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The map label for this gene is yqeC [H]

Identifier: 103485611

GI number: 103485611

Start: 112555

End: 113532

Strand: Direct

Name: yqeC [H]

Synonym: Sala_0114

Alternate gene names: 103485611

Gene position: 112555-113532 (Clockwise)

Preceding gene: 103485610

Following gene: 103485612

Centisome position: 3.36

GC content: 61.55

Gene sequence:

>978_bases
ATGCGTCTTGCAATGATCGGCCTCGGCCGCATGGGTGCCAATATCGCGCGTCGGCTGATGCGCGGCGGCCACGAGGTCGT
CGCCTTCAATCGCGATCCGGCCGCGGTTACTCAGCTCGCCGGTGAAGGTGCCATCGGAGCGAATTCGCTTGAAGATGTCG
TCGCCAAACTCACTGCGCCGCGGATCTTCTGGGTAATGCTCCCGGCGGGCGCTCCCACCCAAGACACGGTCGACAAGCTG
ATGGAATTGTCGGAGCCCGGCGACATCATCATCGATGGCGGCAACAGCTTCTACAAAGACGACATCAAATGTGGTGCTGC
GGCAAGGGACAAGGGGCTCCATTATATCGATGTTGGCACATCAGGCGGGATATGGGGGCTCGAACGCGGTTATTGCATGA
TGATCGGCGGCGACAAGGAGATCGTCGATCTGCTGGATCCCATCTTCGATACGCTCGCGCCGGGCTATGGTTCGATCGTC
CGCACCATTGGACGCGACGCGCCCGACAGTCGCGCCGAGCGCGGCTATATCCACGCCGGCCCAACCGGCGCCGGGCATTT
CGTCAAGATGGTCCACAACGGAATCGAATATGGCCTGATGCAGGCCTATGCCGAGGGCTTCGACATTCTCAAGGGCAAGT
CCTCCGAACGGCTCGAGCCTGATGAACGCTTCGACATCAACCTGACCGACGTGGCCGAAGTCTGGCGTCGCGGCAGTGTC
ATCTCGTCCTGGCTGCTCGACCTTTGCGCGATCGGCCTGGCCAGGGATCCGATGCTCGAGCAATTCACCGGCCAGGTCTC
GGACTCTGGCGAGGGCCGGTGGACGATCGATGCGGCAATGGAAGAAGCCGTCCCGGCCTATGTCCTTTCGGCCGCCTTGT
TTGCGCGCTACCGCAGCCGCGTCGACCACACTTTTGGCGACAAGCTTCTCTCGGCGATGCGCTTTGGCTTCGGTGGGCAT
GTCGAGATGCCGCAATAA

Upstream 100 bases:

>100_bases
TAACCTGCCAGCGAGCGGTGCGGTCTCGTTGGATCGTGACGGCGGGGCGTTGGTCGGAACTGTCCGCGCCGGGTGAACTT
CTGACAGAAGGATTTGAACA

Downstream 100 bases:

>100_bases
GTGACGCGTCACGCTATCCGGCGCTATGAAAACTATAGGCACAGCCTATTGGAAAAACGTCTGGCTCACTGCGATAGTCG
GCGCAACGGCTGACACAGAA

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MRLAMIGLGRMGANIARRLMRGGHEVVAFNRDPAAVTQLAGEGAIGANSLEDVVAKLTAPRIFWVMLPAGAPTQDTVDKL
MELSEPGDIIIDGGNSFYKDDIKCGAAARDKGLHYIDVGTSGGIWGLERGYCMMIGGDKEIVDLLDPIFDTLAPGYGSIV
RTIGRDAPDSRAERGYIHAGPTGAGHFVKMVHNGIEYGLMQAYAEGFDILKGKSSERLEPDERFDINLTDVAEVWRRGSV
ISSWLLDLCAIGLARDPMLEQFTGQVSDSGEGRWTIDAAMEEAVPAYVLSAALFARYRSRVDHTFGDKLLSAMRFGFGGH
VEMPQ

Sequences:

>Translated_325_residues
MRLAMIGLGRMGANIARRLMRGGHEVVAFNRDPAAVTQLAGEGAIGANSLEDVVAKLTAPRIFWVMLPAGAPTQDTVDKL
MELSEPGDIIIDGGNSFYKDDIKCGAAARDKGLHYIDVGTSGGIWGLERGYCMMIGGDKEIVDLLDPIFDTLAPGYGSIV
RTIGRDAPDSRAERGYIHAGPTGAGHFVKMVHNGIEYGLMQAYAEGFDILKGKSSERLEPDERFDINLTDVAEVWRRGSV
ISSWLLDLCAIGLARDPMLEQFTGQVSDSGEGRWTIDAAMEEAVPAYVLSAALFARYRSRVDHTFGDKLLSAMRFGFGGH
VEMPQ
>Mature_325_residues
MRLAMIGLGRMGANIARRLMRGGHEVVAFNRDPAAVTQLAGEGAIGANSLEDVVAKLTAPRIFWVMLPAGAPTQDTVDKL
MELSEPGDIIIDGGNSFYKDDIKCGAAARDKGLHYIDVGTSGGIWGLERGYCMMIGGDKEIVDLLDPIFDTLAPGYGSIV
RTIGRDAPDSRAERGYIHAGPTGAGHFVKMVHNGIEYGLMQAYAEGFDILKGKSSERLEPDERFDINLTDVAEVWRRGSV
ISSWLLDLCAIGLARDPMLEQFTGQVSDSGEGRWTIDAAMEEAVPAYVLSAALFARYRSRVDHTFGDKLLSAMRFGFGGH
VEMPQ

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=330, Percent_Identity=33.6363636363636, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1788341, Length=315, Percent_Identity=31.4285714285714, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI145693186, Length=213, Percent_Identity=23.943661971831, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=307, Percent_Identity=34.5276872964169, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321695, Length=310, Percent_Identity=33.5483870967742, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321977, Length=311, Percent_Identity=33.4405144694534, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24639279, Length=307, Percent_Identity=34.5276872964169, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 35216; Mature: 35216

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLAMIGLGRMGANIARRLMRGGHEVVAFNRDPAAVTQLAGEGAIGANSLEDVVAKLTAP
CEEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHCCC
RIFWVMLPAGAPTQDTVDKLMELSEPGDIIIDGGNSFYKDDIKCGAAARDKGLHYIDVGT
EEEEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCCHHHCCCEEEEECC
SGGIWGLERGYCMMIGGDKEIVDLLDPIFDTLAPGYGSIVRTIGRDAPDSRAERGYIHAG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHCCEEECC
PTGAGHFVKMVHNGIEYGLMQAYAEGFDILKGKSSERLEPDERFDINLTDVAEVWRRGSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCHH
ISSWLLDLCAIGLARDPMLEQFTGQVSDSGEGRWTIDAAMEEAVPAYVLSAALFARYRSR
HHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
VDHTFGDKLLSAMRFGFGGHVEMPQ
HHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRLAMIGLGRMGANIARRLMRGGHEVVAFNRDPAAVTQLAGEGAIGANSLEDVVAKLTAP
CEEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHCCC
RIFWVMLPAGAPTQDTVDKLMELSEPGDIIIDGGNSFYKDDIKCGAAARDKGLHYIDVGT
EEEEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCCHHHCCCEEEEECC
SGGIWGLERGYCMMIGGDKEIVDLLDPIFDTLAPGYGSIVRTIGRDAPDSRAERGYIHAG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHCCEEECC
PTGAGHFVKMVHNGIEYGLMQAYAEGFDILKGKSSERLEPDERFDINLTDVAEVWRRGSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCHH
ISSWLLDLCAIGLARDPMLEQFTGQVSDSGEGRWTIDAAMEEAVPAYVLSAALFARYRSR
HHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
VDHTFGDKLLSAMRFGFGGHVEMPQ
HHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]