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The map label for this gene is tmk [H]

Identifier: 197294197

GI number: 197294197

Start: 43168

End: 43815

Strand: Direct

Name: tmk [H]

Synonym: PAa_0039

Alternate gene names: 197294197

Gene position: 43168-43815 (Clockwise)

Preceding gene: 197294196

Following gene: 197294198

Centisome position: 4.91

GC content: 27.78

Gene sequence:

>648_bases
ATGACAAATAAATTAATTAGTTTTGAAGGTATTGACGGAAGTGGCAAAACTACTTTAATTAACGAATTAAAAGCTTTTTT
TGAAAATAAAGGCTATAAAACCAAAGTTTTTCAAGGTTTAGGCAGTTCCATCGTTGGAAAAGAAATCAGAAATTTATTTT
TACATCAATCCAAAATAAGCCCTAAAACTAAATATTTATTAAGCCTTGCCAACATGATGCAATCCCAAGATGAATTAATA
ATCCCTGCTTTATTGAGTGGTTGTCTTGTTCTAGTGGACCGTTGGTATGATTCTACTTTTGCGTATCAAAGCAAAGGTAA
TTACATAGATTATGATGATAAAATTACTTCAAAAATCATCAATTATTTCTTAATTAAACCTAAATTAACTTTTTACCTAG
ATATTGACCCTAAAATTGGGCTAAAACGAAAACAAACCCAATCAAATCATAAATTAGACCTCATTGAGAAAAAACCCTTA
AATTATTTTAAAAATGTCCGCGCACATTATTTAAACCAACAAAAATACTGTAATGATTCAAATTGTAAACACCAAAATTG
CCATCATTTCTTAATTAACGCAACCAACTCGCAAAAAGAAAATTTAGACCAAATAATGAAAATTTTAATCAACAAACAAA
TATTTTAA

Upstream 100 bases:

>100_bases
TTATTTTCCAATTCAGCTAATCTCTTCTTACAAAACTTACTAACCAACCAATTCATTCCCTTTTCACCTATTAATTTAAT
TAAAAAGATGGTTCGCCCTA

Downstream 100 bases:

>100_bases
TTAAAGGAGCATAAATAATATGAATTATCAAAAAACTTTTTATCGCAAAGGAATTAAAACAGCTATAAAATTTGTTGCTG
AATATAGCCCAGATGGTAAA

Product: Thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MTNKLISFEGIDGSGKTTLINELKAFFENKGYKTKVFQGLGSSIVGKEIRNLFLHQSKISPKTKYLLSLANMMQSQDELI
IPALLSGCLVLVDRWYDSTFAYQSKGNYIDYDDKITSKIINYFLIKPKLTFYLDIDPKIGLKRKQTQSNHKLDLIEKKPL
NYFKNVRAHYLNQQKYCNDSNCKHQNCHHFLINATNSQKENLDQIMKILINKQIF

Sequences:

>Translated_215_residues
MTNKLISFEGIDGSGKTTLINELKAFFENKGYKTKVFQGLGSSIVGKEIRNLFLHQSKISPKTKYLLSLANMMQSQDELI
IPALLSGCLVLVDRWYDSTFAYQSKGNYIDYDDKITSKIINYFLIKPKLTFYLDIDPKIGLKRKQTQSNHKLDLIEKKPL
NYFKNVRAHYLNQQKYCNDSNCKHQNCHHFLINATNSQKENLDQIMKILINKQIF
>Mature_214_residues
TNKLISFEGIDGSGKTTLINELKAFFENKGYKTKVFQGLGSSIVGKEIRNLFLHQSKISPKTKYLLSLANMMQSQDELII
PALLSGCLVLVDRWYDSTFAYQSKGNYIDYDDKITSKIINYFLIKPKLTFYLDIDPKIGLKRKQTQSNHKLDLIEKKPLN
YFKNVRAHYLNQQKYCNDSNCKHQNCHHFLINATNSQKENLDQIMKILINKQIF

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=178, Percent_Identity=34.2696629213483, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 24969; Mature: 24838

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKLISFEGIDGSGKTTLINELKAFFENKGYKTKVFQGLGSSIVGKEIRNLFLHQSKIS
CCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCC
PKTKYLLSLANMMQSQDELIIPALLSGCLVLVDRWYDSTFAYQSKGNYIDYDDKITSKII
HHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHH
NYFLIKPKLTFYLDIDPKIGLKRKQTQSNHKLDLIEKKPLNYFKNVRAHYLNQQKYCNDS
HHHEECCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCC
NCKHQNCHHFLINATNSQKENLDQIMKILINKQIF
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TNKLISFEGIDGSGKTTLINELKAFFENKGYKTKVFQGLGSSIVGKEIRNLFLHQSKIS
CCCEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCC
PKTKYLLSLANMMQSQDELIIPALLSGCLVLVDRWYDSTFAYQSKGNYIDYDDKITSKII
HHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHH
NYFLIKPKLTFYLDIDPKIGLKRKQTQSNHKLDLIEKKPLNYFKNVRAHYLNQQKYCNDS
HHHEECCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCC
NCKHQNCHHFLINATNSQKENLDQIMKILINKQIF
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA