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The map label for this gene is dut [H]

Identifier: 197294565

GI number: 197294565

Start: 512973

End: 513434

Strand: Reverse

Name: dut [H]

Synonym: PAa_0520

Alternate gene names: 197294565

Gene position: 513434-512973 (Counterclockwise)

Preceding gene: 197294566

Following gene: 197294564

Centisome position: 58.35

GC content: 30.74

Gene sequence:

>462_bases
ATGTCTCAAAAAAAAAGGTTTTTTGAAAAAATAACCCTTTATCAAACCGAAAATATTAATCTTCCTCAAAGACAAACCGA
AAAAAGTGGAGGATATGATTTTGAAGCAGCCCAAAATATAGAAATAAAACCACAAACAGTTCAATTAGTTCCTACAGGAA
TTAAGGCTTTTTTTTCTGAAAACGAAACACTCTTGATTTATGCAAGGTCATCTTTGGCTTTGAAAAAACAATTAATGATG
GCAAACGGTGTTGGAGTGGTTGATAGCGATTATTATAATAATTTGCAAAATGAAGGTCATATTTTTATCCCCTTATATAA
TTTTTCTTCTCAAACTGTTAAAATTGAAAAGGGAGAAAGAATAGCCCAAGGGATTTTTCAACCTTTTTTATTAAGCACAA
ATGAAGAAAAACCTTCTTTTTTAAGAAAAGGCGGCTTTGGTAGCACCACTAAAAACAACTAA

Upstream 100 bases:

>100_bases
TAATAATGGAATTAATTTTTTGCAGCAAAAGTAAATATCTGGATGATGAAAAACGCATCAATTTTGATTTTAAAAAATAA
GAAAGGAGTTTTTTAATTTT

Downstream 100 bases:

>100_bases
AAAAGTTATTAATATAACAAATTATTTGCTAAATAGTTTGAAATATGCTAAAATAATTTAGGCAAAAAAATCTCTTTTAT
TTGTTTTTCTTTTCTTAATT

Product: DeoxyUTP pyrophosphatase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MSQKKRFFEKITLYQTENINLPQRQTEKSGGYDFEAAQNIEIKPQTVQLVPTGIKAFFSENETLLIYARSSLALKKQLMM
ANGVGVVDSDYYNNLQNEGHIFIPLYNFSSQTVKIEKGERIAQGIFQPFLLSTNEEKPSFLRKGGFGSTTKNN

Sequences:

>Translated_153_residues
MSQKKRFFEKITLYQTENINLPQRQTEKSGGYDFEAAQNIEIKPQTVQLVPTGIKAFFSENETLLIYARSSLALKKQLMM
ANGVGVVDSDYYNNLQNEGHIFIPLYNFSSQTVKIEKGERIAQGIFQPFLLSTNEEKPSFLRKGGFGSTTKNN
>Mature_152_residues
SQKKRFFEKITLYQTENINLPQRQTEKSGGYDFEAAQNIEIKPQTVQLVPTGIKAFFSENETLLIYARSSLALKKQLMMA
NGVGVVDSDYYNNLQNEGHIFIPLYNFSSQTVKIEKGERIAQGIFQPFLLSTNEEKPSFLRKGGFGSTTKNN

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=141, Percent_Identity=31.2056737588652, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI4503423, Length=141, Percent_Identity=31.2056737588652, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI70906441, Length=141, Percent_Identity=31.2056737588652, Blast_Score=63, Evalue=9e-11,
Organism=Escherichia coli, GI1790071, Length=113, Percent_Identity=34.5132743362832, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 17383; Mature: 17252

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKKRFFEKITLYQTENINLPQRQTEKSGGYDFEAAQNIEIKPQTVQLVPTGIKAFFSE
CCHHHHHHHHHHEEECCCCCCCHHHHHCCCCCCCCCCCCCEECCCEEEEEECCHHHHHCC
NETLLIYARSSLALKKQLMMANGVGVVDSDYYNNLQNEGHIFIPLYNFSSQTVKIEKGER
CCEEEEEECCCHHHHHHHHHHCCCCEECCHHHHCCCCCCEEEEEEECCCCCEEEEECCCH
IAQGIFQPFLLSTNEEKPSFLRKGGFGSTTKNN
HHHHHHHHHEECCCCCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SQKKRFFEKITLYQTENINLPQRQTEKSGGYDFEAAQNIEIKPQTVQLVPTGIKAFFSE
CHHHHHHHHHHEEECCCCCCCHHHHHCCCCCCCCCCCCCEECCCEEEEEECCHHHHHCC
NETLLIYARSSLALKKQLMMANGVGVVDSDYYNNLQNEGHIFIPLYNFSSQTVKIEKGER
CCEEEEEECCCHHHHHHHHHHCCCCEECCHHHHCCCCCCEEEEEEECCCCCEEEEECCCH
IAQGIFQPFLLSTNEEKPSFLRKGGFGSTTKNN
HHHHHHHHHEECCCCCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]