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The map label for this gene is uvrC [H]

Identifier: 197294510

GI number: 197294510

Start: 449680

End: 451473

Strand: Direct

Name: uvrC [H]

Synonym: PAa_0452

Alternate gene names: 197294510

Gene position: 449680-451473 (Clockwise)

Preceding gene: 197294505

Following gene: 197294511

Centisome position: 51.1

GC content: 28.32

Gene sequence:

>1794_bases
ATGTCATCACTTTTAGAAAAAATAAAAAATTTACCACTAAATCCAGGTTGTTATCTTTTTAAAAACAAAAATAATACTAT
TATTTATGTTGGCAAAGCTAAAAAATTGCGAAAAAGAGTACAAAGTTATTTTATTAAAGGGCACAACCGAAAAACAACTT
GTATGGTTCAAGAAATTAGTGATGTTTTTTATGTTATCACTAACAACGAACAAGAAGCCTTAATTTTAGAAGCTAATTTG
ATTAAAGAACATACCCCCAAATATAACTTCAAGCTTTTAGATGACAAAACTTATCCTTATCTTGAAATCACTCAAGAAAA
AGATCCTCAATTAAAAATCTCACGTTTTAAAAAAATCCCCCCAGGAAAAGTTCTTTTCGGACCTTATCCCAATCTCAACA
GTACCAAAGAAACTTTAAAATTACTTCATTTTTTATATCCTTTAAGAAGATGCCCTCTTTCTGCCAAAAAACCTTGTCTT
CATTTTCATATTAATCAATGTTTAGGACCTTGTGCACTTAAAAATGTTGATTATCGTCCCAACATAGAAGCAATTACTAA
TTTTTTAAAAGGCGATACTAAAATTATTTTAAAAAAAATAAAACTTTTAATGCAAGAAGCAAGTCAACAAAGATTTTATG
AAAAAGCTCAAGAATATCGCGATATGCTTATTCACATTCAAAACACCACCAAAAAACAAATTATTAGTCACCAAAAAATA
AAAAATTGCGATATTTTGGCCTATGTTTATAATGACGACCAAATAGCGATTCAAATTTTAAAAATGCAACAAGGAAATAT
TGTTGATTCACATCGTAGTGTTTTTTCTTATGTCGGTTATCCTCAGGAAAATATCAACAATTATCTTGCTTTGTATTATC
AATCAAAACTCAAACCAGAATTAATTATTACTGGCAAAAACACACATAACCTTACTTCTCCAGAAAGCAATACACAACAA
CAAGAAGCCATTTTATTTAGTGCAGAATTATTATCCCAAACCTTAAAAACTAAAGTTGTTGTTGCCAAAATTGGAGATAA
AAAAAAGCTATATTCGTTAGCTTTAAAAAATGCTCAAAATGATTTGATGCAAAATAATTTACTTTACCAAAGCAAAGACC
AAGCGATTCAAGAAGCTTTAGATCAATTAGCAATTATTTTTAATAAAGACATTAAAAGGATTGATGTTTTTGATAATTCA
CAGTTATTTGGTCAAGCTTTTGTTTCAGCACGAATTGTTTTTGATCAGTTTGATTTTAAAAAACCACTTTATCGTGTTTT
TCATATTAAAGATAATGATCCTAATGAATTTACAAGCTTTGAAGAAGTTTTAACTCGTTCTTATCAAAAAAAAGATAAAG
AGGAATTAGTAAAACCAAATTTAATTTTAGTTGATGGCGGTTTGTGGCAATTAAAAGCAGGATTCCAAGCTTTAAACCAA
CTAAATCTTGATATTGCTTTAGGAGCTTTACAAAAAAATGACAAACATCAGTTAGAATGCCTTCTTACTTCGCATAATAA
AATTGCTTTAACTCCAAAACCCCGATTATTCGCCTTTTTAAAAAGATTAAGCGAAGAGGTGCATCGTTTTGTGGTTAAAT
TTCATCATAAAACTAAAAATAAATTAGATTATCAAACCGTTTTATCTCAAATTAAAGGAATTGGTGCCAAACGTCACAAA
ATTATTTTAAATCACTTTAACAGTTGGGAGGATTTAAAAAAGGCTTCTTGGGAAACTTTTGAAAAAATAGGTATTTCCAA
AGAAATTTTTGAAGCAATTAAAAGCAAACTTTAA

Upstream 100 bases:

>100_bases
TAATAAAAATGATAGTGTTTTACAAAAAAATAATTTTTTTAAATTATTAATTAATGAAAAAAATTGCTAATTTATAAAAA
AATAAGGATCGCATTCAATA

Downstream 100 bases:

>100_bases
AAATTAGTTAACAGCAATTGCTTCTTAATTTTTTTGTTTGTTTTAAAAATTATTTTATGGGTAGTTAAAAAGTTTTGAAG
GTTTGTTTTCGTTTTTCATT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MSSLLEKIKNLPLNPGCYLFKNKNNTIIYVGKAKKLRKRVQSYFIKGHNRKTTCMVQEISDVFYVITNNEQEALILEANL
IKEHTPKYNFKLLDDKTYPYLEITQEKDPQLKISRFKKIPPGKVLFGPYPNLNSTKETLKLLHFLYPLRRCPLSAKKPCL
HFHINQCLGPCALKNVDYRPNIEAITNFLKGDTKIILKKIKLLMQEASQQRFYEKAQEYRDMLIHIQNTTKKQIISHQKI
KNCDILAYVYNDDQIAIQILKMQQGNIVDSHRSVFSYVGYPQENINNYLALYYQSKLKPELIITGKNTHNLTSPESNTQQ
QEAILFSAELLSQTLKTKVVVAKIGDKKKLYSLALKNAQNDLMQNNLLYQSKDQAIQEALDQLAIIFNKDIKRIDVFDNS
QLFGQAFVSARIVFDQFDFKKPLYRVFHIKDNDPNEFTSFEEVLTRSYQKKDKEELVKPNLILVDGGLWQLKAGFQALNQ
LNLDIALGALQKNDKHQLECLLTSHNKIALTPKPRLFAFLKRLSEEVHRFVVKFHHKTKNKLDYQTVLSQIKGIGAKRHK
IILNHFNSWEDLKKASWETFEKIGISKEIFEAIKSKL

Sequences:

>Translated_597_residues
MSSLLEKIKNLPLNPGCYLFKNKNNTIIYVGKAKKLRKRVQSYFIKGHNRKTTCMVQEISDVFYVITNNEQEALILEANL
IKEHTPKYNFKLLDDKTYPYLEITQEKDPQLKISRFKKIPPGKVLFGPYPNLNSTKETLKLLHFLYPLRRCPLSAKKPCL
HFHINQCLGPCALKNVDYRPNIEAITNFLKGDTKIILKKIKLLMQEASQQRFYEKAQEYRDMLIHIQNTTKKQIISHQKI
KNCDILAYVYNDDQIAIQILKMQQGNIVDSHRSVFSYVGYPQENINNYLALYYQSKLKPELIITGKNTHNLTSPESNTQQ
QEAILFSAELLSQTLKTKVVVAKIGDKKKLYSLALKNAQNDLMQNNLLYQSKDQAIQEALDQLAIIFNKDIKRIDVFDNS
QLFGQAFVSARIVFDQFDFKKPLYRVFHIKDNDPNEFTSFEEVLTRSYQKKDKEELVKPNLILVDGGLWQLKAGFQALNQ
LNLDIALGALQKNDKHQLECLLTSHNKIALTPKPRLFAFLKRLSEEVHRFVVKFHHKTKNKLDYQTVLSQIKGIGAKRHK
IILNHFNSWEDLKKASWETFEKIGISKEIFEAIKSKL
>Mature_596_residues
SSLLEKIKNLPLNPGCYLFKNKNNTIIYVGKAKKLRKRVQSYFIKGHNRKTTCMVQEISDVFYVITNNEQEALILEANLI
KEHTPKYNFKLLDDKTYPYLEITQEKDPQLKISRFKKIPPGKVLFGPYPNLNSTKETLKLLHFLYPLRRCPLSAKKPCLH
FHINQCLGPCALKNVDYRPNIEAITNFLKGDTKIILKKIKLLMQEASQQRFYEKAQEYRDMLIHIQNTTKKQIISHQKIK
NCDILAYVYNDDQIAIQILKMQQGNIVDSHRSVFSYVGYPQENINNYLALYYQSKLKPELIITGKNTHNLTSPESNTQQQ
EAILFSAELLSQTLKTKVVVAKIGDKKKLYSLALKNAQNDLMQNNLLYQSKDQAIQEALDQLAIIFNKDIKRIDVFDNSQ
LFGQAFVSARIVFDQFDFKKPLYRVFHIKDNDPNEFTSFEEVLTRSYQKKDKEELVKPNLILVDGGLWQLKAGFQALNQL
NLDIALGALQKNDKHQLECLLTSHNKIALTPKPRLFAFLKRLSEEVHRFVVKFHHKTKNKLDYQTVLSQIKGIGAKRHKI
ILNHFNSWEDLKKASWETFEKIGISKEIFEAIKSKL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=615, Percent_Identity=29.2682926829268, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1788037, Length=177, Percent_Identity=28.8135593220339, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69412; Mature: 69280

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2 ; PS00047 HISTONE_H4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLLEKIKNLPLNPGCYLFKNKNNTIIYVGKAKKLRKRVQSYFIKGHNRKTTCMVQEIS
CHHHHHHHHCCCCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCHHHHHEECC
DVFYVITNNEQEALILEANLIKEHTPKYNFKLLDDKTYPYLEITQEKDPQLKISRFKKIP
CEEEEEECCCCCEEEEEEHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHCCCC
PGKVLFGPYPNLNSTKETLKLLHFLYPLRRCPLSAKKPCLHFHINQCLGPCALKNVDYRP
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHCCHHHHCCCCCCC
NIEAITNFLKGDTKIILKKIKLLMQEASQQRFYEKAQEYRDMLIHIQNTTKKQIISHQKI
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHC
KNCDILAYVYNDDQIAIQILKMQQGNIVDSHRSVFSYVGYPQENINNYLALYYQSKLKPE
CCCEEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHHCCCCHHHHCCEEEEEECCCCCCE
LIITGKNTHNLTSPESNTQQQEAILFSAELLSQTLKTKVVVAKIGDKKKLYSLALKNAQN
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHH
DLMQNNLLYQSKDQAIQEALDQLAIIFNKDIKRIDVFDNSQLFGQAFVSARIVFDQFDFK
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHEEHHHCCC
KPLYRVFHIKDNDPNEFTSFEEVLTRSYQKKDKEELVKPNLILVDGGLWQLKAGFQALNQ
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEECCHHHHHHHHHHHHH
LNLDIALGALQKNDKHQLECLLTSHNKIALTPKPRLFAFLKRLSEEVHRFVVKFHHKTKN
CCCEEEEECCCCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLDYQTVLSQIKGIGAKRHKIILNHFNSWEDLKKASWETFEKIGISKEIFEAIKSKL
CCHHHHHHHHHHCCCCCHHHEEEHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SSLLEKIKNLPLNPGCYLFKNKNNTIIYVGKAKKLRKRVQSYFIKGHNRKTTCMVQEIS
HHHHHHHHCCCCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCHHHHHEECC
DVFYVITNNEQEALILEANLIKEHTPKYNFKLLDDKTYPYLEITQEKDPQLKISRFKKIP
CEEEEEECCCCCEEEEEEHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHCCCC
PGKVLFGPYPNLNSTKETLKLLHFLYPLRRCPLSAKKPCLHFHINQCLGPCALKNVDYRP
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHCCHHHHCCCCCCC
NIEAITNFLKGDTKIILKKIKLLMQEASQQRFYEKAQEYRDMLIHIQNTTKKQIISHQKI
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHC
KNCDILAYVYNDDQIAIQILKMQQGNIVDSHRSVFSYVGYPQENINNYLALYYQSKLKPE
CCCEEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHHCCCCHHHHCCEEEEEECCCCCCE
LIITGKNTHNLTSPESNTQQQEAILFSAELLSQTLKTKVVVAKIGDKKKLYSLALKNAQN
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHH
DLMQNNLLYQSKDQAIQEALDQLAIIFNKDIKRIDVFDNSQLFGQAFVSARIVFDQFDFK
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHEEHHHCCC
KPLYRVFHIKDNDPNEFTSFEEVLTRSYQKKDKEELVKPNLILVDGGLWQLKAGFQALNQ
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEECCHHHHHHHHHHHHH
LNLDIALGALQKNDKHQLECLLTSHNKIALTPKPRLFAFLKRLSEEVHRFVVKFHHKTKN
CCCEEEEECCCCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLDYQTVLSQIKGIGAKRHKIILNHFNSWEDLKKASWETFEKIGISKEIFEAIKSKL
CCHHHHHHHHHHCCCCCHHHEEEHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA