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The map label for this gene is tmk [H]

Identifier: 197294494

GI number: 197294494

Start: 428912

End: 429499

Strand: Direct

Name: tmk [H]

Synonym: PAa_0431

Alternate gene names: 197294494

Gene position: 428912-429499 (Clockwise)

Preceding gene: 197294493

Following gene: 197294495

Centisome position: 48.74

GC content: 26.87

Gene sequence:

>588_bases
TTGAAAATAAAGGCTATCAAATCAAAGTTTTTTCAAGGTTTAGGCAGTTCCATCGTTGGAAAAGAAATCAGAAATTTATT
TTTACATCAATCCAAAATAAGCCCTAAAACTAAATATTTATTAAGCCTTGCCAACATGTTGCAAACCCAAGATGAATTAA
TATTCCCTGCTTTATTGAGTGGTTATCTTGTTCTTGTTGACCGTTGGTATGGTTCTACTTTTGCTTATCAAAGCAAAGGC
AATTACATAGATTATGATGATAAAATTACTTCAAAAATCATCAATCATTTCTTAATTAAACCTAAATTAACTTTTTACCT
AGATATTGACCCTAAAATTGGGATACAACGTAAACAAAACCAAACAAATCATAAATTAGACCTCATTGAACGAAAACCTT
TAAATTATTTTGAAAATGTCCGTAAACATTATTTAAACCAACATAAATACTGTAATGATGCAAATTGCAACCACAAAAAT
TGTAATCATTTTTTAATTAATGCAACCAAATCCCAAAAAGATAATTTAGAACAAACCACACAAATATTAATTAAAAAAAT
ATATTATAAAAAAGGAGAAATCAAATGA

Upstream 100 bases:

>100_bases
TTAAAAAGATGGTTCACCCTAATGACAAATAAATTAATTAGTTTTGAAGGTGTTGACGGAAGTGGCAAAACTACTTTAAT
TAATGAATTAAAAAAATATT

Downstream 100 bases:

>100_bases
CAAAAAAAGAATTAATCAAAAACCTCGCAGTAATGAATAACACTTCGGTTACTCAAACTCAAGATTTTTACAATTCGTTT
GAAAATGCTTTAATTGAAGC

Product: Thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MKIKAIKSKFFQGLGSSIVGKEIRNLFLHQSKISPKTKYLLSLANMLQTQDELIFPALLSGYLVLVDRWYGSTFAYQSKG
NYIDYDDKITSKIINHFLIKPKLTFYLDIDPKIGIQRKQNQTNHKLDLIERKPLNYFENVRKHYLNQHKYCNDANCNHKN
CNHFLINATKSQKDNLEQTTQILIKKIYYKKGEIK

Sequences:

>Translated_195_residues
MKIKAIKSKFFQGLGSSIVGKEIRNLFLHQSKISPKTKYLLSLANMLQTQDELIFPALLSGYLVLVDRWYGSTFAYQSKG
NYIDYDDKITSKIINHFLIKPKLTFYLDIDPKIGIQRKQNQTNHKLDLIERKPLNYFENVRKHYLNQHKYCNDANCNHKN
CNHFLINATKSQKDNLEQTTQILIKKIYYKKGEIK
>Mature_195_residues
MKIKAIKSKFFQGLGSSIVGKEIRNLFLHQSKISPKTKYLLSLANMLQTQDELIFPALLSGYLVLVDRWYGSTFAYQSKG
NYIDYDDKITSKIINHFLIKPKLTFYLDIDPKIGIQRKQNQTNHKLDLIERKPLNYFENVRKHYLNQHKYCNDANCNHKN
CNHFLINATKSQKDNLEQTTQILIKKIYYKKGEIK

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=144, Percent_Identity=30.5555555555556, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22935; Mature: 22935

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKAIKSKFFQGLGSSIVGKEIRNLFLHQSKISPKTKYLLSLANMLQTQDELIFPALLS
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GYLVLVDRWYGSTFAYQSKGNYIDYDDKITSKIINHFLIKPKLTFYLDIDPKIGIQRKQN
HHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
QTNHKLDLIERKPLNYFENVRKHYLNQHKYCNDANCNHKNCNHFLINATKSQKDNLEQTT
CCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHH
QILIKKIYYKKGEIK
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MKIKAIKSKFFQGLGSSIVGKEIRNLFLHQSKISPKTKYLLSLANMLQTQDELIFPALLS
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GYLVLVDRWYGSTFAYQSKGNYIDYDDKITSKIINHFLIKPKLTFYLDIDPKIGIQRKQN
HHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
QTNHKLDLIERKPLNYFENVRKHYLNQHKYCNDANCNHKNCNHFLINATKSQKDNLEQTT
CCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHH
QILIKKIYYKKGEIK
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA