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The map label for this gene is guaA [H]

Identifier: 103486127

GI number: 103486127

Start: 643677

End: 645290

Strand: Reverse

Name: guaA [H]

Synonym: Sala_0634

Alternate gene names: 103486127

Gene position: 645290-643677 (Counterclockwise)

Preceding gene: 103486129

Following gene: 103486125

Centisome position: 19.29

GC content: 65.49

Gene sequence:

>1614_bases
ATGGCCCGGCTTCCTTATCGGCCAGCCATGCCGACTCCCGACCCCTCCGCCGCCCCTGAATCGATCCTGATCATCGACTT
CGGATCGCAAGTCACCCAGCTCATCGCCCGTCGCGTCCGCGAGGCGGGCGTGTATAGCGAGATTGTCCCGTTCAGCGCCG
CCGAGGCGGCGCTCGCACGGATGCGGCCCAAGGGGGTGATCCTGTCAGGATCGCCCGCGTCGGTTCCCGCCGAGGGCAGC
CCGCGCGCACCCCGGTCGATCTTTGACAGCGGCCTGCCGATCCTGGGCATCTGTTACGGCCAGCAGGTGATGAGCCAGCA
GCTCGGCGGAAAAGTCGAACCCGGCGGCATCGATGGCGAACGCGACGGCGAATTCGGCCGCGCCTTCCTGACCGTCACCG
AACCCTGCGTGCTGTTCGATGGGCTGTGGCAGGTCGGCGAACGGCATCAGGTGTGGATGAGCCACGGCGACCGCGTGACC
CGGTTCGCGCCGGGTTTCCGTATCGTGGCAGTCAGCGACGGCGCGCCTTTCGCAGTCATCGCGAATGACGAGCGCCGCTA
TTATGGTACCCAATTCCACCCCGAAGTCGTCCATACCCCCGACGGCGCGAAGCTGATCGCCAATTTCGTGCGCCACGTCT
GCGGGTGCAGCGGCGACTGGACGATGGCCGAGTTTCGCACCACCAAGATCGCCGAAATCCGCGCACAGGTCGGCGACCAG
CGCGTGCTGTGCGGCCTGTCGGGCGGGGTCGACAGCGCGGTCGCCGCGGTGCTGATCCACGAAGCGATCGGCGAACAGCT
GACCTGCGTTTTCGTCGACCACGGCCTCTTGCGCATGAACGAGCGCGAACAGGTCGAACGCCTGTTCCGCGACCATTACA
ACATCCCGCTGGTCGTCGTCGACGCCGAGGAGCGCTTCATGGCGGGGCTTGCGGGCATCACCGACCCCGAACAGAAGCGC
AAGTTCATCGGCGCCGAGTTCATCAATGTGTTCGAGGAAGAGGCCAGGAAGATCGGCGGCGCCGATTTCCTCGCGCAAGG
CACGCTCTATCCCGATGTGATCGAGAGCGTCAGCTTCACCGGCGGGCCGAGCGTCACGATCAAGAGTCATCACAATGTCG
GCGGCCTGCCCGAACGCATGAACATGAAGCTCGTCGAGCCGCTGCGCGAGCTGTTCAAGGACGAGGTCCGCCTGCTCGGC
AAGGAGCTGGGCCTGCCCGACATTTTTGTCGGCCGCCACCCCTTCCCCGGCCCCGGCCTCGCGATCCGCATTCCAGGCGA
AGTCAGCAAAGAGCGCTGCGACATCCTCCGCAAGGCCGATGCGGTCTATCTCGAGGAAATCCGCAACGCCGGGCTGTACG
ATGCGATCTGGCAGGCGTTTGCGGTGCTCCTGCCGGTCAAGACGGTCGGCGTGATGGGCGACGGGCGCACTTACGACCAT
GTCTGCGCGCTGCGCGCCGTGACCTCGACCGATGGCATGACCGCCGACATCTATCCCTTCGACGCCAGCTTCCTGAGCCG
CTGCGCGACGCGCATCATCAACGAGGTGCAGGGCATCAACCGGGTGGTGTATGATTATACGTCGAAGCCGCCGGGGACGA
TCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
CGCCCTGCTTGTCGCGGCGTTCACCTATGTCGCAATTGTCGCAACAATGTGTCGGGGACACGGCCGTTCGACGAGCAGCC
CATATCGACCGCTGGACAGC

Downstream 100 bases:

>100_bases
CGCGCTAGTCCGCGGCGACCACGGTCGCGTCCGCTGGTGCGGCAACCATCGAACCCCACCAGTCGCCAAGCGCGTCGATC
AGCGGCACCAGCCTTTCGCC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MARLPYRPAMPTPDPSAAPESILIIDFGSQVTQLIARRVREAGVYSEIVPFSAAEAALARMRPKGVILSGSPASVPAEGS
PRAPRSIFDSGLPILGICYGQQVMSQQLGGKVEPGGIDGERDGEFGRAFLTVTEPCVLFDGLWQVGERHQVWMSHGDRVT
RFAPGFRIVAVSDGAPFAVIANDERRYYGTQFHPEVVHTPDGAKLIANFVRHVCGCSGDWTMAEFRTTKIAEIRAQVGDQ
RVLCGLSGGVDSAVAAVLIHEAIGEQLTCVFVDHGLLRMNEREQVERLFRDHYNIPLVVVDAEERFMAGLAGITDPEQKR
KFIGAEFINVFEEEARKIGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRLLG
KELGLPDIFVGRHPFPGPGLAIRIPGEVSKERCDILRKADAVYLEEIRNAGLYDAIWQAFAVLLPVKTVGVMGDGRTYDH
VCALRAVTSTDGMTADIYPFDASFLSRCATRIINEVQGINRVVYDYTSKPPGTIEWE

Sequences:

>Translated_537_residues
MARLPYRPAMPTPDPSAAPESILIIDFGSQVTQLIARRVREAGVYSEIVPFSAAEAALARMRPKGVILSGSPASVPAEGS
PRAPRSIFDSGLPILGICYGQQVMSQQLGGKVEPGGIDGERDGEFGRAFLTVTEPCVLFDGLWQVGERHQVWMSHGDRVT
RFAPGFRIVAVSDGAPFAVIANDERRYYGTQFHPEVVHTPDGAKLIANFVRHVCGCSGDWTMAEFRTTKIAEIRAQVGDQ
RVLCGLSGGVDSAVAAVLIHEAIGEQLTCVFVDHGLLRMNEREQVERLFRDHYNIPLVVVDAEERFMAGLAGITDPEQKR
KFIGAEFINVFEEEARKIGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRLLG
KELGLPDIFVGRHPFPGPGLAIRIPGEVSKERCDILRKADAVYLEEIRNAGLYDAIWQAFAVLLPVKTVGVMGDGRTYDH
VCALRAVTSTDGMTADIYPFDASFLSRCATRIINEVQGINRVVYDYTSKPPGTIEWE
>Mature_536_residues
ARLPYRPAMPTPDPSAAPESILIIDFGSQVTQLIARRVREAGVYSEIVPFSAAEAALARMRPKGVILSGSPASVPAEGSP
RAPRSIFDSGLPILGICYGQQVMSQQLGGKVEPGGIDGERDGEFGRAFLTVTEPCVLFDGLWQVGERHQVWMSHGDRVTR
FAPGFRIVAVSDGAPFAVIANDERRYYGTQFHPEVVHTPDGAKLIANFVRHVCGCSGDWTMAEFRTTKIAEIRAQVGDQR
VLCGLSGGVDSAVAAVLIHEAIGEQLTCVFVDHGLLRMNEREQVERLFRDHYNIPLVVVDAEERFMAGLAGITDPEQKRK
FIGAEFINVFEEEARKIGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRLLGK
ELGLPDIFVGRHPFPGPGLAIRIPGEVSKERCDILRKADAVYLEEIRNAGLYDAIWQAFAVLLPVKTVGVMGDGRTYDHV
CALRAVTSTDGMTADIYPFDASFLSRCATRIINEVQGINRVVYDYTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=569, Percent_Identity=36.5553602811951, Blast_Score=306, Evalue=3e-83,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=55.8541266794626, Blast_Score=580, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=37.7391304347826, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71992717, Length=575, Percent_Identity=37.7391304347826, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=37.5432525951557, Blast_Score=301, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6323873, Length=525, Percent_Identity=52.7619047619048, Blast_Score=535, Evalue=1e-153,
Organism=Drosophila melanogaster, GI281365319, Length=554, Percent_Identity=34.4765342960289, Blast_Score=274, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58837; Mature: 58706

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLPYRPAMPTPDPSAAPESILIIDFGSQVTQLIARRVREAGVYSEIVPFSAAEAALAR
CCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHH
MRPKGVILSGSPASVPAEGSPRAPRSIFDSGLPILGICYGQQVMSQQLGGKVEPGGIDGE
CCCCCEEEECCCCCCCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCC
RDGEFGRAFLTVTEPCVLFDGLWQVGERHQVWMSHGDRVTRFAPGFRIVAVSDGAPFAVI
CCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCEEEEEECCCCCEEEE
ANDERRYYGTQFHPEVVHTPDGAKLIANFVRHVCGCSGDWTMAEFRTTKIAEIRAQVGDQ
ECCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
RVLCGLSGGVDSAVAAVLIHEAIGEQLTCVFVDHGLLRMNEREQVERLFRDHYNIPLVVV
EEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHHHCCCCCEEEE
DAEERFMAGLAGITDPEQKRKFIGAEFINVFEEEARKIGGADFLAQGTLYPDVIESVSFT
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCC
GGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRLLGKELGLPDIFVGRHPFPGPGL
CCCEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCE
AIRIPGEVSKERCDILRKADAVYLEEIRNAGLYDAIWQAFAVLLPVKTVGVMGDGRTYDH
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHH
VCALRAVTSTDGMTADIYPFDASFLSRCATRIINEVQGINRVVYDYTSKPPGTIEWE
HHHHHEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCC
>Mature Secondary Structure 
ARLPYRPAMPTPDPSAAPESILIIDFGSQVTQLIARRVREAGVYSEIVPFSAAEAALAR
CCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHH
MRPKGVILSGSPASVPAEGSPRAPRSIFDSGLPILGICYGQQVMSQQLGGKVEPGGIDGE
CCCCCEEEECCCCCCCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCC
RDGEFGRAFLTVTEPCVLFDGLWQVGERHQVWMSHGDRVTRFAPGFRIVAVSDGAPFAVI
CCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCEEEEEECCCCCEEEE
ANDERRYYGTQFHPEVVHTPDGAKLIANFVRHVCGCSGDWTMAEFRTTKIAEIRAQVGDQ
ECCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
RVLCGLSGGVDSAVAAVLIHEAIGEQLTCVFVDHGLLRMNEREQVERLFRDHYNIPLVVV
EEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHHHCCCCCEEEE
DAEERFMAGLAGITDPEQKRKFIGAEFINVFEEEARKIGGADFLAQGTLYPDVIESVSFT
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCC
GGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRLLGKELGLPDIFVGRHPFPGPGL
CCCEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCE
AIRIPGEVSKERCDILRKADAVYLEEIRNAGLYDAIWQAFAVLLPVKTVGVMGDGRTYDH
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHH
VCALRAVTSTDGMTADIYPFDASFLSRCATRIINEVQGINRVVYDYTSKPPGTIEWE
HHHHHEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA