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The map label for this gene is mro [H]

Identifier: 103486230

GI number: 103486230

Start: 742845

End: 743924

Strand: Reverse

Name: mro [H]

Synonym: Sala_0738

Alternate gene names: 103486230

Gene position: 743924-742845 (Counterclockwise)

Preceding gene: 103486232

Following gene: 103486229

Centisome position: 22.24

GC content: 58.06

Gene sequence:

>1080_bases
TTGCACCACAGCACAGCAACCGAGACCGAGTTCGGAACGCTCGACAATGGGGACATTGTGAAGCGCATCAAGCTCGCAAA
TGAAAGCGGCATGTCGGTAGGAATCATCACCTACGGCGCGTCCCTGCAATCGGTCTGCGTTCCCGACCGATATGGTGTAT
TTGCCGATGTCGCAGCGGGTTATGCCACGCTCGACGACTATCTCCGCAAGCCGCAGTATTTCGGATCGACCGTCGGGCGG
GTCGCCAATCGGCTCGCGAAGGCCCGTTTCACATTGAACGGCAAAGATTATGTGGTTTCGGCCAATGATGGCTCCAATTC
GCTCCATGGCGGAGCACGGGGATTCGACAAGGTCAACTGGACCGTGACCCACAGGAGCGATCGGTCGGTCACCATGCAAT
ATGTCAGTCCCGACGGCGATCAGGGCTATCCCGGCACCTTGACCGTCGGCGCAACCTATGCACTTGGCGCAGACAATGAA
TTGAGCGTCCACTACCGCGCCACCACCGACGCGACCACCCTGGTTAACCTGTCAAACCATGTTTACTGGAATCTGGGCGG
GGAAGGCGCGGCCTATAGCGCGATGGGCCACCGTCTGACGATCCACGCGGATCATTTTCTCCCCGTTGATTCCGAGCTGA
TCCCGACCGGTGAAATGCGTCATGTCGAAGACAGTCTGTTCGATTTTCGCATGGGCAAGGTCATCGGCGACGATGTTGGC
AGGATGGACGATGAGCAACTCGGCTTCGGTCTGGGTTATGATCATAATTGGGTCGTCGGCGACGAAGTTGCCGCCGCGCC
GCGGCCGGTGGCAAAGCTGATTGATCCCCGTTCGGGGCGAGCCATGACTTTGCTGTCCAACCAACCCGGCCTGCAATTCT
ACTCGGGCAACTTCTTTGACGGCACGACGCGGGGCAAGGCGGGAAAGTCCTATTGCCGCGGCGATGCCATCGCACTCGAG
CCGCAACAATTTCCCGATGCGCCCAACCAGCCTGGCTTCGGCTCAATAGCACTTCAACCCGGCCAAACCTATTCCAACAT
GATTATCTGGCGATTTGAATTGTCGGAGGAGCGATCATGA

Upstream 100 bases:

>100_bases
TCGCGGCGGTCTGTGGTTCGACAGCCACCACCCCCAATCCCGCCTGTTGTCTGCCTCGATCGTTTATCATATAAATCATC
TCAATTGGAAAGGGGTTAGT

Downstream 100 bases:

>100_bases
GGGCAGAAAAATCGGCATTATTTCTCGCGCTCATGGTGCTGGGCGGCTGTGCAACGGCGCCTGGGAGGCCGACTATAAGC
AATCCTGTCATCGACGAAAA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MHHSTATETEFGTLDNGDIVKRIKLANESGMSVGIITYGASLQSVCVPDRYGVFADVAAGYATLDDYLRKPQYFGSTVGR
VANRLAKARFTLNGKDYVVSANDGSNSLHGGARGFDKVNWTVTHRSDRSVTMQYVSPDGDQGYPGTLTVGATYALGADNE
LSVHYRATTDATTLVNLSNHVYWNLGGEGAAYSAMGHRLTIHADHFLPVDSELIPTGEMRHVEDSLFDFRMGKVIGDDVG
RMDDEQLGFGLGYDHNWVVGDEVAAAPRPVAKLIDPRSGRAMTLLSNQPGLQFYSGNFFDGTTRGKAGKSYCRGDAIALE
PQQFPDAPNQPGFGSIALQPGQTYSNMIIWRFELSEERS

Sequences:

>Translated_359_residues
MHHSTATETEFGTLDNGDIVKRIKLANESGMSVGIITYGASLQSVCVPDRYGVFADVAAGYATLDDYLRKPQYFGSTVGR
VANRLAKARFTLNGKDYVVSANDGSNSLHGGARGFDKVNWTVTHRSDRSVTMQYVSPDGDQGYPGTLTVGATYALGADNE
LSVHYRATTDATTLVNLSNHVYWNLGGEGAAYSAMGHRLTIHADHFLPVDSELIPTGEMRHVEDSLFDFRMGKVIGDDVG
RMDDEQLGFGLGYDHNWVVGDEVAAAPRPVAKLIDPRSGRAMTLLSNQPGLQFYSGNFFDGTTRGKAGKSYCRGDAIALE
PQQFPDAPNQPGFGSIALQPGQTYSNMIIWRFELSEERS
>Mature_359_residues
MHHSTATETEFGTLDNGDIVKRIKLANESGMSVGIITYGASLQSVCVPDRYGVFADVAAGYATLDDYLRKPQYFGSTVGR
VANRLAKARFTLNGKDYVVSANDGSNSLHGGARGFDKVNWTVTHRSDRSVTMQYVSPDGDQGYPGTLTVGATYALGADNE
LSVHYRATTDATTLVNLSNHVYWNLGGEGAAYSAMGHRLTIHADHFLPVDSELIPTGEMRHVEDSLFDFRMGKVIGDDVG
RMDDEQLGFGLGYDHNWVVGDEVAAAPRPVAKLIDPRSGRAMTLLSNQPGLQFYSGNFFDGTTRGKAGKSYCRGDAIALE
PQQFPDAPNQPGFGSIALQPGQTYSNMIIWRFELSEERS

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=353, Percent_Identity=41.3597733711048, Blast_Score=258, Evalue=6e-69,
Organism=Escherichia coli, GI1786971, Length=344, Percent_Identity=36.046511627907, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17557428, Length=331, Percent_Identity=32.9305135951662, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI115533334, Length=331, Percent_Identity=32.9305135951662, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319493, Length=306, Percent_Identity=27.7777777777778, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324399, Length=348, Percent_Identity=24.4252873563218, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322004, Length=344, Percent_Identity=25.8720930232558, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24668278, Length=343, Percent_Identity=39.067055393586, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24668282, Length=350, Percent_Identity=40.5714285714286, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24659048, Length=351, Percent_Identity=39.8860398860399, Blast_Score=237, Evalue=8e-63,
Organism=Drosophila melanogaster, GI24583720, Length=361, Percent_Identity=36.8421052631579, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24641876, Length=349, Percent_Identity=33.810888252149, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39026; Mature: 39026

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00636 DNAJ_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHSTATETEFGTLDNGDIVKRIKLANESGMSVGIITYGASLQSVCVPDRYGVFADVAAG
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCEEECCCCCCCHHHHHCC
YATLDDYLRKPQYFGSTVGRVANRLAKARFTLNGKDYVVSANDGSNSLHGGARGFDKVNW
HHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCCCCCCCEEE
TVTHRSDRSVTMQYVSPDGDQGYPGTLTVGATYALGADNELSVHYRATTDATTLVNLSNH
EEEECCCCEEEEEEECCCCCCCCCCEEEECEEEEECCCCEEEEEEEECCCCEEEEEECCE
VYWNLGGEGAAYSAMGHRLTIHADHFLPVDSELIPTGEMRHVEDSLFDFRMGKVIGDDVG
EEEEECCCCCEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
RMDDEQLGFGLGYDHNWVVGDEVAAAPRPVAKLIDPRSGRAMTLLSNQPGLQFYSGNFFD
CCCHHHCCEECCCCCCEEECCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCEEECCCEEC
GTTRGKAGKSYCRGDAIALEPQQFPDAPNQPGFGSIALQPGQTYSNMIIWRFELSEERS
CCCCCCCCCHHHCCCEEEECHHHCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MHHSTATETEFGTLDNGDIVKRIKLANESGMSVGIITYGASLQSVCVPDRYGVFADVAAG
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCEEECCCCCCCHHHHHCC
YATLDDYLRKPQYFGSTVGRVANRLAKARFTLNGKDYVVSANDGSNSLHGGARGFDKVNW
HHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCCCCCCCEEE
TVTHRSDRSVTMQYVSPDGDQGYPGTLTVGATYALGADNELSVHYRATTDATTLVNLSNH
EEEECCCCEEEEEEECCCCCCCCCCEEEECEEEEECCCCEEEEEEEECCCCEEEEEECCE
VYWNLGGEGAAYSAMGHRLTIHADHFLPVDSELIPTGEMRHVEDSLFDFRMGKVIGDDVG
EEEEECCCCCEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
RMDDEQLGFGLGYDHNWVVGDEVAAAPRPVAKLIDPRSGRAMTLLSNQPGLQFYSGNFFD
CCCHHHCCEECCCCCCEEECCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCEEECCCEEC
GTTRGKAGKSYCRGDAIALEPQQFPDAPNQPGFGSIALQPGQTYSNMIIWRFELSEERS
CCCCCCCCCHHHCCCEEEECHHHCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]