Click here to switch to the map view.

The map label for this gene is dnaC [H]

Identifier: 197294285

GI number: 197294285

Start: 176730

End: 178073

Strand: Reverse

Name: dnaC [H]

Synonym: PAa_0148

Alternate gene names: 197294285

Gene position: 178073-176730 (Counterclockwise)

Preceding gene: 197294286

Following gene: 197294284

Centisome position: 20.24

GC content: 29.61

Gene sequence:

>1344_bases
ATGAGTGAATATAACAAAAAAAAGCCTTATAGCCCCGAAGCAGAGCAGGCTTTACTAGGGGTTTTATTATTAAACCCCGA
AAAAGTACCTTTTGTTCTTGATTTGATTAACGAAGATTGCCTTTATGAGGCCAAACATAAATATATTTTTAAAGCGATGA
AGCAACTTCATCAAGAAGGACATGCAATTGATTATGTTTCTGTGAGTTCTTCCTTAGAAAACGAAAAGTTATTAAGTAAA
ATTGGCAACATTGATTATTTAATTGAATTGGTGGAGATGACCCCTGCAAGTGAATATTTAGAAACATATATTGATTTAAT
TAAGGAAACTGCTTTAAAAAGAGAAATTATGGAGACCGCTTCTTACTTAGCTCAAAAAGGATATGACCAAATTGATGTTC
AAAGTTATTTAGATGAAGCAGAAGAAAAAATCTTTAATTTAACTCAAAGAAAAAAAACAAGTGATTTATTAGATTTAAAA
AATTTGTTAAAAGAGATTAAAAGTAAAAATATTCAAGCACAACAAAAAAAAGATTTAGCGGGTTTTTCCACGGGTTTTGA
AAATCTTGACAACATTACTTTAGGTTTGAAACCTGAAGAATTTATTATTATTGCAGCCCGTCCTTCGATGGGTAAAAGTA
CTTTTATGATTAATTTAGCTCTTAATGTAGCTAATTCCAAATATAATTCTCAATCGCCTCATGTTGCTATCTTTAGTTTA
GAGATGTCCAACGAACAACTAGCAATGAGAATGTTGAGTTCTGTTTCCAAAGTAGAACATAAAAAAATTCAATTAAGTCG
CGTTGATAAAGAAGATAAATTAATTTTAGAAATAGCAATTGATAAGATGAATAAATTAAATATTTATTTTGATGATTCGG
CTACAGTGAACATTTTAGATATCAAAGCTAAATGTCGTAAATTAAAAAGCCAAAATAAATTAGATGTTGTTATGATAGAT
TATTTACAATTAATTCGCAAATCTCAAAAAACTAATCGTCAAGAAGAAGTGGCAGAAATTTCTCAAAGCTTAAAACAAAT
AGCTCGTGAATTAAAAATCCCTGTAATTGCTTTATCTCAATTATCAAGGGATGTTGAAAAAAGAGAAGACAAAAGGCCTG
TTTTATCCGATTTAAGAGACTCAGGATCGATAGAACAAGACGCTGATATTGTTATGTTTTTATATCGAGAAGATTATTAT
AAAAAAGAAAGAAATGTAATTCCTGGAAAAGTTCAAGTAATTATTGCCAAAAATCGTCAAGGAGCTGTGGGCGTCCGCGA
ATTTAGTCTTAATTTTGATTTGATGTTGTTTACTGAAATAGAATCTTATGTTAGCGAAAATTGA

Upstream 100 bases:

>100_bases
AAAATGAAATTACTTCTGTAGGTATTTATCATATTGATGTCAATTTAACCGAACAAATTAAGGCTACTTTTTTTCTCAAC
GTAATTGAAAGAAAAAATAA

Downstream 100 bases:

>100_bases
TTTCAAAATCAAACTTTCCTTCCATTGATTTGGTTTATCGAAAATAAAAAAAGAGGAGATAAAAGTTAAATATGCTTGCG
AGACTTAAAAAAATTCAACA

Product: Replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSEYNKKKPYSPEAEQALLGVLLLNPEKVPFVLDLINEDCLYEAKHKYIFKAMKQLHQEGHAIDYVSVSSSLENEKLLSK
IGNIDYLIELVEMTPASEYLETYIDLIKETALKREIMETASYLAQKGYDQIDVQSYLDEAEEKIFNLTQRKKTSDLLDLK
NLLKEIKSKNIQAQQKKDLAGFSTGFENLDNITLGLKPEEFIIIAARPSMGKSTFMINLALNVANSKYNSQSPHVAIFSL
EMSNEQLAMRMLSSVSKVEHKKIQLSRVDKEDKLILEIAIDKMNKLNIYFDDSATVNILDIKAKCRKLKSQNKLDVVMID
YLQLIRKSQKTNRQEEVAEISQSLKQIARELKIPVIALSQLSRDVEKREDKRPVLSDLRDSGSIEQDADIVMFLYREDYY
KKERNVIPGKVQVIIAKNRQGAVGVREFSLNFDLMLFTEIESYVSEN

Sequences:

>Translated_447_residues
MSEYNKKKPYSPEAEQALLGVLLLNPEKVPFVLDLINEDCLYEAKHKYIFKAMKQLHQEGHAIDYVSVSSSLENEKLLSK
IGNIDYLIELVEMTPASEYLETYIDLIKETALKREIMETASYLAQKGYDQIDVQSYLDEAEEKIFNLTQRKKTSDLLDLK
NLLKEIKSKNIQAQQKKDLAGFSTGFENLDNITLGLKPEEFIIIAARPSMGKSTFMINLALNVANSKYNSQSPHVAIFSL
EMSNEQLAMRMLSSVSKVEHKKIQLSRVDKEDKLILEIAIDKMNKLNIYFDDSATVNILDIKAKCRKLKSQNKLDVVMID
YLQLIRKSQKTNRQEEVAEISQSLKQIARELKIPVIALSQLSRDVEKREDKRPVLSDLRDSGSIEQDADIVMFLYREDYY
KKERNVIPGKVQVIIAKNRQGAVGVREFSLNFDLMLFTEIESYVSEN
>Mature_446_residues
SEYNKKKPYSPEAEQALLGVLLLNPEKVPFVLDLINEDCLYEAKHKYIFKAMKQLHQEGHAIDYVSVSSSLENEKLLSKI
GNIDYLIELVEMTPASEYLETYIDLIKETALKREIMETASYLAQKGYDQIDVQSYLDEAEEKIFNLTQRKKTSDLLDLKN
LLKEIKSKNIQAQQKKDLAGFSTGFENLDNITLGLKPEEFIIIAARPSMGKSTFMINLALNVANSKYNSQSPHVAIFSLE
MSNEQLAMRMLSSVSKVEHKKIQLSRVDKEDKLILEIAIDKMNKLNIYFDDSATVNILDIKAKCRKLKSQNKLDVVMIDY
LQLIRKSQKTNRQEEVAEISQSLKQIARELKIPVIALSQLSRDVEKREDKRPVLSDLRDSGSIEQDADIVMFLYREDYYK
KERNVIPGKVQVIIAKNRQGAVGVREFSLNFDLMLFTEIESYVSEN

Specific function: Participates In Initiation And Elongation During Chromosome Replication; It Exhibits DNA-Dependent ATPase Activity And Contains Distinct Active Sites For ATP Binding, DNA Binding, And Interaction With DNAc Protein, Primase, And Other Prepriming Proteins.

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain [H]

Homologues:

Organism=Escherichia coli, GI1790486, Length=441, Percent_Identity=39.2290249433107, Blast_Score=308, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136 [H]

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 51330; Mature: 51199

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEYNKKKPYSPEAEQALLGVLLLNPEKVPFVLDLINEDCLYEAKHKYIFKAMKQLHQEG
CCCCCCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
HAIDYVSVSSSLENEKLLSKIGNIDYLIELVEMTPASEYLETYIDLIKETALKREIMETA
CEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SYLAQKGYDQIDVQSYLDEAEEKIFNLTQRKKTSDLLDLKNLLKEIKSKNIQAQQKKDLA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GFSTGFENLDNITLGLKPEEFIIIAARPSMGKSTFMINLALNVANSKYNSQSPHVAIFSL
HHHHCCCCCCCEEECCCCCEEEEEEECCCCCCCEEEEEEEEEECCCCCCCCCCCEEEEEE
EMSNEQLAMRMLSSVSKVEHKKIQLSRVDKEDKLILEIAIDKMNKLNIYFDDSATVNILD
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCEEEEEE
IKAKCRKLKSQNKLDVVMIDYLQLIRKSQKTNRQEEVAEISQSLKQIARELKIPVIALSQ
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LSRDVEKREDKRPVLSDLRDSGSIEQDADIVMFLYREDYYKKERNVIPGKVQVIIAKNRQ
HHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHCCCCCCEEEEEEEECCC
GAVGVREFSLNFDLMLFTEIESYVSEN
CCCEEEEEECCCEEEEHHHHHHHHCCC
>Mature Secondary Structure 
SEYNKKKPYSPEAEQALLGVLLLNPEKVPFVLDLINEDCLYEAKHKYIFKAMKQLHQEG
CCCCCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
HAIDYVSVSSSLENEKLLSKIGNIDYLIELVEMTPASEYLETYIDLIKETALKREIMETA
CEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SYLAQKGYDQIDVQSYLDEAEEKIFNLTQRKKTSDLLDLKNLLKEIKSKNIQAQQKKDLA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GFSTGFENLDNITLGLKPEEFIIIAARPSMGKSTFMINLALNVANSKYNSQSPHVAIFSL
HHHHCCCCCCCEEECCCCCEEEEEEECCCCCCCEEEEEEEEEECCCCCCCCCCCEEEEEE
EMSNEQLAMRMLSSVSKVEHKKIQLSRVDKEDKLILEIAIDKMNKLNIYFDDSATVNILD
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCEEEEEE
IKAKCRKLKSQNKLDVVMIDYLQLIRKSQKTNRQEEVAEISQSLKQIARELKIPVIALSQ
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LSRDVEKREDKRPVLSDLRDSGSIEQDADIVMFLYREDYYKKERNVIPGKVQVIIAKNRQ
HHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHCCCCCCEEEEEEEECCC
GAVGVREFSLNFDLMLFTEIESYVSEN
CCCEEEEEECCCEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1312531 [H]