BacMap

Definition	Candidatus Phytoplasma australiense, complete genome.
Accession	NC_010544
Length	879,959

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The map label for this gene is gmk [H]

Identifier: 197294243

GI number: 197294243

Start: 115074

End: 115712

Strand: Direct

Name: gmk [H]

Synonym: PAa_0105

Alternate gene names: 197294243

Gene position: 115074-115712 (Clockwise)

Preceding gene: 197294242

Following gene: 197294244

Centisome position: 13.08

GC content: 30.2

Gene sequence:

>639_bases
ATGAAATTAAACCAAAAAGGGCTTTTAATAGTTCTTTCAGGCCCTTCTGGCGTTGGCAAAGCAACAGTTAGAAAAGCTTT
ATTTGAAATGAAAAATCATAATTTTGTTTATTCTATTTCATCAACAACAAGAAAACCTAGATTAGGCGAACAAGAAGGAA
AAGACTATTATTTTCTCACTAAAGAAGAATTTGAATTAGGAATCAAAAATAACAAATTTTTAGAATGGGCTAAATTTATT
GATAATTATTATGGTACTTCTCGTAAACAAGTGGAAGATTACCTAAAAGAAGGCAAAGAAGTTTTTTTAGAAATCGAAGT
AGAAGGGGCAACCCAATTAAGAAAAAAAAAGTTTCGTAATGCAGTTTTCATTTTTTTAGTTCCTCCTGAAAAAAAAGTCC
TTTATGAAAGGTTGAAAAAAAGGGGAACAGAATCAGCCGACAAAATACAACAACGTATTATGAAAGCTGATAAAGAATTC
CCTTTAGCTCATAAATATGATTATATTGTTGTTAATGATGATGTTTTCAATGCCGCTGATCGGATTATTGCAATTATTAG
AGCGGAACATGCAAAAACTAAACGTAGTATTCGTAATTATTTAAAGATTTTGGAGAATGATGGTTATGCCGAACAATAA

Upstream 100 bases:

>100_bases
TTTAATTTTGCTTTTAAATTCTTAATAAAATTCAAGAAGTGTTTTTTCAAATTCTATTCAAATAAGTTTATGTAAATTTT
GGAGAAAAAGGTATGTTAAG

Downstream 100 bases:

>100_bases
ACAAATGAATAAAGAAGGTTTAAGTTATCCTTCGATTGATAAATTATTAGATAAAGTTGATTCTAAATATAAATTAGTTC
ATATAGCTAGTAAAATAGCT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKLNQKGLLIVLSGPSGVGKATVRKALFEMKNHNFVYSISSTTRKPRLGEQEGKDYYFLTKEEFELGIKNNKFLEWAKFI
DNYYGTSRKQVEDYLKEGKEVFLEIEVEGATQLRKKKFRNAVFIFLVPPEKKVLYERLKKRGTESADKIQQRIMKADKEF
PLAHKYDYIVVNDDVFNAADRIIAIIRAEHAKTKRSIRNYLKILENDGYAEQ

Sequences:

>Translated_212_residues
MKLNQKGLLIVLSGPSGVGKATVRKALFEMKNHNFVYSISSTTRKPRLGEQEGKDYYFLTKEEFELGIKNNKFLEWAKFI
DNYYGTSRKQVEDYLKEGKEVFLEIEVEGATQLRKKKFRNAVFIFLVPPEKKVLYERLKKRGTESADKIQQRIMKADKEF
PLAHKYDYIVVNDDVFNAADRIIAIIRAEHAKTKRSIRNYLKILENDGYAEQ
>Mature_212_residues
MKLNQKGLLIVLSGPSGVGKATVRKALFEMKNHNFVYSISSTTRKPRLGEQEGKDYYFLTKEEFELGIKNNKFLEWAKFI
DNYYGTSRKQVEDYLKEGKEVFLEIEVEGATQLRKKKFRNAVFIFLVPPEKKVLYERLKKRGTESADKIQQRIMKADKEF
PLAHKYDYIVVNDDVFNAADRIIAIIRAEHAKTKRSIRNYLKILENDGYAEQ

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=190, Percent_Identity=33.1578947368421, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4504221, Length=190, Percent_Identity=33.1578947368421, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI226874831, Length=190, Percent_Identity=33.1578947368421, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI38570142, Length=179, Percent_Identity=29.0502793296089, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI262118255, Length=166, Percent_Identity=30.7228915662651, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI4505237, Length=166, Percent_Identity=30.7228915662651, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI262118259, Length=166, Percent_Identity=30.7228915662651, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI262118263, Length=166, Percent_Identity=30.7228915662651, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI14780902, Length=194, Percent_Identity=26.8041237113402, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI119943106, Length=178, Percent_Identity=30.3370786516854, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI186972120, Length=166, Percent_Identity=27.710843373494, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI186700629, Length=166, Percent_Identity=27.710843373494, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI186700627, Length=166, Percent_Identity=27.710843373494, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI119943108, Length=178, Percent_Identity=30.3370786516854, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI261862237, Length=178, Percent_Identity=30.3370786516854, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI111154074, Length=165, Percent_Identity=32.1212121212121, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI21389483, Length=204, Percent_Identity=27.4509803921569, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI21361598, Length=191, Percent_Identity=27.2251308900524, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21536464, Length=185, Percent_Identity=26.4864864864865, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI148539628, Length=153, Percent_Identity=30.0653594771242, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI148539578, Length=153, Percent_Identity=30.0653594771242, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI218156338, Length=153, Percent_Identity=30.0653594771242, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1790080, Length=191, Percent_Identity=40.8376963350785, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193203132, Length=190, Percent_Identity=38.9473684210526, Blast_Score=136, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17508835, Length=190, Percent_Identity=38.9473684210526, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71988041, Length=179, Percent_Identity=30.7262569832402, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71988048, Length=179, Percent_Identity=30.7262569832402, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17557440, Length=168, Percent_Identity=29.1666666666667, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71984092, Length=151, Percent_Identity=27.1523178807947, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17556244, Length=119, Percent_Identity=33.6134453781513, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=42.8571428571429, Blast_Score=149, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21356141, Length=151, Percent_Identity=41.7218543046358, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI161077626, Length=180, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24640542, Length=180, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45554489, Length=180, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI85724806, Length=180, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI281362230, Length=167, Percent_Identity=26.3473053892216, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648808, Length=167, Percent_Identity=26.3473053892216, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330166, Length=186, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221330164, Length=186, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221330162, Length=186, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI85816281, Length=137, Percent_Identity=29.1970802919708, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI85816106, Length=137, Percent_Identity=29.1970802919708, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI161078487, Length=167, Percent_Identity=26.3473053892216, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45551002, Length=137, Percent_Identity=29.1970802919708, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI161078485, Length=167, Percent_Identity=26.3473053892216, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24648810, Length=167, Percent_Identity=26.3473053892216, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281362232, Length=167, Percent_Identity=26.3473053892216, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45554804, Length=160, Percent_Identity=26.25, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281360700, Length=160, Percent_Identity=26.25, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641282, Length=160, Percent_Identity=26.25, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45554818, Length=160, Percent_Identity=26.25, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641280, Length=160, Percent_Identity=26.25, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161077752, Length=160, Percent_Identity=26.25, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24769; Mature: 24769

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNQKGLLIVLSGPSGVGKATVRKALFEMKNHNFVYSISSTTRKPRLGEQEGKDYYFLT
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEE
KEEFELGIKNNKFLEWAKFIDNYYGTSRKQVEDYLKEGKEVFLEIEVEGATQLRKKKFRN
HHHHEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCC
AVFIFLVPPEKKVLYERLKKRGTESADKIQQRIMKADKEFPLAHKYDYIVVNDDVFNAAD
EEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHH
RIIAIIRAEHAKTKRSIRNYLKILENDGYAEQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKLNQKGLLIVLSGPSGVGKATVRKALFEMKNHNFVYSISSTTRKPRLGEQEGKDYYFLT
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEE
KEEFELGIKNNKFLEWAKFIDNYYGTSRKQVEDYLKEGKEVFLEIEVEGATQLRKKKFRN
HHHHEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCC
AVFIFLVPPEKKVLYERLKKRGTESADKIQQRIMKADKEFPLAHKYDYIVVNDDVFNAAD
EEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHH
RIIAIIRAEHAKTKRSIRNYLKILENDGYAEQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA