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The map label for this gene is rnc [H]

Identifier: 197294673

GI number: 197294673

Start: 626210

End: 626878

Strand: Reverse

Name: rnc [H]

Synonym: PAa_0631

Alternate gene names: 197294673

Gene position: 626878-626210 (Counterclockwise)

Preceding gene: 197294674

Following gene: 197294672

Centisome position: 71.24

GC content: 29.75

Gene sequence:

>669_bases
ATGAATACTGAACATTTTTTAAAAAAACTAAATATTGTTCCCAAAAACATCGCTTTATACCGCAAAGCTTTAACTCACAG
TTCTTATTCCAATGAAAAAGAATTTTTGCAAGAAAACAATGAAAGATTAGAGTTTTTAGGCGATGCTATTATTGGACTTT
TAATGGCAGACTATTTATACCAAAAAAATAAGGAAAATGAAGGCGTTATGACTAAAAAGAGAGCTCAAGCTGTTTGTGAA
AAGTCTTTAACCATTTATGCCAAAAGTATTAATTTACAAAATTATCTTTTTTTAGGAAAAGGAGAAAAAAACAAAGATTT
TAATACCAAAAGCATTATTGCTGATGCTTTTGAAGCTTTGTTTGGTGCTATTTATCTAGATTTGGGTTATAATTCCGCTA
AAAAAGTTTTTCAAAGATTGGTCATTCCTCATTTGCCAAAAGCAATTGACATTATTGATTTTAAAACACAATTGCAAGAA
ATAGTACAATCCGAAAAAAAGATTATTCAATACAAAATAGTTTCAGAAGAGGGACCTGCACATTCCAAAAAATTTATCGC
CGAAGTTTATTTAGACAAAAAAATATTAGGGAGCGGTGAAGGGACAACCAAAAAAGAAGCAGAACAAAAAGCCGCTCAAG
AAGCGTTATCAAAATTAGCAAAAAGATAA

Upstream 100 bases:

>100_bases
CTCAAGCTTATGCTTTTTGTCAAGCTATTTTGCAAGCTCAAAAAATGATTGCGGCCAATATTAATCAAAAAATTAGTCAA
ATATTAGAGAAACAAGCATC

Downstream 100 bases:

>100_bases
CTAGGGTAAGGTTTTTGTATTTGCTACAATTACAAAATAAAATACAAAATAAAAAAAACAAATAAAAAAAAATAACCCCC
CCGAGAGAGTCATTATTAAA

Product: DsRNA-specific ribonuclease

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MNTEHFLKKLNIVPKNIALYRKALTHSSYSNEKEFLQENNERLEFLGDAIIGLLMADYLYQKNKENEGVMTKKRAQAVCE
KSLTIYAKSINLQNYLFLGKGEKNKDFNTKSIIADAFEALFGAIYLDLGYNSAKKVFQRLVIPHLPKAIDIIDFKTQLQE
IVQSEKKIIQYKIVSEEGPAHSKKFIAEVYLDKKILGSGEGTTKKEAEQKAAQEALSKLAKR

Sequences:

>Translated_222_residues
MNTEHFLKKLNIVPKNIALYRKALTHSSYSNEKEFLQENNERLEFLGDAIIGLLMADYLYQKNKENEGVMTKKRAQAVCE
KSLTIYAKSINLQNYLFLGKGEKNKDFNTKSIIADAFEALFGAIYLDLGYNSAKKVFQRLVIPHLPKAIDIIDFKTQLQE
IVQSEKKIIQYKIVSEEGPAHSKKFIAEVYLDKKILGSGEGTTKKEAEQKAAQEALSKLAKR
>Mature_222_residues
MNTEHFLKKLNIVPKNIALYRKALTHSSYSNEKEFLQENNERLEFLGDAIIGLLMADYLYQKNKENEGVMTKKRAQAVCE
KSLTIYAKSINLQNYLFLGKGEKNKDFNTKSIIADAFEALFGAIYLDLGYNSAKKVFQRLVIPHLPKAIDIIDFKTQLQE
IVQSEKKIIQYKIVSEEGPAHSKKFIAEVYLDKKILGSGEGTTKKEAEQKAAQEALSKLAKR

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=190, Percent_Identity=28.4210526315789, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI155030236, Length=190, Percent_Identity=28.4210526315789, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1788920, Length=210, Percent_Identity=32.8571428571429, Blast_Score=91, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=231, Percent_Identity=27.7056277056277, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17506883, Length=231, Percent_Identity=27.7056277056277, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17137682, Length=222, Percent_Identity=29.2792792792793, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25268; Mature: 25268

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTEHFLKKLNIVPKNIALYRKALTHSSYSNEKEFLQENNERLEFLGDAIIGLLMADYLY
CCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QKNKENEGVMTKKRAQAVCEKSLTIYAKSINLQNYLFLGKGEKNKDFNTKSIIADAFEAL
HCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHH
FGAIYLDLGYNSAKKVFQRLVIPHLPKAIDIIDFKTQLQEIVQSEKKIIQYKIVSEEGPA
HHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
HSKKFIAEVYLDKKILGSGEGTTKKEAEQKAAQEALSKLAKR
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTEHFLKKLNIVPKNIALYRKALTHSSYSNEKEFLQENNERLEFLGDAIIGLLMADYLY
CCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QKNKENEGVMTKKRAQAVCEKSLTIYAKSINLQNYLFLGKGEKNKDFNTKSIIADAFEAL
HCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHH
FGAIYLDLGYNSAKKVFQRLVIPHLPKAIDIIDFKTQLQEIVQSEKKIIQYKIVSEEGPA
HHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
HSKKFIAEVYLDKKILGSGEGTTKKEAEQKAAQEALSKLAKR
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA