCAAATTGCTCGGGATCATC
GGCATGGGACGCATCGGCCTGGCGGTCGCGCGGCGCGCGCGCGCGTTCGGCCTGTCGATCCATTATCACAACCGTCGGCG
CCTGCCTGAGGCGATCGAGGAAGAGCTGGGCGCGAGCTATCATGCCAGCGTCGATACGCTGCTGCGCATCAGCGACGTGG
TGACGATCCACTGTCCGCACACCGCCGAAACGCACGAGATGGTCAACGCCGCGCGCATCGGCGCGATGAAACCGACCGCC
TACCTCATCAACACCGCGCGTGGCGAGATCGTCGATGAAAAGGCGCTGATCGCGGCGCTCCAGACCGGGCGCATCGCCGG
GGCCGGGCTCGACGTCTATACCCACGAACCCGCGGTCGATCCCGCGCTGCTCGCGCTCCAGAATGTCGTGCTGCTCCCGC
ATCTGGGTTCAGCGACGATCGAGGGGCGCGAAGCGTCGGGCGAAAAGGTGATCGCCAATATCCGCGCCTGGTGCGACGGG
CACCGGCCGCCCGATCAGGTGCTGGAGGGGTGGGCCTAA

Upstream 100 bases:

>100_bases
CATTATCAACCGGCCGCATGGGACACAAAGCCGGTCGTCCACAGGCTTGACCCCGCCTGCCCCCTTGACCCCTCCACGCT
GGCGCGCTCTATCGGCGGCC

Downstream 100 bases:

>100_bases
GCCCACCATCCAGTCCCAATTCGCTTTCCCGTTTGGGACTTAGCGCTGACTACATTTGAGGTCGATCACCCGCATCGCCA
AGTCGCTTGGACTTCCGCCT

Product: glycolate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MPDSSRPKRPRVIVTRQLMPHVEARMAELFDVALSAHDHAFTKDELKAAVADCDVLVPTVTDTIDAEVIGAAGDRLKLIA
NFGAGVDHIDLAAARAKGIMVSNTPGVFTEDTADMTMALILSVPRRLAEGEKLMRSGKWAGWAPSAMLGHRVGGKLLGII
GMGRIGLAVARRARAFGLSIHYHNRRRLPEAIEEELGASYHASVDTLLRISDVVTIHCPHTAETHEMVNAARIGAMKPTA
YLINTARGEIVDEKALIAALQTGRIAGAGLDVYTHEPAVDPALLALQNVVLLPHLGSATIEGREASGEKVIANIRAWCDG
HRPPDQVLEGWA

Sequences:

>Translated_332_residues
MPDSSRPKRPRVIVTRQLMPHVEARMAELFDVALSAHDHAFTKDELKAAVADCDVLVPTVTDTIDAEVIGAAGDRLKLIA
NFGAGVDHIDLAAARAKGIMVSNTPGVFTEDTADMTMALILSVPRRLAEGEKLMRSGKWAGWAPSAMLGHRVGGKLLGII
GMGRIGLAVARRARAFGLSIHYHNRRRLPEAIEEELGASYHASVDTLLRISDVVTIHCPHTAETHEMVNAARIGAMKPTA
YLINTARGEIVDEKALIAALQTGRIAGAGLDVYTHEPAVDPALLALQNVVLLPHLGSATIEGREASGEKVIANIRAWCDG
HRPPDQVLEGWA
>Mature_331_residues
PDSSRPKRPRVIVTRQLMPHVEARMAELFDVALSAHDHAFTKDELKAAVADCDVLVPTVTDTIDAEVIGAAGDRLKLIAN
FGAGVDHIDLAAARAKGIMVSNTPGVFTEDTADMTMALILSVPRRLAEGEKLMRSGKWAGWAPSAMLGHRVGGKLLGIIG
MGRIGLAVARRARAFGLSIHYHNRRRLPEAIEEELGASYHASVDTLLRISDVVTIHCPHTAETHEMVNAARIGAMKPTAY
LINTARGEIVDEKALIAALQTGRIAGAGLDVYTHEPAVDPALLALQNVVLLPHLGSATIEGREASGEKVIANIRAWCDGH
RPPDQVLEGWA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=327, Percent_Identity=34.8623853211009, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI23308577, Length=278, Percent_Identity=36.3309352517986, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI61743967, Length=326, Percent_Identity=35.2760736196319, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI4557497, Length=326, Percent_Identity=35.2760736196319, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI145580578, Length=249, Percent_Identity=38.5542168674699, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI4557499, Length=249, Percent_Identity=38.5542168674699, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=38.5542168674699, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI87082289, Length=308, Percent_Identity=38.961038961039, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789279, Length=290, Percent_Identity=33.1034482758621, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787645, Length=332, Percent_Identity=27.4096385542169, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081824, Length=242, Percent_Identity=29.3388429752066, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788660, Length=268, Percent_Identity=25, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=281, Percent_Identity=33.0960854092527, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=261, Percent_Identity=34.0996168582375, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=36.046511627907, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322116, Length=319, Percent_Identity=32.2884012539185, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320925, Length=259, Percent_Identity=35.1351351351351, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324964, Length=219, Percent_Identity=34.2465753424658, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=288, Percent_Identity=28.125, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=161, Percent_Identity=30.4347826086957, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=162, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=42.3076923076923, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI45552429, Length=242, Percent_Identity=39.6694214876033, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24585514, Length=242, Percent_Identity=39.6694214876033, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI28574282, Length=242, Percent_Identity=39.6694214876033, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI45551003, Length=242, Percent_Identity=39.6694214876033, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI28574284, Length=242, Percent_Identity=39.6694214876033, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI28574286, Length=244, Percent_Identity=37.7049180327869, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24646446, Length=225, Percent_Identity=40, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646448, Length=225, Percent_Identity=40, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646452, Length=225, Percent_Identity=40, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646450, Length=225, Percent_Identity=40, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI62472511, Length=225, Percent_Identity=40, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI19921140, Length=265, Percent_Identity=33.5849056603774, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24585516, Length=264, Percent_Identity=30.6818181818182, Blast_Score=138, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35609; Mature: 35477

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSSRPKRPRVIVTRQLMPHVEARMAELFDVALSAHDHAFTKDELKAAVADCDVLVPTV
CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEECCC
TDTIDAEVIGAAGDRLKLIANFGAGVDHIDLAAARAKGIMVSNTPGVFTEDTADMTMALI
CCCCCCCEECCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHH
LSVPRRLAEGEKLMRSGKWAGWAPSAMLGHRVGGKLLGIIGMGRIGLAVARRARAFGLSI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEHHHCCCHHHHHHHHHHHHHEEEE
HYHNRRRLPEAIEEELGASYHASVDTLLRISDVVTIHCPHTAETHEMVNAARIGAMKPTA
EECCCCCCHHHHHHHHCCCHHCCHHHHHEEEEEEEEECCCCCHHHHHHHHHHHCCCCCHH
YLINTARGEIVDEKALIAALQTGRIAGAGLDVYTHEPAVDPALLALQNVVLLPHLGSATI
HEEECCCCCHHHHHHHHHHHHCCCEECCCCEEEECCCCCCHHHHHHHHHHEECCCCCCEE
EGREASGEKVIANIRAWCDGHRPPDQVLEGWA
CCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCC
>Mature Secondary Structure 
PDSSRPKRPRVIVTRQLMPHVEARMAELFDVALSAHDHAFTKDELKAAVADCDVLVPTV
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEECCC
TDTIDAEVIGAAGDRLKLIANFGAGVDHIDLAAARAKGIMVSNTPGVFTEDTADMTMALI
CCCCCCCEECCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHH
LSVPRRLAEGEKLMRSGKWAGWAPSAMLGHRVGGKLLGIIGMGRIGLAVARRARAFGLSI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEHHHCCCHHHHHHHHHHHHHEEEE
HYHNRRRLPEAIEEELGASYHASVDTLLRISDVVTIHCPHTAETHEMVNAARIGAMKPTA
EECCCCCCHHHHHHHHCCCHHCCHHHHHEEEEEEEEECCCCCHHHHHHHHHHHCCCCCHH
YLINTARGEIVDEKALIAALQTGRIAGAGLDVYTHEPAVDPALLALQNVVLLPHLGSATI
HEEECCCCCHHHHHHHHHHHHCCCEECCCCEEEECCCCCCHHHHHHHHHHEECCCCCCEE
EGREASGEKVIANIRAWCDGHRPPDQVLEGWA
CCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA