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The map label for this gene is dnaX [H]

Identifier: 197294665

GI number: 197294665

Start: 618865

End: 620673

Strand: Direct

Name: dnaX [H]

Synonym: PAa_0623

Alternate gene names: 197294665

Gene position: 618865-620673 (Clockwise)

Preceding gene: 197294654

Following gene: 197294666

Centisome position: 70.33

GC content: 25.87

Gene sequence:

>1809_bases
TTGGTAGTGTCTTATCTTGTTTTATATAGAAAATATCGACCTCAAACTTTTCAAGACGTTGTCGGACAAAAATTTATTAT
TCAAACTTTAAAAAATGCTATTAGATATCAAAAAATTAACCACTGTTATCTTTTCAGCGGAAACAAAGGAACTGGAAAAA
CAACTTTAGCCAAAATATTTGCTAAAGTTATTAATTGCATATATCCTCAATCAGGAGACGTTTGCAATAAATGCACGTCA
TGCCTTGGATCTTTGCAAACAAACAACGATATTGTGGAACTTGACGGAGCTTCTTATAATGGAGTTGATGAAATAAGAGA
GATCCAAGACAAGGCCCAATATAAACCCCACATTGGAAAAAATAAAGTCTATATTATCGATGAAGTTCATGTTTTAACTC
CCAATGCTTTTAACGCTTTATTAAAAATTTTAGAAGAGCCACCAAAACATGTTGTCTTTATTTTAATAACCACACAAATG
CACAAAATTCCTGAAACTATTTTATCCCGTGCGCAAAGTTTTTCTTTTGAAAATTTAAGCCTTGAAAATATCATTTTACA
ATTAAAAAAAATTACCAATTTAGAAAAAATTGTAATTACTGATGATGCTATCAAAGATATTGCTAACTATTCTGAAGGAA
GCATGCGCAATGCTTTAAGTTTATTAGATCAAATAAGTTCTTATCAAAATAATTTAATTACTTCTGAAGATATTGCAGAA
ATCAAAGGAGTTGTATCAGGAAGTTTTTTAAAAAATTTATTTTGTTGCCTTATCGAAAGAAACTACAATCAAGCGTTAAA
ATTACTAAACAAAGCGGTTGATTCAGGGAAAAACCTTGATTTATTAGTTGCCAATTTAATTAATTCCTTAAAAAATTATT
TCTTAGAACAATTAAAACAAAATGAAAAAGAGCAAAATGAAAATTTAGGCAAAAAAAATATAAATAATTACGAGCTTGAG
TTGCAAATTGATTTTATTTTGCAAATTTTTTTAAAATTACAACAAAATTTAAAAAAAAGCAGTCAAAAAAAAGATTTATT
AGAAATTGCTTTTATACAAATATGTTATTTTTCTCCTTCTCATCAAAATTTATCAATATCAGAGACTGAAAAAATCTTAA
AACCAAATGCAACTAAAATTGAAATTGAAAAAACAAAAGTAATTAGCGAAAAAAAACCTGATTTAAATAATTTTTCCAAG
TCAATCCAAAAAAAAGAAGAAGCATTAATTTATCCAAAAAAAGAACAAACGATAACAAATAATACTTCTACTTCTAATTT
TGCTTCTAATTCTTATTTTAAAATTTCTTCTTTAAAAAATTTAGCAGACATTGCTTTAAATATTTTATCCGATAAAAATG
AAAGCCAAAGACAAAAAATCGCTAACGCTTGGCACAAGTTAAATACAAATTATAATTTTTCTTCTAAAAATATCGCTCAA
CTCTTATATAAAGGAAGTATGGCTGCTTTAAGTCAAAAAAAAGAAATGATTTTAGTTTACCAAGACGAAATCGCCTGTAA
ACAAATGTTAAAAGACGTTAACAACAAGATTAAAAATAAAGCTTTAAAAATTTTAAATAATAAAAGTTGTCTTGTTAAAG
ATTATATTTGTTTTTTAGAAAAAGATTATAAAGATTTAGTAACTTTTTTACAAAATAATTCTCCTGACTTAATCGAACAT
TTTTTGGAAAATTGCAATTGGGATCTAGATTTATATAAAACTAGAGAAAAGGCGGAAGAACTATCTTTTATTGTTCAATT
CGCTTATGATTTGTTTGGTAAAGATAAAGTAGAAGTAATAAATGAATGA

Upstream 100 bases:

>100_bases
AAAAAAAATATATTGTGTTATAATAATATAAGAGATTTTTTTAATTAAAATTTTTCGATCATTATATTTTTTTATTTTTT
TTATAAGTGATTAAAAGGAG

Downstream 100 bases:

>100_bases
CTATAGGAGTTAATGCATAAAAATGGACACTCAATCAAATATATTAGAAAAATTAAGAAAAATGCAAGAAACAATTGAAA
ACGTACAAAAACAATTGGAA

Product: DNA polymerase III, gamma/tau subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MVVSYLVLYRKYRPQTFQDVVGQKFIIQTLKNAIRYQKINHCYLFSGNKGTGKTTLAKIFAKVINCIYPQSGDVCNKCTS
CLGSLQTNNDIVELDGASYNGVDEIREIQDKAQYKPHIGKNKVYIIDEVHVLTPNAFNALLKILEEPPKHVVFILITTQM
HKIPETILSRAQSFSFENLSLENIILQLKKITNLEKIVITDDAIKDIANYSEGSMRNALSLLDQISSYQNNLITSEDIAE
IKGVVSGSFLKNLFCCLIERNYNQALKLLNKAVDSGKNLDLLVANLINSLKNYFLEQLKQNEKEQNENLGKKNINNYELE
LQIDFILQIFLKLQQNLKKSSQKKDLLEIAFIQICYFSPSHQNLSISETEKILKPNATKIEIEKTKVISEKKPDLNNFSK
SIQKKEEALIYPKKEQTITNNTSTSNFASNSYFKISSLKNLADIALNILSDKNESQRQKIANAWHKLNTNYNFSSKNIAQ
LLYKGSMAALSQKKEMILVYQDEIACKQMLKDVNNKIKNKALKILNNKSCLVKDYICFLEKDYKDLVTFLQNNSPDLIEH
FLENCNWDLDLYKTREKAEELSFIVQFAYDLFGKDKVEVINE

Sequences:

>Translated_602_residues
MVVSYLVLYRKYRPQTFQDVVGQKFIIQTLKNAIRYQKINHCYLFSGNKGTGKTTLAKIFAKVINCIYPQSGDVCNKCTS
CLGSLQTNNDIVELDGASYNGVDEIREIQDKAQYKPHIGKNKVYIIDEVHVLTPNAFNALLKILEEPPKHVVFILITTQM
HKIPETILSRAQSFSFENLSLENIILQLKKITNLEKIVITDDAIKDIANYSEGSMRNALSLLDQISSYQNNLITSEDIAE
IKGVVSGSFLKNLFCCLIERNYNQALKLLNKAVDSGKNLDLLVANLINSLKNYFLEQLKQNEKEQNENLGKKNINNYELE
LQIDFILQIFLKLQQNLKKSSQKKDLLEIAFIQICYFSPSHQNLSISETEKILKPNATKIEIEKTKVISEKKPDLNNFSK
SIQKKEEALIYPKKEQTITNNTSTSNFASNSYFKISSLKNLADIALNILSDKNESQRQKIANAWHKLNTNYNFSSKNIAQ
LLYKGSMAALSQKKEMILVYQDEIACKQMLKDVNNKIKNKALKILNNKSCLVKDYICFLEKDYKDLVTFLQNNSPDLIEH
FLENCNWDLDLYKTREKAEELSFIVQFAYDLFGKDKVEVINE
>Mature_602_residues
MVVSYLVLYRKYRPQTFQDVVGQKFIIQTLKNAIRYQKINHCYLFSGNKGTGKTTLAKIFAKVINCIYPQSGDVCNKCTS
CLGSLQTNNDIVELDGASYNGVDEIREIQDKAQYKPHIGKNKVYIIDEVHVLTPNAFNALLKILEEPPKHVVFILITTQM
HKIPETILSRAQSFSFENLSLENIILQLKKITNLEKIVITDDAIKDIANYSEGSMRNALSLLDQISSYQNNLITSEDIAE
IKGVVSGSFLKNLFCCLIERNYNQALKLLNKAVDSGKNLDLLVANLINSLKNYFLEQLKQNEKEQNENLGKKNINNYELE
LQIDFILQIFLKLQQNLKKSSQKKDLLEIAFIQICYFSPSHQNLSISETEKILKPNATKIEIEKTKVISEKKPDLNNFSK
SIQKKEEALIYPKKEQTITNNTSTSNFASNSYFKISSLKNLADIALNILSDKNESQRQKIANAWHKLNTNYNFSSKNIAQ
LLYKGSMAALSQKKEMILVYQDEIACKQMLKDVNNKIKNKALKILNNKSCLVKDYICFLEKDYKDLVTFLQNNSPDLIEH
FLENCNWDLDLYKTREKAEELSFIVQFAYDLFGKDKVEVINE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=259, Percent_Identity=27.7992277992278, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI194306571, Length=262, Percent_Identity=27.4809160305344, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI194306567, Length=262, Percent_Identity=27.4809160305344, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI4506491, Length=296, Percent_Identity=25, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI31881687, Length=296, Percent_Identity=25, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI31563534, Length=292, Percent_Identity=25, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI194306569, Length=179, Percent_Identity=27.9329608938547, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786676, Length=374, Percent_Identity=34.2245989304813, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1787119, Length=263, Percent_Identity=25.0950570342205, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17554730, Length=228, Percent_Identity=27.1929824561404, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17541988, Length=299, Percent_Identity=26.0869565217391, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71986063, Length=232, Percent_Identity=28.0172413793103, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=299, Percent_Identity=29.4314381270903, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324478, Length=234, Percent_Identity=29.4871794871795, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322528, Length=302, Percent_Identity=25.8278145695364, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19921076, Length=272, Percent_Identity=27.9411764705882, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI18859927, Length=256, Percent_Identity=28.125, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17647857, Length=292, Percent_Identity=25.3424657534247, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 69061; Mature: 69061

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVSYLVLYRKYRPQTFQDVVGQKFIIQTLKNAIRYQKINHCYLFSGNKGTGKTTLAKIF
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHH
AKVINCIYPQSGDVCNKCTSCLGSLQTNNDIVELDGASYNGVDEIREIQDKAQYKPHIGK
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
NKVYIIDEVHVLTPNAFNALLKILEEPPKHVVFILITTQMHKIPETILSRAQSFSFENLS
CEEEEEEEEEEECCHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCC
LENIILQLKKITNLEKIVITDDAIKDIANYSEGSMRNALSLLDQISSYQNNLITSEDIAE
HHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
IKGVVSGSFLKNLFCCLIERNYNQALKLLNKAVDSGKNLDLLVANLINSLKNYFLEQLKQ
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
NEKEQNENLGKKNINNYELELQIDFILQIFLKLQQNLKKSSQKKDLLEIAFIQICYFSPS
HHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
HQNLSISETEKILKPNATKIEIEKTKVISEKKPDLNNFSKSIQKKEEALIYPKKEQTITN
CCCCCHHHHHHHHCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCCCCCC
NTSTSNFASNSYFKISSLKNLADIALNILSDKNESQRQKIANAWHKLNTNYNFSSKNIAQ
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
LLYKGSMAALSQKKEMILVYQDEIACKQMLKDVNNKIKNKALKILNNKSCLVKDYICFLE
HHHHCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KDYKDLVTFLQNNSPDLIEHFLENCNWDLDLYKTREKAEELSFIVQFAYDLFGKDKVEVI
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
NE
CC
>Mature Secondary Structure
MVVSYLVLYRKYRPQTFQDVVGQKFIIQTLKNAIRYQKINHCYLFSGNKGTGKTTLAKIF
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHH
AKVINCIYPQSGDVCNKCTSCLGSLQTNNDIVELDGASYNGVDEIREIQDKAQYKPHIGK
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
NKVYIIDEVHVLTPNAFNALLKILEEPPKHVVFILITTQMHKIPETILSRAQSFSFENLS
CEEEEEEEEEEECCHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCC
LENIILQLKKITNLEKIVITDDAIKDIANYSEGSMRNALSLLDQISSYQNNLITSEDIAE
HHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
IKGVVSGSFLKNLFCCLIERNYNQALKLLNKAVDSGKNLDLLVANLINSLKNYFLEQLKQ
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
NEKEQNENLGKKNINNYELELQIDFILQIFLKLQQNLKKSSQKKDLLEIAFIQICYFSPS
HHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
HQNLSISETEKILKPNATKIEIEKTKVISEKKPDLNNFSKSIQKKEEALIYPKKEQTITN
CCCCCHHHHHHHHCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCCCCCC
NTSTSNFASNSYFKISSLKNLADIALNILSDKNESQRQKIANAWHKLNTNYNFSSKNIAQ
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
LLYKGSMAALSQKKEMILVYQDEIACKQMLKDVNNKIKNKALKILNNKSCLVKDYICFLE
HHHHCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KDYKDLVTFLQNNSPDLIEHFLENCNWDLDLYKTREKAEELSFIVQFAYDLFGKDKVEVI
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
NE
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]