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The map label for this gene is lysS [H]

Identifier: 134302700

GI number: 134302700

Start: 1780825

End: 1782507

Strand: Reverse

Name: lysS [H]

Synonym: FTW_1899

Alternate gene names: 134302700

Gene position: 1782507-1780825 (Counterclockwise)

Preceding gene: 134302701

Following gene: 134302694

Centisome position: 93.89

GC content: 35.83

Gene sequence:

>1683_bases
ATGAGTAGTAAATTAAAAGATTTGATAAAAACAACGATAAAAGAATATTTAGAAGCTAATGATATCACAGTTAAAGATGC
TATTAGAGGCAAGATTAGAGAGCAGATTAGTGAGTTTTTAGGCGAGGTAAGCGAGATAAATGAGCAGGTTAAAGAACAAA
TTTCAGCGCTTGTGAAAAAGCATGTAACAGAATTACAAGAAAGCTCACAAATTGCTTTAAGAAAAGAAAAGCTAAAAACT
TTAGCTCAGCAAAATAATGGCATAAGCCATCCAAATAGTTTCCGAAGAAATGCTGTTGCTATAGAGTTACAGGCTCGCTA
TGCTGATAAGACTAAGCAAGAATTAGAAGAGCTAGATAATAAACAACAATATAGTTTGACAGGTAGAGTAGTTCTACGCC
GTGTCATGGGTAAAGCATCTTTTATAACACTACAAGATTATACTGGTAGAATCCAAGTTTATCTAAAAAAGAGTGACTTG
CCAGATGGGCAATATGAAACTTTTAAGAATCTATGTGACTTGGGTGATATAGTTGGTATTACTGGTACTATGTTTAAGAC
AAATACTGGTGAACTTTCTGTTGAAGCAAATCACTTTGAGATTTTGACAAAGGCAATTCGTCCTTTGCCTGATAAATTCC
ATGGTTTGGCAGATCAAGAAATGAGATATCGTCAAAGATATGTTGATTTAATTACAAATGAAAAGGCAAGAGAAGTCTTT
AAAGTACGCTCAAAAGTTGTGAACTTTATCCGTAACTATTTTGATAGACTAGATTTTATGGAAGTAGAGACGCCGATGAT
GCATGTTTTGCAAGGTGGTGCTGCTGCTAAGCCATTTAAAACTCATCACAATGCTTTGGATATGCCTTTATATTTGCGTA
TTGCTCCAGAACTTTATCTAAAAAGACTAGTTGTTGGTGGTTTTGAGCGAGTTTATGAGATAAACCGTAATTTTAGAAAC
GAAGGTGTATCTTCACGCCATAATCCAGAATTTACAATGCTAGAGTTCTATATGGCGTATGCTGATTATAATGACCTTAT
GGATCTAACAGAAGATATGCTATCTAAACTTGTACAGGAAGTAATTGGTAGCGAGATACTTGAGTATGGTGAGTATAAAA
TCAACTTTGGTGGTAAGTACGAACGAATCTCAATGGTTGACTCAATTGTTAAGTATAATGATGATATTACCAAAGAAGAT
TTAGTAACATTTGAATCTGCTAAAAAGATTGCTGAGAAACTAAAAATAAAAGTTGAAGCTTACCATGAACTTGGACATTT
GATAAACGAAATATTTGAAGAAACTGTCGAGCATCAGCTTATTCAACCGACATTTATTACAGATTATCCAGCTGTAGTTT
CACCATTGGCGCGTAGACAAGACGGTAACCCTGAGTTTACCGATAGATTTGAGTTCTTTATTGGAGCACGTGAAGTTGCT
AACGGCTTCTCTGAGCTAAATGATGCTGAAGATCAAGCAGAGCGTTTCAGAAAACAGGTTGAAGCTGCGGCATCTGGAGA
TGATGAAGCTATGCCTTATGACAAAGACTATATCCGCGCACTAGAGTATGGTATGCCTCCTACAGCGGGACAAGGAATCG
GTATTGATAGACTGGTAATGTATCTAACAAACTCTCAATCAATTAGAGATGTGATTCTATTTCCGCATATGAAGCCTGAG
TAA

Upstream 100 bases:

>100_bases
CGCCAATTTGAAAATTGATTCAGATAGTTTTATTTTCTAATCATTTGTTTTTTTGGGGCTACTAATTGCTAATGTGCAAC
AAATAATTACAGGGTTTAAA

Downstream 100 bases:

>100_bases
AATATGTCAAAAAAAATTACTAAAATTTTTATTTAAAAATATTTATAGTCCAGATATTGTTTCTAAAAAATTTATTCAAA
AGTTTGTACACGCAGATTAT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MSSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKKHVTELQESSQIALRKEKLKT
LAQQNNGISHPNSFRRNAVAIELQARYADKTKQELEELDNKQQYSLTGRVVLRRVMGKASFITLQDYTGRIQVYLKKSDL
PDGQYETFKNLCDLGDIVGITGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYRQRYVDLITNEKAREVF
KVRSKVVNFIRNYFDRLDFMEVETPMMHVLQGGAAAKPFKTHHNALDMPLYLRIAPELYLKRLVVGGFERVYEINRNFRN
EGVSSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQEVIGSEILEYGEYKINFGGKYERISMVDSIVKYNDDITKED
LVTFESAKKIAEKLKIKVEAYHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNPEFTDRFEFFIGAREVA
NGFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVMYLTNSQSIRDVILFPHMKPE

Sequences:

>Translated_560_residues
MSSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKKHVTELQESSQIALRKEKLKT
LAQQNNGISHPNSFRRNAVAIELQARYADKTKQELEELDNKQQYSLTGRVVLRRVMGKASFITLQDYTGRIQVYLKKSDL
PDGQYETFKNLCDLGDIVGITGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYRQRYVDLITNEKAREVF
KVRSKVVNFIRNYFDRLDFMEVETPMMHVLQGGAAAKPFKTHHNALDMPLYLRIAPELYLKRLVVGGFERVYEINRNFRN
EGVSSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQEVIGSEILEYGEYKINFGGKYERISMVDSIVKYNDDITKED
LVTFESAKKIAEKLKIKVEAYHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNPEFTDRFEFFIGAREVA
NGFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVMYLTNSQSIRDVILFPHMKPE
>Mature_559_residues
SSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKKHVTELQESSQIALRKEKLKTL
AQQNNGISHPNSFRRNAVAIELQARYADKTKQELEELDNKQQYSLTGRVVLRRVMGKASFITLQDYTGRIQVYLKKSDLP
DGQYETFKNLCDLGDIVGITGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYRQRYVDLITNEKAREVFK
VRSKVVNFIRNYFDRLDFMEVETPMMHVLQGGAAAKPFKTHHNALDMPLYLRIAPELYLKRLVVGGFERVYEINRNFRNE
GVSSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQEVIGSEILEYGEYKINFGGKYERISMVDSIVKYNDDITKEDL
VTFESAKKIAEKLKIKVEAYHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNPEFTDRFEFFIGAREVAN
GFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVMYLTNSQSIRDVILFPHMKPE

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=449, Percent_Identity=43.4298440979955, Blast_Score=381, Evalue=1e-105,
Organism=Homo sapiens, GI194272210, Length=449, Percent_Identity=43.4298440979955, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI45439306, Length=481, Percent_Identity=23.4927234927235, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI40789249, Length=261, Percent_Identity=25.6704980842912, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI226491502, Length=339, Percent_Identity=24.4837758112094, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790571, Length=487, Percent_Identity=60.9856262833676, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1789256, Length=493, Percent_Identity=60.2434077079107, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI87082379, Length=321, Percent_Identity=30.8411214953271, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788173, Length=263, Percent_Identity=27.7566539923954, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17535925, Length=534, Percent_Identity=38.5767790262172, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17535927, Length=534, Percent_Identity=38.5767790262172, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71994340, Length=485, Percent_Identity=41.0309278350515, Blast_Score=374, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17551876, Length=463, Percent_Identity=24.1900647948164, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32566633, Length=281, Percent_Identity=26.3345195729537, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320242, Length=519, Percent_Identity=41.4258188824663, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324256, Length=422, Percent_Identity=31.5165876777251, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323011, Length=500, Percent_Identity=25.4, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321807, Length=451, Percent_Identity=24.1685144124169, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325153, Length=269, Percent_Identity=26.0223048327138, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640849, Length=511, Percent_Identity=40.9001956947162, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24640851, Length=511, Percent_Identity=40.9001956947162, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI17136276, Length=458, Percent_Identity=22.4890829694323, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24584738, Length=264, Percent_Identity=28.7878787878788, Blast_Score=83, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 64556; Mature: 64425

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKK
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVTELQESSQIALRKEKLKTLAQQNNGISHPNSFRRNAVAIELQARYADKTKQELEELDN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCEEEEEEEHHHHHHHHHHHHHHCC
KQQYSLTGRVVLRRVMGKASFITLQDYTGRIQVYLKKSDLPDGQYETFKNLCDLGDIVGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
TGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYRQRYVDLITNEKAREVF
CCEEEECCCCCEEEECHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCHHHHHHH
KVRSKVVNFIRNYFDRLDFMEVETPMMHVLQGGAAAKPFKTHHNALDMPLYLRIAPELYL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCEEEEECHHHHH
KRLVVGGFERVYEINRNFRNEGVSSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGSEILEYGEYKINFGGKYERISMVDSIVKYNDDITKEDLVTFESAKKIAEKLKIKVEA
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNPEFTDRFEFFIGAREVA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
NGFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVM
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHH
YLTNSQSIRDVILFPHMKPE
HHCCCCCHHHEEECCCCCCC
>Mature Secondary Structure 
SSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKK
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVTELQESSQIALRKEKLKTLAQQNNGISHPNSFRRNAVAIELQARYADKTKQELEELDN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCEEEEEEEHHHHHHHHHHHHHHCC
KQQYSLTGRVVLRRVMGKASFITLQDYTGRIQVYLKKSDLPDGQYETFKNLCDLGDIVGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
TGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYRQRYVDLITNEKAREVF
CCEEEECCCCCEEEECHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCHHHHHHH
KVRSKVVNFIRNYFDRLDFMEVETPMMHVLQGGAAAKPFKTHHNALDMPLYLRIAPELYL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCEEEEECHHHHH
KRLVVGGFERVYEINRNFRNEGVSSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGSEILEYGEYKINFGGKYERISMVDSIVKYNDDITKEDLVTFESAKKIAEKLKIKVEA
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNPEFTDRFEFFIGAREVA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
NGFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVM
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHH
YLTNSQSIRDVILFPHMKPE
HHCCCCCHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA