Click here to switch to the map view.

The map label for this gene is obgE

Identifier: 197294635

GI number: 197294635

Start: 586416

End: 587681

Strand: Reverse

Name: obgE

Synonym: PAa_0591

Alternate gene names: 197294635

Gene position: 587681-586416 (Counterclockwise)

Preceding gene: 197294636

Following gene: 197294634

Centisome position: 66.79

GC content: 31.99

Gene sequence:

>1266_bases
GTGTTTAGTTTGCATTTTATTGATGAGGCTTTTAATGAAGTTTATGCTGGCAACGGCGGTCATGGAATTGTTGCTTTTCG
TAGAGAAAAATATGTTCCTTTCGGCGGTCCTGCTGGTGGAAATGGTGGCAACGGCGGGTCTGTTATTTTTGTCGGAGAAC
AAGGAGAAACAACTTTACTTAAGTTAAAATATCAAAAACACCTTAAAGCTTCTCATGGTTTTAATGGCAAAAATAAGAGT
CAGAATGGTGCCAATGCTCCCCATCTTTATGTAAAAGTCCCCTTAGGAACGGTTTTTTTTACTATGGATAACCATTTTTT
AGGAGAAATTTTACATCATCAAGAAACTTTGGTGATTGCTAAGGGCGGCAAAGGCGGAAGAGGCAACAAAGCATTAGCGA
ATTTTAAAAATCCTGCCCCTAGTTATGCTGAAAAAGGCGATTTAGGTGAGCATTTTAAAATTAAAATCCAATTAAAAGTT
TTAGCTGACGTTGGTTTGCTAGGTTTTCCTAGTGTTGGTAAATCCTCTTTAATTTCTTTAATTTCTAAAGCCCAACCAAA
AATAGATTCTTACCCCTTCACTACTTTATTTCCTCATTTAGGGGTGGTTTTAATTGATGGCTTTAGTTTTGTCATAGCTG
ATTTGCCTGGTTTAATCCCTAATGCTCATTTAGGTCAAGGATTAGGGATTCAATTTTTAAAACATATTGAAAGATGTCGT
GTTTTAGTCCATTTAATTAGTATGCAAAGTCTTGACCCTTATAAAGATTATGTTGCTTTAAATAAAGAGTTGCAACAATA
CAACTCAACTTTAGTTGAAAAAAAACAAATTATTGTAGCTAATAAGATGGATTTACCTGATGCTGAAAAAAAACTAAAAG
ATTTACAAAAAAAGCTTTCGGATGTCACAATTATTCCACTTTCTTTAATTAACTTTTATAACATTGAAAAATTAAAGTAT
GCTATCAAAAATTTGCTTCAAAAAACACCTTTTGTTATCCCTAAACACGACAATTTTAAAGTATATGACCTTAATTCTGA
AACTCAAACTTTTACCATTAATAAAAATAAAGAAGGCGTTTTTGTTGTTTCAGGTCGTCAAGTGGAAATTTTTTCTCATC
GTACTGATTTTAACAATGAAGCAGCTGTCAAAAGATTTAACTATTTGTTAAAGAAAATAGGAATTGAAGAAGCTTTAAAA
CAAAAAGGAGCAAAACTAGGAGATCAAGTAAAAATTTGTAATTATTTATTTGATTTTGTAATTTGA

Upstream 100 bases:

>100_bases
TTGCTAAAATTAGTGGTATTATTAAATATGAATCTAAAAGAGGCAATCGCAAAAAAGTTTCTGTTTATCCTCAATAATTT
TTTTATGCTACTGAAAGAAG

Downstream 100 bases:

>100_bases
TTTTGAAGGTATAAATCCTTTAATTATGTTAAAATAAAGCCAATTTTTTTATATCTTTTATTTAACTTTTTTTACTATCC
GATGTGATTTAGGCAGGAAA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MFSLHFIDEAFNEVYAGNGGHGIVAFRREKYVPFGGPAGGNGGNGGSVIFVGEQGETTLLKLKYQKHLKASHGFNGKNKS
QNGANAPHLYVKVPLGTVFFTMDNHFLGEILHHQETLVIAKGGKGGRGNKALANFKNPAPSYAEKGDLGEHFKIKIQLKV
LADVGLLGFPSVGKSSLISLISKAQPKIDSYPFTTLFPHLGVVLIDGFSFVIADLPGLIPNAHLGQGLGIQFLKHIERCR
VLVHLISMQSLDPYKDYVALNKELQQYNSTLVEKKQIIVANKMDLPDAEKKLKDLQKKLSDVTIIPLSLINFYNIEKLKY
AIKNLLQKTPFVIPKHDNFKVYDLNSETQTFTINKNKEGVFVVSGRQVEIFSHRTDFNNEAAVKRFNYLLKKIGIEEALK
QKGAKLGDQVKICNYLFDFVI

Sequences:

>Translated_421_residues
MFSLHFIDEAFNEVYAGNGGHGIVAFRREKYVPFGGPAGGNGGNGGSVIFVGEQGETTLLKLKYQKHLKASHGFNGKNKS
QNGANAPHLYVKVPLGTVFFTMDNHFLGEILHHQETLVIAKGGKGGRGNKALANFKNPAPSYAEKGDLGEHFKIKIQLKV
LADVGLLGFPSVGKSSLISLISKAQPKIDSYPFTTLFPHLGVVLIDGFSFVIADLPGLIPNAHLGQGLGIQFLKHIERCR
VLVHLISMQSLDPYKDYVALNKELQQYNSTLVEKKQIIVANKMDLPDAEKKLKDLQKKLSDVTIIPLSLINFYNIEKLKY
AIKNLLQKTPFVIPKHDNFKVYDLNSETQTFTINKNKEGVFVVSGRQVEIFSHRTDFNNEAAVKRFNYLLKKIGIEEALK
QKGAKLGDQVKICNYLFDFVI
>Mature_421_residues
MFSLHFIDEAFNEVYAGNGGHGIVAFRREKYVPFGGPAGGNGGNGGSVIFVGEQGETTLLKLKYQKHLKASHGFNGKNKS
QNGANAPHLYVKVPLGTVFFTMDNHFLGEILHHQETLVIAKGGKGGRGNKALANFKNPAPSYAEKGDLGEHFKIKIQLKV
LADVGLLGFPSVGKSSLISLISKAQPKIDSYPFTTLFPHLGVVLIDGFSFVIADLPGLIPNAHLGQGLGIQFLKHIERCR
VLVHLISMQSLDPYKDYVALNKELQQYNSTLVEKKQIIVANKMDLPDAEKKLKDLQKKLSDVTIIPLSLINFYNIEKLKY
AIKNLLQKTPFVIPKHDNFKVYDLNSETQTFTINKNKEGVFVVSGRQVEIFSHRTDFNNEAAVKRFNYLLKKIGIEEALK
QKGAKLGDQVKICNYLFDFVI

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=325, Percent_Identity=37.5384615384615, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI111955139, Length=333, Percent_Identity=33.9339339339339, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI111955063, Length=190, Percent_Identity=36.8421052631579, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI58761500, Length=181, Percent_Identity=27.6243093922652, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789574, Length=304, Percent_Identity=43.0921052631579, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17508313, Length=316, Percent_Identity=40.1898734177215, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17552324, Length=309, Percent_Identity=29.4498381877023, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321962, Length=159, Percent_Identity=39.622641509434, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129375, Length=257, Percent_Identity=38.9105058365759, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24585318, Length=331, Percent_Identity=32.02416918429, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21356473, Length=145, Percent_Identity=33.7931034482759, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_PHYAS (B1VAF2)

Other databases:

- EMBL:   AM422018
- RefSeq:   YP_001799176.1
- ProteinModelPortal:   B1VAF2
- SMR:   B1VAF2
- GeneID:   6799413
- GenomeReviews:   AM422018_GR
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- ProtClustDB:   PRK12297
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 46754; Mature: 46754

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSLHFIDEAFNEVYAGNGGHGIVAFRREKYVPFGGPAGGNGGNGGSVIFVGEQGETTLL
CCEEHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEE
KLKYQKHLKASHGFNGKNKSQNGANAPHLYVKVPLGTVFFTMDNHFLGEILHHQETLVIA
EEEHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCEEEEEECCHHHHHHHCCCCEEEEE
KGGKGGRGNKALANFKNPAPSYAEKGDLGEHFKIKIQLKVLADVGLLGFPSVGKSSLISL
ECCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCHHHHHHH
ISKAQPKIDSYPFTTLFPHLGVVLIDGFSFVIADLPGLIPNAHLGQGLGIQFLKHIERCR
HHHCCCCCCCCCHHHHHHHCCEEEECCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VLVHLISMQSLDPYKDYVALNKELQQYNSTLVEKKQIIVANKMDLPDAEKKLKDLQKKLS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHH
DVTIIPLSLINFYNIEKLKYAIKNLLQKTPFVIPKHDNFKVYDLNSETQTFTINKNKEGV
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCEEEEEECCCCEE
FVVSGRQVEIFSHRTDFNNEAAVKRFNYLLKKIGIEEALKQKGAKLGDQVKICNYLFDFV
EEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHC
I
C
>Mature Secondary Structure
MFSLHFIDEAFNEVYAGNGGHGIVAFRREKYVPFGGPAGGNGGNGGSVIFVGEQGETTLL
CCEEHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEE
KLKYQKHLKASHGFNGKNKSQNGANAPHLYVKVPLGTVFFTMDNHFLGEILHHQETLVIA
EEEHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCEEEEEECCHHHHHHHCCCCEEEEE
KGGKGGRGNKALANFKNPAPSYAEKGDLGEHFKIKIQLKVLADVGLLGFPSVGKSSLISL
ECCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCHHHHHHH
ISKAQPKIDSYPFTTLFPHLGVVLIDGFSFVIADLPGLIPNAHLGQGLGIQFLKHIERCR
HHHCCCCCCCCCHHHHHHHCCEEEECCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VLVHLISMQSLDPYKDYVALNKELQQYNSTLVEKKQIIVANKMDLPDAEKKLKDLQKKLS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHH
DVTIIPLSLINFYNIEKLKYAIKNLLQKTPFVIPKHDNFKVYDLNSETQTFTINKNKEGV
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCEEEEEECCCCEE
FVVSGRQVEIFSHRTDFNNEAAVKRFNYLLKKIGIEEALKQKGAKLGDQVKICNYLFDFV
EEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA